Article
Critical Care Medicine
Julien Bohe, Hassane Abidi, Vincent Brunot, Amna Klich, Kada Klouche, Nicholas Sedillot, Xavier Tchenio, Jean-Pierre Quenot, Jean-Baptiste Roudaut, Nicolas Mottard, Fabrice Thiolliere, Jean Dellamonica, Florent Wallet, Bertrand Souweine, Alexandre Lautrette, Jean-Charles Preiser, Jean-Francois Timsit, Charles-Herve Vacheron, Ali Ait Hssain, Delphine Maucort-Boulch
Summary: This study aimed to compare individualized glucose control with conventional glucose control among ICU patients. While there were significant differences in glycemic control between the groups, the 90-day survival probability did not show significant differences. However, non-diabetic patients in the IC group had a higher risk of 90-day mortality compared to the CC group.
INTENSIVE CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Ailsa J. McKay, Laura H. Gunn, Thirunavukkarasu Sathish, Eszter Vamos, Manjula Nugawela, Azeem Majeed, German Molina, Sobha Sivaprasad
Summary: This study found that attainment of key primary care indicators such as HbA1c and blood pressure was negatively associated with the incidence of diabetic retinopathy (DR) among patients with type 2 diabetes in England. However, cholesterol indicator attainment showed no association. Attainment of these indicators was also associated with a lower incidence of sight-threatening diabetic retinopathy (STDR).
Article
Medicine, General & Internal
Hoda Atef Abdelsattar Ibrahim, Sherif Kaddah, Sara Mohamed Elkhateeb, Abeer Aboalazayem, Aya Ahmed Amin, Mahmoud M. Marei
Summary: The prevalence of glycaemic dysregulation is high in paediatric patients with acute surgical abdomen. Random blood sugar (RBS) has a significant correlation with total leucocytic count (TLC). HbA1c and RBS can be used as inflammatory markers for surgical acute abdomen.
ANNALS OF MEDICINE
(2023)
Article
Plant Sciences
Xiao-yan Chen, Wen-wen Jiang, Yan-ling Liu, Zhao-xia Ma, Jian-qiang Dai
Summary: This study shows that geniposide promotes wound healing in diabetic rats through its anti-inflammatory action, reducing inflammatory cell infiltration and fibroblast proliferation. It also modulates the expression levels of pro-inflammatory factors. Further research is needed to evaluate its antibacterial activity and effects on skin regeneration.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Health Care Sciences & Services
Ho-Ming Su, Wen-Hsien Lee, Ying-Chih Chen, Yi-Hsueh Liu, Jiun-Chi Huang, Pei-Yu Wu, Szu-Chia Chen
Summary: This study aimed to identify the major determinants of longitudinal change of HbA(1c) in non-diabetic patients. Factors such as new-onset hypertension, body mass index, glucose levels, cholesterol, and kidney function were found to be significantly associated with changes in HbA(1c) levels over time.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Xiandong Li, Chao Li, Mingchao Shi, Yang Qu, Longwen Huo, Zeyu Hao, Feixue Yue, Lin Gan, Shouchun Wang
Summary: The study found that ABG and FBG are independent predictors of poor functional outcome in patients with AIS undergoing MT, and FBG has a higher predictive ability than ABG and HbA1c.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Nutrition & Dietetics
Xinye Li, Wandia Kimita, Jaelim Cho, Juyeon Ko, Sakina H. Bharmal, Maxim S. Petrov
Summary: The study found that increased intake of dietary fiber was associated with reduced fasting plasma glucose levels in individuals with new-onset prediabetes or diabetes after acute pancreatitis. Specifically, intake of vegetables and nuts showed significant associations with lower fasting plasma glucose levels. Increasing dietary fiber intake, particularly from vegetables and nuts, may help prevent the development of new-onset diabetes after acute pancreatitis.
Article
Obstetrics & Gynecology
Jayakumari Chellamma, R. V. Jayakumar, Abilash Nair, C. Nirmala, Jabbar Puthiyaveettil Khadar, C. P. Vijayan, Asha Babu, Anjana Gopi
Summary: This study aimed to define the normal value of glycated haemoglobin (HbA1c) in non-diabetic pregnant women at term pregnancy. The results showed that the average HbA1c in non-diabetic pregnant women admitted for safe confinement was 5.00 (+/- 0.39) %. The reference range for normal HbA1c at term in these women was found to be 4.3-5.9%.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Gastroenterology & Hepatology
Irene Cacciola, Giuseppina Russo, Roberto Filomia, Concetta Pitrone, Gaia Caccamo, Annalisa Giandalia, Angela Alibrandi, Maria Stella Franze, Serena Porcari, Sergio Maimone, Carlo Saitta, Giovanni Squadrito, Giovanni Raimondo
Summary: The study found that DAA-based HCV cure leads to a significant and persistent improvement in glycemic control in HCV/diabetic patients with chronic hepatitis, while only providing a transient benefit for cirrhotic HCV/diabetic subjects.
LIVER INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Yuta Hamamoto, Kazuhisa Ouhara, Tsuyoshi Miyagawa, Tomoaki Shintani, Nao Komatsu, Mikihito Kajiya, Shinji Matsuda, Tsuyoshi Fujita, Shinya Sasaki, Tomoyuki Iwata, Haruya Ohno, Masayasu Yoneda, Noriyoshi Mizuno, Hidemi Kurihara
Summary: This study investigated the relationship between masticatory disorders and diabetic microvascular complications. The results showed that patients with type 2 diabetes who had diabetic neuropathy had significantly reduced masticatory efficiency. Effective mastication is an important factor in successful diet therapy for diabetes, and for patients with diabetic neuropathy, it may be necessary to combine individualized therapies from dentists and nutritionists, taking into consideration the level of masticatory dysfunction, to prevent the progression of diabetic complications.
Review
Nutrition & Dietetics
Omorogieva Ojo, Xiaohua Wang, Osarhumwese Osaretin Ojo, Joanne Brooke, Yiqing Jiang, Qingqing Dong, Trevor Thompson
Summary: This study conducted a systematic review and network meta-analysis to examine the effects of prebiotics and oral antidiabetic agents on gut microbiome in patients with type 2 diabetes. The findings suggest that prebiotics have a significant impact in reducing HbA1c levels, while the effects on other indicators are not significant.
Article
Medicine, Research & Experimental
Xin Wang, Guangyu Wu, Dan Shen, Xia Zhang, Wenying Yang
Summary: This study aimed to investigate the level of, and risk factors for, residual hyperglycaemia in Chinese individuals with type 2 diabetes (T2D) who initiated basal insulin treatment. The results showed that some patients may still experience high blood glucose levels 3-6 months after initiating treatment, and higher glycated haemoglobin and lower fasting plasma glucose levels could be risk factors for residual hyperglycaemia.
ADVANCES IN THERAPY
(2022)
Article
Obstetrics & Gynecology
Catarina Chaves, Filipe M. Cunha, Mariana Martinho, Susana Garrido, Margarida Silva-Vieira, Catarina Estevinho, Anabela Melo, Odete Figueiredo, Ana Morgado, Claudia Nogueira, Maria C. Almeida, Margarida Almeida
Summary: This study aimed to investigate the association between first-trimester fasting glycaemia (FTG) and glycated haemoglobin (HbA1c) cut-off values with postpartum oral glucose tolerance test (OGTT) outcomes in women with hyperglycemia during pregnancy. The study found that FTG and HbA1c cut-off values of 99 mg/dL and 5.4% respectively were associated with lower likelihood of type 2 diabetes mellitus (T2DM), highlighting the importance of early pregnancy screening for undiagnosed diabetes.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Review
Endocrinology & Metabolism
Tabitha D. Thornton-Swan, Laura C. Armitage, Aisling M. Curtis, Andrew J. Farmer
Summary: This systematic review investigates the predictive value of random blood glucose testing during hospitalization for undiagnosed diabetes. The study found that in-hospital blood glucose screening can facilitate diabetes diagnosis and the proportion of hyperglycemic patients with undiagnosed diabetes varies substantially, suggesting a need for further research and standardization.
Article
Medicine, General & Internal
Fatima A. Elfaki, Rama M. Chandika, Saleha H. Kahlani, Huda H. Hakami, Ahlam Sh. Hakami, Abdulrahman A. Alsayegh, Abdulrahim Y. Dighriri, Husameldin E. Khalafalla
Summary: Saudi Arabia has a high number of diabetic patients, with the majority having poor glycemic control. Fruit consumption is associated with better control of HbA1c, while pastries/pizza consumption is linked to higher levels of HbA1c.
Article
Health Care Sciences & Services
Mathias Akugizibwe, Flavia Zalwango, Chaka Moreen Namulundu, Ivan Namakoola, Josephine Birungi, Joseph Okebe, Max Bachmann, Murdoch Jamie, Shabbar Jaffar, Marie Claire Van Hout
Summary: This study explores the impact of integrating HIV, diabetes, and hypertension care on HIV stigma dynamics in Uganda. It finds that integrated care reduces healthcare visits, costs, and stigma, improves patient-provider relationships, and enhances healthcare providers' capacity to manage multiple chronic conditions. However, challenges at the service level and societal discrimination among HIV patients remain.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Otorhinolaryngology
Elizabeth Mairenn Garden, Kala Kumaresan, Allan Clark, Carl Martin Philpott
Summary: This study aimed to scale and produce reference values for the Olfactory Disorders Questionnaire (ODQ) based on the severity of depression according to the Becks Depression Inventory (BDI). The results showed that the higher the ODQ score, the higher the risk of depression. These findings should guide clinical practice to ensure appropriate care and support is provided for those with olfactory dysfunction.
CLINICAL OTOLARYNGOLOGY
(2023)
Review
Endocrinology & Metabolism
Omar G. Mustafa, Masud Haq, Umesh Dashora, Erwin Castro, Ketan K. Dhatariya
Summary: Hyperosmolar Hyperglycaemic State (HHS) is a medical emergency with high mortality. It affects those with pre-existing/new type 2 diabetes mellitus and is increasingly seen in children/young adults. The treatment involves clinical assessment and monitoring, interventions, prevention of harm, and a gradual decline in osmolality and blood glucose levels.
Article
Gastroenterology & Hepatology
Emily W. Lopes, Simon S. M. Chan, Mingyang Song, Jonas F. Ludvigsson, Niclas Hakansson, Paul Lochhead, Allan Clark, Kristin E. Burke, Ashwin N. Ananthakrishnan, Amanda J. Cross, Domenico Palli, Manuela M. Bergmann, James M. Richter, Andrew T. Chan, Ola Olen, Alicja Wolk, Hamed Khalili
Summary: This study aimed to estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Using several cohorts in the US and Europe, the researchers created modifiable risk scores and healthy lifestyle scores, and found that a significant number of CD and UC cases could be prevented through lifestyle modification.
Article
Clinical Neurology
Toby Smith, Michael Mansfield, Sarah Hanson, Allie Welsh, Reema Khoury, Allan Clark, Emma Dures, Jo Adams
Summary: This study examines the use of informal support among people with chronic pain. The results show that individuals who receive informal care are primarily female, older, and have multiple medical conditions. The informal care provided often involves everyday activities and is most frequently provided by partners or children. Despite reporting greater disability and symptoms, there were no differences in health status, loneliness, or well-being between those who received care and those who did not.
BRITISH JOURNAL OF PAIN
(2023)
Article
Public, Environmental & Occupational Health
Mizanur Khondoker, Alexander Macgregor, Max O. Bachmann, Michael Hornberger, Chris Fox, Lee Shepstone
Summary: This study identified several multimorbidity clusters associated with the risk of developing dementia, including mental health, cardiometabolic, inflammatory/autoimmune, and cancer-related conditions. The highest risk was observed in clusters dominated by mental health and cardiometabolic conditions. Inflammatory/autoimmune cluster had an intermediate risk, while the cancer cluster had the lowest risk. Neither C reactive protein nor Apolipoprotein E genotype moderated the effects of multimorbidity clusters on dementia risk.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Medicine, General & Internal
Nan Zhao, Kritika Pandey, Skanthesh Lakshmanan, Ran Zhao, Jingchun Fan, Junhua Zhang, Max O. Bachmann, Hong Fan, Fujian Song
Summary: This study evaluated the main characteristics and result reporting of registered COVID-19 interventional trials of traditional Chinese medicine and traditional Indian medicine. Significant differences were found in design quality, target sample size, trial participants, and reporting of trial results between countries. COVID-19 trials of traditional medicine were less likely to report results compared to trials of conventional medicine.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Alistair Lumb, Shivani Misra, Gerry Rayman, Parizad Avari, Daniel Flanagan, Pratik Choudhary, Ketan Dhatariya
Summary: There is inconsistency in the use of technology to support inpatient diabetes care in the UK, despite the significant increase in the use of wearable diabetes technologies in the outpatient setting. An online survey revealed variation between organizations in terms of utilizing technology for safe and effective inpatient diabetes care. Guidance has been developed to drive improvements and ensure the proper use of technology, enhancing the safety and effectiveness of inpatient diabetes care.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Jingtong Huang, Andrea M. M. Yeung, Richard M. M. Bergenstal, Kristin Castorino, Eda Cengiz, Ketan Dhatariya, Isabella Niu, Jennifer L. L. Sherr, Guillermo E. E. Umpierrez, David C. C. Klonoff
Summary: Ketone bodies are produced by the liver and used in states of low carbohydrate availability. High ketone concentrations can be present in diabetic ketoacidosis. Beta-hydroxybutyrate is the main ketone in blood during DKA, while acetoacetate is the main ketone in urine as DKA resolves.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Otorhinolaryngology
Shyam A. Gokani, Andreas Espehana, Ana C. Pratas, Louis Luke, Ekta Sharma, Jennifer Mattock, Jelena Gavrilovic, Allan Clark, Tom Wileman, Carl M. Philpott
Summary: This study aimed to identify and summarize clinical studies of biomarkers in adults with chronic rhinosinusitis (CRS) to guide future research into CRS endotypes. The study identified numerous potential biomarkers for differentiating CRS phenotypes. Future studies should focus on the prognostic role of nasal tissue biomarkers or expand on the more limited studies of nasal secretions and nasal lavage fluid.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2023)
Article
Medicine, Research & Experimental
Nsika Sithole, Alison Castle, Siyabonga Nxumalo, Lusanda Mazibuko, Thabang Manyaapelo, Shafika Abrahams-Gessel, Siphephelo Dlamini, Dickman Gareta, Joanna Orne-Gliemann, Kathy Baisley, Max Bachmann, Nombulelo Magula, Thomas A. Gaziano, Mark J. Siedner
Summary: This is a study aimed at improving blood pressure control among hypertensive patients in rural South Africa through a technology-supported, community-based intervention. The study will compare three different strategies and evaluate their effectiveness, acceptability, fidelity, sustainability, and cost-effectiveness. The importance of this study lies in its potential to provide references for similar interventions and evaluations in rural and resource-limited areas.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Gastroenterology & Hepatology
Andreas Koulouris, Gabriella Baio, Allan Clark, Leo Alexandre
Summary: This study aimed to develop a risk prediction model for opioid use in patients with inoperable pancreatic cancer. The study found that opioid use is prevalent in this population and is associated with poor prognosis. The model based on clinical and radiological variables showed good discrimination and calibration.
Article
Multidisciplinary Sciences
Shyam Ajay Gokani, Matthew Jefferson, Jelena Gavrilovic, Allan Clark, Falk Hildebrand, Tom Wileman, Claire Hopkins, Carl Philpott
Summary: This study aims to correlate clinical parameters and treatment response with CRS endotypes by analyzing biomarkers in nasal tissue and bacterial swabs. It could provide the foundation for patient classification and predicting treatment outcomes.
Article
Medicine, Research & Experimental
Kala Kumaresan, Sara Bengtsson, Saber Sami, Allan Clark, Thomas Hummel, James Boardman, Juliet High, Rashed Sobhan, Carl Philpott
Summary: Smell loss is a common problem, and viral infections are the second most common cause. Smell loss can have negative impacts on quality of life, and effective therapeutic treatment options are lacking. Previous studies suggest the regenerative potential of vitamin A in olfactory receptor neurons. This study aims to compare intranasally delivered vitamin A with no intervention to determine its efficacy.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Respiratory System
Rebecca Ferris, Tun Maung, Christopher Atkins, Dayle Terrington, Allan Clark, Prasad Manivarmane, Andrew Wilson
Summary: This study aimed to test the repeatability of three patient reported outcome measures in people with sarcoidosis associated fatigue. The results showed good agreement between the baseline and 3-month measurements, indicating that these measures are reliable in assessing fatigue and health-related quality of life in this population over a period of 12 weeks.
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
(2023)