Article
Agriculture, Dairy & Animal Science
Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Honglin Liu, Qifa Li
Summary: The study identified NORHA as a highly expressed lncRNA in atretic follicles, inducing granulosa cell apoptosis by influencing the activities of the miR-183-96-182 cluster and FoxO1 axis. This comprehensive perspective sheds light on lncRNA regulation of follicular atresia.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Shunshun Han, Jianping Wang, Can Cui, Chunlin Yu, Yao Zhang, Diyan Li, Menggen Ma, Huarui Du, Xiaosong Jiang, Qing Zhu, Chaowu Yang, Huadong Yin
Summary: This study explores the regulatory molecular mechanisms of follicular atresia in chickens and reveals the role of autophagy and apoptosis in this process. It also highlights the importance of fibromodulin in regulating autophagy and provides insights into broodiness and poultry production improvement.
Article
Cell Biology
Feng Yang, Qiang Liu, Yanhong Chen, Huizhen Ye, Han Wang, Shenming Zeng
Summary: The study conducted quantitative proteomic and phosphoproteomic analyses on ovarian follicular atresia in porcine, identifying potential biomarkers and pathways involved in the process. The findings suggest novel explanations for the regulation of follicular atresia by analyzing dynamic changes in protein expression and phosphorylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Kexin Wang, Xinyue Zhang, Miaosi Zhang, Xin Li, Jiao Xie, Suwen Liu, Qun Huang, Jilite Wang, Qingbin Guo, Hao Wang
Summary: Traditional Chinese medicines with hyperoside such as Acanthopanax senticosus and Crataegus pinnatifida have demonstrated anti-oxidative stress properties. Hyperoside, the main component of antioxidant herbs, may delay the onset of neurodegenerative diseases. This study investigated the therapeutic mechanism of hyperoside as a natural antioxidant against Alzheimer's disease in Caenorhabditis elegans and PC12 cells, showing its ability to reduce reactive oxygen species levels and neurotoxicity induced by A beta 42.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Dongmei Jiang, Chunyang Niu, Qian Sun, Xiaoguang An, Chengweng Ji, Weikang Ling, Liang Li, Hua Zhao, Chunchun Han, Hehe Liu, Jiwei Hu, Bo Kang
Summary: Oxidative stress is the main cause of ovarian dysfunction due to damage to granulosa cells (GCs). Ferritin heavy chain (FHC) may regulate ovarian function by mediating GCs apoptosis. However, the specific regulatory function of FHC in follicular GCs is still unclear.
Article
Biochemistry & Molecular Biology
Mengnan Ma, Huiming Wang, Yi Zhang, Jinbi Zhang, Jingge Liu, Zengxiang Pan
Summary: The study identified that ssc-circINHA-001 plays a role in resisting GC apoptosis by enhancing INHBA expression through adsorbing miR-214-5p, miR-7144-3p, and miR-9830-5p. Low expression of ssc-circINHA-001 increases free miRNAs, inhibits INHBA expression, and leads to GC apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Si Yang, Jie Chen, Bingchun Ma, Jinglei Wang, Jiaxiang Chen
Summary: LPC has been found to inhibit cell viability and induce apoptosis and autophagy in mouse ovarian granulosa cells, with the involvement of oxidative stress and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Dongmei Jiang, Xin Wang, Xuemin Zhou, Zelong Wang, Shuo Li, Qian Sun, Yilong Jiang, Chengweng Ji, Weikang Ling, Xiaoguang An, Bo Kang
Summary: This study investigated the effects of spermidine on oxidative stress and apoptosis in goose granulosa cells (GCs), and found that spermidine alleviated these effects by inducing autophagy. The results showed that spermidine could inhibit oxidative stress and apoptosis by regulating the expression of autophagy-related proteins.
Article
Agriculture, Multidisciplinary
Xuan Zhang, Yuanyuan Chen, Hongmin Li, Baobao Chen, Zhaojun Liu, Gang Wu, Chengyu Li, Rongyang Li, Yan Cao, Jiaqi Zhou, Ming Shen, Honglin Liu, Jingli Tao
Summary: The study found that Sulforaphane can alleviate the adverse effects of hypoxia on porcine granulosa cells by activating antioxidant defenses and mitophagy through nuclear factor erythroid 2-related factor 2 (NFE2L2).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Reproductive Biology
Zhengda Li, Ziyun Ruan, Yun Feng, Yanxin Wang, Jun Zhang, Canqiang Lu, Deshun Shi, Fenghua Lu
Summary: This study investigated the potential relationship between follicular atresia, granulosa cell autophagy, and N6-methyladenosine (m6A) modification. The findings revealed that autophagy in granulosa cells increased with the degree of follicle atresia, while the overall m6A level decreased. Rapamycin treatment induced atresia in cultured follicles, whereas 3-Methyladenine inhibited follicular atresia. The study also showed that METTL3 levels were lower and FTO levels were higher in progressed atretic follicle granulosa cells compared to healthy follicle granulosa cells. Overall, the results suggest that m6A modification can regulate autophagy in granulosa cells and play a role in the process of porcine follicular atresia.
Article
Cell Biology
Xiaowei Qin, Wenqing Dang, Xiaofeng Yang, Kai Wang, Ermias Kebreab, Lihua Lyu
Summary: The inactivation of protein neddylation has been found to play an important role in regulating the proliferation of sheep follicular granulosa cells. Inhibition of neddylation significantly attenuated cell proliferation and induced apoptosis in sheep follicular granulosa cells. Furthermore, neddylation inactivation affected multiple signaling pathways and mitochondrial functions, leading to changes in cell physiology.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Bo Zhai, Xu Li, Zhongli Zhao, Yang Cao, Xinxin Liu, Zheng Liu, Huihai Ma, Wenfa Lu
Summary: Melatonin is a potent scavenger of active oxygen and also functions as a reproductive hormone with regulatory effects on animal reproduction, particularly in the ovaries. The protective mechanisms of melatonin against oxidative damage in granulosa cells, especially in sheep, remain unclear. Our study explored the mechanisms of melatonin in alleviating apoptosis in sheep granulosa cells induced by H2O2 through the MAP3K8-FOS pathway.
Article
Biochemical Research Methods
Xin Shan, Tong Yu, Xu Yan, Jianling Wu, Yani Fan, Xiaoyu Guan, Fugui Fang, Yinghui Lin, Yunhai Zhang, Yunsheng Li, Ya Liu
Summary: This study identified proteins and pathways involved in porcine follicular atresia through protein labeling and mass spectrometry analysis, finding 399 differentially abundant proteins between healthy and atretic follicles. These results establish a foundation for elucidating the mechanism of follicular atresia in swine.
JOURNAL OF PROTEOMICS
(2021)
Article
Biochemistry & Molecular Biology
Gaoqing Xu, Yangyunyi Dong, Zhe Wang, He Ding, Jun Wang, Jing Zhao, Hongyu Liu, Wenfa Lv
Summary: The study found that melatonin can promote mitophagy and inhibit oxidative-stress-induced apoptosis and mitochondrial injury in bovine ovarian granulosa cells through the SIRT1/FoxO1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Weifeng Zhu, Ming Ge, Xiuyu Li, Jiangfeng Wang, PanPan Wang, Tiange Tai, Yuxi Wang, Jianxu Sun, Guangliang Shi
Summary: The study found that hyperoside inhibited spleen injury caused by zearalenone through its antioxidant and anti-apoptotic effects. This provides a new treatment option for immune system diseases caused by zearalenone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)