Article
Immunology
Poyee Lau, Guanxiong Zhang, Shuang Zhao, Long Liang, Hailun Zhang, Guowei Zhou, Mien-Chie Hung, Xiang Chen, Hong Liu
Summary: This study reveals the important role of SPHK1 in tumor immunity and shows that its inhibition can suppress tumor growth and promote antitumor immunity. Additionally, SPHK1 and MTA3 are identified as biological markers for predicting the efficacy of anti-PD-1 mAb therapy in melanoma patients.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jin Lei, Bowen Chen, Meiru Song, Linzhi Zhang, Xinfeng Zhang, Xiaoqiang Gao, Yinyin Li, Yinying Lu, Shi Zuo
Summary: TKI combined with PD-1 inhibitors showed better prognosis and manageable toxicity in uHCC patients after sorafenib failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Ying Cheng, Hui Li, Liang Zhang, Jing-Jing Liu, Chang-Liang Yang, Shuang Zhang
Summary: In recent years, immune checkpoint inhibitors have made significant breakthroughs in the treatment of lung cancer, with combination immunotherapy being widely used to improve efficacy. The combination of PD-1/PD-L1 inhibitors with other treatment modalities is a current research focus.
CHINESE MEDICAL JOURNAL
(2021)
Review
Immunology
Quanqing Tang, Shihao Li, Gaozhen Huang, Hongwei Liu
Summary: Urothelial carcinoma (UC) is a common malignant tumor. Platinum-based chemotherapy has been the standard treatment for metastatic UC, but immune checkpoint inhibitors (ICIs) offer hope for patients unfit for platinum therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Rilan Bai, Jiuwei Cui
Summary: Antibodies targeting PD-1/PD-L1 have been considered breakthrough therapies for cancer. In addition to T cell-driven immune responses, blocking PD-1/PD-L1 may also enhance the function and activity of NK cells, which are often overlooked in previous studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Gang Liu, Xiaolan Lv, Yanling Ding, Yongbo Guo
Summary: This study aims to evaluate the efficacy and safety of PD1/PD-L1 inhibitor immunotherapy combined chemotherapy for inoperable advanced lung cancer through screening eligible studies and providing scientific evidence to guide clinical drug use.
Article
Oncology
Zaishang Li, Xueying Li, Wayne Lam, Yabing Cao, Hui Han, Xueqi Zhang, Jiequn Fang, Kefeng Xiao, Fangjian Zhou
Summary: Comparing anti-PD-1 and anti-PD-L1 therapies in platinum-resistant UC patients reveals that anti-PD-1 therapy exhibits better antitumor activity, with comparable safety profiles and survival outcomes. This systematic comparison may enhance treatment awareness in this patient population.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Keywan Mortaezaee, Jamal Majidpoor
Summary: CD8+ T cells play a crucial role in combating cancer, but their infiltration and effector function are often impaired in cancer patients, leading to defective immunity and resistance to immunotherapy. The exclusion and exhaustion of CD8+ T cells are major factors contributing to the limited durability of immune checkpoint inhibitor therapy. Identifying and targeting factors responsible for defective CD8+ T cell infiltration and function could provide a promising supplementary approach in patients undergoing anti-PD-1/PD-L1 therapy. Recent development of bispecific antibodies against PD-(L)1 and key factors within the tumor microenvironment holds great potential in enhancing the effectiveness and safety of cancer immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Zana Karami, Keywan Mortezaee, Jamal Majidpoor
Summary: To overcome resistance and relapse in immune checkpoint inhibitor therapy, researchers have developed bispecific inhibitors that can simultaneously target transforming growth factor-beta (TGF-β) signaling and PD-1/PD-L1 pathways. These inhibitors reinvigorate immune response, inhibit regulatory T cells, and increase the density of anti-tumor macrophages, leading to reduced relapse rates and durable anticancer therapy. The bispecific approach is particularly effective in HPV-positive patients and those with high PD-L1 expression or immune-excluded phenotype. It can also be safely combined with other therapies like vaccination, radiation, and chemotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Keywan Mortezaee, Jamal Majidpoor
Summary: The low frequency of durable responses in patients treated with immune checkpoint inhibitors (ICIs) requires additional strategies to enhance immune responses against cancer. Transforming growth factor-beta (TGF-beta) is a cytokine often expressed in tumors and promotes an immunosuppressive tumor microenvironment (TME). TGF-beta also influences the efficacy of anti-PD-1/PD-L1 therapy. Combining TGF-beta inhibitors with anti-PD(L)1 has shown promising results, and clinical trials are currently underway to investigate the use of agents with bifunctional capacity and fusion proteins to reinvigorate immune responses against advanced stage cancers, particularly those with an immunologically cold ecosystem.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nadia Mensali, Pierre Dillard, Artem Fayzullin, Hakan Koksal, Gustav Gaudernack, Gunnar Kvalheim, Else Marit Inderberg, Sebastien Walchli
Summary: The success of adoptive cell therapy relies on the ability of immune cells to persist and function optimally in the tumor microenvironment. Novel genetic strategies to manipulate the PD1/PD-L1 axis can improve antitumor immunity and reveal new targets through PD-L1 positivity.
Article
Dermatology
Kazufumi Shirouchi, Sachiko Koshikawa, Koichiro Shinya, Hideaki Watanabe, Miki Izumi, Kiyoshi Yoshimura, Hirohiko Sueki
Summary: This study found that the expression of PD-1 and PD-L1 is decreased in patients with lichen planus, which may lead to increased infiltration of inflammatory cells targeting the epidermis. Further research is needed to elucidate the mechanism behind this phenomenon.
JOURNAL OF DERMATOLOGY
(2021)
Article
Oncology
Topias Karjula, Hanna Elomaa, Anne Niskakangas, Olli Mustonen, Iiris Puro, Teijo Kuopio, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T. Seppala, Erkki-Ville Wirta, Eero Sihvo, Juha P. Vayrynen, Fredrik Yannopoulos, Olli Helminen
Summary: The study found that CD3(+) and CD8(+) T-cell density and PD-1/PD-L1 expression have prognostic value in pulmonary metastases of colorectal cancer. T-cell infiltration is higher in pulmonary metastases compared to primary tumors. High CD3(+) and CD8(+) cell density are associated with better survival, while high PD-L1 expression is associated with favorable prognosis.
Article
Biochemistry & Molecular Biology
Chihiro Tanaka, Takuro Kobori, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: The ERM family scaffold proteins play a role in PD-L1 expression in HeLa cells, with ezrin potentially acting as a scaffold protein for PD-L1 and regulating its protein expression. This finding suggests ezrin could be a therapeutic target for cervical cancer, improving immune checkpoint blockade therapy.
Article
Oncology
Hayato Kawachi, Tadaaki Yamada, Akihiro Yoshimura, Kenji Morimoto, Masahiro Iwasaku, Shinsaku Tokuda, Young Hak Kim, Takayuki Shimose, Koichi Takayama
Summary: This study aims to evaluate the clinical efficacy of combining erlotinib and ramucirumab for the treatment of treatment-naive EGFR mutation-positive NSCLC with high PD-L1 expression.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Takayo Ota, Masanobu Nakano, Noriko Tanaka, Tomohiro Suzumura, Nozomi Miyatake, Yoshikazu Hasegawa, Tomohiro Ozaki, Hiroshi Tsukuda, Masahiro Fukuoka
CLEVELAND CLINIC JOURNAL OF MEDICINE
(2016)
Review
Pharmacology & Pharmacy
Shigeki Mitsuoka, Tomoya Kawaguchi, Akihito Kubo, Shun-ichi Isa, Kazuhisa Asai, Masato Uji, Tetsuya Watanabe, Kenji Sawa, Naoki Yoshimoto, Takako Oka, Toshiyuki Nakai, Tomohiro Suzumura, Hidenori Tanaka, Kuniomi Matsuura, Tatsuo Kimura, Naruo Yoshimura, Shinzoh Kudoh, Kazuto Hirata
EXPERT OPINION ON PHARMACOTHERAPY
(2016)
Article
Medicine, General & Internal
Yoshiya Matsumoto, Tomoya Kawaguchi, Norio Yamamoto, Kenji Sawa, Naoki Yoshimoto, Tomohiro Suzumura, Tetsuya Watanabe, Shigeki Mitsuoka, Kazuhisa Asai, Tatsuo Kimura, Naruo Yoshimura, Yuko Kuwae, Kazuto Hirata
Article
Oncology
Naruo Yoshimura, Takuhito Tada, Yoshiya Matsumoto, Kenji Sawa, Naoki Yoshimoto, Tomohiro Suzumura, Hidenori Tanaka, Shigeki Mitsuoka, Tatsuo Kimura, Tomohiro Tamiya, Tomonori Hirashima, Tomoya Kawaguchi, Shinzoh Kudoh, Masako Hosono, Kazuto Hirata
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2018)
Article
Respiratory System
Norio Yamamoto, Tetsuya Watanabe, Kazuhiro Yamada, Toshiyuki Nakai, Tomohiro Suzumura, Kazuki Sakagami, Naoki Yoshimoto, Kanako Sato, Hidenori Tanaka, Shigeki Mitsuoka, Kazuhisa Asai, Tatsuo Kimura, Hiroshi Kanazawa, Kazuto Hirata, Tomoya Kawaguchi
JOURNAL OF THORACIC DISEASE
(2019)
Article
Respiratory System
A. Sugitani, K. Asai, T. Watanabe, T. Suzumura, K. Kojima, H. Kubo, K. Sato, N. Ijiri, K. Yamada, T. Kimura, S. Fukumoto, K. Hirata, T. Kawaguchi
Article
Oncology
Yoshiya Matsumoto, Kenji Sawa, Mitsuru Fukui, Jun Oyanagi, Naoki Yoshimoto, Tomohiro Suzumura, Tetsuya Watanabe, Hiroyasu Kaneda, Shigeki Mitsuoka, Kazuhisa Asai, Tatsuo Kimura, Nobuyuki Yamamoto, Kazuto Hirata, Yasuhiro Koh, Tomoya Kawaguchi
Review
Oncology
Koichi Ogawa, Hiroyasu Kaneda, Tamaki Kawamoto, Yoko Tani, Motohiro Izumi, Yoshiya Matsumoto, Kenji Sawa, Tomohiro Suzumura, Tetsuya Watanabe, Shigeki Mitsuoka, Kazuhisa Asai, Tomoya Kawaguchi
INVESTIGATIONAL NEW DRUGS
(2020)
Article
Respiratory System
Motohiro Izumi, Tomohiro Suzumura, Koichi Ogawa, Yoshiya Matsumoto, Kenji Sawa, Naoki Yoshimoto, Yoko Tani, Tetsuya Watanabe, Hiroyasu Kaneda, Shigeki Mitsuoka, Kazuhisa Asai, Tomoya Kawaguchi
JOURNAL OF THORACIC DISEASE
(2020)
Article
Oncology
Takayo Ota, Tomoya Fukui, Yoshiro Nakahara, Takayuki Takeda, Junji Uchino, Takako Mouri, Keita Kudo, Saki Nakajima, Tomohiro Suzumura, Masahiro Fukuoka
Article
Multidisciplinary Sciences
Motohiro Izumi, Jun Oyanagi, Kenji Sawa, Mitsuru Fukui, Koichi Ogawa, Yoshiya Matsumoto, Yoko Tani, Tomohiro Suzumura, Tetsuya Watanabe, Hiroyasu Kaneda, Shigeki Mitsuoka, Kazuhisa Mai, Masahiko Ohsawa, Nobuyuki Yamamoto, Yasuhiro Koh, Tomoya Kawaguchi
Summary: The study revealed different mutation profiles within tumors of the same patient, with EGFR, KRAS, TP53, or PARP1 mutations being concurrently detected in some MPLC cases. EGFR mutations were significantly more frequent in never or light smokers and females.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Motohiro Izumi, Kenji Sawa, Jun Oyanagi, Ikue Noura, Mitsuru Fukui, Koichi Ogawa, Yoshiya Matsumoto, Yoko Tani, Tomohiro Suzumura, Tetsuya Watanabe, Hiroyasu Kaneda, Shigeki Mitsuoka, Kazuhisa Asai, Noritoshi Nishiyama, Masahiko Ohsawa, Nobuyuki Yamamoto, Yasuhiro Koh, Tomoya Kawaguchi
Summary: The study revealed that non-smokers or light smokers and females were unlikely to express PD-L1, regardless of the tumor site. Additionally, EGFR mutations and co-occurring KRAS and STK11 or TP53 mutations were associated with the tumor microenvironment. Furthermore, pathological subtypes may impact the efficacy of immune therapy due to their potential correlations with regulatory T cells.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Kenji Nakahama, Hiroyasu Kaneda, Koichi Ogawa, Yoshiya Matsumoto, Yoko Tani, Tomohiro Suzumura, Shigeki Mitsuoka, Tetsuya Watanabe, Kazuhisa Asai, Tomoya Kawaguchi
Summary: This report demonstrates the concurrent use of immune checkpoint inhibitor and anti-TB treatment in limited TB infection area.
Article
Medicine, General & Internal
Takayo Ota, Tomohiro Suzumura, Takamune Sugiura, Yoshikazu Hasegawa, Kimio Yonesaka, Masaru Makihara, Hiroshi Tsukuda, Takuhito Tada, Masahiro Fukuoka
CLINICAL CASE REPORTS
(2016)