VEGF-C induced by TGF- β1 signaling in gastric cancer enhances tumor-induced lymphangiogenesis

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

(2018) Rikke B. Holmgaard et al.   Journal for ImmunoTherapy of Cancer

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

SIX1 Promotes Tumor Lymphangiogenesis by Coordinating TGF  Signals That Increase Expression of VEGF-C

(2014) D. Liu et al.   CANCER RESEARCH

Transforming Growth Factor-  as a Therapeutic Target in Hepatocellular Carcinoma

(2014) G. Giannelli et al.   CANCER RESEARCH

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Differential regulation of TGF-β–induced, ALK-5–mediated VEGF release by SMAD2/3 versus SMAD1/5/8 signaling in glioblastoma

(2014) Katharina Seystahl et al.   NEURO-ONCOLOGY

Lymphangiogenic and Angiogenic Microvessel Density in Chinese Patients with Gastric Carcinoma: Correlation with Clinicopathologic Parameters and Prognosis

(2013) Fang Cao et al.   Asian Pacific Journal of Cancer Prevention

Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer

(2012) Yonghui Wu et al.   GUT

Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction

(2012) Yasuhiro Suzuki et al.   KIDNEY INTERNATIONAL

Transforming Growth Factor-β in the Gastrointestinal and Hepatic Tumor Microenvironment

(2011) Bhagelu Ram Achyut et al.   GASTROENTEROLOGY

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Prognostic Significance of Intratumoral and Peritumoral Lymphatic Density and Blood Vessel Density in Invasive Breast Carcinomas

(2008) Yasser M. El-Gohary et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

TGFβ in Cancer

(2008) Joan Massagué   CELL