Journal
CURRENT MEDICINAL CHEMISTRY
Volume 26, Issue 22, Pages 4166-4177Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867324666170523140925
Keywords
Cardiovascular disease; diabetes; diabetic cardiomyopathy; calcium homeostasis; oxidative stress; endothelial dysfunction
Funding
- Spanish Ministry of Economy and Competitiveness [BFU2016-74932-C2-2-P, BFU2013-45564-C2-2-P]
- Institute of Health Carlos III (ISCIII) [PI15/00203]
- Andalusia Government [PI-0108-2012, PI -0313-2016, P10-CVI-6095]
- nonprofit foundation 'Fundacion Progreso y Salud' of the Andalusian Regional Ministry of Health
- Consejeria de Innovacion Ciencia y Empresa, Junta de Andalucia
- Spanish Ministry of Economy, Industry and Competitiveness
- Institute of Health Carlos III [RD12/0019/0028, RD16/0011/0034, PI16/00259]
- FEDER Funds
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The pathophysiology linking diabetes and cardiovascular disease (CND) is complex and multifactorial. The specific type of cardiomyopathy associated with diabetes, known as diabetic cardiomyopathy (DCM), is recognized as asymptomatic progression of structural and functional remodeling in the heart of diabetic patients in the absence of coronary atherosclerosis and hypertension. In other words, the presence of heart disease specifically in diabetic patients is also known as diabetic heart disease. This article reviews the impact of diabetes in heart and vascular beds focusing on molecular mechanisms involving the oxidative stress, the inflammation, the endothelium dysfunction and the alteration of the homeostasis of calcium, among others mechanisms. Understanding these mechanisms will help identify and treat CVD in patients with diabetes, as well as to plan efficient strategies to mitigate DCM impact in those patients.
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