Article
Endocrinology & Metabolism
D. Abdulkhalikova, A. Sustarsic, E. Vrtacnik Bokal, N. Jancar, M. Jensterle, T. Burnik Papler
Summary: This study aimed to investigate the effects of weight loss on the endometrium specific proteome, endocrine-metabolic characteristics, and motor capabilities of obese women with PCOS and infertility. The results showed increased protein abundance in certain proteins and decreased abundance in others in the endometrium after weight loss, as well as significant reductions in fasting blood glucose and free testosterone levels, and improvements in body composition and physical capacity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Valeria Calcaterra, Elvira Verduci, Hellas Cena, Vittoria Carlotta Magenes, Carolina Federica Todisco, Elisavietta Tenuta, Cristina Gregorio, Rachele De Giuseppe, Alessandra Bosetti, Elisabetta Di Profio, Gianvincenzo Zuccotti
Summary: PCOS is common in obese adolescents and is associated with insulin resistance. Early dietary intervention is recommended for these patients to restore ovulation and protect fertility.
Review
Biology
Chan-Hee Kim, Seon-Heui Lee
Summary: This study observed significant improvements in reproductive function and metabolic index in the group that underwent lifestyle modifications compared to the control group. The combination therapy of diet and exercise showed better results in improving insulin levels and menstrual cycles.
Article
Reproductive Biology
Mahtab Badri-Fariman, Amirmansour Alavi Naeini, Khadijeh Mirzaei, Ashraf Moeini, Mostafa Hosseini, Seyedeh Elaheh Bagheri, Milad Daneshi-Maskooni
Summary: The study found that food insecurity, quasi-western dietary patterns, low economic levels, and waist circumference were significantly associated with a higher risk of polycystic ovary syndrome (PCOS), while physical activity and healthy dietary patterns were negatively correlated with the risk of PCOS. PCOS patients had inadequate and unbalanced dietary intake of essential nutrients.
JOURNAL OF OVARIAN RESEARCH
(2021)
Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Cynthia Wan, Julia D. Xiong, Julia Michalak, Isabella B. Xavier, Kiran Ganga, Chau Thien Tay, Jessica A. Grieger, Stephen A. Parry, Lisa J. Moran, Marla E. Lujan
Summary: This study aimed to explore and compare the dietary and physical activity behaviors between women with polycystic ovary syndrome (PCOS) and those without PCOS. The findings indicated that women with PCOS had lower overall diet quality, poorer dietary intake (higher cholesterol and lower magnesium and zinc), and lower levels of physical activity compared to women without PCOS. These results highlight the need for targeted interventions to address these lifestyle behaviors in order to manage the complications associated with PCOS.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study demonstrated that in women with PCOS, lifestyle modifications combined with synbiotic supplementation can significantly decrease body weight, waist circumference, hip circumference, and thigh circumference, as well as lead to a significant reduction in serum testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study found that synbiotic supplementation can enhance the effects of lifestyle modifications on weight and testosterone levels in patients with PCOS, leading to significant improvements.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Nutrition & Dietetics
Wenqian Li, Chang Liu, Qingmei Yang, Ying Zhou, Min Liu, Hongying Shan
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease with unclear etiology. Hyperandrogenism interacts with insulin resistance and overweight/obesity, leading to ovulation disorders in PCOS. Oxidative stress (OS) is closely related to ovulation disorders in PCOS, and antioxidants can improve the OS state.
FRONTIERS IN NUTRITION
(2022)
Article
Obstetrics & Gynecology
Xinxia Chen, Emilia Koivuaho, Terhi T. Piltonen, Mika Gissler, Catharina Lavebratt
Summary: The study indicated that maternal PCOS/anovulatory infertility may lead to an increased risk of offspring obesity at early age and diabetes in female offspring during late adolescence. It also suggested that children of mothers with PCOS have an increased risk of subtle signs of cardiometabolic alterations.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Jin Yu, Yulai Zhou, Jie Ding, Danying Zhang, Chaoqin Yu, Hefeng Huang
Summary: This study aimed to investigate the metabolic characteristics of overweight women with PCOS and analyze the possible mechanisms. The results showed that overweight PCOS patients were prone to hypertension, diabetes, low gonadal levels, and insulin resistance. Inflammatory cytokines CXCL12/SDF-1, Serpin E1/PAI-1, and MIF were predicted to play a crucial role in inducing insulin resistance in overweight PCOS through various biological functions and signal transductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ida Marie Boisen, Anders Rehfeld, Iris Mos, Nadia Nicholine Poulsen, John Erik Nielsen, Peter Schwarz, Lars Rejnmark, Steen Dissing, Pernille Bach-Mortensen, Anders Juul, Hans Brauner-Osborne, Beate Lanske, Martin Blomberg Jensen
Summary: This study elucidates the important role of CaSR in human sperm, particularly in sensing calcium, magnesium, and bicarbonate ions, and participating in sperm activation and the acrosome reaction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Ban Sato, Seiya Kanai, Daiki Sakaguchi, Kodai Yajima, Yu Matsumoto, Kazunori Morohoshi, Shinji Kagaya, Nobuo Izumo, Minoru Ichinose, Woojin Kang, Mami Miyado, Kenji Miyado, Natsuko Kawano
Summary: LF supplementation ameliorates fertility problems in overweight mice but does not effectively reverse female infertility in obese mice.
Review
Endocrinology & Metabolism
Sarah Thornburgh, Audrey J. Gaskins
Summary: This review provides a comprehensive overview of the literature on B vitamins and fertility, with a focus on B vitamin supplementation and fertility outcomes among women with polycystic ovary syndrome (PCOS). The evidence suggests that B vitamins, particularly folate and vitamin B12, have a positive effect on fecundability and fertility in women. Furthermore, recent studies indicate that these effects may be even more pronounced in women with menstrual cycle dysfunction, a common symptom of PCOS. Intervention studies among PCOS women have shown that folic acid supplementation may improve metabolic profiles and potentially alleviate some hallmark features of PCOS. While none of these intervention studies have directly examined fertility outcomes, there is potential for B vitamin supplementation to improve reproductive health in PCOS women by reducing homocysteine levels or other clinical/biochemical features.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2022)
Article
Obstetrics & Gynecology
Christiane Lundegaard Haas, Anette Varbo, Peter Norkjaer Laursen, Volker Schnecke, Adam H. Balen
Summary: This study examines the associations between baseline BMI and change in body weight with the likelihood of pregnancy in women with PCOS. The results show that higher baseline BMI is associated with a lower chance of pregnancy, while weight loss is associated with an increased chance of pregnancy. The findings suggest that weight loss is beneficial for overweight/obese women with PCOS who are seeking to become pregnant.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara E. Stinson, Jens-Christian Holm, Torben Hansen, Marie-France Hivert, Klaus Bonnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Agostino Di Ciaula, Gabriella Garruti, David Q. -H. Wang, Piero Portincasa
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Maria De Angelis, Gabriella Garruti, Fabio Minervini, Leonilde Bonfrate, Piero Portincasa, Marco Gobbetti
CURRENT MEDICINAL CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Agostino Di Ciaula, Gabriella Garruti, Gema Fruhbeck, Maria De Angelis, Ornella de Bari, David Q-H Wang, Frank Lammert, Piero Portincasa
CURRENT MEDICINAL CHEMISTRY
(2019)
Review
Endocrinology & Metabolism
Angelo Cignarelli, Marco Castellana, Giorgio Castellana, Sebastio Francesco, Francesco Brescia, Annalisa Natalicchio, Gabriella Garruti, Luigi Laviola, Onofrio Resta, Francesco Giorgino
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Nutrition & Dietetics
Domenica Maria Di Palo, Gabriella Garruti, Agostino Di Ciaula, Emilio Molina-Molina, Harshitha Shanmugam, Maria De Angelis, Piero Portincasa
Review
Gastroenterology & Hepatology
Harshitha Shanmugam, Emilio Molina-Molina, Domenica Maria Di Palo, Maria Felicia Faienza, Agostino Di Ciaula, Gabriella Garruti, David Q-H Wang, Piero Portincasa
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2020)
Review
Biochemistry & Molecular Biology
Jacek Baj, Robert Sitarz, Marek Lokaj, Alicja Forma, Marcin Czeczelewski, Amr Maani, Gabriella Garruti
Article
Medicine, General & Internal
Harshitha Shanmugam, Agostino Di Ciaula, Domenica Maria Di Palo, Emilio Molina-Molina, Gabriella Garruti, Maria Felicia Faienza, Karel VanErpecum, Piero Portincasa
Summary: The study found that people in Europe generally gained weight during the lockdown period, with higher weight gain observed in Italy. Those with no physical activity and low adherence to the Mediterranean diet had a higher increase in body weight. Strict social containment measures may increase the risk of metabolic abnormalities in the medium to long term.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Piero Portincasa, Leonilde Bonfrate, David Q. -H. Wang, Gema Fruhbeck, Gabriella Garruti, Agostino Di Ciaula
Summary: Type 2 and type 1 diabetes are common endocrine disorders that are associated with gastrointestinal dysfunction and increased cancer risk. Metabolic alterations and gastrointestinal dysfunction can lead to symptoms in the upper and/or lower gastrointestinal tract, affecting a significant percentage of diabetic patients. Therefore, a comprehensive assessment of gastrointestinal function is important in the management of diabetes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Hala Abdallah, Mohamad Khalil, Ilaria Farella, Stephy JohnBritto, Elisa Lanza, Sergio Santoro, Gabriella Garruti, Piero Portincasa, Agostino Di Ciaula, Leonilde Bonfrate
Summary: This study assessed the effects of Ramadan intermittent fasting on anthropometric and metabolic indices, gastrointestinal symptoms, and motility. The results showed that Ramadan fasting decreased body weight, BMI, and waist circumference, improved gastrointestinal symptoms and motility, and also improved metabolic profile and insulin resistance.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Gabriella Garruti, Piero Portincasa
Summary: Obesity is a global epidemic caused by a combination of genetic predisposition and environmental factors. Gut microbiota plays a critical role in regulating energy metabolism, fat production and storage, as it serves as a major interface between external factors and internal mechanisms. Changes in microbiota composition are associated with overweight and obesity, leading to alterations in metabolic homeostasis, insulin resistance and chronic inflammation. Animal studies have identified specific genera and microbial-derived metabolites associated with different obesity phenotypes, but more longitudinal studies are needed in humans to confirm their effectiveness.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Medicine, General & Internal
Emilio Molina-Molina, Gabriella Garruti, Harshitha Shanmugam, Domenica Maria Di Palo, Ignazio Grattagliano, Tecla Mastronuzzi, Piero Portincasa
ROMANIAN JOURNAL OF INTERNAL MEDICINE
(2020)
Article
Medicine, General & Internal
Gabriella Garruti, Michele De Fazio, Palma Capuano, Gennaro Martinez, Maria T. Rotelli, Francesco Puglisi, Nicola Palasciano, Francesco Giorgino
ANNALS OF MEDICINE AND SURGERY
(2020)
Review
Critical Care Medicine
Piero Portincasa, Emilio Molina-Molina, Gabriella Garruti, David Q. -H. Wang
JOURNAL OF CRITICAL CARE MEDICINE
(2019)