Article
Medicine, General & Internal
Susanne J. Maurer, Veronika Habdank, Juergen Horer, Peter Ewert, Oktay Tutarel
Summary: This study aimed to investigate the risk factors for poor outcome in patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD). The results showed that NT-proBNP is an independent predictor of all-cause mortality in PAH-CHD patients. The role of CRP and uric acid should be further studied.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sandra Skogby, Eva Goossens, Bengt Johansson, Philip Moons, Ewa-Lena Bratt
Summary: Young adults with congenital heart disease perceive and experience various factors influencing continued follow-up care. Motivation, sense of connectedness with healthcare providers, and care accessibility are key factors affecting their decision to continue follow-up. Holistic approaches, improved skills among healthcare providers, and person-centered care are essential in developing preventive strategies to prevent discontinuation.
Review
Medicine, General & Internal
Katharina Meinel, Martin Koestenberger, Hannes Sallmon, Georg Hansmann, Guido E. Pieles
Summary: Invasive assessment in the catheterization laboratory is the gold standard for diagnosing pulmonary hypertension in children, but transthoracic echocardiography (TTE) is the initial diagnostic tool. Guidelines suggest key echocardiographic variables for screening, but these may not apply to patients with congenital heart disease (CHD). Misinterpretation of TTE variables can lead to delayed diagnosis and therapy, or unnecessary invasive procedures with risks in the pediatric age group.
Article
Cardiac & Cardiovascular Systems
Amadeo-Jose Wals-Rodriguez, Maria-Jose Rodriguez-Puras, Rocio Garcia-Orta, Juan Robledo, Eduardo Moreno, Carmen Federero, Rocio Camacho, Begona Manso, Nuria Hernandez, Jose Maria Cubero, Raquel Ladron Abia, Pilar Cejudo Ramos, Antonio Ordonez, Pastora Gallego
Summary: The study found that the survival rate of adults with PAH-CHD receiving vasodilator treatment was 65%, with the highest mortality rate in the pre-tricuspid group. Older age was associated with higher risk of death, and predictors of poor outcome included pericardial effusion, oxygen saturation, and genetic syndromes.
Article
Medicine, General & Internal
Mai Baquedano, Samantha E. de Jesus, Filippo Rapetto, Gavin J. Murphy, Gianni Angelini, Umberto Benedetto, Patricia Caldas, Prashant K. Srivastava, Orhan Uzun, Karen Luyt, Cecilia Gonzalez Corcia, Demetris Taliotis, Serban Stoica, Deborah A. Lawlor, Andrew R. Bamber, Alison Perry, Katie L. Skeffington, Ikenna Omeje, John Pappachan, Andrew D. Mumford, Richard J. M. Coward, Damien Kenny, Massimo Caputo
Summary: This study aims to establish a prospective cohort of patients with congenital heart disease (CHD) undergoing cardiac procedures. It will collect clinical data, biological samples, and participant questionnaires to investigate risk factors, predictors, and the effects of surgery on outcomes.
Article
Public, Environmental & Occupational Health
Marie Tindborg, Anders Koch, Mikael Andersson, Klaus Juul, Uka Wilhjelm Geisler, Bolette Soborg, Sascha Wilk Michelsen
Summary: The incidence rates of heart disease (HD) and congenital heart disease (CHD) were compared between young Inuit populations in Greenland and Denmark. It was found that the incidence rate of HD was lower in Greenland compared to Denmark, while the incidence rates of CHD were similar in both countries. Individuals of Inuit/mixed ethnicity had a higher risk of both HD and CHD compared to non-Inuit individuals in both countries.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Massimo Stefano Silvetti, Luc Bruyndonckx, Alice Maltret, Roman Gebauer, Joanna Kwiatkowska, Laszlo Kornyei, Sonia Albanese, Cristina Raimondo, Christian Paech, Maciej Kempa, Gabor Fesus, Reinoud E. Knops, Nico Andreas Blom, Fabrizio Drago
Summary: This study aims to investigate the indications, complications, and outcomes of subcutaneous-implantable cardiac defibrillators (S-ICDs) in young patients. The results showed that S-ICDs had good efficacy and safety in young patients, with better outcomes in patients with BMI > 20 and newer implantation techniques.
Article
Pediatrics
Thomas Zoller, Maria Antonia Prioli, Maria Clemente, Mara Pilati, Camilla Sandrini, Giovanni Battista Luciani, Marco Deganello Saccomani, Benjamim Ficial, Marcella Gaffuri, Giorgio Piacentini, Lucia Calciano, Angelo Pietrobelli
Summary: This study evaluated the associations of age and disease severity with anthropometric indices and weight status in paediatric patients with congenital heart disease (CHD). The findings indicated that weight status increased with age, and children with mild or moderate heart defects had a higher risk of obesity. Furthermore, there were differences in the frequency of sports activity among different levels of disease severity.
Article
Cardiac & Cardiovascular Systems
Pei-Ni Jone, D. Dunbar Ivy, Amanda Hauck, Tara Karamlou, Uyen Truong, Ryan D. Coleman, Juan Pablo Sandoval, Maria Jesus del Cerro Marin, Pirooz Eghtesady, Kathryn Tillman, Usha S. Krishnan
Summary: Patients with pulmonary hypertension associated with congenital heart disease pose challenges due to underlying anatomical and hemodynamic abnormalities, and there are currently no consensus recommendations on how to manage this group of patients. This document aims to describe different subgroups of pulmonary hypertension associated with congenital heart disease, discuss imaging modalities for patient evaluation, outline medical and surgical management considerations, address disparities within this population, and identify future research needs.
CIRCULATION-HEART FAILURE
(2023)
Review
Peripheral Vascular Disease
Matthew R. Lippmann, Ami B. Bhatt
Summary: This review examines the primary prevention of ASCVD in young ACHD patients, discussing unique considerations for ASCVD risk reduction in ACHD patients and the underutilization of preventative strategies in this population.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Medicine, General & Internal
Qun Miao, Sandra Dunn, Shi Wu Wen, Jane Lougheed, Cynthia Maxwell, Jessica Reszel, Kaamel Hafizi, Mark Walker
Summary: This study investigates the interrelationships between maternal socioeconomic status, race, and congenital heart diseases (CHD) among infants. The results suggest that infants born to mothers living in lower-income neighborhoods and neighborhoods with fewer individuals with a university degree have a higher likelihood of developing CHD. Additionally, black mothers have a higher odds of giving birth to a child with CHD. Further research is needed to examine the impact of racial variation on CHD.
Article
Medicine, General & Internal
Aikeliyaer Ainiwaer, Kaisaierjiang Kadier, Anniwaer Abulizi, Wen Qing Hou, Rena Rehemuding, Halimulati Maimaiti, Mubalake Yakufu, Xiang Ma, Yi-Tong Ma
Summary: This study investigates the association between red cell distribution width (RDW) and the RDW to platelet count ratio (RPR) with cardiovascular diseases (CVDs). The study also examines the population differences and dose-response relationships in this association. There are statistical heterogeneities in the association between RDW, RPR distributions, and the prevalence of CVDs across sex, smoking status, and age groups.
Article
Pediatrics
Arthur Gavotto, Pascal Amedro, Gilles Cambonie
Summary: We report a case of a neonate with a severe pulmonary hypertension associated with an abnormal origin of the right pulmonary artery from the right brachiocephalic artery, in a context of left congenital diaphragmatic hernia (CDH). To the best of our knowledge, this combination of malformations has not been reported before.
Article
Critical Care Medicine
Daniela Ravizzoni Dartora, Adrien Flahault, Thuy Mai Luu, Anik Cloutier, Jessica Simoneau, Michel White, Anie Lapointe, Andreanne Villeneuve, Jean-Luc Bigras, Gabriel Altit, Anne Monique Nuyt
Summary: This study found that adults born preterm have alterations in right ventricular systolic function, with a more pronounced impact in the case of bronchopulmonary dysplasia (BPD). While respiratory function is also affected in preterm individuals, especially those with BPD, there was no observed association between respiratory function indices and right ventricular systolic function.
Article
Respiratory System
Steven H. Abman, Mary P. Mullen, Lynn A. Sleeper, Eric D. Austin, Erika B. Rosenzweig, John P. Kinsella, Dunbar Ivy, Rachel K. Hopper, J. Usha Raj, Jeffrey Fineman, Roberta L. Keller, Angela Bates, Usha S. Krishnan, Catherine M. Avitabile, Alexander Davidson, Marc D. Natter, Kenneth D. Mandl
Summary: The study found a significant proportion of pediatric PH patients with Group 3 disorders, reflecting the growing recognition of PH in diverse developmental lung diseases. Greater precision of clinical phenotyping based on disease-specific characterization may further enhance care and research of pediatric PH.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Correction
Cardiac & Cardiovascular Systems
Colin J. McMahon, Skaiste Sendzikaite, Anusha Jegatheeswaran, Yiu-Fai Cheung, David S. Majdalany, Vibeke Hjortdal, Andrew N. Redington, Jeffrey P. Jacobs, Maryam Asoodar, Matthew Sibbald, Tal Geva, Jeroen J. G. van Merrienboer, Justin T. Tretter
CARDIOLOGY IN THE YOUNG
(2023)
Article
Pediatrics
Dimpna C. C. Albert-Brotons, Waleed Alharkan, Reem Beheri, Mohammed AlHaddad, Yasser Alali, Yasser Alheraish, Aziza Chedrawi, Zohair AlHalees
Summary: This article presents a case of a 10-year-old boy who developed severe locked-in syndrome after heart transplantation. The patient had a spontaneous recovery after supportive treatment and substitution of calcineurin inhibitor with an mTOR inhibitor (sirolimus). This is the first reported case of locked-in syndrome post-heart transplant in pediatrics cases in the literature.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Virology
Margret Paar, Faisal Aziz, Caren Sourij, Norbert J. Tripolt, Harald Kojzar, Alexander Mueller, Peter Pferschy, Anna Obermayer, Tamara Banfic, Bruno Di Geronimo Quintero, Nandu Goswami, Axel Schlagenhauf, Martin Koestenberger, Thomas Baernthaler, Thomas Wagner, Andelko Hrzenjak, Willibald Wonisch, Gilbert Reibnegger, Reinhard B. Raggam, Harald Sourij, Gerhard Cvirn
Summary: The coagulation responses of people with diabetes to COVID-19 vaccination were only subclinical and comparable to those observed in healthy individuals.
Article
Medicine, General & Internal
Katharina Meinel, Felicitas Korak, Martin Dusleag, Tanja Strini, Daniela Baumgartner, Ante Burmas, Hannes Sallmon, Barbara Zieger, Axel Schlagenhauf, Martin Koestenberger
Summary: This study explores the relationship between hemodynamic alterations in Fontan patients and hemostatic dysbalance and Fontan-associated liver disease. The accumulation of bile acids is found to be related to certain hemostatic factors, and aspirin may reduce complications. Screening for AVWS is recommended for Fontan patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Dmitry Bobylev, Klea Hysko, Murat Avsar, Tomislav Cvitkovic, Elena Petena, Samir Sarikouch, Mechthild Westhoff Bleck, Georg Hansmann, Axel Haverich, Alexander Horke
Summary: Patients with congenital heart disease often require surgical or percutaneous valve replacement after initial repair. Simultaneous replacement of both semilunar valves is challenging and associated with increased complexity, morbidity, and mortality. This study analyzes the outcomes of simultaneous aortic and pulmonary valve replacements following multiple surgical interventions for congenital heart disease.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Article
Cardiac & Cardiovascular Systems
Astrid E. Lammers, Jan Marek, Gerhard-Paul Diller, Sheila G. Haworth, Shahin Moledina
Summary: This study aimed to develop a comprehensive and simple echocardiographic risk stratification for children with pulmonary arterial hypertension (PAH). Through echocardiographic assessment of 63 children with PAH, it was found that right atrial area and left ventricular diastolic eccentricity index were robust predictors of transplant-free survival. Additionally, a combination of right atrial area, left ventricular diastolic eccentricity index, and tricuspid annular plane systolic excursion were identified as independent predictors of mortality. These findings suggest the potential use of simple risk scores for prognosis determination in children with PAH.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Massimiliano Cantinotti, Pietro Marchese, Marco Scalese, Raffaele Giordano, Eliana Franchi, Nadia Assanta, Martin Koestenberger, Benjamin T. Barnes, Simona Celi, Vivek Jani, Inga Voges, Shelby Kutty
Summary: This study demonstrates the feasibility and reproducibility of blood speckle tracking echocardiography in the aortas of healthy children, which allows for direct quantification of interventricular and aortic flow profiles. These findings provide a baseline for evaluating aortic flow patterns in children with congenital and acquired heart disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Pediatrics
Nathalie Oeffl, Marlies Krainer, Stefan Kurath-Koller, Martin Koestenberger, Bernhard Schwaberger, Berndt Urlesberger, Lukas P. Mileder
Summary: This article provides a comprehensive review of electric countershock therapy in neonatal arrhythmias, showing that it is an effective treatment option, especially in atrial flutter. Among the 113 reported cases, atrial flutter was the most common arrhythmia.
Review
Pediatrics
Nathalie Oeffl, Lukas Schober, Patrick Faudon, Sabrina Schweintzger, Martin Manninger, Martin Koestenberger, Hannes Sallmon, Daniel Scherr, Stefan Kurath-Koller
Summary: Antiarrhythmic drugs are important for treating pediatric arrhythmias, but there is a lack of official guidelines on this topic. Some medications have specific dosage recommendations, while others have broad recommendations. To avoid uncertainties and errors in dosing, we summarized published dosage recommendations for antiarrhythmic drugs in children. It is recommended for centers to develop their own protocols for pediatric antiarrhythmic drug therapy due to variations in availability, regulatory approval, and experience.
Article
Cardiac & Cardiovascular Systems
Colin J. Mcmahon, Ornella Milanesi, Olli Pitkaenen-Argillander, Dimpna C. Albert-Brotons, Ina Michel-Behnke, Inga Voges, Skaiste Sendzikaite, Ruth Heying
Summary: There is significant variation in instructional design and assessment among European paediatric cardiac centres. A wide range of assessment tools are used, with verbal summative feedback being the most common.
CARDIOLOGY IN THE YOUNG
(2023)
Review
Medicine, General & Internal
Massimiliano Cantinotti, Colin Joseph McMahon, Pietro Marchese, Martin Koestenberger, Marco Scalese, Eliana Franchi, Giuseppe Santoro, Nadia Assanta, Xander Jacquemyn, Shelby Kutty, Raffaele Giordano
Summary: The aim of this review is to assess the strengths and limitations of echocardiographic parameters and scores used to predict favorable outcome in complex congenital heart diseases (CHDs) with a borderline right ventricle. A systematic search was conducted in the National Library of Medicine and 22 studies were analyzed. The studies showed variability in the echocardiographic parameters and cutoff values used, making it difficult to determine the recommended measures. Despite these limitations, certain scores and measurements, such as TV/MV ratios and RV end-diastolic area, were found to be accurate predictors of successful repair in larger studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Christine Rossmann, Cornelia Ranz, Gerd Kager, Gerhard Ledinski, Martin Koestenberger, Willibald Wonisch, Thomas Wagner, Sebastian P. Schwaminger, Bruno Di Geronimo, Andelko Hrzenjak, Seth Hallstoem, Gilbert Reibnegger, Gerhard Cvirn, Margret Paar
Summary: This study investigated whether metformin can inhibit the oxidation of LDL, a crucial step in the development of endothelial dysfunction and atherosclerosis. The results showed that metformin effectively reduced lipid hydroperoxide formation and decreased the oxidation level of LDL. This study suggests that metformin, in addition to its glucose-lowering effect, may be a suitable agent for inhibiting the development of atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Thomas Jack, Julia Carlens, Franziska Diekmann, Hosan Hasan, Philippe Chouvarine, Nicolaus Schwerk, Carsten Mueller, Ivonne Wieland, Igor Tudorache, Gregor Warnecke, Murat Avsar, Alexander Horke, Fabio Ius, Dmitry Bobylev, Georg Hansmann
Summary: A prospective observational study at Hannover Medical School showed that lung transplantation (LuTx) in children with end-stage pulmonary arterial hypertension (PAH) resulted in excellent midterm outcomes with 100% survival at 2 years post-LuTx. Postoperative VA-ECMO support facilitated early extubation and contributed to sustained biventricular reverse-remodeling and improved systolic function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pediatrics
Tanguy Dutilleux, Nesrine Farhat, Ruth Heying, Marie-Christine Seghaye, Maurice Beghetti
Summary: This case report presents a 7-year-old boy with idiopathic pulmonary arterial hypertension (IPAH), who initially presented with cardiac murmur and exercise intolerance. Pulmonary hypertension was confirmed by echocardiography and cardiac catheterization. Despite treatment with sildenafil and bosentan, the patient's pulmonary artery pressure remained stable but not decreased. Subsequent follow-up showed an increase in estimated pulmonary pressure and worsening of the child's condition.
Article
Cardiac & Cardiovascular Systems
Philippe Chouvarine, Klea Hysko, Stephen Y. Chan, Paulo Oliveira, Bradley A. Maron, Stella Kourembanas, Georg Hansmann
PULMONARY CIRCULATION
(2023)