Article
Clinical Neurology
Merve Uyar, Susanne Lezius, Carsten Buhmann, Monika Poetter-Nerger, Robert Schulz, Stephanie Meier, Christian Gerloff, Jens Kuhle, Chi-un Choe
Summary: This study evaluated the relationship between diabetes and HbA1c levels with neuroaxonal damage and cognitive impairment in Parkinson's disease patients. The results showed that diabetes and high HbA1c levels were associated with increased neuroaxonal damage and cognitive impairment.
MOVEMENT DISORDERS
(2022)
Article
Endocrinology & Metabolism
Chen Long, Yaling Tang, Jiangsheng Huang, Suo Liu, Zhenhua Xing
Summary: This study found that increased variability in HbA1c and fasting glycemia is associated with a higher risk of severe hypoglycemic events in patients with T2DM. Fasting plasma glucose variability is a more sensitive indicator than HbA1c variability.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Mei -Huey Shiau, Baai-Shyun Hurng, Ying-Wei Wang, Chih-Jung Yeh
Summary: This study examined the association between socioeconomic position trajectories and frailty in the elderly population in Taiwan. The findings suggest that a disadvantaged life-course socioeconomic position is associated with increased risks of frailty in older age.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Medical Laboratory Technology
Michael Fang, Natalie Daya, Josef Coresh, Robert H. Christenson, Elizabeth Selvin
Summary: Glycated albumin has excellent diagnostic performance in identifying undiagnosed diabetes in the general population, suggesting its potential usefulness as an alternative test for diagnosing diabetes when standard tests are unavailable.
CLINICAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Magdalena Milewska, Zuzanna Przekop, Dorota Szostak-Wegierek, Mariola Chrzanowska, Filip Raciborski, Iwona Traczyk, Beata Irena Sinska, Boleslaw Samolinski
Summary: This study investigates the prevalence of sarcopenia in the elderly Polish population and its association with obesity and co-existing diseases. The results indicate a higher risk of sarcopenia in elderly women compared to men, which increases with age. The presence of co-existing diseases also increases the risk of sarcopenia in the elderly population.
Article
Geriatrics & Gerontology
Che Wang, Xinru Guo, Xieguanxuan Xu, Shuang Liang, Wenling Wang, Fanglei Zhu, Siyang Wang, Jie Wu, Li Zhang, Xuefeng Sun, Xiangmei Chen, Guangyan Cai
Summary: This study aimed to determine frailty-associated factors in elderly CKD I-IV patients and early identify and intervene in frailty of elderly CKD patients. The results showed that sarcopenia was independently associated with an increased risk for frailty in elderly CKD I-IV patients. Patients with sarcopenia, advanced age, high CKD stage, high waist-hip ratio, and low serum albumin level should be assessed for frailty.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Multidisciplinary Sciences
Piia Lavikainen, Emma Aarnio, Miika Linna, Kari Jalkanen, Hilkka Tirkkonen, Paivi Rautiainen, Tiina Laatikainen, Janne Martikainen
Summary: Customized treatments are crucial for improving health outcomes and maximizing treatment benefits for patients with diabetes. Identifying data-driven trajectories based on similarities in glycated haemoglobin patterns can provide insights into the clinical and economic relevance for different patient groups, enabling personalized medicine.
Article
Medicine, General & Internal
Tae Kyung Yoo, Mi Yeon Lee, Sul A. Lee, Eun Sun Cheong, Mi Hae Seo, Ki Chul Sung
Summary: Abnormal glucose metabolism, as indicated by HbA1c levels, is significantly associated with cancer-related mortality in non-diabetic individuals. The relationship between HbA1c levels and cancer-related mortality varies by cancer type, with some cancers showing positive associations and others showing inverse associations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rasoul Kowsar, Alireza Mansouri
Summary: This study used a multi-level approach to establish the relationship between diabetes, blood biochemical markers, age, and BMI. The findings identified BMI and HbA1c as the best predictors of T2D.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Y. Ma, X. Li, Y. Pan, R. Zhao, X. Wang, X. Jiang, S. Li
Summary: Cognitive frailty was found to be associated with falls in older people in a population-based longitudinal study. It may serve as a risk factor for falls, and early screening might be beneficial in fall prevention.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Brenda Bongaerts, Oliver Kuss, Fabrice Bonnet, Hungta Chen, Andrew Cooper, Peter Fenici, Marilia B. Gomes, Niklas Hammar, Linong Ji, Kamlesh Khunti, Jesus Medina, Antonio Nicolucci, Marina V. Shestakova, Hirotaka Watada, Wolfgang Rathmann
Summary: This study aimed to identify different HbA1c trajectories in T2D patients starting second-line glucose-lowering therapy. Four distinct trajectories were found, with most patients achieving stable good or highly improved long-term glycaemic control. However, one-fifth of participants showed moderate or poor glycaemic control during follow-up.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Joao Soares Felicio, Hana Andrade de Rider Britto, Pedro Celeira Cortez, Fabricio de Souza Resende, Manuela Nascimento de Lemos, Lorena Vilhena de Moraes, Vitoria Teixeira de Aquino, Fernanda de Souza Parente, Natercia Neves Marques de Queiroz, Joao Felicio Abrahao Neto, Angelica Leite de Alcantara, Wanderson Maia da Silva, Norberto Jorge Kzan de Souza Neto, Pedro Paulo Freire Piani, Icaro Jose Araujo de Souza, Lilian de Souza D'Albuquerque Silva, Maria Clara Neres Iunes de Oliveira, Nivin Mazen Said, Gabriela Nascimento de Lemos, Franciane Trindade Cunha de Melo, Daniela Lopes Gomes, Ana Carolina Contente Braga de Souza, Melissa de Sa Oliveira dos Reis, Valeria Suenya Galvao Leal, Isabel Jane Campos Lobato, Karem Mileo Felicio
Summary: Vitamin D levels are associated with glycemic control and diabetic kidney disease in patients with diabetes, independent of each other. Low levels of Vitamin D are correlated with higher rates of albuminuria in diabetic patients. Further studies are needed to confirm if the relationship between vitamin D levels and albuminuria precedes the loss of renal function in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Infectious Diseases
Peng Lu, Yu Zhang, Qiao Liu, Xianyan Ding, Wen Kong, Limei Zhu, Wei Lu
Summary: The study found that individuals with diabetes are at a higher risk of developing tuberculosis, especially when they are not overweight. Targeted screening should be considered based on these findings.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Fuxia Yang, Nan Li, Lu Yang, Jie Chang, Aijuan Yan, Wenshi Wei
Summary: The study revealed that pre-stroke frailty is an independent risk factor for 28-day mortality and 28-day or 1-year severe disability in elderly patients with acute cerebral infarction. Age, severity of cerebral infarction, and co-infection are also independent risk factors for 1-year mortality.
FRONTIERS IN NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Chiara Maccarone, Daniele Coraci, Andrea Bernini, Nicola Sarandria, Marta Rossella Valente, Anna Chiara Frigo, Yannis Dionyssiotis, Stefano Masiero
Summary: This study investigated the prevalence of sarcopenia in a cohort of patients over 65 with musculoskeletal conditions. Associations between sarcopenia and alterations in nutritional status and Body Mass Index (BMI) were also examined. The results showed that 46.1% of the patients had overt sarcopenia, and 10.1% had severe sarcopenia. There were significant associations between sarcopenia and lower values of BMI and Mini Nutritional Assessment (MNA). Customized and multidisciplinary rehabilitation programs are needed for elderly patients with musculoskeletal concerns.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Laurent Malisoux, Paul Gette, Anne Backes, Nicolas Delattre, Daniel Theisen
Summary: This study investigates the differences in running kinematics and kinetics between a stiff and soft version of running shoes, aiming to further understand the mechanisms behind the protective effects of greater cushioning. The results suggest that the stiff shoe version is associated with increased mechanical burden on the musculoskeletal system, particularly around the ankle joint.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Correction
Health Care Sciences & Services
Gloria A. Aguayo, Lu Zhang, Michel Vaillant, Moses Ngari, Magali Perquin, Valerie Moran, Laetitia Huiart, Rejko Krueger, Francisco Azuaje, Cyril Ferdynus, Guy Fagherazzi
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Severine Sabia, Archana Singh-Manoux
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Geriatrics & Gerontology
Benjamin Landre, Celine Ben Hassen, Mika Kivimaki, Mikaela Bloomberg, Aline Dugravot, Alexis Schniztler, Severine Sabia, Archana Singh-Manoux
Summary: This study examined changes in physical and mental functioning before the onset of frailty using repeat data spanning 25 years. The results showed that differences in trajectories of physical and mental functioning were observable 25 years before the onset of frailty. Furthermore, lower physical and mental functioning scores at age 50 were associated with an increased risk of developing frailty at older ages.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Medicine, General & Internal
Mathilde Chen, Benjamin Landre, Pedro Marques-Vidal, Vincent T. van Flees, April C. E. van Gennip, Mikaela Bloomberg, Manasa S. Yerramalla, Mohamed Amine Benadjaoud, Severine Sabia
Summary: The study found that monitoring the movement behaviors of older adults can predict their mortality risk, and these features are important for diversifying the guidelines for physical activity and sedentary behavior in older populations.
Article
Geriatrics & Gerontology
Mikaela Bloomberg, Aline Dugravot, Andrew Sommerlad, Mika Kivimaki, Archana Singh-Manoux, Severine Sabia
Summary: Education plays a crucial role in explaining sex differences in cognitive function, with middle-income countries showing larger disadvantages for females compared to the United States.
Article
Clinical Neurology
Celine Ben Hassen, Marcos D. Machado-Fragua, Benjamin Landre, Aurore Fayosse, Julien Dumurgier, Mika Kivimaki, Severine Sabia, Archana Singh-Manoux
Summary: This study found that abnormal lipid levels in midlife are associated with a higher risk of dementia in women, but only for events occurring after the first 20 years of follow-up. No associations were observed in men.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Emmanuel Cognat, Severine Sabia, Alexandra Fayel, Matthieu Lilamand, Ron Handels, Sara Fascendini, Sverre Bergh, Giovanni B. Frisoni, Andrea Fabbo, Magdalina Tsolaki, Lutz Frolich, Oliver Peters, Paola Merlo, Alfonso Ciccone, Patrizia Mecocci, Julien Dumurgier, Carlo A. Defanti, Jacques Hugon, Claire Paquet
Summary: A study found that the profiles of behavioral and psychological symptoms of dementia (BPSD) vary depending on etiology in patients with mild-to-moderate BPSD. However, it is not known if similar differences exist in patients with severe BPSD.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Marion Tharrey, Olivier Klein, Torsten Bohn, Laurent Malisoux, Camille Perchoux
Summary: Growing evidence suggests that exposure to greenspace has a positive effect on cardiometabolic health. This study investigated the long-term associations between residential greenness exposure and metabolic syndrome (MetS) and its components. Objective measures of greenness were used, and an increase in Soil-Adjusted Vegetation Index (SAVI) was found to help prevent MetS and improve HDL-cholesterol and fasting plasma glucose levels. However, the impact of increased greenness on cardiometabolic outcomes was mixed. Further longitudinal research is needed to better understand the effects of different types of greenness exposure.
Article
Endocrinology & Metabolism
Paul Collings, Anne A. Backes, Gloria Aguayo, Guy Fagherazzi, Laurent Malisoux
Summary: This study found that replacing sedentary time with moderate-to-vigorous physical activity (MVPA) is beneficially associated with adiposity and cardiometabolic health markers. Replacing sedentary time with light physical activity is effective in reducing body fat and fasting insulin, and has better predictive effects on triglycerides and apolipoprotein B/A1 ratio. Increasing sleep time, by reducing sedentary time, can lower obesity risk in short sleepers.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Clinical Neurology
Melina Regy, Aline Dugravot, Severine Sabia, Elodie Bouaziz-Amar, Claire Paquet, Bernard Hanseeuw, Archana Singh-Manoux, Julien Dumurgier
Summary: This study found that ATN profiles are associated with mortality, with patients showing isolated evidence of neurodegeneration having a higher short-term mortality rate, and AD patients having the highest long-term mortality rate.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Jonas R. Schaarup, Martin S. Christensen, Adam Hulman, Christian S. Hansen, Dorte Vistisen, Adam G. Tabak, Daniel R. Witte, Lasse Bjerg
Summary: This study examines the association between autonomic nervous function and arterial stiffness. The autonomic nervous function was evaluated using heart rate variability (HRV) indices and resting heart rate (rHR), while arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV). The results show that a decrease in HRV and unchanged rHR are associated with higher levels of PWV, especially in younger individuals.
Article
Cardiac & Cardiovascular Systems
Paul J. Collings, Anne Backes, Laurent Malisoux, ORISCAV LUX Study Grp
Summary: Reallocating time from sleep period, sedentary time, and light physical activity to moderate-to-vigorous physical activity (MVPA) is associated with lower carotid-femoral pulse wave velocity (cfPWV), which is beneficial for arterial health. For habitually short sleepers, reallocating sedentary time to the sleep period is also favorable.
Article
Neurosciences
Andres Gil-Salcedo, Aline Dugravot, Aurore Fayosse, Benjamin Landre, Manasa S. Yerramalla, Severine Sabia, Alexis Schnitzler
Summary: The study aims to evaluate the association between BMI and ADL, IADL and mobility limitations in post-stroke population at different ages, as well as the differences by sex. The results showed significant association between BMI and limitations in ADL, IADL and mobility in both men and women regardless of stroke status. The association differs between stroke and non-stroke patients, and also differs between men and women.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Marcos D. Machado-Fragua, Severine Sabia, Aurore Fayosse, Celine Ben Hassen, Frank Van der Heide, Mika Kivimaki, Archana Singh-Manoux
Summary: Metabolically healthy obesity before age 60 is associated with an increased risk of incident dementia, but this association disappears when metabolic health and obesity are assessed after the age of 70.