Article
Oncology
Yuki Nakagami, Shoichi Hazama, Nobuaki Suzuki, Shin Yoshida, Shinobu Tomochika, Hiroto Matsui, Yoshitaro Shindo, Yukio Tokumitsu, Satoshi Matsukuma, Yusaku Watanabe, Michihisa Iida, Ryouichi Tsunedomi, Shigeru Takeda, Tomonobu Fujita, Yutaka Kawakami, Hiroyuki Ogihara, Yoshihiko Hamamoto, Tatsuya Ioka, Tsuyoshi Tanabe, Tomio Ueno, Hiroaki Nagano
Summary: The combination of low CD4(+) and low FOXP3(+) T-cell densities resulted in extremely poor RFS in patients with T3/T4a stage II CRC, suggesting the consideration of adjuvant chemotherapy for these patients.
Article
Immunology
Mohammad A. Al-Mterin, Khaled Murshed, Eyad Elkord
Summary: This study investigates the correlations between different T cell subsets and immune checkpoint-expressing CD4(+) T cells in CRC patients. The results show positive correlations between different immune checkpoint-expressing CD4(+) T cells and Treg subsets, especially in the tumor microenvironment. These findings contribute to a better understanding of the mechanisms of Treg-mediated immunosuppression in cancer.
Article
Immunology
Mohammad A. Al-Mterin, Khaled Murshed, Eyad Elkord
Summary: This study investigates the correlations between T regulatory cell subsets and immune checkpoint-expressing CD4(+) T cells in colorectal cancer patients. The findings show that these highly immunosuppressive cells have the potential to inhibit inflammatory responses in the tumor microenvironment. Understanding these correlations can enhance our understanding of the mechanisms of Treg-mediated immunosuppression in cancer.
Article
Oncology
Nanna Jorgensen, Thomas Vauvert F. Hviid, Lise B. Nielsen, Ida M. H. Sonderstrup, Jens Ole Eriksen, Bent Ejlertsen, Anne-Marie Gerdes, Torben A. Kruse, Mads Thomassen, Maj-Britt Jensen, Anne-Vibeke Laenkholm
Summary: The study found that the expression of CD4 and CD8 in BRCA-associated breast cancer is related to certain clinicopathological characteristics and BRCA gene status. A high percentage of CD4, CD8, or FOXP3 positive cells is significantly associated with lower mortality in BRCA1- and BRCA2-associated breast cancer, suggesting a prognostic role of specific T-cell subsets in these patients.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Fengwei Gao, Kunlin Xie, Qiwen Xiang, Yan Qin, Panyu Chen, Haifeng Wan, Yang Deng, Jiwei Huang, Hong Wu
Summary: This study found a dose-response relationship between TILs concentration in tumors and overall survival as well as disease-free survival in HCC patients, validating the prognostic value of TILs. Additionally, hepatitis B or C virus infection patients had higher TILs intensity in the para-tumor tissue.
Article
Oncology
Tianzhen He, Yibo Chen, De Yang, Md Sahidul Islam, Chon-Kit Chou, Jiarui Liu, Denise L. Faustman, Joost J. Oppenheim, Xin Chen
Summary: This study found that an anti-mouse TNFR2 antibody TY101 can inhibit the proliferative expansion of Tregs and promote their death. In a mouse tumor model, TY101 antibody treatment effectively inhibited tumor growth and triggered potent antitumor immune responses.
Article
Oncology
Kosuke Kobayashi, Yoshihiro Ono, Yuki Kitano, Atsushi Oba, Takafumi Sato, Hiromichi Ito, Yoshihiro Mise, Eiji Shinozaki, Yosuke Inoue, Kensei Yamaguchi, Akio Saiura, Yu Takahashi
Summary: This study aimed to investigate biologic prognostic factors in patients with resectable colorectal liver metastasis (CLM). High tumor marker levels were identified as independent poor prognostic factors for patients with resectable CLM and perioperative chemotherapy was found to improve long-term outcomes for patients with CLM and high tumor marker levels.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Yanping Hu, Jiuzhou Zhao, Yihang Shen, Chengjuan Zhang, Qingxin Xia, Guoqiang Zhang, Bo Wang, Bing Wei, Rentao Yu, Jie Ma, Yongjun Guo
Summary: The study found that CD8 + CD279+ cells are an independent prognostic factor for DFS in CRC patients, with high levels of CD8 + CD279+ cells associated with better DFS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Safa Can Efil, Gunes Guner, Deniz Can Guven, Burcu Celikten, Elvin Celebiyev, Hakan Taban, Aytekin Akyol, Aynur Isik, Sadettin Kilickap, Suayib Yalcin, Omer Dizdar
Summary: The study investigated the prognostic and predictive value of systemic inflammatory indices and CD8(+) tumor infiltrating lymphocytes (TILs) in colon cancer patients. It was found that high systemic inflammatory indices and low CD8(+) TILs were associated with shorter disease-free survival. Among patients with stage II disease, high combined inflammation score had significant benefits from adjuvant chemotherapy.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Oncology
Hyung-Don Kim, Jwa Hoon Kim, Yeon-Mi Ryu, Danbee Kim, Sunmin Lee, Jaehoon Shin, Seung-Mo Hong, Ki-Hun Kim, Dong-Hwan Jung, Gi Won Song, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Baek-Yeol Ryoo, Jae Ho Jeong, Kyu-pyo Kim, Sang-Yeob Kim, Changhoon Yoo
Summary: The density of T cell subsets, including CD8(+) T cells and different types of CD4(+) T cells, is higher in the tumor margin compared to the stroma and tumor core in biliary tract cancer patients treated with gemcitabine plus cisplatin. A high density of FoxP3(-) CD4(+) helper T cells in the tumor margin may be associated with better clinical outcomes.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Biotechnology & Applied Microbiology
Miao Qin, Gang Chen, Jinxia Hou, Li Wang, Qunfeng Wang, Lina Wang, Dan Jiang, Ye Hu, Bei Xie, Jing Chen, Hulai Wei, Guangxian Xu
Summary: This study aimed to investigate the features and prognosis of tumor-infiltrating lymphocytes (TILs) in colorectal cancer (CRC). By integrating multiple databases, it was found that macrophages were enriched in CRC, and there were higher numbers of CD4 + T cells, B cells, and CD8 + T cells. The infiltrating level of TIL subgroups from highest to lowest was consistently dendritic cells, CD8 + T cells, CD4 + T cells, neutrophils, B cells, and macrophages, regardless of specific gene mutations or somatic copy number variation (sCNV). Additionally, CD4+ TILs and CD8+ TILs were found to have potential prognostic value in CRC, and age was negatively associated with CD8+ TILs and B cell infiltration. Furthermore, CRC patients aged over 70 years showed a better response to immune-checkpoint blockade.
Review
Oncology
Sandra Pavicevic, Sophie Reichelt, Deniz Uluk, Isabella Lurje, Cornelius Engelmann, Dominik P. Modest, Uwe Pelzer, Felix Krenzien, Nathanael Raschzok, Christian Benzing, Igor M. Sauer, Sebastian Stintzing, Frank Tacke, Wenzel Schoening, Moritz Schmelzle, Johann Pratschke, Georg Lurje
Summary: Cholangiocarcinoma is a rapidly increasing global malignancy of the biliary tract, often presenting with advanced or unresectable disease. Biomarkers obtained from patients' serum or tumor tissue could help guide therapy and identify those at higher risk of recurrence. Genetic aberrations in cholangiocarcinoma have also been linked with improved response to targeted therapies. This review provides an overview of prognostic and predictive biomarkers in cholangiocarcinoma.
Article
Oncology
Ruanmin Zou, Ruihong Gu, Xia Yu, Yingying Hu, Junhui Yu, Xiangyang Xue, Xueqiong Zhu
Summary: This study reveals that the distribution of infiltrating immune cells affects their function in cervical cancer. An immune model based on immune cell infiltration can effectively predict survival, potentially helping to identify suitable candidates for chemoradiotherapy.
Article
Oncology
Dawei Chen, Qingshan Li, Haibo Yu
Summary: This study aimed to investigate the expression levels and prognostic roles of MMR, Ki67, and LVI in colorectal liver metastases (CRLM). The study found that MMR, Ki67, and LVI were significantly correlated with prognosis. Multivariate analysis showed that higher serum CA199 levels, N1-2 stage, the presence of LVI, higher Ki67, and pMMR all predicted worse overall survival (OS) and disease-free survival (DFS) in CRLM patients. A nomogram model was constructed to predict the OS of these patients after liver metastasis surgery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Jiateng Zhong, Yu Qin, Pei Yu, Weiyue Xia, Baoru Gu, Xinlai Qian, Yuhan Hu, Wei Su, Zheying Zhang
Summary: Tumor-infiltrating immune cells play an important role in prognosis and immunotherapy of colorectal cancer. The CIBERSORT method was used to analyze immune cell proportions in CRC data and a prognostic model with high specificity and sensitivity was constructed.
FRONTIERS IN GENETICS
(2022)