Article
Endocrinology & Metabolism
J. Everts-Graber, S. Reichenbach, B. Gahl, H. R. Ziswiler, U. Studer, T. Lehmann
Summary: Patients who received zoledronate after denosumab discontinuation had fewer vertebral fractures, while all subsequent therapies were able to maintain bone mineral density to some extent. Factors such as age, BMI, treatment duration, prior therapy, and BMD gains during denosumab treatment influenced bone mineral density loss, while bone turnover markers correlated with total hip bone loss and treatment duration.
Article
Health Care Sciences & Services
Sara Jane Cromer, Kristin M. D'Silva, Elaine W. Yu, Joan Landon, Rishi J. Desai, Seoyoung C. Kim
Summary: The study found that the use of denosumab has surpassed all other bone-directed therapies over the past decade, especially since its approval in 2010. The use of denosumab also showed increasing trends among patients with osteoporosis, malignancies, and recent fractures. However, it is noteworthy that the proportion of using any bone-directed therapy after fractures is low and has declined over time.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Elena Tsourdi, Gaia Tabacco, Anda Mihaela Naciu, Nicola Napoli, Fabio Vescini, Andrea Palermo
Summary: The study found that there is currently insufficient data to prove the significant impact of bone therapies on glucose metabolism in diabetic patients. It is uncertain whether antiosteoporotic drugs have different effects on fracture incidence between diabetic and nondiabetic patients. More research is needed to address these issues and provide stronger recommendations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Sang-Min Park, Sung Jun Go, Heesoo Han, Jung Wee Park, Young-Kyun Lee, Ho-Joong Kim, Jin S. Yeom, Kyung-Hoi Koo
Summary: This study evaluated the incidence of subsequent vertebral fractures in elderly hip fracture patients after surgical treatment and identified risk factors for these fractures. The findings showed that subsequent vertebral fractures did not affect mortality rates after hip fractures, with age, low BMI, and comorbidities being significant risk factors for mortality. Timely management is important for preventing subsequent vertebral fractures in these patients.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Endocrinology & Metabolism
Tsai-Sheng Fu, Ting-Shuo Huang, Chi-Chin Sun, Yu-Chiau Shyu, Fang-Ping Chen
Summary: The study demonstrates that bisphosphonate treatment significantly reduces the risk of second hip fracture and mortality in patients with initial hip fracture. Factors such as gender, comorbidities, and complications also play a significant role in determining the prognosis.
Article
Chemistry, Multidisciplinary
Joao Andre Correia, Jose Ricardo Ferreira, Miguel Amaral Nunes, Antonio Capelo, Miguel de Araujo Nobre, Francisco Salvado
Summary: VSP and CAD/CAM-customized materials facilitated complete resection of necrotic bone and rigid fixation in MRONJ patients, leading to simplified approach with shorter operative times, reduced morbidity, and predictable results.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Ting-Cheng Chao, Hsin-Pai Lee, Jung-Chou Wu, Chien-Jen Hsu
Summary: This retrospective study aimed to investigate the occurrence and impact of cardiac events for geriatric patients undergoing hip fracture surgeries. The study found that 93.7% of cardiac events occurred in patients with a history of cardiovascular disease. Therefore, pre-operative transthoracic echocardiography is recommended for geriatric patients with cardiac disease histories to detect the risk of developing cardiac events earlier.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yi-Lun Tsai, Chih-Hsing Wu, Chia-Chun Li, Chien-An Shih, Yin-Fan Chang, Jawl-Shan Hwang, Ta-Wei Tai
Summary: This study aimed to assess the impact of drug adherence and treatment duration for denosumab on mortality risk after hip fracture surgery. Lower all-cause mortality risk was associated with drug intervals of 7 months or less and longer treatment duration. The study highlights the importance of proper denosumab administration.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
A. Atmaca, I. Demirci, C. Haymana, I. Tasci, I. Sahin, E. Cakal, N. Ata, S. Dagdelen, S. Salman, R. Emral, M. Sahin, O. Celik, T. Demir, D. Ertugrul, U. Unluturk, M. Caglayan, I. Satman, A. Sonmez
Summary: This study evaluated the association between the use of anti-osteoporosis drugs in women and COVID-19 outcomes, finding that there was no significant impact on the risk of hospitalization, ICU admission, or mortality. The use of these drugs did not independently influence the outcomes of COVID-19.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Oncology
Raiza Querrer, Nathalia Ferrare, Nilce Melo, Cristine Miron Stefani, Paula Elaine Diniz dos Reis, Carla Ruffeil Moreira Mesquita, Gabriel Alvares Borges, Andre Ferreira Leite, Paulo Tadeu Figueiredo
Summary: Bisphosphonate-related ONJ and denosumab-related ONJ exhibit differences in imaging characteristics, with the former showing bone sequestra increase, cortical bone lysis, and bone density increase, while the latter showing larger bone sequestra, more frequent periosteal reactions, and mandibular canal enhancement.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Endocrinology & Metabolism
Judith Everts-Graber, Daniel Lehmann, John-Patrik Burkard, Benoit Schaller, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This study aimed to determine the risk of ONJ in a real-world population, showing a higher incidence rate in patients receiving denosumab therapy compared to those receiving BPs, with previous BP therapy potentially being an additional risk factor for ONJ development.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ken Iseri, Juan Jesus Carrero, Marie Evans, Bjorn Runesson, Peter Stenvinkel, Bengt Lindholm, Hans E. Berg, Li Fellaner-Tsai, Abdul Rashid Qureshi
Summary: Hip fracture incidence and subsequent mortality have decreased in the Swedish general population, but remain higher in dialysis patients, with no consistent improvement in post-fracture mortality rates among dialysis patients. Men in both populations seem to have less decline in hip fracture incidence compared to women.
Article
Endocrinology & Metabolism
S-B Lee, Y. Park, D-W Kim, J-W Kwon, J-W Ha, J-H Yang, B. H. Lee, K-S Suk, S-H Moon, H-S Kim, H-M Lee
Summary: As the number of subsequent fractures increased, the mortality risk showed a positive correlation, with hip fracture having the greatest association with mortality risk.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Alessandro Cartei, Enrico Mossello, Alice Ceccofiglio, Gaia Rubbieri, Gianluca Polidori, Claudia Ranalli, Alessandra Cammilli, Massimo Curcio, Maria Chiara Cavallini, Giulio Maria Mannarino, Andrea Ungar, Giulio Toccafondi, Adriano Peris, Niccolo Marchionni, Carlo Rostagno
Summary: This study found that postoperative delirium has an independent negative impact on long-term disability, but not on mortality. Therefore, prevention and treatment of postoperative delirium are crucial in reducing the risk of long-term disability.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Dennis M. Black, Katherine Condra, Annette L. Adams, Richard Eastell
Summary: Bisphosphonate use is associated with an increased risk of atypical femur fractures (AFFs), but it significantly reduces the risk of hip fractures and osteoporosis. The risk of AFFs varies between Asians and Caucasians, potentially due to differences in femoral geometry.
Article
Health Care Sciences & Services
Tanja A. Stamm, Yuki Seidler, Margaret R. Andrews, Mohammad Eghbali, Juliet Kiguli, Valentin Ritschl, Maisa Omara, Gertraud Schaffer, Erika Mosor
Summary: In this study, the perspectives of patient representatives from all six WHO regions were explored, and suggestions for care redesign after the pandemic were extracted. The results revealed the unprecedented inequity and stigmatization experienced by disadvantaged people in healthcare, and proposed methods to address these issues.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2022)
Article
Medicine, General & Internal
Martina Behanova, Judith Haschka, Berthold Reichardt, Hans-Peter Dimai, Heinrich Resch, Jochen Zwerina, Roland Kocijan
Summary: Pelvic fractures are increasingly common in the elderly population, with a greater increase observed in men. Pelvic fracture itself contributes to higher mortality in individuals aged 65 and above.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Rheumatology
Andrea Marques, Philipp Bosch, Annette de Thurah, Yvette Meissner, Louise Falzon, Chetan Mukhtyar, Johannes W. J. Bijlsma, Christian Dejaco, Tanja A. Stamm
Summary: Remote care shows similar or better results compared to face-to-face treatment in terms of efficacy, safety, adherence, and user perception outcomes. However, available studies suffer from heterogeneity in outcomes and methods, as well as a substantial risk of bias.
Article
Rheumatology
Daniel Aletaha, Andreas Kerschbaumer, Kastriot Kastrati, Christian Dejaco, Maxime Dougados, Iain B. McInnes, Naveed Sattar, Tanja A. Stamm, Tsutomu Takeuchi, Michael Trauner, Desiree van der Heijde, Marieke Voshaar, Kevin L. Winthrop, Angelo Ravelli, Neil Betteridge, Gerd-Ruediger R. Burmester, Johannes W. J. Bijlsma, Vivian Bykerk, Roberto Caporali, Ernest H. Choy, Catalin Codreanu, Bernard Combe, Mary K. Crow, Maarten de Wit, Paul Emery, Roy M. Fleischmann, Cem Gabay, Merete Lund Hetland, Kimme L. Hyrich, Annamaria Iagnocco, John D. Isaacs, Joel M. Kremer, Xavier Mariette, Peter Merkel, Eduardo F. Mysler, Peter Nash, Michael T. Nurmohamed, Karel Pavelka, Gyula Poor, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Anja Strangfeld, Yoshiya Tanaka, Josef S. Smolen
Summary: This paper is an updated consensus document on the medical use of IL-6 pathway inhibition in the treatment of inflammatory diseases. The document provides comprehensive consensus statements based on systematic literature research and expert opinion, covering various aspects of IL-6 pathway inhibitors, including dosing, indications, and clinical considerations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: The revised Boolean remission criteria, using a higher patient global assessment threshold, classify more patients as achieving remission and increase the agreement with index-based remission criteria without jeopardizing predictive value for radiographic or functional outcomes.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Maisa Omara, Tanja Stamm, Katrin Bekes
Summary: The aim of this study was to describe the challenges and opportunities of implementing dental patient-reported outcomes (dPROs) in clinical care and to determine lessons learned and next steps for implementation. The results showed that integrating dPROMs in clinical settings is achievable and is an important first step towards implementing value-based oral healthcare (VBOHC).
JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE
(2023)
Article
Surgery
Hannes Beiglbock, Eric Morth, Berthold Reichardt, Tanja Stamm, Bianca Itariu, Jurgen Harreiter, Jakob Eichelter, Gerhard Prager, Alexandra Kautzky-Willer, Peter Wolf, Michael Krebs
Summary: Bariatric surgery has a positive effect on fertility in women, but the ideal time for conception following the surgery is still unknown. This study analyzed the health outcomes in children born to mothers who had undergone bariatric surgery, and found that the surgery-to-delivery interval did not have a significant impact on the health outcome of the children.
Article
Medicine, General & Internal
Carmen Trost, Stephan Heisinger, Philipp T. Funovics, Reinhard Windhager, Gerhard M. Hobusch, Tanja Stamm
Summary: The objective of this study is to investigate the effects and consequences of surgical treatment of patients with musculoskeletal malignancies on everyday life. Data collection and analysis were conducted using a modified form of grounded theory. The study involved 16 interviews and the main category that emerged from the analysis emphasized the importance of implementing psychosocial care involving the social environment and the role of relatives/partners in the recovery process. The study also highlighted the need for improved communication between specialists and family physicians.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Environmental Sciences
Christoph Janka, Tanja Stamm, Georg Heinze, Thomas E. E. Dorner
Summary: Persistent stress and inadequate coping strategies have adverse effects on physical and mental health. Teaching adults the skills to effectively manage stress could contribute to the prevention of stress-related diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Rheumatology
Maarten H. P. Butink, Casper Webers, Suzanne M. M. Verstappen, Louise Falzon, Neil Betteridge, Dieter Wiek, Anthony D. Woolf, Tanja A. Stamm, Gerd R. Burmester, Johannes W. J. Bijlsma, Robin Christensen, Annelies Boonen
Summary: A systematic review found that non-pharmacological interventions have small effects on work participation in people with rheumatic and musculoskeletal diseases. The effectiveness of these interventions depends on contextual factors such as disease, population risk status, intervention characteristics, and outcome of interest.
Letter
Rheumatology
Paul Studenic, Daniel Aletaha, Tanja A. Stamm, Maarten de Wit, Diane Lacaille, Josef S. Smolen, David Felson
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Tanja A. Stamm, Julia Partheymueller, Erika Mosor, Valentin Ritschl, Sylvia Kritzinger, Alessia Alunno, Jakob-Moritz Eberl
Summary: Findings from two conjoint experiments conducted in Austria and Italy revealed that tailored vaccination campaigns based on previous vaccination status are more effective. For the unvaccinated, campaign messages conveying community spirit had a positive effect, while offering positive incentives was pivotal to the decision-making of those vaccinated once or twice. Among the triple vaccinated, vaccination readiness increased when adapted vaccines were offered, but costs and medical dissensus reduced their likelihood to get vaccinated. Failing to mobilize the triple vaccinated is likely to result in booster vaccination rates falling short of expectations.
Review
Rheumatology
Ioannis Parodis, Alvaro Gomez, Alexander Tsoi, Jun Weng Chow, Denise Pezzella, Charlotte Girard, Tanja A. Stamm, Carina Bostrom
Summary: This systematic literature review provides evidence for the non-pharmacological management of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) to inform EULAR recommendations. Physical activity, patient education, and self-management are widely studied and found to be effective strategies. Psychological interventions improve quality of life in SLE, while phototherapy and laser treatment improve cutaneous manifestations in SSc.
Review
Oncology
C. -S Leonhardt, T. Stamm, T. Hank, G. Prager, O. Strobel
Summary: This study aims to explore the definition of oligometastatic disease (OMD) in pancreatic ductal adenocarcinoma (PDAC) and the use of local consolidative treatment (LCT). The findings reveal a lack of consensus on the definition of OMD in PDAC, with significant variation between studies and methodological issues. This highlights the need for a consensus definition of OMD.