Review
Biochemistry & Molecular Biology
Daniela Damiani, Mario Tiribelli
Summary: The prognosis of acute myeloid leukemia (AML) remains unsatisfactory due to poor response to therapy or relapse, which can be attributed to the over-expression of multidrug resistance (MDR) proteins. ABCG2, an efflux transporter responsible for inducing MDR in leukemic cells, has the ability to extrude many antineoplastic drugs, leading to AML resistance and/or relapse. This review focuses on the expression and role of ABCG2, as well as its regulation and potential inhibition to counteract drug resistance and improve outcomes in AML patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Luyan Gao, Xuefeng Chen, Sheng Feng, Ying Lu, Kai Song, Huaying Shen, Yun Wang, Linsen Jiang, Zhi Wang
Summary: This study analyzed clinical data of elderly peritoneal dialysis (PD) patients and compared patient and technique survival rates between two age groups (65-74 years old and >= 75 years old). The results showed that cardiovascular events were the main cause of death, with higher patient survival in the younger age group and similar technique survival rates in both groups. Older age, lower prealbumin, higher creatinine, not being on activated vitamin D, and high Charlson's comorbidity index score were identified as independent risk factors for death.
Article
Oncology
Antonio Solana-Altabella, Juan Eduardo Megias-Vericat, Octavio Ballesta-Lopez, Blanca Boluda, Isabel Cano, Evelyn Acuna-Cruz, Rebeca Rodriguez-Veiga, Laura Torres-Minana, Claudia Sargas, Miguel A. Sanz, Carmela Borrell-Garcia, Eduardo Lopez-Briz, Jose Luis Poveda-Andres, Javier De la Rubia, Pau Montesinos, David Martinez-Cuadron
Summary: There is limited literature addressing the economic costs and burden of secondary acute myeloid leukemia (sAML). This study analyzed these factors in a real-life population of sAML patients receiving intensive chemotherapy induction. The findings show increased costs and longer hospital stays in elderly patients with sAML and intensive treatment regimens. The study also highlights the lack of research specific to this population and diagnosis, which adds value to the obtained results.
Article
Nutrition & Dietetics
Maria Barberia-Latasa, Maira Bes-Rastrollo, Rafael Perez-Araluce, Miguel Angel Martinez-Gonzalez, Alfredo Gea
Summary: The Mediterranean Alcohol Drinking Pattern (MADP) shows a significant reduction in all-cause mortality risk, with high adherence to the MADP score recommended for individuals aged 50 and above who choose to drink alcohol.
Article
Geriatrics & Gerontology
Kaisa Koivunen, Elina Sillanpaa, Matti Munukka, Erja Portegijs, Taina Rantanen
Summary: This study compared the functional capacity changes in two population-based older cohorts born 28 years apart. The results showed that the later cohort exhibited significantly better results in maximal functional capacity tests, indicating that current 75- and 80-year-old individuals in Finland are living longer with improved physical functioning.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Orthopedics
Alessandro Aprato, Luisangelo Sordo, Angelo Costantino, Luigi Sabatini, Luca Barberis, Diego Testa, Alessandro Masse
Summary: The study reported a 15.7% conversion rate to total knee replacement (TKR) at 20 years after arthroscopic meniscectomy (AM), with significant predictors for subsequent TKR including female sex, older age, lateral meniscectomy, malalignment, and advanced chondral lesion. Age 60 to 70 years at the time of AM and lateral meniscectomy were negative predictor factors for achieving equal or superior Knee Injury and Osteoarthritis Outcome Score (KOOS) scores adjusted for age and sex.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Review
Oncology
Dong-Yeop Shin
Summary: The TP53 gene is frequently mutated in various human cancers and is the first tumor suppressor gene discovered. Mutations within the DNA-binding domain of TP53 result in loss of DNA-binding capability of p53 protein. However, the phenotypic landscape of TP53 mutations is complex and presents a significant challenge in developing effective treatment strategies. TP53-mutated AML is associated with poor prognosis and is classified as a distinct subgroup within AML. Current standard treatments are largely ineffective for TP53-mutated AML, and there is an urgent need for novel treatment approaches.
Article
Environmental Studies
Nick Gales
Summary: This article examines the current status and relevance of the International Whaling Commission (IWC) as it celebrates its 75th year of operation. It highlights the changes and challenges faced by the IWC, including Japan's withdrawal from the International Convention for the Regulation of Whaling, Iceland's consideration of ending its commercial whaling program, and the impact of the COVID-19 pandemic. The article emphasizes the importance of the IWC's role in addressing non-whaling threats and suggests that it has the potential to expand its leadership role through collaborations with relevant multi-lateral agencies and conventions.
Article
Urology & Nephrology
Alex Zhu, Juan Andino, Stephanie Daignault-Newton, Zoey Chopra, Aruna Sarma, James M. M. Dupree
Summary: There is an age-related decline in male testosterone production. It is important to use age-specific cutoffs for low testosterone levels in the evaluation of young men presenting with testosterone deficiency.
JOURNAL OF UROLOGY
(2022)
Article
Orthopedics
Dhruv S. S. Shankar, Naina Rao, Christopher A. A. Colasanti, Rae Lan, Anthony A. A. Essilfie, Thomas Youm
Summary: The study aimed to evaluate the impact of age on the time required for older FAIS patients, in the 50-75 year age range, to achieve the Patient Acceptable Symptom State (PASS) following primary hip arthroscopy compared to younger patients. While there were no significant differences in achieving the Minimum Clinically Important Difference (MCID) and Substantial Clinical Benefit (SCB), older patients experienced a delay in achieving PASS compared to younger patients. This suggests that age may play a role in the postoperative recovery timeline for FAIS patients.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Transplantation
Rozemarijn Snoek, Richard H. van Jaarsveld, Tri Q. Nguyen, Edith D. J. Peters, Martin G. Elferink, Robert F. Ernst, Maarten B. Rookmaaker, Marc R. Lilien, Eric Spierings, Roel Goldschmeding, Nine V. A. M. Knoers, Bert van der Zwaag, Arjan D. van Zuilen, Albertien M. van Eerde
Summary: Genetic testing in chronic kidney disease patients, especially those with high likelihood of genetic disease, can provide early diagnosis, impact prognosis and treatment, and reduce the need for invasive biopsies.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Oncology
Zachary D. Epstein-Peterson, Barbara Spitzer, Andriy Derkach, Juan E. Arango, Joseph G. W. McCarter, Juan S. Medina-Martinez, Erin McGovern, Noushin Rahnamay Farnoud, Ross L. Levine, Martin S. Tallman
Summary: There is a lack of data on the treatment approach and clinical outcomes in younger patients with myelodysplastic syndromes (MDS), particularly in terms of genomic profiling. This study analyzed patients aged 20-50 at diagnosis and found that younger patients with de novo MDS often have high-risk disease features, including adverse cytogenetics, higher R-IPSS, and alterations in genes related to epigenetic and transcription pathways.
Article
Psychology, Multidisciplinary
Krzysztof Mackala, Dariusz Mroczek, Pawel Chmura, Marek Konefal, Damian Pawlik, Bartosz Ochman, Jan Chmura, Bartlomiej Paleczny, Rafal Seredynski, Malgorzata Wyciszkiewicz, Adrianna Nowicka-Czudak, Wojciech Lopusiewicz, Dorota Adamiec, Szczepan Wiecha, Piotr Ponikowski, Beata Ponikowska
Summary: This research examines the relationship between marathon performance and muscle stiffness changes in recreational runners aged 50+ years. The study found that long-distance running exercise (marathon) in older recreational runners did not significantly affect muscle stiffness. However, there was reduced muscle stiffness in the triceps of the calf in the dominant leg.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Claire de Moreuil, Raphael Le Mao, Emmanuelle Le Moigne, Brigitte Pan-Petesch, Cecile Tromeur, Clement Hoffmann, Pierre-Yves Salaun, Michel Nonent, Marc Danguy des Deserts, Xavier Savary, Marie Guegan, Elise Poulhazan, Christophe Leroyer, Karine Lacut, Francis Couturaud
Summary: In patients with a first VTE under 50 years old, a first unprovoked episode and a family history of VTE, but not gender, were associated with a high risk of long-term recurrence.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Cindy S. Lee, Alana Lewin, Beatriu Reig, Laura Heacock, Yiming Gao, Samantha Heller, Linda Moy
Summary: Screening mammography should be continued for women aged 75 and older as it has higher sensitivity, specificity, cancer detection rate, and positive predictive values in this population. Early detection of breast cancer in older women reduces invasive treatment and mortality risks. Shared decision making and consideration of individual values, overall health status, and comorbidities are important in guiding screening decisions for this age group.
Letter
Hematology
Asa Derolf, Gunnar Juliusson, Lina Benson, Yngvar Floisand, Vladimir Lazarevic, Petar Antunovic, Lars Mollgard, Soren Lehmann, Bertil Uggla, Anders Wahlin, Martin Hoglund, Stefan Deneberg
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Letter
Hematology
Albin Osterroos, Anna Eriksson, Petar Antunovic, Jorg Cammenga, Stefan Deneberg, Vladimir Lazarevic, Fryderyk Lorenz, Lars Mollgard, Asa R. Derolf, Bertil Uggla, Lovisa Wennstrom, Emma Olander, Martin Hoglund, Gunnar Juliusson, Soren Lehmann
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Editorial Material
Hematology
Vladimir Lj Lazarevic, Bertil Johansson
EXPERT REVIEW OF HEMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Carl Sanden, Henrik Lilljebjorn, Christina Orsmark Pietras, Rasmus Henningsson, Karim H. Saba, Niklas Landberg, Hanna Thorsson, Sofia von Palffy, Pablo Pena-Martinez, Carl Hogberg, Marianne Rissler, David Gisselsson, Vladimir Lazarevic, Gunnar Juliusson, Helena Agerstam, Thoas Fioretos
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Louise Pettersson, Yilun Chen, Anthony M. George, Robert Rigo, Vladimir Lazarevic, Gunnar Juliusson, Lao H. Saal, Mats Ehinger
LEUKEMIA & LYMPHOMA
(2020)
Letter
Hematology
Kristina B. Lundin-Strom, Andrea Biloglav, Vladimir Lazarevic, Mikael Behrendtz, Anders Castor, Bertil Johansson
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Aldana Rosso, Gunnar Juliusson, Fryderyk Lorenz, Soren Lehmann, Asa Derolf, Stefan Deneberg, Martin Jadersten, Petar Antunovic, Jorg Cammenga, Lars Mollgard, Lovisa Wennstrom, Emma Olander, Mats Ehinger, Linda Fogelstrand, Martin Hoglund, Vladimir Lj Lazarevic
Summary: The Swedish national guidelines for AML treatment recommend analyzing MRD using MFC in the clinical setting. Most AML patients in complete remission after intensive chemotherapy had MRD-negative results, but there was no clear association with overall survival. Clinician awareness of the importance of MRD status could improve treatment outcomes.
LEUKEMIA & LYMPHOMA
(2021)
Article
Oncology
Louise Pettersson, Benjamin Holmgren, Gunnar Juliusson, Vladimir Lj Lazarevic, Mats Ehinger
Summary: The mutational pattern of NPM1-mutated de novo AML may differ in very old patients compared to younger ones, with a significant enrichment of TET2 and SRSF2 mutations and a reduced frequency of DNMT3A mutations observed in the former group.
LEUKEMIA & LYMPHOMA
(2021)
Letter
Hematology
Gunnar Juliusson, Oskar Hagberg, Vladimir Lj Lazarevic, Soren Lehmann, Martin Hoglund
Review
Medicine, General & Internal
V. Lj. Lazarevic
Summary: The definition of older age in AML is arbitrary, with various age thresholds used in clinical studies. Treatment decisions for older AML patients should be personalized and shared through dialogue with patients and their families. Despite advances in research and therapy, curing older patients with AML remains a challenge.
JOURNAL OF INTERNAL MEDICINE
(2021)
Letter
Oncology
Rebeqa Gunnarsson, Minjun Yang, Andrea Biloglav, Vladimir Lazarevic, Kajsa Paulsson, Bertil Johansson
Article
Hematology
Gunnar Juliusson, Martin Jadersten, Stefan Deneberg, Soren Lehmann, Lars Mollgard, Lovisa Wennstrom, Petar Antunovic, Jorg Cammenga, Fryderyk Lorenz, Emma Olander, Vladimir Lj Lazarevic, Martin Hoglund
