Article
Environmental Sciences
Mauricio Ergas, Daniela Figueroa, Kurt Paschke, Mauricio A. Urbina, Jorge M. Navarro, Luis Vargas-Chacoff
Summary: The study found the potential presence of microplastics in the gastrointestinal tract of Antarctic and sub-Antarctic fish. Cellulose fibers were the most common type of microfiber found. The results suggest that laundry greywater discharges from human settlements are the main source of these pollutants in Antarctic fish.
MARINE POLLUTION BULLETIN
(2023)
Article
Fisheries
Luis Vargas-Chacoff, Francisco Dann, Kurt Paschke, Ricardo Oyarzun-Salazar, Daniela Nualart, Danixa Martinez, Jonathan M. Wilson, Pedro M. Guerreiro, Jorge M. Navarro
Summary: Global warming is affecting stenothermal sedentary intertidal fish species in Antarctica, specifically the Antarctic spiny plunderfish Harpagifer antarcticus. Research shows that freshening caused osmotic imbalances in H. antarcticus, affecting the transport and regulatory mechanisms of key organs.
JOURNAL OF FISH BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Danixa Martinez, Catalina Moncada-Kopp, Kurt Paschke, Jorge M. Navarro, Luis Vargas-Chacoff
Summary: The study demonstrates that Antarctic fish can induce cellular stress response in their tissues when exposed to thermal and saline variations, with the response mainly occurring in the liver and being influenced by both temperature and salinity.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Iltan Aklan, Nilufer Sayar-Atasoy, Fei Deng, Hyojin Kim, Yavuz Yavuz, Jacob Rysted, Connor Laule, Debbie Davis, Yulong Li, Deniz Atasoy
Summary: This study investigated the role of downstream neural circuits of serotonergic neurons in regulating feeding in rats. Using optogenetics and other methods, the researchers found that these circuits interact with satiety hormones, revealing the regulatory mechanisms of these hormones.
MOLECULAR METABOLISM
(2023)
Article
Multidisciplinary Sciences
Sarfraj Ahmad Siddiqui, Sanjay Singh, Atul Rawat, Md Arshad, Sudhir Kumar
Summary: Stress-related neuropsychiatric disorders affect nearly everyone worldwide, with females experiencing higher levels of stress and anxiety. The role of serotonin receptor in stress and anxiety is thought to contribute to the sex-based difference between male and female animals. The current preclinical study investigates the role of serotonin 5HT-5A and 5B receptor in stress and anxiety in male and female rodents, revealing a region-specific association between these receptors under stressful conditions.
Article
Biodiversity Conservation
Manuel Novillo, Eugenia Moreira, Gustavo Macchi, Esteban Barrera-Oro
Summary: Our study on the reproductive biology of Harpagifer antarcticus in Paradise Bay, Western Antarctic Peninsula, provided additional reproductive parameters and histological analysis of gonads, clarifying the spawning period of the species in the area. The research confirmed that H. antarcticus spawns during summer at this site, in contrast to an earlier spawning period at the South Orkney Islands. This suggests that environmental factors may influence the timing of reproduction in these populations.
Article
Biology
Julia Saravia, Kurt Paschke, Ricardo Oyarzun-Salazar, C-H Christina Cheng, Jorge M. Navarro, Luis Vargas-Chacoff
Summary: In experiments with Antarctic fish, two different heating rates had similar effects on stress responses at the molecular and physiological levels, with no significant difference in CTMax values between the two rates. The lack of up-regulated response of heat shock proteins and the general transcriptional pattern trending to downregulation were consistent findings, suggesting that the faster heating rate of 1 degrees C/min may be suitable for studying cold-adapted stenothermic fish without overestimating thermal tolerance or inducing damage from longer heat exposure.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jean E. M. Ramirez, Ahmed B. Alarabi, Fadi T. Khasawneh, Fatima Z. Alshbool
Summary: Serotonin amplifies platelet functional responses by binding to 5HT(2A)R. However, developing antagonists for 5HT(2A)R as therapeutic agents in cardiovascular diseases has been challenging. In this study, a custom-made 5HT(2A)RAb was found to block platelet function and protect against thrombogenesis without impairing normal hemostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Katarzyna D. D. Rosikon, Megan C. C. Bone, Hakeem O. O. Lawal
Summary: Neurotransmitters play a crucial role in signal transmission between neurons and their targets. Monoamine neurotransmitters like dopamine, serotonin, and histamine are present in both invertebrates and mammals and regulate key physiological functions. This review explores the known amine neurotransmitters in invertebrates and discusses their biological and modulatory functions.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kishore K. Joshi, Tarmie L. Matlack, Stephanie Pyonteck, Mehul Vora, Ralph Menzel, Christopher Rongo
Summary: Metazoans utilize protein homeostasis pathways to respond to adverse conditions, with the nervous system playing a role in regulating proteostasis in different tissues. This study reveals that Caenorhabditis elegans uses biogenic amine neurotransmitters to modulate UPS proteostasis in epithelia by promoting eicosanoid production through P450 monooxygenases, ultimately maintaining protein turnover.
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Fisheries
R. Oyarzun-Salazar, J. J. Rojas, J. P. Pontigo, O. Mardones, J. L. P. Munoz, P. Dantagnan, L. Vargas-Chacoff
Summary: The study found that E. maclovinus juveniles tolerate temperatures between 15 and 20 degrees Celsius, but temperatures of 25 degrees Celsius or higher could have lethal effects.
Article
Fisheries
Luis Vargas-Chacoff, Francisco Dann, Kurt Paschke, Ricardo Oyarzun-Salazar, Daniela Nualart, Danixa Martinez, Jonathan M. Wilson, Pedro M. Guerreiro, Jorge M. Navarro
Summary: Global warming is affecting stenothermal sedentary intertidal fish species in Antarctica, specifically the Antarctic spiny plunderfish Harpagifer antarcticus. Research shows that freshening caused osmotic imbalances in H. antarcticus, affecting the transport and regulatory mechanisms of key organs.
JOURNAL OF FISH BIOLOGY
(2021)
Article
Fisheries
F. J. Morera, J. Saravia, C. A. Loncoman, J. P. Pontigo, R. Oyarzun-Salazar, C. Contreras, C. Vargas-Lagos, J. L. Munoz, L. Vargas-Chacoff
Summary: Smoltification is a crucial stage in Atlantic salmon aquaculture, and the NKA test is currently used to determine fish adaptability to seawater. Research has shown that BK channel expression in gills decreases during smoltification on an industrial scale, suggesting a potential new complementary test for assessing the level of smoltification more precisely.
Article
Biochemistry & Molecular Biology
Danixa Martinez, Catalina Moncada-Kopp, Kurt Paschke, Jorge M. Navarro, Luis Vargas-Chacoff
Summary: The study demonstrates that Antarctic fish can induce cellular stress response in their tissues when exposed to thermal and saline variations, with the response mainly occurring in the liver and being influenced by both temperature and salinity.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Fisheries
Carolina Vargas-Lagos, Danixa Martinez, Jose Luis Munoz, Ricardo Enriquez, Francisco Morera, Luis Vargas-Chacoff
Summary: This study found that Francisella noatunensis can be horizontally transmitted between Atlantic salmon and Eleginops maclovinus. Infected fish showed changes in their immune response, while cohabitating fish did not. This research is important for understanding bacterial transmission mechanisms and preventing fish diseases.
Article
Fisheries
R. Oyarzun-Salazar, C. Vargas-Lagos, P. Orellana, P. Dantagnan, J. L. P. Munoz, A. Romero, L. Vargas-Chacoff
Summary: The study found that challenged with the pathogen of aquaculture relevance has a significant impact on the fatty acid profile of Eleginops maclovinus, especially the high dose of the pathogen has a greater effect on the fatty acid profile.
Article
Biochemistry & Molecular Biology
O. Mardones, R. Oyarzun-Salazar, B. S. Labbe, J. M. Miguez, L. Vargas-Chacoff, J. L. P. Munoz
Summary: This study evaluated the impact of food passage time on the secretion of serotonin and melatonin, as well as the activity of digestive enzymes, in the gastrointestinal tract of Atlantic salmon. The results showed that food passage time directly influences the secretion of serotonin and the activity of digestive enzymes, and the diet composition also regulates the gastrointestinal function of Atlantic salmon.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Fisheries
Daniela Diaz-Ibarrola, Danixa Martinez, Carolina Vargas-Lagos, Julia Saravia, Luis Vargas-Chacoff
Summary: This study discovered that different portions of the gut may have different immune responses to bacterial pathogens, indicating the importance of understanding the specific parts of the gut that are more susceptible to infection. This finding has significant implications for the development and modification of functional foods.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Adolfo Isla, Patricio Sanchez, Pamela Ruiz, Romina Albornoz, Juan P. Pontigo, Maria Cecilia Rauch, Christopher Hawes, Luis Vargas-Chacoff, Alejandro J. Yanez
Summary: Piscirickettsia salmonis infection in Atlantic salmon leads to changes in blood parameters, including decreased red blood cell count, increased white blood cell count, decreased iron and magnesium levels, as well as hepatotoxicity symptoms and decreased blood glucose levels. Monitoring these blood parameters can effectively monitor the physiological status of Atlantic salmon infected with Piscirickettsia salmonis.
JOURNAL OF FISH BIOLOGY
(2022)
Article
Fisheries
Julia Saravia, Kurt Paschke, Juan Pablo Pontigo, Daniela Nualart, Jorge M. Navarro, Luis Vargas-Chacoff
Summary: This study evaluated the innate immune response of Notothenioid fish under thermal stress, showing differences in response to high temperatures between species in vivo. Temperature had a minor effect on primary cell cultures, which primarily responded to condition and time.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Chi-Hing Christina Cheng, Angel G. Rivera-Colon, Bushra Fazal Minhas, Loralee Wilson, Niraj Rayamajhi, Luis Vargas-Chacoff, Julian M. Catchen
Summary: The genome of the basal South American notothenioid Eleginops maclovinus has been sequenced and compared with other fish genomes to determine its phylogenetic position as well as its relationship with Antarctic cryonotothenioids. The study also analyzed the repertoire of circadian rhythm genes in E. maclovinus and assessed their functionality. The findings support E. maclovinus as the closest sister species and ancestral proxy of cryonotothenioids.
Article
Biochemistry & Molecular Biology
Waldo Acevedo, Rodrigo Moran-Figueroa, Luis Vargas-Chacoff, Francisco J. Morera, Juan Pablo Pontigo
Summary: This study characterizes the NLRP3 inflammasome in Atlantic salmon through structural modeling, functional transcript expression determination, and transcriptome analysis. The results suggest a similar composition and function of the NLRP3 inflammasome in Atlantic salmon and mammals. The adaptation to seawater in Atlantic salmon leads to down-regulation of inflammasome-related genes and temporary detrimental effects on the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Daniela P. P. Nualart, Francisco Dann, Ricardo Oyarzun-Salazar, Francisco J. J. Morera, Luis Vargas-Chacoff
Summary: This study used primary cell cultures of the head kidney from three salmonid species to analyze their response to bacterial and viral stimuli and evaluate markers of the innate and adaptive immune response. The results showed that the head kidney primary cell cultures from the three species responded differently to different stimuli, indicating their potential role in immune responses and as targets of immunoregulatory factors.
Article
Agriculture, Dairy & Animal Science
Luis Vargas-Chacoff, Daniela Nualart, Carolina Vargas-Lagos, Francisco Dann, Jose Luis Munoz, Juan Pablo Pontigo
Summary: This study aims to determine the transcriptional effect of tryptophan and cortisol on primary cell cultures of salmon head and posterior kidney. Results indicate activation of the kynurenine pathway and serotonin activity when stimulated with tryptophan and cortisol. Understanding the activation pathway and its relationship with stress levels associated with fish culture is essential for reducing economic losses.
Article
Fisheries
Danixa Martinez, Daniela Nualart, Carlos Loncoman, Juan C. Opazo, Kattina Zabala, Francisco J. Morera, Gonzalo A. Mardones, Luis Vargas-Chacoff
Summary: This study investigates the role of HMG proteins in the immune response of fish, specifically focusing on BbX protein. The results show that BbX protein is highly expressed in the intestinal tissue and liver of E. maclovinus. In addition, BbX protein expression levels increase in response to P. salmonis injection and thermal stress. These findings suggest that BbX protein may play a role in the response mechanism to temperature and bacterial stimulation in fish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sang Hyuck Lee, Mi Ae Kim, Young Chang Sohn
Summary: This study characterized the CCAP signaling system in Pacific abalone and revealed its relationship with the calcium/PKC and cAMP/PKA signal transduction pathways. It provides new insights into the evolutionary origins of the NPS and OT/VP signaling systems in protostomes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Hanna Scheuffele, Erica V. Todd, John A. Donald, Timothy D. Clark
Summary: Global warming is causing an increase in extreme weather events, affecting ecosystems and the behavior of ectotherms. More research is needed to understand the impact of diurnal thermal variability and improve climate change predictions.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jaakko Haverinen, Ahmed Badr, Markus Eskelinen, Matti Vornanen
Summary: The acclimatization of certain ectothermic vertebrates to winter conditions involves reduced energy consumption, achieved through decreased movement activity, depression of cellular functions, or switching to anaerobic energy production. This study on crucian carp showed that winter-acclimatized fish exhibited lower metabolic rates and a shift to anaerobic energy production during anoxia. Winter dormancy in crucian carp is achieved through active reduction of energy consumption, a slowed metabolic rate, and a direct response to oxygen absence.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Maria Cruz Sueiro, Cynthia A. Awruch, Gustavo M. Somoza, Walter S. Svagelj, Maria G. Palacios
Summary: According to life-history theory, there might be different immunological strategies between reproductive and non-reproductive periods due to limited resources. Our study on two sympatric marine fish species, rockfish and sandperch, found that reproductive individuals showed lower immune function, but higher levels of natural antibodies in rockfish females, compared to their non-reproductive counterparts. On the other hand, reproductively active sandperch males showed lower levels of natural antibodies and higher neutrophil to lymphocyte ratio and spleen index compared to non-reproductive males. The study highlights the species-specific patterns of immunity and the potential influence of resource limitation and abiotic factors on immune trade-offs in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
James B. Cummins, Dane A. Crossley II
Summary: This study focuses on cardiovascular development in altricial bird species, which has been less studied compared to precocial species. The researchers investigated the cholinergic and adrenergic receptor mediated control of arterial blood pressure and heart rate in the neotropic cormorant. The findings suggest that both cholinergic and adrenergic tone play a role in cardiovascular regulation in embryonic birds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ru Xia, Hong-Kang Liu, Xi-Feng Liu, Xin Deng, Chuan-Jie Qin, Yuan-Fa He, Shi-Mei Lin, Yong-Jun Chen
Summary: This study cloned the genes encoding glucokinase and glucose-6-phosphatase catalytic subunit in largemouth bass, revealing their distribution and transcriptional regulation. The results showed that the functions of G6pc and Gck in LMB were highly conserved in evolution, and the interconversion of glucose and G6P in the liver was well regulated at the transcript level under high starch diet, but a futile cycle was induced after a glucose load.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)