Article
Polymer Science
Won Lee, Nark-Kyoung Rho, Eun-Jung Yang
Summary: Although the mode of action of hyaluronic acid (HA) filler injections remains unclear, it is associated with various non-vascular inflammatory complications. Impurities in hyaluronic acid fillers may lead to an immune response. This study aimed to identify any impurities in hyaluronic acid fillers available on the market, and found contaminant particles such as silicon and aluminum isotopes.
Article
Surgery
Nazim Gumus, M. Baver Acaban, Hatice Oruc Demirbag
Summary: This study investigates the biological impact of hyaluronic acid (HA) in reshaping ear cartilage by injecting HA dermal filler in rabbit ears. The results show that HA can stimulate cartilage regeneration by increasing extracellular matrix synthesis and chondrogenesis, particularly in direct contact with the ear cartilage.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Dong Gil You, Jae Yoon An, Wooram Um, Jae Min Jung, Byeong Hoon Oh, Van Quy Nguyen, Jueun Jeon, Jungmi Lee, Dong-Gyu Jo, Yong Woo Cho, Jae Hyung Park
Summary: Hyaluronic acid-based hydrogels have the potential to reduce wrinkles, while stem cell-derived extracellular vesicles can improve the dermal microenvironment, prolong collagen generation, and serve as a potential antiaging filler for reprogramming the dermis environment.
Article
Medicine, General & Internal
Jonathan Arnold, Valerie L. Marmolejo
Summary: Vascular assessment is crucial for wound care, and current noninvasive vascular studies may not provide accurate perfusion information. Near-infrared imaging can offer additional diagnostic assessment for wounds where perfusion is a concern, but correct interpretation of these images is critical for clinical decision-making.
Article
Biochemistry & Molecular Biology
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park
Summary: The study showed that beta-ionone can mitigate the inhibitory effects of dexamethasone on collagen and hyaluronic acid synthesis in human dermal fibroblasts. It promoted collagen production and hyaluronic acid levels, while inhibiting cortisol binding to GR and subsequent GR signaling.
Article
Cell Biology
Ardeshir Abbasi, Nafiseh Pakravan, Zuhair Mohammad Hassan
Summary: Understanding the multifaceted effects of reactive oxygen species (ROS) on cancer cells is crucial in tumor biology. Studies show that high-dose treatment with H2O2 + HA is more effective in inducing apoptosis, reducing proliferation, and causing cell cycle arrest in 4T1 cancer cells under both normoxic and hypoxic conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Infectious Diseases
Demetris Savva, Gopi Battineni, Francesco Amenta, Giulio Nittari
Summary: The ongoing COVID-19 vaccination program presents an opportunity for public health authorities to navigate the current pandemic crisis. Reports have shown that hyaluronic acid soft tissue fillers may cause delayed inflammatory reactions following COVID-19 vaccination, emphasizing the importance of patient education prior to receiving such injections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Luciena Cegatto Martins Ortigosa, Fabiano Carvalho Lenzoni, Maria Victoria Suarez, Artur Antonio Duarte, Luiz Euribel Prestes-Carneiro
Summary: Brazil ranked second in the world for the number of aesthetic procedures carried out in 2019. This paper presents five case reports of delayed hypersensitivity reaction to hyaluronic acid dermal filler after COVID-19 vaccination. Additional vaccination for new variants, including omicron, will be necessary; therefore, aesthetic professionals should be aware of this possibility and advise patients accordingly.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Dermatology
Fernando Urdiales-Galvez, Francisco M. De cabo-Frances, Isabel Bove
Summary: Ultrasound examinations can help determine the nature of previous dermal filler procedures, with different patterns identified for different types of fillers. This valuable tool allows specialists to choose the best therapeutic approach for patients who have undergone aesthetic treatments in the past.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Jiajing Zhao, Ziwei Chen, Xiaoshuo Li, Zheren Tong, Zijin Xu, Peishi Feng, Ping Wang
Summary: This study investigated the properties of HA/PLA composite hydrogels as dermal fillers. The results showed that the composite hydrogel had enhanced biocompatibility and biological performance, with decreased stiffness and no adverse reactions. Additionally, it exhibited excellent anti-wrinkle effects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Surgery
Laszlo Mark Czumbel, Sandor Farkasdi, Noemi Gede, Alexandra Miko, Dezso Csupor, Anita Lukacs, Valeria Gaal, Szabolcs Kiss, Peter Hegyi, Gabor Varga
Summary: This study investigated the effectiveness of hyaluronic acid (HA) for lip augmentation through meta-analysis and systematic review and found that HA injection is an efficient method for increasing lip fullness for at least up to 6 months after augmentation. The majority of treatment-related adverse effects were mild or moderate, with a small number of serious adverse effects identified. More well-designed randomized controlled trials are still needed to strengthen the existing evidence.
FRONTIERS IN SURGERY
(2021)
Article
Medicine, Research & Experimental
Adam Green, Tanvir Hossain, David M. Eckmann
Summary: The study aimed to quantify the effects of HBOT on mitochondrial dynamics and bioenergetics in cells relevant to wound healing. It found that different HBOT conditions produced intracellular distinctions and inhomogeneities in mitochondrial function, leading to reduced cell motility and ATP-linked respiration. These effects were still present 6 hours after exposure, suggesting the need for alternative parameters to support intracellular bioenergy supply and wound healing.
Article
Dermatology
Ceyhun Arici, Zeynep Tosuner
Summary: Two patients presented with subcutaneous palpable masses in the lower eyelid area after hyaluronic acid filler injection. Surgical excision revealed foreign-body granulomatous reaction, consistent with the formation of dermal filler-related granulomas years after injection. Patients should be informed about the possibility of mass formation and clinicians should be vigilant for delayed hypersensitivity reactions.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Ophthalmology
A. Martel, J. Lagier, E. Sarfati, T. Malet, F. Rocher, A. Kauert, S. Baillif, B. Chignon-Sicard
Summary: This study presents a new case of filler-induced blindness (FIB) with partial visual recovery and introduces a personalized treatment algorithm based on fluorescein angiography findings. The treatment includes antiplatelet medication, steroids, intraocular pressure lowering medications, and hyperbaric oxygen treatment (HBOT).
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2022)
Article
Chemistry, Multidisciplinary
So-Jung Gwak, Yu Bin Lee, Eun Joo Lee, Kyoung Hwan Park, Sun-Woong Kang, Kang Moo Huh
Summary: The market for injectable dermal fillers is booming due to growing interest in appearance management. However, the durability and retention time of hyaluronic acid (HA) hydrogels, commonly used as fillers, are limited. This study introduces acetylated hyaluronic acid-divinyl sulfone (AcHA-DVS) hydrogels as a promising solution to improve the physical properties and gel retention time of HA fillers.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Respiratory System
Abilash Ravi, Saheli Chowdhury, Annemiek Dijkhuis, Barbara S. Dierdorp, Tamara Dekker, Rianne Kruize, Yanaika S. Sabogal Pineros, Christof J. Majoor, Peter J. Sterk, Rene Lutter
Summary: This study reveals that bronchial epithelial cells in asthma patients have a defective translocation of the translational repressor TIAR, resulting in epithelial hyperresponsiveness. This hyperresponsiveness is further increased upon exposure to rhinovirus and applies to the bronchoconstrictor endothelin-1, potentially contributing to airway obstruction.
