Journal
CANCER BIOLOGY & THERAPY
Volume 21, Issue 1, Pages 72-80Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384047.2019.1665953
Keywords
CD16a; VHH; CEA; phage display; bispecific antibody; single domain antibody
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CD16a (Fc gamma RIIIa) mediates the antibody dependent cellular cytotoxicity (ADCC) and is important for anti-tumor activities of many therapeutic antibodies. Bispecific antibody targeting natural killer (NK) cells has been studied for cancer therapy. In this work, anti-CD16a single-domain antibodies were identified from hCD16a immunized camel. Bispecific antibodies are then constructed by fusing these single domain antibodies with an anti-CEA single domain antibody. These bispecific antibodies can recruite NK cells to kill CEA-positive tumor cells, and inhibit tumor growth in vivo, suggesting that these anti-CD16a single domain antibodies are powerful tools to engaging NK cells for cancer therapy.
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