Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells

Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress

(2019) Eric Moeglin et al.   Cancers

Update on PARP Inhibitors in Breast Cancer

(2018) Alexandra S. Zimmer et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

The evolving landscape of predictive biomarkers of response to PARP inhibitors

(2018) Anish Thomas et al.   JOURNAL OF CLINICAL INVESTIGATION

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

(2018) Alan Ashworth et al.   Nature Reviews Clinical Oncology

PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53

(2018) Qi Liu et al.   ONCOGENE

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

Deletion of ATM in tumor but not endothelial cells improves radiation response in a primary mouse model of lung adenocarcinoma

(2018) Jordan A Torok et al.   CANCER RESEARCH

PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification

(2018) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DNA Repair in Prostate Cancer: Biology and Clinical Implications

(2017) Joaquin Mateo et al.   EUROPEAN UROLOGY

ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib

(2017) Chen Wang et al.   Translational Oncology

Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC

(2017) Lars F. Petersen et al.   Oncotarget

Targeting the ATR-CHK1 Axis in Cancer Therapy

(2017) Stuart Rundle et al.   Cancers

ATM Mutations in Cancer: Therapeutic Implications

(2016) M. Choi et al.   MOLECULAR CANCER THERAPEUTICS

ATM protein is deficient in over 40% of lung adenocarcinomas

(2016) Liza C. Villaruz et al.   Oncotarget

Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition

(2016) Junko Murai et al.   Oncotarget

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis

(2015) Jonathan F. Goodwin et al.   CANCER CELL

Replication-induced DNA damage after PARP inhibition causes G2delay, and cell line-dependent apoptosis, necrosis and multinucleation

(2015) Idun Dale Rein et al.   CELL CYCLE

New distinct compartments in the G2phase of the cell cycle defined by the levels of γH2AX.

(2015) Idun Dale Rein et al.   CELL CYCLE

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle

(2015) I. A. Shaltiel et al.   JOURNAL OF CELL SCIENCE

Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines

(2014) Eiji Kubota et al.   CELL CYCLE

ATM: Expanding roles as a chief guardian of genome stability

(2014) Yosef Shiloh   EXPERIMENTAL CELL RESEARCH

ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status

(2013) C. J. Huntoon et al.   CANCER RESEARCH

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53

(2012) Chris T. Williamson et al.   EMBO Molecular Medicine

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Heat shock protein 90  (HSP90 ), a substrate and chaperone of DNA-PK necessary for the apoptotic response

(2012) S. Solier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

(2011) A Peasland et al.   BRITISH JOURNAL OF CANCER

The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases

(2011) Stéphanie Solier et al.   CELL CYCLE

Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis

(2011) Kyung-Jong Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

(2011) Philip M Reaper et al.   Nature Chemical Biology

The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo

(2010) V. J. Weston et al.   BLOOD

Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells

(2010) P. Gottipati et al.   CANCER RESEARCH

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

ATM Deficiency Sensitizes Mantle Cell Lymphoma Cells to Poly(ADP-Ribose) Polymerase-1 Inhibitors

(2010) C. T. Williamson et al.   MOLECULAR CANCER THERAPEUTICS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

(2010) Wael Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

(2010) C. E. Strom et al.   NUCLEIC ACIDS RESEARCH

PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data

(2009) C. D. Greenman et al.   BIOSTATISTICS

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity

(2008) Christopher J. Lord et al.   DNA REPAIR

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE