Article
Anesthesiology
Ria E. Hopkins, Gabrielle Campbell, Louisa Degenhardt, Suzanne Nielsen, Fiona Blyth, Milton Cohen, Natasa Gisev
Summary: Although multimodal management is recommended for chronic noncancer pain (CNCP), little is known about the long-term treatment utilization patterns among individuals using opioids. This study conducted in Australia found that many Australians using opioids for CNCP also used nonopioid pharmacological and nonpharmacological treatments. However, some treatment use was inconsistent with guidelines and the use of nonpharmacological treatments was associated with having private health insurance.
Article
Medicine, General & Internal
Natasa Gisev, Luke Buizen, Ria E. Hopkins, Andrea L. Schaffer, Benjamin Daniels, Chrianna Bharat, Timothy Dobbins, Sarah Larney, Fiona Blyth, David C. Currow, Andrew Wilson, Sallie-Anne Pearson, Louisa Degenhardt
Summary: The objective of this population-based cohort study was to identify 5-year trajectories of prescription opioid use and examine the characteristics of each trajectory group. The results suggest that most individuals initiating treatment with prescription opioids had relatively low and time-limited exposure over a 5-year period. A small proportion of individuals had sustained or increasing use, and they were typically older with more comorbidities and higher use of psychotropic and other analgesic drugs.
Article
Rheumatology
Ian C. Scott, James Bailey, Chris White, Christian D. Mallen, Sara Muller
Summary: This study found that opioid prescribing is common in the management of inflammatory arthritis (IA) pain, despite limited evidence of efficacy and potential harms.
Article
Medicine, General & Internal
Victor Mayoral Rojals, Angeles Canos Verdecho, Begona Soler Lopez
Summary: This study aims to assess the quality of treatment for chronic pain patients referred to specialized pain units. The findings show that 9.8% of patients were not receiving any analgesic treatment before referral, and 88.1% of patients experienced treatment modifications after referral. Women patients had higher levels of pain severity and changes in the diagnosis of the underlying condition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Belinda Butcher, Elizabeth Hutchings, Belinda Fazekas, Katherine Clark, Debra Rowett, David Currow
Summary: Despite heterogeneity in the results, ketorolac may have a certain effect in sparing opioids; there is insufficient data to analyze the frequency of opioid use or the need for rescue medication.
PALLIATIVE MEDICINE
(2022)
Article
Medicine, General & Internal
In-Ae Song, Hey-Ran Choi, Tak Kyu Oh
Summary: This study investigated the prevalence and factors associated with long-term opioid use among patients with chronic non-cancer pain (CNCP) in South Korea. The study found that long-term opioid use increased among CNCP patients from 2010 to 2019. Certain factors were identified as potential risk factors for long-term opioid use, and long-term opioid use was associated with increased 10-year all-cause mortality among CNCP patients.
Article
Oncology
Kevin T. Liou, Kelly M. Trevino, Salimah H. Meghani, Q. Susan Li, Gary Deng, Deborah Korenstein, Jun J. Mao
Summary: The study evaluated the preference for acupuncture as a treatment option among cancer patients with attitudinal barriers to pharmacological pain management. It found that a significant proportion of patients preferred acupuncture over analgesics, especially those with fears of analgesic side effects. Other factors such as gender and attitudes/beliefs about acupuncture also played a role in predicting acupuncture preference.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Anesthesiology
Nafisseh S. Warner, Michelle Mielke, Brandon P. Verdoorn, David S. Knopman, William M. Hooten, Elizabeth B. Habermann, David O. Warner
Summary: This manuscript summarizes the evidence and critical knowledge gaps regarding the relationships between pain, opioid analgesics, and cognition in older adults. It provides a conceptual framework to guide future research in optimizing analgesic outcomes in older adults while minimizing deleterious effects on cognition.
Review
Geriatrics & Gerontology
Laura A. Dowd, Amanda J. Cross, Felicity Veal, Choon Ean Ooi, J. Simon Bell
Summary: Effective interventions can improve analgesic use and appropriateness in long-term care facilities. Interventions involving prescribers, pharmacists, and nurses, with an educational component, are most effective. Combining education and decision support also shows promise. Medication review interventions can lead to changes in medication prescription.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Anesthesiology
Ana Johnson, Brian Milne, Narges Jamali, Matthew Pasquali, Ian Gilron, Steve Mann, Kieran Moore, Erin Graves, Joel Parlow
Summary: This study aimed to examine the association between duration of postoperative opioid prescriptions and healthcare costs and resource utilization in senior patients following hip and knee replacement. The study found that chronic opioid use after surgery was associated with higher resource utilization and healthcare costs.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Article
Pharmacology & Pharmacy
Aina Perello-Bratescu, Christian Dursteler, Maria Asuncion Alvarez-Carrera, Laura Granes, Belchin Kostov, Antoni Siso-Almirall
Summary: In chronic non-cancer pain, the evidence of the effectiveness of strong opioids is limited but their use is becoming increasingly common. A population-based study in Catalonia found that a significant number of patients, especially women and those over 80 years old, were prescribed strong opioids for CNCP in primary care settings for extended periods.
Article
Clinical Neurology
Motoki Sonohata, Shihomi Wada, Yuichi Koretaka, Yasuhide Morioka, Hirokazu Mishima, Masaaki Mawatari
Summary: This study investigated the incidence of opioid-induced constipation in patients using opioid analgesics for chronic non-cancer pain in Japan. The study found a significant association between opioid use and constipation, emphasizing the importance of appropriate treatment for constipation in these patients.
Article
Anesthesiology
F. Plass, C. Nicolle, M. Zamparini, G. Al Issa, A. L. Fiant, Y. Le Roux, J. L. Gerard, M. O. Fischer, A. Alves, J. -L. Hanouz
Summary: Lidocaine infusion during bariatric surgery did not result in a clinically significant difference in postoperative oxycodone consumption compared to the control group.
Article
Oncology
Daisuke Nishizawa, Takeshi Terui, Kunihiko Ishitani, Shinya Kasai, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata, Kazutaka Ikeda
Summary: Considerable individual differences in sensitivity to opioids have been observed. In a genome-wide association study of cancer pain patients, specific SNPs were found to be significantly associated with opioid analgesic requirements. These findings may contribute to personalized pain treatment.
Article
Urology & Nephrology
Kam Wa Chan, J. David Smeijer, Meir Schechter, Niels Jongs, Priya Vart, Donald E. Kohan, Ron T. Gansevoort, Adrian Liew, Sydney C. W. Tang, Christoph Wanner, Dick de Zeeuw, Hiddo J. L. Heerspink
Summary: Pain is common among patients with diabetes and chronic kidney disease, and the use of commonly prescribed drugs is limited due to their nephrotoxicity. This study investigated the association between the endothelin receptor antagonist atrasentan and pain and prescription of analgesics. The findings suggest that atrasentan may reduce pain-related events and the use of analgesics in patients with type 2 diabetes and chronic kidney disease.
KIDNEY INTERNATIONAL
(2023)