rAAV6-mediated miR-29b delivery suppresses renal fibrosis

First AAV gene therapy poised for landmark approval

(2017) Eric Smalley   NATURE BIOTECHNOLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Understanding the mechanisms of kidney fibrosis

(2015) Dong Zhou et al.   Nature Reviews Nephrology

rAAV9 combined with renal vein injection is optimal for kidney-targeted gene delivery: conclusion of a comparative study

(2014) C J Rocca et al.   GENE THERAPY

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

AAV-Mediated Gene Therapy for Research and Therapeutic Purposes

(2014) R. Jude Samulski et al.   Annual Review of Virology

MicroRNA-29b Inhibits Diabetic Nephropathy in db/db Mice

(2013) Hai-Yong Chen et al.   MOLECULAR THERAPY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

TGF- 1-Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

(2012) F. T. Borges et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

miRNA-29b Suppresses Prostate Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition Signaling

(2012) P. Ru et al.   MOLECULAR CANCER THERAPEUTICS

The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury

(2012) Alison J. Kriegel et al.   PHYSIOLOGICAL GENOMICS

TGF- /Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

(2011) W. Qin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Suppression of microRNA-29 Expression by TGF- 1 Promotes Collagen Expression and Renal Fibrosis

(2011) B. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Adeno-associated viral vector transduction of green fluorescent protein in kidney: effect of unilateral ureteric obstruction

(2008) Keiichi Ito et al.   BJU INTERNATIONAL

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY