Article
Environmental Sciences
Na Fu, Jie Yu, Lin Zhu, Lilin Yang, Lina Ma, Jie He, Huawen Yu, Jinqing Liu, Yu Tian, Jie Xu
Summary: The study investigated the effects of Nonylphenol (NP) exposure on cognitive dysfunction and synaptic plasticity impairment. It also explored the mechanism of microRNA (miR) 219a-5p regulation of N-methyl-D-aspartate receptor (NMDAR) in NP-induced synaptic plasticity impairment. The findings showed that NP exposure reduced learning and memory abilities, disrupted synaptic structure, and decreased neurotransmitter content. In addition, high expression of miR-219a-5p inhibited the expression of NMDAR. This study provides a scientific basis for preventing cognitive impairment caused by NP exposure and developing targeted drug treatments.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Neurosciences
Xin Li, Zhuo-Jun Du, Jun-Nan Xu, Zhi-Man Liang, Song Lin, Hao Chen, Shu-Ji Li, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Gao
Summary: Pharmacological manipulation of mGluR5 suggests its involvement in anxiety disorders, but the mechanism behind its role in stress-induced anxiety-like behavior is unclear. This study found that chronic restraint stress and mGluR5 knockdown lead to anxiety-like behavior and impaired inhibitory synaptic inputs in hippocampal CA1 pyramidal neurons. However, positive allosteric modulator of mGluR5 can rescue anxiety-like behavior and restore inhibitory synaptic inputs. These findings highlight the essential role of mGluR5 in mediating stress-induced anxiety-like behavior in hippocampal CA1 pyramidal neurons.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhujin Song, Zhijuan Bian, Zhengrong Zhang, Xuncui Wang, Aisong Zhu, Guoqi Zhu
Summary: Memantine reduces LPS-induced depression-like behaviors, NLRP3 inflammasome activation, and astrocyte activation by modulating the NMDAR/calpain-1 signaling axis. Additionally, astrocytic Kir4.1 may regulate NLRP3 inflammasome activation and contribute to depression-like behaviors.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Neurosciences
Qian Sun, Eric W. Buss, Yu-Qiu Jiang, Bina Santoro, David H. Brann, Daniel A. Nicholson, Steven A. Siegelbaum
Summary: Entorhinal cortex neurons establish monosynaptic connections onto distal apical dendrites of CA1 and CA2 pyramidal neurons through the perforant path. The efficacy of the perforant path inputs varies substantially as a function of presynaptic firing rate, with CA2 showing stronger excitation compared to CA1. Blockade of NMDARs significantly reduces temporal summation in CA1, while having little impact on CA2 responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Costanza Angelini, Alessandro Morellato, Annalisa Alfieri, Lisa Pavinato, Tiziana Cravero, Olga Teresa Bianciotto, Vincenzo Salemme, Dora Natalini, Giorgia Centonze, Alessandra Raspanti, Tina Garofalo, Donatella Valdembri, Guido Serini, Andrea Marcantoni, Andrea Becchetti, Maurizio Giustetto, Emilia Turco, Paola Defilippi
Summary: NMDARs play a crucial role in neuronal transmission, learning, and memory. This study demonstrates that the scaffold protein p140Cap directly binds to the GluN2A subunit of NMDAR and modulates GluN2A-associated molecular network. It is also shown that p140Cap is important for the recruitment of GluN2A-containing NMDARs and for the association between GluN2A and PSD95 in the synaptic compartment.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Yanling Liang, Yuxin Ma, Jieqin Wang, Lei Nie, Xusheng Hou, Wenyu Wu, Xingmei Zhang, Yinghong Tian
Summary: This study investigated the role of leptin in neuropathic pain and found that leptin promotes neuropathic pain by enhancing NR2B-mediated currents and nNOS expression. The data suggest an important cellular link between the spinal effects of leptin and the extrasynaptic NMDAR-nNOS-mediated cellular mechanism of neuropathic pain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Psychiatry
Kangyu Jin, Shiyi Zhang, Chaonan Jiang, Ripeng Liu, Bing Chen, Haoyang Zhao, Qin Zhang, Zhe Shen, Pengfeng Xu, Xiaohan Hu, Jianping Jiao, Jing Lu, Manli Huang
Summary: This study investigates the role of Reelin in Major Depressive Disorder (MDD) through clinical trials and animal experiments. The research finds that Reelin levels in plasma decrease in drug-naive patients with first-episode MDD and increase after treatment. Additionally, the study shows that Reelin is involved in regulating hippocampal synaptic plasticity, and it may be a potential therapeutic target for MDD.
PSYCHIATRY RESEARCH
(2022)
Article
Biology
Yaling Dai, Sinuo Wang, Minguang Yang, Peiyuan Zhuo, Yanyi Ding, Xiaoling Li, Yajun Cao, Xiaoqin Guo, Huawei Lin, Jing Tao, Lidian Chen, Weilin Liu
Summary: This study found that electroacupuncture treatment has protective effects on vascular cognitive impairment (VCI) by enhancing BOLD signal in the hippocampus and entorhinal cortex. The miR-219a gene plays a crucial role in regulating VCI, and inhibiting miR-219a can improve VCI and enhance learning and memory.
BIOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Xingzhi He, Yang Wang, Guangjun Zhou, Jing Yang, Jiarui Li, Tao Li, Hailan Hu, Huan Ma
Summary: The γCaMKII isoform is highly expressed in hippocampal inhibitory interneurons and is activated by high-frequency stimulation. It co-localizes with the postsynaptic protein PSD-95 and regulates the phosphorylation and trafficking of AMPARs induced by chemical LTP.
NEUROSCIENCE BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Bingjin Li, Wei Yang, Tongtong Ge, Yao Wang, Ranji Cui
Summary: This article discusses the candidate mechanisms by which stress can lead to dysregulated microglia, which in turn contribute to the pathogenesis of depressive disorders. It suggests that changes in microglial function can strongly influence neuronal network activity through dysregulated cytokine secretion and increased release of neurotoxic metabolites, thereby contributing to pathological outcomes in response to stress.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Neurosciences
Harry George, Zafar I. Bashir, Shobbir Hussain
Summary: Biallelic loss-of-function NSUN2 mutations have been associated with Autism Spectrum Condition (ASC), and NSun2-deficiency can cause intellectually disability disorder syndrome, which can sometimes display autistic behavior. The study suggests that protein synthesis-dependent synaptic plasticity dysregulation may be a mechanism associated with autism phenotypes.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Behavioral Sciences
Mohamad Azmeer Effendy, Suleiman Yunusa, Noorul Hamizah Mat, Ahmad Tarmizi Che Has, Christian P. Mueller, Zurina Hassan
Summary: Mitragynine can modify hippocampal synaptic transmission, with the involvement of AMPA and NMDA glutamate receptors.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Le Xu, Yiying Zhou, Linbo Hu, Hongde Jiang, Yibei Dong, Haowei Shen, Zhongze Lou, Siyu Yang, Yunxin Ji, Liemin Ruan, Xiaoqin Zhang
Summary: In this study, APP/PS1 mice were used as a transgenic model of AD. The results showed impaired NMDAR function, synaptic plasticity, and disrupted neuronal morphology in the hippocampal CA1 of 8-month-old APP/PS1 mice, contributing to cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Ning Jiang, Hong Huang, Haixia Wang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xin-Min Liu
Summary: The Shen Yuan prescription, comprising Panax ginseng and Polygala tenuifolia, has shown superior antidepressant activity compared with individual components. It successfully reversed depressive-like behaviors induced by chronic social defeat stress (CSDS) in mice, by promoting hippocampal neurogenesis and activating the BDNF signaling pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Neurosciences
Yi-Shu Yin, Yuan-Bing Zhu, Jun-Lian Liu, Quan-Chun Fan, Xiao-Rui Wu, Shuang Zhao, Jia-Ping Wang, Yu Liu, Yong-Zhi Li, Wei-Hong Lu
Summary: This study aimed to investigate the changes in hippocampus synaptic plasticity under long-term spaceflight composite stress (LSCS). Male rats were exposed to a simulated LSCS environment for 42 days. The results showed significant weight loss, anxiety, and depressive behaviors in rats exposed to LSCS. Synaptic structure was severely damaged, and both long-term potentiation and NMDA receptor channel currents were significantly impaired. Further analysis revealed decreased expression of key subtype proteins on this channel in response to LSCS.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)