Review
Oncology
Lori A. Leslie
Summary: When choosing therapy for patients with indolent non-Hodgkin lymphoma, factors such as age and comorbid conditions need to be considered. While incurable, iNHL is a chronic disease with a long overall survival period. Despite advancements in available therapies, progress in iNHL has been slow.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Hematology
Dennis A. Eichenauer, Horst Muller, Leonard Elger, Helen Goergen, Michael Fuchs, Stefanie Kreissl, Boris Boll, Volker Diehl, Bastian von Tresckow, Peter Borchmann, Andreas Engert
Summary: NHL after cHL is a rare event that primarily affects older individuals, with a five-year event-free survival and overall survival estimates of 36.9% and 44.2% respectively.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Shih-Shih Chen, Jacqueline C. Barrientos, Gerardo Ferrer, Morgan King-Richards, Yu-Ju Chen, Priyadarshini Ravichandran, Michael Ibrahim, Yasmine Kieso, Sheila Waters, Jeffery L. Kutok, Marisa Peluso, Sujata Sharma, David T. Weaver, Jonathan A. Pachter, Kanti R. Rai, Nicholas Chiorazzi
Summary: Our study demonstrates the essential roles of PI3K-δ in CLL B-cell survival and migration, and PI3K-γ in T-cell migration and macrophage polarization. Dual inhibition of PI3K-δ and PI3K-γ effectively reduces leukemia burden. Duvelisib treatment shows promising results for patients refractory to BTKi.
CLINICAL CANCER RESEARCH
(2023)
Article
Dermatology
A. Goyal, D. O'Leary, K. Goyal, N. Rubin, M. Janakiram
Summary: Patients with mycosis fungoides (MF) have an increased risk of developing various types of cancers, with those developing non-Hodgkin lymphoma (NHL), lung cancer, and bladder cancer tending to be diagnosed at earlier stages and showing better 5-year overall survival. Regular pigmented-lesion-focused skin examinations are recommended for MF patients, along with smoking cessation counseling and ensuring up-to-date cancer screenings. Regular imaging and lab testing for second malignancy screening require further study and expert consensus.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Veterinary Sciences
Joana N. R. Dias, Ana S. Andre, Sandra I. I. Aguiar, Solange Gil, Luis Tavares, Frederico Aires-da-Silva
Summary: The new era of immune-oncology presents challenges and opportunities, with the use of a canine model in cancer immunotherapy drug development being widely recognized. Comparative research between human and canine NHL can provide valuable insights into treatment strategies. Additionally, the canine model may help bridge the gap between preclinical studies and clinical trials.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
H. Dean Hosgood, Meghan Davitt, Richard Cawthon, Stephanie J. Weinstein, Batel Blechter, Jason Y. Y. Wong, Mohammad L. Rahman, Wei Hu, Satu Mannisto, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Summary: This study suggests that a higher fraction of mitochondrial DNA with breaks is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Article
Immunology
Laura E. Martinez, Larry I. Magpantay, Yu Guo, Priya Hegde, Roger Detels, Shehnaz K. Hussain, Marta Epeldegui
Summary: The study revealed significantly higher levels of EVs bearing PD-L1, CD40, TNF-RII, and/or IL-6R alpha in AIDS-NHL cases compared to controls. EVs carrying these molecules were found to be significantly and positively associated with AIDS-NHL risk, suggesting their potential as biomarkers for early detection of NHL in PLWH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kyla L. Trkulja, Farheen Manji, John Kuruvilla, Rob C. Laister
Summary: Exportin-1 (XPO1) plays a key role in the nuclear export pathway and is often overexpressed in cancer. In non-Hodgkin lymphoma (NHL), high XPO1 expression is associated with poor prognosis due to its role in exporting proteins and RNA involved in cancer progression and treatment resistance. This article discusses the proteins and RNA transcripts identified as XPO1 cargo in NHL, as well as the research on XPO1 inhibitors like selinexor and other selective inhibitors of nuclear export (SINEs) for treating NHL. Studies on the anti-cancer effects of SINEs in vitro, in vivo, and in clinical settings, both as monotherapy and in combination, are also reviewed. The limitations of current research and future directions for improving the clinical utility of SINE compounds in NHL are discussed.
Article
Oncology
Allini Mafra, Mathieu Laversanne, Mary Gospodarowicz, Paulo Klinger, Neimar De Paula Silva, Marion Pineros, Eva Steliarova-Foucher, Freddie Bray, Ariana Znaor
Summary: Global patterns of non-Hodgkin lymphoma (NHL) in 2020 were evaluated using the GLOBOCAN 2020 database. The study found that Eastern Asia, Northern America, and South-Central Asia had the highest number of NHL cases. Incidence rates were higher in men than in women, with the highest rates in Australia, New Zealand, Northern America, Northern Europe, and Western Europe. The highest mortality rates were found in regions in Africa, Western Asia, and Oceania.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: This study assessed the association between historic environmental pollutant emissions and chemical mixtures in house dust with non-Hodgkin lymphoma (NHL). The results showed a significant positive association between RSEI scores and NHL in long-term residents in Detroit, while significant inverse associations were found in two other study centers. These findings highlight the importance of considering historic and cumulative environmental exposures and using residential histories for diseases with long latency periods like NHL.
ENVIRONMENTAL RESEARCH
(2023)
Article
Hematology
Tanya Siddiqi, Jacob D. Soumerai, Kathleen A. Dorritie, Deborah M. Stephens, Peter A. Riedell, Jon Arnason, Thomas J. Kipps, Heidi H. Gillenwater, Lucy Gong, Lin Yang, Ken Ogasawara, Jerill Thorpe, William G. Wierda
Summary: Lisocabtagene maraleucel, an autologous CD19-directed CAR T-cell therapy, shows promising safety and efficacy in patients with relapsed/refractory CLL/SLL, providing a potential new treatment option for these patients who develop resistance to current therapies.
Article
Hematology
Miguel Alcoceba, Maria Garcia-Alvarez, M. Carmen Chillon, Cristina Jimenez, Alejandro Medina, Alicia Anton, Oscar Blanco, Luis G. Diaz, Pilar Tamayo, Veronica Gonzalez-Calle, Maria Jesus Vidal, Rebeca Cuello, Francisco Javier Diaz Galvez, Jose Antonio Queizan, Alejandro Martin, Marcos Gonzalez, Ramon Garcia-Sanz, M. Eugenia Sarasquete
Summary: The study utilizing liquid biopsy with ctDNA revealed genetic features of HL patients, identifying several genes related to poor prognosis. The number of variants in high-quality ctDNA samples was associated with disease severity in patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Health Care Sciences & Services
Sonia Guadalupe Barreno-Rocha, Sandra Guzman-Silahua, Ernesto German Cardona-Munoz, Maria Guadalupe Zavala-Cerna, David Eduardo Munoz Gaytan, Carlos Riebeling-Navarro, Benjamin Rubio-Jurado, Arnulfo Hernan Nava-Zavala
Summary: A retrospective cohort study was performed on patients diagnosed with Non-Hodgkin Lymphoma. The presence of autoantibodies was observed in 30 out of 39 patients, while 9 patients did not have autoantibodies. However, there were no statistically significant differences between the two groups in terms of clinical, demographic, staging, and prognosis characteristics. Further research on a broader panel of autoantibodies is needed to explore the relationship between their presence and the clinical outcome of patients.
Article
Oncology
Muhammad Saad Hamid, Sarah C. Rutherford, Hyejeong Jang, Seongho Kim, Krish Patel, Nancy L. Bartlett, Mary-Kate Malecek, Marcus P. Watkins, Kami J. Maddocks, David A. Bond, Tatyana A. Feldman, Gabriela Magarelli, Ranjana H. Advani, Michael A. Spinner, Andrew M. Evens, Mansi Shah, Sairah Ahmed, Deborah M. Stephens, Pamela Allen, Michael T. Tees, Reem Karmali, Bruce D. Cheson, Maryam Sarraf, Christopher Strouse, Neil A. Bailey, John M. Pagel, Radhakrishnan Ramchandren
Summary: This retrospective study evaluated the outcomes comparing therapy escalation with continuation of therapy in Hodgkin Lymphoma patients. The results showed heterogeneity of approaches, with less than 25% benefiting from therapy escalation.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Meeting Abstract
Hematology
Neil Bailey, Tori Braun, Megumi Bailey, Tenzin Tsomo, Jennie Szeto, Sandra Benitez Kruidenier, Vanessa Dunleavy, Joanna Fesler, Gayle Funk, Sonia Glennie, Judson Hall, Julia Parker, Daniel Egan, Raya Mawad, Carol A. Dean, Suzan Sullivan, Chia Lu, Heidi Hohmann, Jordan Briggs, Krish Patel
Meeting Abstract
Hematology
Anthony R. Mato, William G. Wierda, Weiyun Z. Ai, Ian W. Flinn, Michael Tees, Manish R. Patel, Krish Patel, Susan O'Brien, David A. Bond, Lindsey E. Roeker, Tanya Siddiqi, Michael L. Wang, Clare Sun, Omar Abdel-Wahab, Amanda Schwab, May Tan, Erin Meredith, Melissa A. Gessner, Su Young Kim, Adrian Wiestner, Alexey Danilov
Meeting Abstract
Hematology
Meghan C. Thompson, Catherine C. Coombs, Lindsey E. Roeker, Jeffrey L. Jensen, Nirav N. Shah, Thomas Luo, Krish Patel, Neil Bailey, Bita Fakhri, Toby A. Eyre, Paola Ghione, Joanna M. Rhodes, Andrew D. Zelenetz, Justin Taylor, Maria Lia Palomba, Kendall Meyer, Danielle Rao, Yehudit Fox, Julia H. Aronson, Sarah Court, Omar Abdel-Wahab, Anthony R. Mato
Meeting Abstract
Hematology
Michael L. Wang, Nirav N. Shah, Wojciech Jurczak, Pier Luigi Zinzani, Toby A. Eyre, Chan Y. Cheah, Chaitra S. Ujjani, Youngil Koh, Koji Izutsu, James N. Gerson, Ian W. Flinn, Benoit Tessoulin, Alvaro J. Alencar, Shuo Ma, Ewa Lech-Maranda, Joanna M. Rhodes, Krish Patel, Jennifer A. Woyach, Nicole Lamanna, Yucai Wang, Constantine S. Tam, John F. Seymour, Talha Munir, Hirokazu Nagai, Francisco Hernandez-Ilizaliturri, Anita Kumar, Andrew D. Zelenetz, Preetesh Jain, Binoj Nair, Donald E. Tsai, Minna Balbas, Richard A. Walgren, Paolo B. Abada, Chunxiao Wang, Junjie Zhao, Anthony R. Mato
Meeting Abstract
Hematology
Geoffrey Shouse, Andy Kaempf, Max J. Gordon, David Yashar, Audrey M. Sigmund, Gordon Smilnak, Steven M. Bair, Agrima Mian, Lindsey A. Fitzgerald, Amneet Bajwa, Samantha Jaglowski, Neil Bailey, Mazyar Shadman, Krish Patel, Deborah M. Stephens, Manali Kamdar, Brian T. Hill, Jordan Gauthier, Reem Karmali, Loretta J. Nastoupil, Adam S. Kittai, Alexey Danilov
Meeting Abstract
Hematology
Arushi Khurana, Megumi Bailey, Madiha Iqbal, Radhika Bansal, Catherine J. Lee, Bradley Hunter, Matthew A. Lunning, Samantha Jaglowski, Michael D. Jain, Saurabh Dahiya, Veronika Bachanova, Umar Farooq, Sairah Ahmed, Brian T. Hill, Javier L. Munoz, Krish Patel, Olalekan O. Oluwole, Yi Lin
Meeting Abstract
Hematology
Krish Patel, Peter A. Riedell, Herve Tilly, Sairah Ahmed, Jean-Marie Michot, Herve Ghesquieres, Jean Marc Schiano de Collela, Asher Chanan-Khan, Kamal Bouabdallah, Benoit Tessoulin, Sunil Iyengar, Meixiao Long, Raphael Clynes, Jitendra Kanodia, Lei Bao, Ying Ding, Jianhua Jin, William B. Ainsworth, Raman Garcha, Steve Kye, Tycel J. Phillips
Article
Oncology
Alan Z. Skarbnik, Krish Patel
Summary: Follicular lymphoma (FL) is a common lymphoma with a variable clinical course. The response to treatment decreases with each line of therapy, and poor survival outcomes are associated with disease progression within 24 months of initial treatment. Although rituximab-based regimens are preferred for early lines of treatment, there is no clear standard of care for third-line treatment or later.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Anthony R. Mato, Jennifer A. Woyach, Jennifer R. Brown, Paolo Ghia, Krish Patel, Toby A. Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine S. Tam, Nirav N. Shah, Catherine C. Coombs, Chaitra S. Ujjani, Bita Fakhri, Chan Y. Cheah, Manish R. Patel, Alvaro J. Alencar, Jonathon B. Cohen, James N. Gerson, Ian W. Flinn, Shuo Ma, Deepa Jagadeesh, Joanna M. Rhodes, Francisco Hernandez-Ilizaliturri, Pier L. Zinzani, John F. Seymour, Minna Balbas, Binoj Nair, Paolo Abada, Chunxiao Wang, Amy S. Ruppert, Denise Wang, Donald E. Tsai, William G. Wierda, Wojciech Jurczak
Summary: Pirtobrutinib, a noncovalent BTK inhibitor, showed efficacy in patients with CLL or SLL who had previously received covalent BTK inhibitor treatment. The most common adverse events were infections, bleeding, and neutropenia.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Meeting Abstract
Hematology
Richard R. Furman, William G. Wierda, Anna Schuh, Piers Em Patten, Jorge M. Chaves, Jennifer R. Brown, Talha Munir, Peter Martin, Farrukh T. Awan, Deborah M. Stephens, Paolo Ghia, Jacqueline C. Barrientos, Krish Patel, Jennifer A. Woyach, Anna Butturini, Marianne de Borja, Min Hui Wang, Susan O'Brien, John C. Byrd
Meeting Abstract
Oncology
Paolo Strati, Lori Ann Leslie, Parveen Shiraz, L. Elizabeth Budde, Olalekan O. Oluwole, Matthew Ulrickson, Aravind Ramakrishnan, Jennifer Sun, Rhine Shen, Justyna Kanska, Peter McCroskery, Jinghui Dong, Marco Andreas Schupp, Hairong Xu, Krish Patel
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Anthony Mato, Alexey Valeryevich Danilov, Manish R. Patel, Michael Timothy Tees, Ian W. Flinn, Weiyun Z. Ai, Krish Patel, Michael Wang, Susan M. O'Brien, Srinand Nandakumar, May Tan, Erin Meredith, Melissa Gessner, Su Young Kim, Adrian Wiestner, William G. Wierda
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Krish Patel, Dahlia Sano, Michael Maris, Alexander M. Lesokhin, Gottfried Von Keudell, Kimberley Doucette, Radhakrishnan Ramchandren, Dmitri Pavlov, Robert A. Uger, Naomi Molloy, Ingmar Bruns, Anita Scheuber, Swaminathan Padmanabhan Iyer
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Krish Patel, Robert Z. Orlowski, Kimberley Doucette, Michael Maris, Matthew James Pianko, Radhakrishnan Ramchandren, Don A. Stevens, David H. Vesole, Robert A. Uger, Anita Scheuber, Naomi Molloy, Ingmar Bruns, Alexander M. Lesokhin
JOURNAL OF CLINICAL ONCOLOGY
(2022)
