Integrated Target‐Based and Phenotypic Screening Approaches for the Identification of Anti‐Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis

(2018) Surendra Dawadi et al.   ACS Medicinal Chemistry Letters

A high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis

(2017) Alyssa J. Manning et al.   METHODS

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

(2017) Keertan Dheda et al.   Lancet Respiratory Medicine

Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis

(2016) Olivia Vergnolle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy

(2015) Audrey L. Lamb   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis

(2015) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increasing the structural coverage of tuberculosis drug targets

(2015) Loren Baugh et al.   TUBERCULOSIS

Iron acquisition strategies in mycobacteria

(2015) Zhuo Fang et al.   TUBERCULOSIS

Iron-Regulated Protein HupB of Mycobacterium tuberculosis Positively Regulates Siderophore Biosynthesis and Is Essential for Growth in Macrophages

(2014) S. D. Pandey et al.   JOURNAL OF BACTERIOLOGY

Pharmacokinetic andIn VivoEfficacy Studies of the Mycobactin Biosynthesis Inhibitor Salicyl-AMS in Mice

(2013) Shichun Lun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Disruption of Mycobactin Biosynthesis Leads to Attenuation of Mycobacterium tuberculosis for Growth and Virulence

(2013) P. Vineel Reddy et al.   JOURNAL OF INFECTIOUS DISEASES

Development of Mycobacterium tuberculosis Whole Cell Screening Hits as Potential Antituberculosis Agents

(2013) Christopher B. Cooper   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists

(2013) Christelle Moreau et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Dual Read-Out Assay to Evaluate the Potency of Compounds Active against Mycobacterium tuberculosis

(2013) Juliane Ollinger et al.   PLoS One

Adenylating Enzymes in Mycobacterium tuberculosis as Drug Targets

(2012) Benjamin P. Duckworth et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Analyses of MbtB, MbtE, and MbtF Suggest Revisions to the Mycobactin Biosynthesis Pathway in Mycobacterium tuberculosis

(2012) M. D. McMahon et al.   JOURNAL OF BACTERIOLOGY

Mutational and Phylogenetic Analyses of the Mycobacterial mbt Gene Cluster

(2011) S. S. Chavadi et al.   JOURNAL OF BACTERIOLOGY

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Assessing compound binding to the Eg5 motor domain using a thermal shift assay

(2009) Patricia A. McDonnell et al.   ANALYTICAL BIOCHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY