News Item
Multidisciplinary Sciences
Ewen Callaway
Summary: Advancements in artificial intelligence enable researchers to create original molecules within seconds instead of months.
News Item
Multidisciplinary Sciences
Ewen Callaway
Summary: Microbial molecules from soil, seawater, and human bodies are among the least understood substances on Earth.
Article
Biology
Kelvin F. Cho, Shawn M. Gillespie, Nicholas A. Kalogriopoulos, Michael A. Quezada, Martin Jacko, Michelle Monje, Alice Y. Ting
Summary: In this study, the researchers developed a transcriptional recorder called TRACC, which detects cell-cell contacts and converts them into stable gene expression. TRACC showed high specificity and sensitivity in detecting cell-cell contacts and was successfully used to study interactions between neurons and glioma.
Article
Plant Sciences
Zeenat B. Noordally, Matthew M. Hindle, Sarah F. Martin, Daniel D. Seaton, T. Ian Simpson, Thierry Le Bihan, Andrew J. Millar
Summary: This study compared transcriptome data with partial proteome and phosphoproteome data from the alga Ostreococcus tauri. They found that 10% of quantified proteins and two-thirds of phosphorylated proteins showed rhythmic changes. Mathematical modeling indicated that light-stimulated protein synthesis could explain the clustering of protein peaks during the daytime. The study also observed anticipatory phosphorylation before dawn, suggesting clock-regulated phosphodawn prepares the cells for daytime functions.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Oncology
Rui Wu, Megan S. Lim
Summary: Anaplastic large cell lymphomas (ALCL) are mature T-cell neoplasms characterized by the expression of CD30 and anaplastic cytomorphology. ALCL can be classified into ALK+ ALCL, ALK- ALCL, and breast implant-associated ALCL (BI-ALCL). ALK-ALCLs are a heterogeneous group with different clinical, immunophenotypic, and genetic features. There are various genetic abnormalities and fusion partner genes identified in ALCL, and some remain to be characterized. This review also discusses the pathobiological features of primary cutaneous ALCL and recent insights into ALCL pathogenesis.
FRONTIERS IN ONCOLOGY
(2023)
News Item
Multidisciplinary Sciences
Ewen Callaway
Summary: AlphaFold neural network has created a 'totally transformative' database with over 350,000 structures from Homo sapiens and 20 model organisms.
Article
Environmental Sciences
Supatta Chueycham, Chantragan Srisomsap, Daranee Chokchaichamnankit, Jisnuson Svasti, Karin Hummel, Katharina Nobauer, Omid Hekmat, Ebrahim Razzazi-Fazeli, Sutin Kingtong
Summary: The study investigated the toxic effects of DDT on hooded oysters, revealing alterations in mantle tissue and differential expression of stress response and cytoskeletal proteins in response to DDT exposure. These findings improve understanding of DDT toxicity and the molecular response of oyster proteome to DDT exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Xin Cao, Kanmin Mao, Yanan Zhang, Miao Yang, Hongjuan Liu, Xinzheng Wang, Liping Hao
Summary: This study investigated the mechanism of hepatotoxicity induced by mercury chloride (HgCl2) using proteomics and network toxicology at the animal and cellular levels. HgCl2 showed significant hepatotoxicity in C57BL/6 mice and HepG2 cells, involving oxidative stress, mitochondrial dysfunction, and inflammatory infiltration. The differentially expressed proteins and enriched pathways provide potential biomarkers and insights into the mechanism of HgCl2-induced hepatotoxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jieying Liu, Tianle Li, Shunhao Zhang, Eryi Lu, Wei Qiao, Huimin Chen, Peng Liu, Xiaoyue Tang, Tianfan Cheng, Hui Chen
Summary: Periodontitis, a disease that leads to gum attachment loss and bone resorption, is caused by the imbalance of oral microbes in the human body. Macrophages, a type of immune cell, play a significant role in the disease by producing IFN beta in response to bacterial infection. This research explores the relationship between macrophages and periodontitis, as well as the role and mechanism of IFN beta on macrophages. IFN beta has the potential to induce the differentiation of macrophages and enhance the production of anti-inflammatory factors. The study also reveals that IL10, a cytokine, may be influenced by IFN beta and promote an anti-inflammatory response in periodontitis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Edgar Uhl, Friederike Wolff, Sriyash Mangal, Henry Dube, Esther Zanin
Summary: The research reveals that the versatile proteasome inhibitor MG132, inactivated with a photolabile protection group, can be restored with blue light irradiation, causing cancer cells to arrest during metaphase of the cell cycle or undergo apoptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Multidisciplinary Sciences
Farizatul Akmawati Yahya, Nur Fariesha Md Hashim, Daud Ahmad Israf Ali, Tham Chau Ling, Manraj Singh Cheema
Summary: Toxicology aims to understand and predict the adverse effects of chemicals and xenobiotics on biological systems. Systems toxicology, utilizing systems biology, can extrapolate and interrelate vast biological system data to better comprehend toxicology-related questions. Shifting from empirical, animal-based testing to a mechanistic understanding is essential for future advancements in toxicology.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Oncology
Konstantina Psatha, Laxmikanth Kollipara, Elias Drakos, Elena Deligianni, Konstantinos Brintakis, Eustratios Patsouris, Albert Sickmann, George Z. Rassidakis, Michalis Aivaliotis
Summary: The activation of wild-type p53 protein in human lymphoma is a promising therapeutic strategy. An in vitro integrative comparative multi-omics analysis of different lymphoma types before and after p53 activation can shed light on the molecular mechanisms involved. Our findings provide valuable insights into the role of specific proteins and pathways in lymphoma pathogenesis and the global effect of nutlin-3a, which can guide targeted studies on lymphoma progression and resistance.
Review
Cell Biology
Paul Dowling, Dieter Swandulla, Kay Ohlendieck
Summary: This review discusses the main bioanalytical methods used in the proteomic characterization of skeletal muscle tissues and the impact of skeletal muscle proteomics on whole-body physiology. Mass spectrometric studies have greatly improved our understanding of protein diversity and muscle tissue, which can be integrated with other omics-type methods to establish a systems biology view of skeletal muscle function.
Article
Biochemical Research Methods
Vicente Rojas, Luis F. Larrondo
Summary: Cell communication is a widespread mechanism in biology for transmitting information about environmental conditions. In this study, cell communication and optogenetics were coupled in yeast to modulate gene expression. The results showed that external light information can be propagated through diffusible signaling molecules to regulate gene expression in a synthetic system involving microbial cells.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yosui Nojima, Masahiko Aoki, Suyong Re, Hidekazu Hirano, Yuichi Abe, Ryohei Narumi, Satoshi Muraoka, Hirokazu Shoji, Kazufumi Honda, Takeshi Tomonaga, Kenji Mizuguchi, Narikazu Boku, Jun Adachi
Summary: This study investigated the anti-tumor efficacy of apatinib against gastric cancer cell lines and found that it differed among different cell lines. The study also revealed that apatinib acts as a multi-kinase inhibitor, predominantly targeting c-Kit. These findings contribute to a deeper understanding of the mechanism of action of apatinib in gastric cancer cells.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
