Review
Immunology
Valeria Morales-Ruiz, Victor Hugo Juarez-Vaquera, Marcos Rosetti-Sciutto, Fausto Sanchez-Munoz, Laura Adalid-Peralta
Summary: This study compared the efficacy of intravenous immunoglobulin (IVIg) administration with corticosteroids, plasmapheresis, and placebo in treating autoimmune neurological diseases. The meta-analysis showed that IVIg treatment was beneficial for patient improvement compared to placebo, had similar effects to plasmapheresis, and had no significant difference in efficacy compared to corticosteroid treatment.
AUTOIMMUNITY REVIEWS
(2022)
Review
Health Care Sciences & Services
Daniel A. Rossignol, Richard E. Frye
Summary: IVIG treatment may be associated with improvements in ASD symptoms, including communication, irritability, hyperactivity, and cognition. However, there is significant variability among studies, and many are limited by the lack of standardized objective outcome measures. Further research is needed to determine the subset of children with ASD who may best respond to this treatment and to investigate potential biomarkers for identifying responsive candidates.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Nutrition & Dietetics
Chongxi Xu, Tong Yi, Siwen Tan, Hui Xu, Yu Hu, Junpeng Ma, Jianguo Xu
Summary: This study assessed the relationship between intravenous or oral vitamin C (Vit-C) therapy and reduced mortality in adults. The results showed that Vit-C treatment significantly reduced the risk of death in sepsis and COVID-19 patients. However, more clinical randomized controlled trials are needed to confirm the association between Vit-C and reduced COVID-19 mortality.
Review
Medicine, General & Internal
Yinglong Wu, Yiyong Wei, Donghang Zhang
Summary: This study aims to compare the analgesic effects of different doses of intravenous dexamethasone on peripheral nerve blocks (PNB) and provide evidence for dose selection.
Review
Nutrition & Dietetics
Huoyan Liang, Qingqing Mu, Wenju Sun, Liming Liu, Simin Qiu, Zili Xu, Yuqing Cui, Yan Yan, Tongwen Sun
Summary: This systematic review and meta-analysis showed that intravenous vitamin C (IVVC) treatment did not improve the 28-day mortality in septic patients. Subgroup analysis indicated a trend of reducing the 28-day mortality in patients with sepsis but not septic shock. IVVC monotherapy was found to decrease the 28-day mortality in septic patients. The study suggests that the combination therapy of Hydrocortisone, Ascorbic acid, Thiamine (HAT) is not superior to IVVC monotherapy for septic patients. Further research is needed to confirm these findings and explore the mechanisms underlying the enhanced efficacy of IVVC monotherapy in septic patients.
FRONTIERS IN NUTRITION
(2023)
Review
Virology
Robert Marcec, Vinko Michael Dodig, Igor Radanovic, Robert Likic
Summary: This systematic review and meta-analysis investigated the potential impact of intravenous immunoglobulin (IVIg) therapy on mortality and length of hospitalisation in adult COVID-19 patients. The results showed that IVIg therapy had no statistically significant effect on mortality or length of hospital stay. However, prospective studies suggested that IVIg may increase the length of hospitalisation in severe COVID-19 patients.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Review
Oncology
Chunyan Sun, Xiaohong Wang, Renyi Zhang, Lingjie Xu, Bin Wang, Jian Li
Summary: This systematic review and meta-analysis investigated the efficacy and safety of intravenous daratumumab (DARA IV) for the treatment of amyloid light-chain (AL) amyloidosis. The results showed that DARA IV treatment had a good response rate and survival rate for patients.
CANCER CELL INTERNATIONAL
(2022)
Review
Neurosciences
Yanbo Yang, Mingjia Chen, Da Wu, Yue Sun, Fan Jiang, Zhouqing Chen, Zhong Wang
Summary: This study evaluated the safety and efficacy of erenumab in patients with episodic migraine and prior migraine treatment failures. The results showed that erenumab significantly reduced monthly migraine days and increased response rate. Higher dosage of erenumab was associated with better efficacy outcomes, without increased risk of adverse events. There was no significant difference in safety outcomes between different dosage groups.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Immunology
Rudra Prosad Goswami, Soumendra Nath Haldar, Moumita Chatterjee, Pallavi RaaphorstVij, Anneke J. van der Kooi, Johan Lim, Joost Raaphorst, Danveer Bhadu, Chiara Gelardi, Maira Giovanna Danieli, Uma Kumar
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of immunoglobulin therapy in idiopathic inflammatory myopathy and juvenile dermatomyositis. The results showed that immunoglobulin therapy improved muscle strength, reduced cutaneous disease activity and dysphagia, and reduced the use of glucocorticoids and immunosuppressants. The therapy was generally safe with a low risk of infection.
AUTOIMMUNITY REVIEWS
(2022)
Review
Nursing
Tamy Colonetti, Isabela de Carvalho Florencio, Pamela Figueiredo, Laura Colonetti, Maria Laura Rodrigues Uggioni, Maria Ines da Rosa, Luciane B. Ceretta, Leonardo Roever, Antonio Jose Grande
Summary: This article critically reviews the scientific evidence of colostrum therapy in premature infants and explores its effects on the immune system. The results show that colostrum may increase lactoferrin levels in the urine of premature newborns after 1 week of intervention.
JOURNAL OF HUMAN LACTATION
(2022)
Review
Pediatrics
Gerasimos Panagiotis Milas, Vasileios Issaris
Summary: This meta-analysis found that proadrenomedullin levels are significantly elevated in neonates with sepsis compared to healthy neonates. Future prospective cohort studies are needed to further assess the diagnostic accuracy of proadrenomedullin in neonatal sepsis.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Ener Cagri Dinleyici, Georg Frey, Ermira Kola, Ulrike Wippermann, Artur Bauhofer, Alexander Staus, Peter Griffiths, Muhamad Azharry, Rinawati Rohsiswatmo
Summary: This article conducted a systematic review and meta-analysis to evaluate the clinical effectiveness of IgM-enriched immunoglobulin in pediatric patients and neonates with sepsis, and the results showed that this treatment method can reduce mortality rates. However, large randomized controlled trials are needed to further substantiate and evaluate these findings.
FRONTIERS IN PEDIATRICS
(2023)
Review
Physiology
Hidero Yoshimoto, Satoshi Fukui, Koki Higashio, Akira Endo, Akira Takasu, Kazuma Yamakawa
Summary: The optimal mean arterial pressure (MAP) target for patients with vasodilatory shock remains controversial. A meta-analysis of three randomized controlled trials including 3,357 patients showed no significant difference in all-cause mortality between lower (60-70 mmHg) and higher (>70 mmHg) MAP target groups. However, supraventricular arrhythmia was higher in the higher MAP group, and renal replacement therapy was reduced in the higher MAP group of patients with chronic hypertension.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Obstetrics & Gynecology
Nouf Alrowaily, Rohan D'Souza, Susan Dong, Soneya Chowdhury, Michelle Ryu, Stefania Ronzoni
Summary: This study evaluated the impact of antibiotic regimens for chorioamnionitis on maternal and neonatal outcomes. The results showed limited evidence to recommend prompt initiation of intrapartum antibiotics upon diagnosis of chorioamnionitis. Well-designed trials using standardized definitions and outcome measures are needed to inform clinical practice regarding the preferred antibiotic regimen, dose, and duration for optimizing maternal and neonatal outcomes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Chemistry, Multidisciplinary
Kun Liu, Lu Wang, Linxia Gong
Summary: This study conducted a meta-analysis of 12258 patients from nine retrospective studies to compare the efficacy of high-dose and low-dose aspirin in the treatment of Kawasaki disease. The results showed that low-dose aspirin plus intravenous immunoglobulin could be as effective as high-dose aspirin in preventing coronary artery abnormality, but high-dose aspirin might be related to reducing fever time and hospitalization time.
JOURNAL OF CHEMISTRY
(2022)