Article
Medicine, General & Internal
Xiaoyun Hu, Guosheng Yuan, Qi Li, Jing Huang, Xiao Cheng, Jinzhang Chen
Summary: High expression of DHX32 is associated with reduced overall survival in HCC patients. DHX32 upregulation induces EMT, promotes mobility and proliferation of HCC cells, and enhances tumor growth in vivo. Silencing DHX32 reverses EMT, inhibits malignancy behaviors of HCC cells, and suppresses tumor growth.
ANNALS OF MEDICINE
(2021)
Article
Cell Biology
Honglei Cui, Danfeng Guo, Xiaodan Zhang, Yaohua Zhu, Zhihui Wang, Yang Jin, Wenzhi Guo, Shuijun Zhang
Summary: The study revealed that ENO3 is significantly down-regulated in HCC patients and is related to poor prognosis. Overexpression of ENO3 inhibited the proliferative, migratory, and invasive abilities of HCC cells, while also inhibiting the EMT process. ENO3 further modulated the transcription of genes associated with proliferation and metastasis capacity of HCC cells by suppressing the Wnt/beta-catenin signal.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yanli Li, Yang Tian, Wei Zhong, Ning Wang, Yafeng Wang, Yan Zhang, Zhuangli Zhang, Jianbo Li, Fang Ma, Zhihong Zhao, Youmei Peng
Summary: The study revealed that Artemisia argyi essential oil (AAEO) effectively inhibits HCC metastasis by targeting DEPDC1, showing significant anti-metastatic effects with low toxicity in vivo.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tengfei Liu, Junming Yu, Chao Ge, Fangyu Zhao, Chunxiao Miao, Wenjiao Jin, Yang Su, Qin Geng, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li, Helei Hou, Hong Li
Summary: BAP31 promotes HCC metastasis by activating the AKT/beta-catenin/Snail pathway, serving as a potential prognostic biomarker and providing valuable information for HCC prognosis and treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chih-Ta Chen, Pei-Hua Wu, Chia-Chi Hu, Hsiao-Ching Nien, Jin-Town Wang, Jin-Chuan Sheu, Lu-Ping Chow
Summary: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths globally, with chronic liver inflammation being a major risk factor. The enzyme IDO1, activated by proinflammatory cytokines, plays a crucial role in modulating the tumor microenvironment and is significantly correlated with HCC. Functionally, IDO1 affects the proliferation and motility of HCC cells, potentially involving the AhR and beta-catenin pathways. These findings provide insights for developing more effective IDO1-targeted therapy for HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juan Kong, Di Li, Shidong Zhang, Huixia Zhang, Yuanyuan Fu, Bo Qian, Chunhua Bei, Shengkui Tan, Xiaonian Zhu
Summary: Okadaic acid (OA) has been found to promote the epithelial-mesenchymal transition (EMT) process of hepatocellular carcinoma cells, enhancing their invasion and migration abilities while decreasing the activity of protein phosphatase 2A (PP2A). This indicates that OA plays a role in promoting metastasis of HCC.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Jin-Wu Hu, Yue Yin, Yang Gao, Yan-Yan Nie, Pei-Yao Fu, Jia-Bin Cai, Kai Zhu, Cheng Huang, Xiao-Wu Huang, Xin-Rong Yang, Ya Cao, Shuang-Jian Qiu, Jia Fan, Jian Zhou
Summary: This study focused on characterizing the role of TM2D1 in hepatocellular carcinoma and found that high TM2D1 expression predicted unfavorable clinical outcomes. TM2D1 overexpression induced HCC cell proliferation, migration, and invasion by activating AKT and beta-catenin signaling, while TM2D1 depletion led to the opposite phenotype in HCC cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Ling Shen, Peng Gu, Chen Qiu, Wen-Tao Ding, Lei Zhang, Wan-Yue Cao, Zu-Yin Li, Bin Yan, Xing Sun
Summary: This study revealed that LPCAT1 is upregulated in HCC tissues and is associated with a poor prognosis in HCC patients. LPCAT1 promotes migration and invasion of HCC cells through regulating epithelial-mesenchymal transition markers. In vivo experiments confirmed that LPCAT1 promotes pulmonary metastasis of HCC and activates the Wnt/beta-catenin signaling pathway.
ANNALS OF HEPATOLOGY
(2022)
Article
Oncology
Lin-wen Wu, X. I. U. Hu
Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer related deaths worldwide. Understanding the cellular mechanisms driving HCC progression is crucial for early diagnosis and the development of novel therapeutic targets. SSNA1 expression was found to be up-regulated in HCC tissues and correlated with poor prognosis. Inhibition of the STAT3/EMT axis mediated by SSNA1 depletion prevented HCC cells from migrating and invading in vitro.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Wenzhou Ding, Ye Fan, Wenbo Jia, Xiongxiong Pan, Guoyong Han, Yao Zhang, Zhiqiang Chen, Yiwei Lu, Jinyi Wang, Jindao Wu, Xuehao Wang
Summary: The study revealed that FER overexpression in HCC is associated with unfavorable clinicopathological characteristics, and FER is regulated by miR-206 to promote cell growth and metastasis in HCC through the NF-κB signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zichang Dai, Qiyuan Huang, Xueran Huang, Chuiyu Zhu, Kashif Rafiq Zahid, Tiancai Liu, Qiuyan Li, Chunmei Wu, Minghui Peng, Xiangyan Xiao, Umar Raza, Nan Yu, Tao Zeng
Summary: The expression of KIN17 is significantly increased in HCC and is associated with tumor progression and metastasis. KIN17 promotes migration and invasion of HCC cells by stimulating the TGF-beta/Smad2 pathway. It could serve as a potential therapeutic target and prognostic biomarker in HCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Multidisciplinary Sciences
Pingping Hu, Bin Zong, Qian Chen, Rui Shao, Miao Chen, Yujie Yang, Genbao Shao
Summary: This study found that microtubule-associated protein 4 (MAP4) plays an important role in hepatocellular carcinoma (HCC). MAP4 overexpression enhanced the migration, invasion abilities, and epithelial mesenchymal transition (EMT) processes of HCC cells. Furthermore, MAP4 promotes HCC cell migration, invasion, and EMT by regulating the GSK38/8-catenin pathway.
Article
Oncology
Elisavet Lioulia, Panagiotis Mokos, Emmanuel Panteris, Dimitra Dafou
Summary: This study demonstrates the UBE2T/MAPK-ERK/beta-catenin axis as a critical regulator of cell state transition and EMT in HCC.
MOLECULAR ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoming Jiang, Zhe Chu, Yang Cao, Ying Tang, Ying Shi, Xu Shi
Summary: Hepatocellular carcinoma (HCC) is a common and deadly malignancy worldwide. This study found that the downregulation of PDLIM2 in HCC is associated with poor prognosis, and overexpressed PDLIM2 can inhibit HCC cell proliferation, migration, invasion, and EMT by regulating beta-catenin, suggesting PDLIM2 as a promising therapeutic target for HCC.
CANCER GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Kaicheng Yang, Jianguang Zhao, Shenghui Liu, Shasha Man
Summary: TFAP2A overexpression is observed in many cases of OSCC, and the key signaling pathway associated is the RELA-TFAP2A-Wnt/β-catenin pathway. It was found that upregulation of RELA can promote the progression of OSCC, and TFAP2A activates the Wnt/β-catenin signaling pathway by targeting the promoter regions of β-catenin. The study suggests that the RELA-TFAP2A-Wnt/β-catenin pathway is a potential target for reducing the aggressiveness of OSCC.
MOLECULAR CARCINOGENESIS
(2023)