Article
Medicine, General & Internal
Nobuko Kitagawa, Noriyuki Kitagawa, Emi Ushigome, Hidetaka Ushigome, Isao Yokota, Naoko Nakanishi, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: The study found that IH-HSBP was associated with an increased risk of diabetic nephropathy among type 2 diabetes mellitus patients with normal or mildly increased albuminuria in the medium to long term. The results support and strengthen previous reports, suggesting that IH-HSBP might be a useful marker in disease prognostication.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Philip C. M. Au, Kathryn C. B. Tan, Bernard M. Y. Cheung, Ian C. K. Wong, Hang-Long Li, Ching-Lung Cheung
Summary: In a study conducted in Hong Kong, it was found that compared to dipeptidyl peptidase-4 inhibitors (DPP4is), the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes was associated with a reduced risk of end-stage renal disease and acute renal failure, as well as a slower decline in estimated glomerular filtration rate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem
Summary: Diabetic nephropathy is a common microvascular complication in type 1 diabetes mellitus. Urinary markers of renal damage or oxidative stress may signal early stages of DN, but their association with blood pressure patterns and glycemic variability in children is not yet well understood. This study found that while microalbuminuria was negative, urinary NGAL/Cr and pentosidine/Cr ratios were significantly elevated in diabetic patients. Additionally, poor nocturnal systolic blood pressure dipping was found in nearly half of the cases, and urinary NGAL/Cr negatively correlated with this dipping pattern. Both NGAL/Cr and pentosidine/Cr ratios were also higher in the high glycemic variability group. Overall, this pilot study highlights the potential role of ABPM and urinary markers in the early detection of diabetic nephropathy, with glycemic variability possibly playing a role in the disease process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yochai Birnbaum, Huan Chen, Dat Tran, Sven Nylander, Yumei Ye
Summary: The combination of dapagliflozin and ticagrelor has additive effects on diabetic nephropathy progression in BTBR ob/ob mice, associated with AMPK activation, reduced NLRP3 inflammasome activation, and increased Akt activation by dapagliflozin.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Huan Chen, Yochai Birnbaum, Regina Ye, Hsiu-Chiung Yang, Mandeep Bajaj, Yumei Ye
Summary: SGLT2 inhibitors increase plasma ketone concentrations and may induce ketoacidosis in diabetes patients. Dehydration can precipitate SGLT2 inhibitor-induced ketoacidosis in type-2 diabetes. Dapagliflozin attenuated the development of ketoacidosis and associated signaling pathways in T1DM mice.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Medicine, General & Internal
Habib Yaribeygi, Mohammad Amin Hemmati, Fatemeh Nasimi, Mina Maleki, Tannaz Jamialahmadi, Ivan Reiner, Zeljko Reiner, Amirhossein Sahebkar
Summary: Diabetic nephropathy involves oxidative stress as one of the main pathologic mechanisms. This study aimed to evaluate the effects of the SGLT2 inhibitor empagliflozin on oxidative stress and renal function in diabetes. Results showed that empagliflozin improved renal function by reducing urea, uric acid, and creatinine levels, increasing antioxidant capacity, and reducing oxidative damage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Aqsa Ashfaq, Myriam Meineck, Andrea Pautz, Ebru Arioglu-Inan, Julia Weinmann-Menke, Martin C. Michel
Summary: A systematic review of studies on SGLT2 inhibitors in rodent models of diabetes showed that these inhibitors not only improved glycemic control but also had various beneficial effects on renal function. These nephroprotective effects were observed in different animal models of type 1 and type 2 diabetes/obesity. SGLT2 inhibitors had positive effects on lipid metabolism, blood pressure, glomerulosclerosis, renal tubular fibrosis, apoptosis, oxidative stress, and inflammation, which are important pathomechanisms for atherosclerosis and renal health. However, more data on female animals and direct comparative studies with other anti-diabetic compounds are needed.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Peripheral Vascular Disease
Shinnosuke Hata, Emi Ushigome, Yukako Hosomi, Takashi Yoshimura, Maya Takegami, Nobuko Kitagawa, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui
Summary: Chronic high home blood pressure is associated with the progression of diabetic nephropathy, and RAAS inhibitors could attenuate the negative effect.
HYPERTENSION RESEARCH
(2023)
Article
Medicine, General & Internal
Cheng-Hung Lee, Chia- Tsai, Yi-Chang Su, Shih-Yi Lin, I-Te Lee, Tsai-Chung Li
Summary: This study found that body constitution independently predicts new-onset albuminuria in individuals with type 2 diabetes. Yin deficiency and phlegm stasis are associated with an increased risk of albuminuria, and this relationship is influenced by glucose control status.
Article
Medicine, General & Internal
Ling Li, Suping Wang, Guoding Huang, Jingyan You
Summary: This study evaluated the effects of a nurse-led program on blood glucose control and the incidence of microalbuminuria in patients with type 2 diabetes. The results showed that the nurse-led program significantly improved blood glucose control and reduced the incidence of microalbuminuria.
Article
Medicine, General & Internal
F. Jansson Sigfrids, E. H. Dahlstrom, C. Forsblom, N. Sandholm, V. Harjutsalo, M. -R. Taskinen, P. -H. Groop
Summary: Remnant cholesterol concentration, but not variability, predicts the progression of diabetic nephropathy and development of severe diabetic retinopathy in patients with type 1 diabetes. However, the causal relationship between remnant cholesterol and these outcomes remains to be elucidated.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Hidetaka Itoh, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Kentaro Kamiya, Atsuhiko Matsunaga, Junya Ako, Koichi Node, Hideo Yasunaga, Issei Komuro
Summary: This study compared the cardiovascular risk differences among individual sodium-glucose cotransporter-2 (SGLT2) inhibitors used for the treatment of diabetes mellitus (DM). The results showed no significant differences in the risks of developing heart failure, myocardial infarction, angina pectoris, stroke, and atrial fibrillation among different SGLT2 inhibitors.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Peripheral Vascular Disease
Jung-Im Shin, Alex R. Chang, Morgan E. Grams, Josef Coresh, Shoshana H. Ballew, Aditya Surapaneni, Kunihiro Matsushita, Henk J. G. Bilo, Juan J. Carrero, Gabriel Chodick, Kenn B. Daratha, Simerjot K. Jassal, Girish N. Nadkarni, Robert G. Nelson, Christoph Nowak, Nikita Stempniewicz, Keiichi Sumida, Jamie P. Traynor, Mark Woodward, Yingying Sang, Ron T. Gansevoort
Summary: Albuminuria is often overlooked in the definition, staging, and prognosis of chronic kidney disease. Despite similar risks of albuminuria between patients with hypertension and diabetes, screening for ACR is low in hypertensive patients. Regular albuminuria screening should be emphasized to enable early detection of chronic kidney disease and initiate treatment with cardiovascular and renal benefits.
Article
Endocrinology & Metabolism
Bruno Verges, Laurence Duvillard, Jean Paul Pais de Barros, Benjamin Bouillet, Sabine Baillot-Rudoni, Alexia Rouland, Jean Michel Petit, Pascal Degrace, Laurent Demizieux
Summary: The study showed that treatment with liraglutide significantly reduced plasma apoB100 and fasting triglyceride levels in patients with T2D, while also increasing the metabolism of triglyceride-rich lipoproteins and LDL. Liraglutide was found to modify gene expression related to apoB100-containing lipoprotein catabolism, potentially reducing cardiovascular risk in T2D patients.
Article
Biochemistry & Molecular Biology
Kazufumi Nakamura, Toru Miyoshi, Masashi Yoshida, Satoshi Akagi, Yukihiro Saito, Kentaro Ejiri, Naoaki Matsuo, Keishi Ichikawa, Keiichiro Iwasaki, Takanori Naito, Yusuke Namba, Masatoki Yoshida, Hiroki Sugiyama, Hiroshi Ito
Summary: There is a strong correlation between diabetes mellitus and heart failure, with diabetes serving as an independent risk factor for heart failure. The link between diabetes and heart failure is not only due to complications such as ischemic heart disease, but also metabolic disorders like glucose toxicity and lipotoxicity caused by insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Rheumatology
Shunichiro Tsukamoto, Naohito Okami, Takayuki Yamada, Kengo Azushima, Takahiro Yamaji, Sho Kinguchi, Kazushi Uneda, Tomohiko Kanaoka, Hiromichi Wakui, Kouichi Tamura
Summary: This systematic review examined the effects of different uric acid-lowering therapy (ULT) medications on kidney function in chronic kidney disease (CKD) patients. The results suggest that Topiroxostat and febuxostat may have better renoprotective effects compared to other ULT medications in CKD patients. Further large-scale, long-term studies are needed to confirm these findings and assess their impact on dialysis induction and major adverse cardiovascular events.
CLINICAL RHEUMATOLOGY
(2022)
Article
Cell Biology
James van der Wolde, Kotaro Haruhara, Victor G. Puelles, David Nikolic-Paterson, John F. Bertram, Luise A. Cullen-McEwen
Summary: This study investigated the progressive loss of podocytes during healthy aging and how the remaining podocytes respond to podocyte depletion at different ages. The results showed that podocyte number per glomerulus did not change in control mice during the examined time period but control mice at 18 months had the largest podocytes and the lowest podocyte density. Podocyte depletion at different ages resulted in different levels of albuminuria and glomerulosclerosis. In addition, the study found that the mTORC1-mediated podocyte hypertrophy played an important role in both physiological aging and adaptive settings.
CELL AND TISSUE RESEARCH
(2022)
Article
Urology & Nephrology
Kotaro Haruhara, Toru Suzuki, Hiromichi Wakui, Kengo Azushima, Daisuke Kurotaki, Wataru Kawase, Kazushi Uneda, Ryu Kobayashi, Kohji Ohki, Sho Kinguchi, Takahiro Yamaji, Ikuma Kato, Kenichi Ohashi, Akio Yamashita, Tomohiko Tamura, Nobuo Tsuboi, Takashi Yokoo, Kouichi Tamura
Summary: Tubular ATRAP-mediated modulation of angiotensin II type 1 receptor signaling affects glomerular manifestations of diabetic nephropathy.
KIDNEY INTERNATIONAL
(2022)
Article
Infectious Diseases
Reimi Mizushima, Kotaro Haruhara, Nei Fukasawa, Mari Satake, Akira Fukui, Kentaro Koike, Nobuo Tsuboi, Hiroyuki Takahashi, Takashi Yokoo
Summary: Invasive pulmonary aspergillosis (IPA) and septic pulmonary embolism (SPE) are serious complications in immunocompromised patients, characterized by multiple nodular lesions in the lungs. Although these diseases share similar features on CT imaging, this case demonstrates distinct transitions in CT imaging that can help suspect the presence of multiple pathogeneses.
BMC INFECTIOUS DISEASES
(2022)
Editorial Material
Peripheral Vascular Disease
Nobuo Tsuboi, Takaya Sasaki, Kotaro Haruhara
HYPERTENSION RESEARCH
(2022)
Review
Peripheral Vascular Disease
Kotaro Haruhara, Go Kanzaki, Nobuo Tsuboi
Summary: Chronic kidney disease is strongly associated with hypertension, and both conditions can aggravate each other. People with low nephron endowment are at higher risk for developing CKD and hypertension. Maintaining optimal blood pressure and reducing urinary protein excretion are crucial for slowing the progression of CKD.
HYPERTENSION RESEARCH
(2023)
Article
Urology & Nephrology
Shinya Yokote, Hiroyuki Ueda, Akihiro Shimizu, Masahiro Okabe, Kotaro Haruhara, Takaya Sasaki, Ryousuke Aoki, Kensuke Joh, Harumi Saeki, Shigeki Tomita, Nobuo Tsuboi, Hitoshi Suzuki, Yusuke Suzuki, Takashi Yokoo
Summary: The SARS-CoV-2 mRNA vaccine is effective against COVID-19, but it may lead to immune-mediated disorders such as IgA nephropathy following mass-scale vaccination. This study evaluated patients diagnosed with IgAN after receiving the vaccine.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Endocrinology & Metabolism
Ryutaro Morita, Shunichiro Tsukamoto, Shota Obata, Takayuki Yamada, Kazushi Uneda, Tatsuki Uehara, Muhammad Ebad Rehman, Kengo Azushima, Hiromichi Wakui, Kouichi Tamura
Summary: In patients with type 2 DM, combination therapy with SGLT2-Is and MRAs is associated with lower albuminuria compared to monotherapy with SGLT2-Is or MRAs alone. Both SGLT2-Is and MRAs alone can significantly reduce the albuminuria. The effects of MRAs on albuminuria are comparable to those of SGLT2-Is.
DIABETES OBESITY & METABOLISM
(2023)
Editorial Material
Peripheral Vascular Disease
Kengo Azushima, Hiromichi Wakui, Kouichi Tamura
HYPERTENSION RESEARCH
(2023)
Article
Physiology
Sarah E. Gazzard, James van Der Wolde, Kotaro Haruhara, John F. Bertram, Luise A. Cullen-McEwen
Summary: This study found that an adverse intrauterine environment, caused by a low protein diet, can lead to reduced podocyte numbers and increased susceptibility to diabetes-induced renal injury. Growth-restricted offspring with low nephron number and normalized podocyte endowment were more susceptible to alterations in glomerular volume and podocyte density, leading to a more rapid onset of albuminuria and renal injury.
PHYSIOLOGICAL REPORTS
(2023)
Article
Urology & Nephrology
Daisuke Kanai, Hiromichi Wakui, Masaaki Hanaoka, Tatsuya Haze, Kengo Azushima, Satoru Shinoda, Shunichiro Tsukamoto, Shinya Taguchi, Sho Kinguchi, Tomohiko Kanaoka, Yoshiyuki Toya, Nobuhito Hirawa, Hideaki Kato, Fumimasa Watanabe, Kanako Hanaoka, Hiroshi Mitsuhashi, Satoshi Yamaguchi, Toshimasa Ohnishi, Kouichi Tamura
Summary: This study investigated the impact of a fourth dose of BNT162b2 vaccine on anti-SARS-CoV-2 antibody titers in hemodialysis patients and healthcare workers. The results showed that the antibody titers decreased significantly after the fourth dose, but multiple vaccinations could extend the duration of humoral immune protection.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Shunichiro Tsukamoto, Tatsuki Uehara, Kengo Azushima, Hiromichi Wakui, Kouichi Tamura
Summary: The incidence of heart failure and chronic kidney disease is increasing, and many patients develop both diseases. Angiotensin receptor-neprilysin inhibitor (ARNI) is a promising therapeutic candidate for both diseases. ARNI has demonstrated superior cardioprotective effects compared with renin-angiotensin system inhibitors (RAS-Is) in large clinical trials. However, it is unclear whether ARNI has long-term renoprotective effects, and it may not provide renoprotective effects beyond RAS-Is in patients with chronic kidney disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Rina Oba, Go Kanzaki, Kotaro Haruhara, Takaya Sasaki, Yusuke Okabayashi, Kentaro Koike, Nobuo Tsuboi, Takashi Yokoo
Summary: This study found that non-dipping pulse rate (PR) is significantly associated with microstructural changes in the kidneys of patients with chronic kidney disease (CKD), including glomerulosclerosis, interstitial fibrosis, tubular atrophy, and arteriosclerosis. Patients with non-dipping PR were older, had worse kidney function, higher blood pressure, and more proteinuria. This finding is important for understanding the pathological mechanisms in CKD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Urology & Nephrology
Shinya Yokote, Nobuo Tsuboi, Akihiro Shimizu, Masahiro Okabe, Kotaro Haruhara, Takaya Sasaki, Hiroyuki Ueda, Takashi Yokoo
Summary: A recent study found a possible link between preexisting microscopic hematuria and postvaccination gross hematuria in IgAN patients. The study observed 417 IgAN patients and found a significant association between preexisting microscopic hematuria and the occurrence of postvaccination gross hematuria.
Article
Urology & Nephrology
Yusuke Okabayashi, Nobuo Tsuboi, Hirokazu Marumoto, Takaya Sasaki, Kotaro Haruhara, Go Kanzaki, Kentaro Koike, Hiroyuki Ueda, Akira Shimizu, Victor G. Puelles, Vivette D'Agati, Takashi Yokoo
Summary: This study applied a new technique to estimate single-nephron parameters in human membranous nephropathy (MN) and found that with advancing stage of the disease, single-nephron glomerular filtration rate (SNGFR) and urinary protein excretion (SNUPE) decreased. The study also revealed that SNGFR was associated with disease progression, while glomerular volume and SNUPE were not.