Article
Oncology
Meghan E. Sise, Qiyu Wang, Harish Seethapathy, Daiana Moreno, Destiny Harden, R. Neal Smith, Ivy A. Rosales, Robert B. Colvin, Sarah Chute, Lynn D. Cornell, Sandra M. Herrmann, Riley Fadden, Ryan J. Sullivan, Nancy J. Yang, Sara Barmettler, Sophia Wells, Shruti Gupta, Alexandra-Chloe Villani, Kerry L. Reynolds, Jocelyn Farmer
Summary: Non-invasive biomarkers such as elevated sIL-2R level and flow cytometric markers of B and T cell dysregulation may aid in the diagnosis of immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Theodoros Michelakos, Filippos Kontos, Tomohiro Kurokawa, Lei Cai, Ananthan Sadagopan, Danielle Krijgsman, Wilko Weichert, Lindy G. Durrant, Peter J. K. Kuppen, Cristina R. Ferrone, Soldano Ferrone
Summary: The expression levels of HLA class I loci gene products were found to be associated with various genetic events and survival outcomes in colon and rectal cancer patients. Higher HLA-A expression in rectal tumors treated with neoadjuvant radiation and high HLA-B/C expression levels were independent predictors of favorable overall survival in colon and rectal cancer. T-cells and HLA-B/C antigens appeared to play a key role in controlling the growth of colon/rectal cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Allergy
Hui Li, Huaqi Wang, Leon Sokulsky, Shaoxia Liu, Rui Yang, Xiaojie Liu, Lujia Zhou, Juan Li, Chun Huang, Fangfang Li, Xu Lei, Hongxia Jia, Jiuling Cheng, Fuguang Li, Ming Yang, Guojun Zhang
Summary: This study identified significantly elevated levels of monocytes, CD8(+) T cells, and macrophages in the bronchoalveolar lavage fluid of patients with asthma exacerbation. Additionally, a complicated molecular framework involving a set of cytokines and intracellular transduction regulators shared across multiple cell clusters was discovered. Moreover, core exacerbation-associated modules activated included pathways such as eukaryotic initiation factor 2 signaling and C-X-C chemokine receptor type 4 signaling in specific cell populations associated with infection.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Rheumatology
Sara S. McCoy, Maxwell Parker, Ilya Gurevic, Rahul Das, Andrea Pennati, Jacques Galipeau
Summary: This study aimed to investigate the immunobiology of IFN-γ-exposed SG-MSCs and the role of the JAK1 and 2 inhibitor, ruxolitinib. The results showed that ruxolitinib inhibits the expression of SG-MSC immunomodulatory markers and chemokines induced by IFN-γ, and reverses IFN-γ-induced CD4(+) T cell chemotaxis. In addition, SG-MSCs were identified as a possible pathogenic cell type in Sjögren's disease due to the higher levels of IFN-γ. These findings support further research on the use of ruxolitinib to treat Sjögren's disease.
Article
Immunology
Sara De Biasi, Marco Mattioli, Marianna Meschiari, Domenico Lo Tartaro, Annamaria Paolini, Rebecca Borella, Anita Neroni, Lucia Fidanza, Stefano Busani, Massimo Girardis, Francesca Coppi, Anna Vittoria Mattioli, Giovanni Guaraldi, Cristina Mussini, Andrea Cossarizza, Lara Gibellini
Summary: There is growing evidence indicating that hyperinflammation, dysregulated T and B cell response, and cytokine storm contribute significantly to the immunopathogenesis of severe COVID-19. IL-6, a pro-inflammatory cytokine, is elevated during SARS-CoV-2 infection. Tocilizumab, an IL-6R blocker, has been shown to improve survival in critically ill patients. However, its effectiveness is still limited in some patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Sara Bjursten, Ankur Pandita, Zhiyuan Zhao, Charlotta Frojd, Lars Ny, Christer Jensen, Tobias Ullerstam, Henrik Jespersen, Jan Boren, Malin Levin, Henrik Zetterberg, Anna Rudin, Max Levin
Summary: This case report highlights the rapid eradication of melanoma brain metastases and the development of near-fatal encephalomyelitis following double immune checkpoint blockade. The expression of ICOS on CD4+ and CD8+ T cells may play a potential role in mediating encephalomyelitis and other serious immune-related adverse events. Early diagnosis of encephalitis could be facilitated by monitoring brain damage markers in blood.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Sambor Grygorczuk, Piotr Czupryna, Justyna Dunaj, Anna Moniuszko-Malinowska, Renata Swierzbinska, Slawomir Pancewicz
Summary: In patients with neuroborreliosis, chemotactic cytokines for T lymphocytes are significantly upregulated in the cerebrospinal fluid, with associations to clinical parameters such as CSF lymphocyte counts and blood-brain barrier disruption. Different cytokines play distinct inflammatory roles in the course of neuroborreliosis.
Article
Oncology
Nobuhiko Imahashi, Rafet Basar, Yuefan Huang, Fang Wang, Natalia Baran, Pinaki Prosad Banerjee, Junjun Lu, Ana Karen Nunez Cortes, Nadima Uprety, Emily Ensley, Luis Muniz-Feliciano, Tamara J. Laskowski, Judy S. Moyes, May Daher, Mayela Mendt, Lucila N. Kerbauy, Mayra Shanley, Li Li, Francesca Lorraine Wei Inng Lim, Hila Shaim, Ye Li, Marina Konopleva, Michael Green, Jennifer Wargo, Elizabeth J. Shpall, Ken Chen, Katayoun Rezvani
Summary: This study shows that activated B cells suppress T-cell responses through metabolic competition, including increased oxygen consumption and glucose deprivation. These findings provide new insights into immunometabolism and its potential implications for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Ming Zheng, Yi-Ming Li, Zhen-Yu Liu, Xin Zhang, Yinghui Zhou, Jian-Li Jiang, Ping Zhu, Xiang-Min Yang, Juan Tang, Zhi-Nan Chen
Summary: Immunotherapy targeting tumor-infiltrating lymphocytes has shown promising potential as a treatment for various cancers, but its efficacy varies across different cancer types and patients. The distribution of TIL-T and TIL-B cells and their interactions with the tumor microenvironment play a crucial role in determining the clinical outcomes. Understanding the prognostic significance of these factors can have important implications for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Jacob T. Bailey, Safiehkhatoon Moshkani, Catherine Rexhouse, Jesse L. Cimino, Michael D. Robek
Summary: Hepatitis B virus (HBV) is a leading cause of viral hepatitis with a significant impact on global mortality. Although there is currently no highly effective cure for chronic HBV infection, immunotherapy has emerged as a potential treatment option due to its association with HBV-specific immune responses. However, the lack of suitable animal models for studying HBV has posed challenges in understanding the natural immune response to the virus. This study used a mouse model of HBV replication and demonstrated the crucial role of CD4(+) T cells in the antibody-mediated clearance of HBsAg, as well as their ability to reverse HBsAg persistence.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Almagul Kurmanova, Gulfairuz Urazbayeva, Aigul Terlikbayeva, Damilya Salimbaeva, Ardak Ayazbekov
Summary: The study conducted a comparative analysis of specific immune cell subpopulations in the peripheral blood of pregnant women with pre-eclampsia during the third trimester. The findings indicated a statistically significant decrease in the levels of T and B lymphocytes with CD4, CD8, and CD19 receptors in pre-eclampsia patients, along with altered expression patterns of activation and apoptosis markers in T lymphocytes, emphasizing the potential diagnostic value of these receptor ratios in pre-eclampsia.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Oncology
Aubrey S. Smith, Hannah M. Knochelmann, Megan M. Wyatt, Guillermo O. Rangel Rivera, Amalia M. Rivera-Reyes, Connor J. Dwyer, Michael B. Ware, Anna C. Cole, David M. Neskey, Mark P. Rubinstein, Bei Liu, Jessica E. Thaxton, Eric Bartee, Chrystal M. Paulos
Summary: TLR agonists can be repurposed ex vivo to condition T cells, improving immunotherapy and revealing the vital role of B cells in the generation of potent CD8(+) T cell-based therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Yang Li, Hanying Huang, Ziang Zhu, Shuzhao Chen, Yang Liang, Lingling Shu
Summary: In this study, the correlation between TSC22D3 expression, immunoinfiltration, and prognostic significance in AML was evaluated. The results showed that knockdown of TSC22D3 significantly attenuated cell proliferation and increased sensitivity to Ara-c drugs. Furthermore, TSC22D3 inhibited the NF-kB/NLRP3 signaling pathway and reduced IL-1b release, thereby inhibiting macrophage polarization and attenuating the pro-inflammatory tumor microenvironment.
Review
Oncology
Joanna Motyka, Aleksandra Kicman, Monika Kulesza, Slawomir Lawicki
Summary: Currently, there is a constant search for tumor markers that can improve breast cancer diagnostics, especially in the early stages. Among the potential markers, chemokines have been found to be closely implicated in tumorigenesis and scientists have evaluated their usefulness in breast cancer diagnosis. This study summarizes the reports on the expression and peripheral blood concentration of ELR-positive CXC chemokines as potential markers and prognostic factors for breast cancer.
Article
Immunology
Manuela Baronio, Francesco Saettini, Luisa Gazzurelli, Stefano Rossi, Antonio Marzollo, Silvia Ricci, Daniele Zama, Boaz Palterer, Canessa Clementina, Lodi Lorenzo, Marco Chiarini, Alessandra Sottini, Luisa Imberti, Chiara Gorio, Linda Rossini, Raffaele Badolato, Alessandro Plebani, Daniele Moratto, Vassilios Lougaris
Summary: Our study found that patients with JS may experience significant numerical and maturational alterations in the T-, B-, and NK-cell compartments. These findings suggest that JS patients should be regularly monitored from an immunological point of view.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Pathology
Kyriakos Chatzopoulos, Vassiliki Kotoula, Georgia-Angeliki Koliou, Eleni Giannoulatou, Kyriaki Papadopoulou, Vasilios Karavasilis, Elissavet Pazarli, Stavroula Pervana, Georgia Kafiri, Georgios Tsoulfas, Sofia Chrisfafi, Helen Sgouramali, Pavlos Papakostas, Dimitrios Pectasides, Prodromos Hytiroglou, George Pentheroudakis, George Fountzilas
Summary: The study revealed associations between morphologic features and genotypes in primary and metastatic colorectal adenocarcinomas. Micronecrosis and brisk tumor-infiltrating lymphocytes were correlated with mutations in metastatic CRC, with implications for overall survival. The findings support a clonal evolution model in CRC metastases accompanied by intense host immune response.
Article
Oncology
Claire Petit, Benjamin Lacas, Jean-Pierre Pignon, Quynh Thu Le, Vincent Gregoire, Cai Grau, Allan Hackshaw, Bjorn Zackrisson, Mahesh K. B. Parmar, Ju-Whei Lee, Maria Grazia Ghi, Giuseppe Sanguineti, Stephane Temam, Maurice Cheugoua-Zanetsie, Brian O'Sullivan, Marshall R. Posner, Everett E. Vokes, Juan J. Cruz Hernandez, Zbigniew Szutkowski, Eric Lartigau, Volker Budach, Rafal Suwinski, Michael Poulsen, Shaleen Kumar, Sarbani Ghosh Laskar, Jean-Jacques Mazeron, Branislav Jeremic, John Simes, Lai-Ping Zhong, Jens Overgaard, Catherine Fortpied, Pedro Torres-Saavedra, Jean Bourhis, Anne Auperin, Pierre Blanchard
Summary: The network meta-analysis suggests that intensifying chemoradiotherapy, using hyperfractionated radiotherapy with concomitant chemotherapy or induction chemotherapy followed by chemoradiotherapy, could improve outcomes for locally advanced head and neck cancer patients.
Article
Oncology
Benjamin Lacas, Alexandra Carmel, Cecile Landais, Stuart J. Wong, Lisa Licitra, Jeffrey S. Tobias, Barbara Burtness, Maria Grazia Ghi, Ezra E. W. Cohen, Cai Grau, Gregory Wolf, Ricardo Hitt, Renzo Corvo, Volker Budach, Shaleen Kumar, Sarbani Ghosh Laskar, Jean-Jacques Mazeron, Lai-Ping Zhong, Werner Dobrowsky, Pirus Ghadjar, Carlo Fallai, Branko Zakotnik, Atul Sharma, Rene-Jean Bensadoun, Maria Grazia Ruo Redda, Severine Racadot, George Fountzilas, David Brizel, Paolo Rovea, Athanassios Argiris, Zoltan Takacsi Nagy, Ju-Whei Lee, Catherine Fortpied, Jonathan Harris, Jean Bourhis, Anne Auperin, Pierre Blanchard, Jean-Pierre Pignon
Summary: The updated results of the study demonstrate the significant improvement in overall survival for head and neck cancer patients with the addition of concomitant chemotherapy, particularly for those with stage III or IV disease. Induction or adjuvant chemotherapy showed less benefit in increasing overall survival. Additionally, efficacy decreases with age progression.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Paraskevi Apostolou, Vasiliki Dellatola, Christos Papadimitriou, Despoina Kalfakakou, Elena Fountzilas, Eleni Faliakou, Georgios Fountzilas, Ourania Romanidou, Irene Konstantopoulou, Florentia Fostira
Summary: CHEK2 germline pathogenic variants are relatively common in Greek breast cancer patients, with the majority of associated breast tumors being hormone receptor positive. Hormone therapy and mastectomy at diagnosis may improve overall survival, and adherence to guidelines for treatment choices is recommended based on the evidence presented.
Article
Oncology
Elena Fountzilas, Sofia Lampaki, Georgia-Angeliki Koliou, Anna Koumarianou, Sofia Levva, Anastasios Vagionas, Athina Christopoulou, Athanasios Laloysis, Amanda Psyrri, Ioannis Binas, Giannis Mountzios, Nikolaos Kentepozidis, Athanassios Kotsakis, Emmanouil Saloustros, Anastasios Boutis, Adamantia Nikolaidi, George Fountzilas, Vassilis Georgoulias, Miltiadis Chrysanthidis, Elias Kotteas, Henry Vo, Marinos Tsiatas, Eleni Res, Helena Linardou, Dimitrios Daoussis, Iliada Bompolaki, Anna Andreadou, George Papaxoinis, Dionisios Spyratos, Helen Gogas, Konstantinos N. Syrigos, Dimitrios Bafaloukos
Summary: The study indicates that in cancer patients receiving ICI therapy, those with pre-existing AID often require monitoring and treatment for immune-related adverse events, but ICI treatment still carries manageable toxicity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Helena Linardou, Nikolaos Spanakis, Georgia-Angeliki Koliou, Athina Christopoulou, Sofia Karageorgopoulou, Nephely Alevra, Anastasios Vagionas, Nikolaos Tsoukalas, Stavroula Sgourou, Elena Fountzilas, Joseph Sgouros, Evangelia Razis, Dimitra Chatzokou, Sofia Lampaki, Eleni Res, Zacharenia Saridaki, Giannis Mountzios, George Saroglou, George Fountzilas
Summary: In cancer patients, despite a high seropositivity rate after receiving two vaccine doses, their antibody titers were significantly lower compared to healthy controls. Monitoring immune responses and understanding clinical factors influencing immunity could aid in adjusting vaccination strategies for vulnerable subgroups.
Article
Oncology
Elena Fountzilas, Vassiliki Kotoula, Georgia-Angeliki Koliou, Michalis Liontos, Kyriaki Papadopoulou, Eleni Giannoulatou, Alexios Papanikolaou, Ioannis Tikas, Sofia Chrisafi, Davide Mauri, Kyriakos Chatzopoulos, Florentia Fostira, Dimitrios Pectasides, Georgios Oikonomopoulos, Dimitra Aivazi, Angeliki Andrikopoulou, Anastasios Visvikis, Gerasimos Aravantinos, Flora Zagouri, George Fountzilas
Summary: The study aimed to improve the predictive accuracy of pathogenic variants in genes participating in the homologous recombination repair system in epithelial ovarian cancer patients by considering additional NGS metrics. The presence of clonal HRR-only variants was found to be associated with improved overall survival, highlighting the importance of variant clonality in predicting outcomes for platinum agents in EOC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
P. Garrido, A. A. Adjei, J. Bajpai, S. Banerjee, A. S. Berghoff, S. P. Choo, E. Felip, A. J. S. Furness, E. Garralda, J. Haanen, A. Letsch, H. Linardou, S. Peters, C. Sessa, J. Tabernero, J. Tsang, J. C-H Yang, M. C. Garassino
Summary: The COVID-19 pandemic has negatively impacted the professional and home lives of oncologists, especially women. Women spent more time on hospital and laboratory tasks, while also dedicating less time to science and personal care compared to men. The reduced research time for female oncologists may have long-lasting career consequences, and the gender gap for promotion to leadership positions may widen further due to the pandemic.
Review
Oncology
Konstantinos Arvanitakis, Triantafyllia Koletsa, Ioannis Mitroulis, Georgios Germanidis
Summary: Hepatocellular carcinoma (HCC) is a major type of liver cancer, and inflammation plays a crucial role in tumor growth and metastasis through tumor-associated macrophages (TAMs). TAMs can have either anti-tumor or pro-tumor functions, and their presence is closely associated with HCC development. This review summarizes the role of TAMs in HCC pathogenesis and highlights their potential application in tumor therapy.
Article
Biochemistry & Molecular Biology
Elena Fountzilas, Maria Kouspou, Alexia Eliades, Kyriaki Papadopoulou, Evangelos Bournakis, Anna Goussia, Marinos Tsiatas, Achilleas Achilleos, Kyriakos Tsangaras, Gaetan Billioud, Charalambos Loizides, Christos Lemesios, Elena Kypri, Marios Ioannides, George Koumbaris, Sofia Levva, Ioannis Vakalopoulos, Athanasios Paliouras, Stavroula Pervana, Filippos Koinis, Redi Bumci, Athina Christopoulou, Soultana Meditskou, Amanda Psyrri, Ioannis Boukovinas, Anastasios Visvikis, Vasilios Karavasilis, George K. K. Koukoulis, Athanasios Kotsakis, Dimitrios Giannakis, George Fountzilas, Philippos C. C. Patsalis
Summary: The data on tumor molecular profiling of European patients with prostate cancer is limited. Our study aimed to assess the prevalence and significance of gene alterations in unselected patients with prostate cancer. We found that clinically relevant somatic gene alterations were present in a significant proportion of European patients with prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chrysostomos Avgeros, Aikaterini Patsatsi, Dimitrios Dimitriadis, Andigoni Malousi, Triantafyllia Koletsa, Despoina Papathemeli, Antonia Syrnioti, Paraskevi Avgerou, Elizabeth Lazaridou, Georgios Tzimagiorgis, Elisavet Georgiou
Summary: This study evaluates the plasma levels of miR-146a and miR-155 in Mycosis Fungoides (MF) patients and investigates their association with SNPs of their genes. The results show that the plasma levels of miR-146a and miR-155 are significantly higher in MF patients compared to controls, especially in early and advanced stages. miR-155 levels are significantly higher in patients with skin tumors or erythroderma. The presence of specific SNPs is associated with the expression of miRs and potentially with disease susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Daniel Paramythiotis, Filippos Kyriakidis, Eleni Karlafti, Triantafyllia Koletsa, Anastasia Tsakona, Petros Papalexis, Aristeidis Ioannidis, Petra Malliou, Smaro Netta, Antonios Michalopoulos
Summary: This article reports a rare case of coexistence of GISTs and AFAP. Multiple GISTs were found in the small intestine during surgery, in addition to colorectal cancer. This highlights the importance of appropriate screening for diseases like AFAP.
MEDICINA-LITHUANIA
(2022)
Article
Multidisciplinary Sciences
Vassiliki Kotoula, Kyriakos Chatzopoulos, Kyriaki Papadopoulou, Eleni Giannoulatou, Georgia-Angeliki Koliou, Vasilios Karavasilis, Elissavet Pazarli, Stavroula Pervana, Georgia Kafiri, Georgios Tsoulfas, Sofia Chrisafia, Helen Sgouramali, Pavlos Papakostas, Dimitrios Pectasides, Prodromos Hytiroglou, George Pentheroudakis, George Fountzilas
Summary: This study highlights the importance of comparing the genotypic and phenotypic differences in tumors from multiple tissue samples of the same patient. Using panel NGS genotyping for matched primary/metastatic tumors in colorectal cancer, the research provides datasets and method descriptions for understanding the nuances of FFPE tumor genotyping and investigating tumor evolution. The study emphasizes the application of tumor NGS genotyping in clinical diagnostic purposes and its significance in research for understanding disease evolution and treatment possibilities.