Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 574, Issue -, Pages 44-51Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2019.04.060
Keywords
Nanoparticles; Self-assembly; Combined therapy; Real-time tracing; Cancer treatment
Categories
Funding
- National Natural Science Foundation of China [21703253, 21774132, 21877052, 31700706]
- Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province [BK20180030]
- Fundamental Research Funds for the Central Universities [JUSRP51712B]
- State Key Laboratory of Biochemical Engineering [2019KF-02]
- Max Planck Society International Partner Group Program
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Herein, an amphipathic polymeric photosensitizer, designated as PEGylated distyryl boron dipyrromethenes with real-time tracing property, is synthesized as a kind of multifunctional carrier to load drugs for combined photodynamic-chemo therapy. The hydrophilic PEG side chains on the carriers prolong its blood circulation time and the self-assembly capacity of PEGylated distyryl boron dipyrromethenes effectively solves the problem of low drug loading efficiency and difficulty in drug release. Meanwhile, with the assistance of the photochemical internalization effect more carriers are taken up and accumulate in the cancer cells. Moreover, the auto-fluorescence of BODIPY can trace and visualize the carriers in cells or tissues and the damage of reactive oxygen species (ROS) to the multidrug resistance (MDR) transporter proteins can overcome MDR in cancer chemotherapy. The IC50 of PEGylated BODIPY is 250 mu g/mL while the IC(50 )decreased to 100 mu g/mL for Dox@ PEGylated BODIPY. As shown in our experiment the self-carriers itself without loading other bioactive constituents can obviously inhibit the growth of cancer cells, and the therapeutic effect is improved after the loading of Dox, indicating the amphipathic polymeric photosensitizer with tracing and self-assembling properties a potential multifunctional cancer treatment platform.
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