Review
Pediatrics
Fernando Moreno-Mateo, Sofia Hidalgo Perea, Karen Brandt Onel
Summary: Recent advancements in MRI imaging and understanding of pathophysiology have improved the diagnosis and treatment of CRMO, with TNF-alpha inhibitors and bisphosphonates showing promising results for symptomatic relief and normalization of bone morphology. Better knowledge of genetic and molecular factors may lead to early diagnosis and development of more effective individualized treatments in the future.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Bridget A. Rafferty, Pooja Thakrar
Summary: CNO/CRMO is an underrecognized autoinflammatory disorder of the skeletal system resulting from immune dysregulation. Diagnosis is often delayed due to vague symptoms and the lack of accepted diagnostic criteria or specific biomarkers. Untreated CRMO can lead to chronic skeletal deformities, arthritis, and chronic pain. Diagnosis requires MRI and WB-MRI. Treatment primarily involves antiinflammatory medications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Review
Immunology
Consolato M. Sergi, Elka Miller, Dina El Demellawy, Fan Shen, Mingyong Zhang
Summary: Chronic recurrent and multifocal osteomyelitis (CRMO) is a continuous autoinflammatory disorder commonly found in children and adolescents. Whole-body MRI plays a crucial role in diagnosing and monitoring the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Marie Robert, Anna Giolito, Heloise Reumaux, Linda Rossi-Semerano, Claire Guillemin, Louis Biarrotte, Damia Leguevaques, Alexandre Belot, Agnes Duquesne, Cecile Frachette, Audrey Laurent, Marine Desjonqueres, Jean-Paul Larbre, Caroline Galeotti, Isabelle Kone-Paut, Perrine Dusser
Summary: This study aimed to investigate the frequency, characteristics and treatment of extra-osseous (EO) manifestations in chronic recurrent multifocal osteomyelitis (CRMO) and whether different phenotypes can benefit from special management. The study included 133 CRMO patients and found that 67.7% of them had EO manifestations, primarily skin lesions, sacroiliitis, enthesitis, arthritis, and gastrointestinal manifestations. Patients with EO manifestations were more likely to be treated with biologics, and a significant number of them achieved complete remission under this treatment.
Article
Pediatrics
Dita Cebecauerova, Hana Malcova, Veronika Koukolska, Zuzana Kvicalova, Ondrej Soucek, Lukas Wagenknecht, Jiri Bronsky, Zdenek Sumnik, Martin Kyncl, Marek Cebecauer, Rudolf Horvath
Summary: Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory bone disorder predominantly affecting children, with associated extraosseous conditions such as psoriasis, inflammatory bowel disease, and arthritis. This study found that CRMO without extraosseous manifestations had a milder course compared to complex CRMO, which was more likely to require escalation to advanced therapy.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Clinical Neurology
Pia S. Zeiner, Leonhard Mann, Katharina Filipski, Tatjana Starzetz, Marie-Therese Forster, Michael W. Ronellenfitsch, Joachim P. Steinbach, Michel Mittelbronn, Marlies Wagner, Patrick N. Harter
Summary: This study retrospectively analyzed 15 patients with PML, finding that patients with MRI-defined iPML had a higher intensity of inflammation, while cPML patients also demonstrated inflammatory tissue alterations. Infiltration of CD163-positive microglia and macrophages correlated with PML lesion size.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Amisha Shah, Margalit Rosenkranz, Mahesh Thapa
Summary: CRMO is a distinct disease primarily affecting children and adolescents, with a waxing and waning course. About one third of patients have spinal involvement, with nonspecific clinical presentation and imaging features that can mimic other diseases. Imaging plays a crucial role in diagnosis and management of CRMO.
Article
Computer Science, Interdisciplinary Applications
Jakub Ceranka, Joris Wuts, Ophelye Chiabai, Frederic Lecouvet, Jef Vandemeulebroucke
Summary: A fully automated computer-aided diagnosis system for the detection and segmentation of metastatic bone disease using whole-body multi-parametric MRI is proposed. The system outperformed state-of-the-art methodologies, achieving a detection sensitivity of 63% with an average of 6.44 false positives per image, and an average lesion Dice coefficient of 0.53.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Medicine, General & Internal
Akshay Waghmode, Nikhith Soman, Aryan Gupta
Summary: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoimmune inflammatory condition that mainly affects children and young adults. Its typical features include recurrent severe bone pain and imaging findings suggestive of osteomyelitis or malignancy. Diagnosis of CRMO requires excluding other possibilities and considering various diagnostic criteria.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Sevinc Tasar, Betul Sozeri
Summary: This study evaluates the clinical and radiological findings of patients with chronic recurrent multifocal osteomyelitis (CRMO) and presents the benefits of using whole-body magnetic resonance imaging (WBMRI) in these patients and the changes made in the imaging technique. Coronary T1-weighted and sagittal STIR sequences are found to contribute significantly to the diagnosis of CRMO. While most patients can be diagnosed with lesions identified from coronal STIR images alone, a small percentage of patients require additional coronal T1-weighted and sagittal STIR sequences for a definite diagnosis.
MEDICAL JOURNAL OF BAKIRKOY
(2023)
Article
Pediatrics
Sarah J. Menashe, Ramesh S. Iyer, Anh-Vu Ngo, Natalie L. Rosenwasser, Yongdong Zhao, Ezekiel Maloney
Summary: This study retrospectively analyzed whole-body MRI results of CRMO patients and correlated them with clinical disease severity at initial rheumatology presentation. The results showed that CRMO lesions were mainly distributed in the pelvis and lower extremities, and the number of lesions detected on MRI at initial presentation had a significant correlation with disease severity. However, other MRI parameters did not correlate with disease severity.
PEDIATRIC RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sarah J. Menashe, Hassan Aboughalia, Yongdong Zhao, Anh-Vu Ngo, Jeffrey P. Otjen, Mahesh M. Thapa, Ramesh S. Iyer
Summary: CRMO is an autoinflammatory bone disease of childhood and adolescence characterized by episodic bone pain. Diagnosis relies heavily on whole-body MRI and differentiates the disease by excluding other disorders with overlapping imaging features.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Wu, Shuchang Zhou, Daniel S. Hippe, Haining Liu, Yujin Wang, Nina A. Mayr, William T. C. Yuh, Liming Xia, Stephen R. Bowen
Summary: The study found that DCE-MRI intensity histogram CoV was significantly associated with malignancy in patients with suspected lung cancer, potentially aiding in the diagnosis of pulmonary lesions and complementing TIC-derived DCE-MRI metrics. Further research is needed to confirm the diagnostic value of DCE-MRI intensity histogram analysis.
ACADEMIC RADIOLOGY
(2021)
Article
Pediatrics
Andressa Guariento, Parth Sharma, Savvas Andronikou
Summary: This study characterized the MR imaging features and patterns of pediatric spinal CRMO/CNO. The results showed that CRMO/CNO typically involves the thoracic spine, vertebral body edema is often focal at the superior vertebral body, and kyphosis and scoliosis occur in about a quarter of children at spinal disease recognition, with vertebral height loss in about a third.
PEDIATRIC RADIOLOGY
(2023)
Article
Rheumatology
Ivana Stojkic, Eric Rubin, Jay Lee, Ashley Sang Eun Lee, Ekemini Akan Ogbu
Summary: Chronic recurrent multifocal osteomyelitis is a rare inflammatory disease that affects children and adolescents. This case report describes an atypical presentation of the disease in an African-American adolescent male with recurrent swelling in the temporal region and skull involvement. The patient showed clinical and laboratory improvement after treatment with indomethacin and pamidronate.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)