Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer
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Title
Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer
Authors
Keywords
Non-small-cell lung cancer, Carbon ion exposure, PARP-1, Matrix metalloproteinases (MMPs), Epithelial-mesenchymal transition (EMT), Metastatic potential
Journal
BMC CANCER
Volume 19, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-08-22
DOI
10.1186/s12885-019-6015-4
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Note: Only part of the references are listed.- Proteomic Analysis of the Downstream Signaling Network of PARP1
- (2018) Yuanli Zhen et al. BIOCHEMISTRY
- Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes
- (2016) Dong Wang et al. GYNECOLOGIC ONCOLOGY
- Effects of PARP-1 inhibitor and ERK inhibitor on epithelial mesenchymal transitions of the ovarian cancer SKOV3 cells
- (2016) Shan Su et al. Pharmacological Reports
- PARP-1 depletion in combination with carbon ion exposure significantly reduces MMPs activity and overall increases TIMPs expression in cultured HeLa cells
- (2016) Atanu Ghorai et al. Radiation Oncology
- Carbon ion irradiation withstands cancer stem cells’ migration/invasion process in Head and Neck Squamous Cell Carcinoma (HNSCC)
- (2016) Coralie Moncharmont et al. Oncotarget
- Carbon ion beam triggers both caspase-dependent and caspase-independent pathway of apoptosis in HeLa and status of PARP-1 controls intensity of apoptosis
- (2015) Atanu Ghorai et al. APOPTOSIS
- PJ-34 inhibits PARP-1 expression and ERK phosphorylation in glioma-conditioned brain microvascular endothelial cells
- (2015) Carla Motta et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells
- (2015) Xiaodong Jin et al. Scientific Reports
- Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells
- (2015) Kathleen A. Bridges et al. Oncotarget
- Cancer statistics, 2014
- (2014) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The role of p38 signaling and poly(ADP-ribosyl)ation-induced metabolic collapse in the osteogenic differentiation-coupled cell death pathway
- (2014) Agnieszka Robaszkiewicz et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The inhibition of PARP but not EGFR results in the radiosensitization of HPV/p16-positive HNSCC cell lines
- (2014) Julian David Güster et al. RADIOTHERAPY AND ONCOLOGY
- NF- B, an Active Player in Human Cancers
- (2014) Y. Xia et al. Cancer Immunology Research
- PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies
- (2013) J.-m. Lee et al. ANNALS OF ONCOLOGY
- Charged particle therapy—optimization, challenges and future directions
- (2013) Jay S. Loeffler et al. Nature Reviews Clinical Oncology
- PARP-1 Regulates Metastatic Melanoma through Modulation of Vimentin-induced Malignant Transformation
- (2013) María Isabel Rodríguez et al. PLoS Genetics
- Ionizing Radiation Promotes Migration and Invasion of Cancer Cells Through Transforming Growth Factor-Beta–Mediated Epithelial–Mesenchymal Transition
- (2011) Yong-Chun Zhou et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
- (2011) Thomas Helleday Molecular Oncology
- Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy
- (2011) Christopher Allen et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Bcl-XL and STAT3 mediate malignant actions of γ-irradiation in lung cancer cells
- (2010) Jin-Nyoung Ho et al. CANCER SCIENCE
- Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer
- (2010) Evette S. Radisky et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53-Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin
- (2009) T. Hay et al. CANCER RESEARCH
- Carbon-Ion Beam Irradiation Effectively Suppresses Migration and Invasion of Human Non–Small-Cell Lung Cancer Cells
- (2009) Yuichi Akino et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation
- (2009) Mohammad B. Hossain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- Loss of tight junction barrier function and its role in cancer metastasis
- (2008) Tracey A. Martin et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radioresistance
- (2008) S J Veuger et al. ONCOGENE
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