Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the bone

Osteopontin as a multifaceted driver of bone metastasis and drug resistance

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Breast cancer risk in premalignant lesions: osteopontin splice variants indicate prognosis

(2018) Kinga Walaszek et al.   BRITISH JOURNAL OF CANCER

Role of Pyk2 in Human Cancers

(2018) Ting Shen et al.   MEDICAL SCIENCE MONITOR

Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells

(2017) Alessandro Genna et al.   JOURNAL OF CELL BIOLOGY

Integrins as Therapeutic Targets: Successes and Cancers

(2017) Sabine Raab-Westphal et al.   Cancers

pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer

(2016) Daniel R.P. Sauter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Expression of the SIBLINGs and their MMP partners in human benign and malignant prostate neoplasms

(2016) Charles C. Anunobi et al.   Oncotarget

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Sustained conditional knockdown reveals intracellular bone sialoprotein as essential for breast cancer skeletal metastasis

(2015) Marineta Kovacheva et al.   Oncotarget

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

(2014) Laetitia Seguin et al.   NATURE CELL BIOLOGY

Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer

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Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β

(2013) Jenny G. Parvani et al.   MOLECULAR BIOLOGY OF THE CELL

BSP Gene Silencing Inhibits Migration, Invasion, and Bone Metastasis of MDA-MB-231BO Human Breast Cancer Cells

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Targeting αV-integrins decreased metastasis and increased survival in a nude rat breast cancer brain metastasis model

(2012) Y. Jeffrey Wu et al.   JOURNAL OF NEURO-ONCOLOGY

MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits

(2012) Hong Liu et al.   NATURE CELL BIOLOGY

High Bone Sialoprotein (BSP) Expression Correlates with Increased Tumor Grade and Predicts a Poorer Prognosis of High-Grade Glioma Patients

(2012) Tao Xu et al.   PLoS One

Bone sialoprotein expression in primary human breast cancer is associated with bone metastases development

(2010) A. Bellahcène et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro

(2010) Maya Boudiffa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone sialoprotein stimulates focal adhesion-related signaling pathways: Role in migration and survival of breast and prostate cancer cells

(2009) Jonathan A.R. Gordon et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression

(2009) Jay S Desgrosellier et al.   NATURE MEDICINE

TREK-1 Is a Novel Molecular Target in Prostate Cancer

(2008) I. Voloshyna et al.   CANCER RESEARCH

The Mammary Progenitor Marker CD61/ 3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis

(2008) F. Vaillant et al.   CANCER RESEARCH