Article
Chemistry, Multidisciplinary
Jens Ducree
Summary: This paper demonstrates a model-based digital twin approach to optimize centrifugo-pneumatic dissolvable-film siphon valves for larger-scale integration of Lab-on-a-Disc systems. Spatial constraints and frequency bandwidth are crucial factors to be considered for efficient design optimization in sample-to-answer automation.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Eadaoin Carthy, Brian Hughes, Eimear Higgins, Phil Early, Cian Merne, Darren Walsh, Anne Parle-McDermott, David J. Kinahan
Summary: The challenge of integrating effective valving mechanisms in the design and manufacture of LoaD devices highlights the need for improved processes. A LoaD device without integrated valving system successfully automated biological workflows and reagent actuation. The optimized LoaD platform demonstrated superior DNA yield at higher cell concentrations.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Snehan Peshin, John Golden, Boyang Gan, Christian Mast, Lawrence Kulinsky
Summary: Lateral flow immunoassays (LFIs) are commonly used point-of-care platforms for chemical and biological tests. The sensitivity of LFIs can be improved by slowing down the flow rate of analytes or controlling the flow using centrifugal force applied on Lab-on-a-Disc platforms. This study investigates the relationship between the speed of liquid advancement in LFIs and the porosity, pore size, and angular velocity of the spinning disc.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Biotechnology & Applied Microbiology
Shivangi Sachdeva, Ronald W. Davis, Amit K. Saha
Summary: POCT allows physicians to detect and diagnose diseases faster than conventional lab-based testing, with particular importance in the COVID-19 pandemic. There are various point-of-care tests and diagnostic devices available in the market, including glucose monitoring, pregnancy testing, and infectious disease testing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Analytical
Snehan Peshin, Marc Madou, Lawrence Kulinsky
Summary: Centrifugal microfluidic platforms enable inexpensive point-of-care diagnostics and offer the ability to transfer complex processes, store reagents, and control flow. Valves play a crucial role in these platforms.
Article
Chemistry, Analytical
Hau Van Nguyen, Vu Minh Phan, Tae Seok Seo
Summary: The proposed prototype portable genetic analyzer can perform RNA extraction, RT-LAMP amplification, and fluorescence detection for ten samples simultaneously in an automatic and high-throughput manner. It utilizes zigzag aliquoting channels and passive valves for sample partitioning and extraction operations.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biotechnology & Applied Microbiology
Nicolas Moser, Ling-Shan Yu, Jesus Rodriguez Manzano, Kenny Malpartida-Cardenas, Anselm Au, Paul Arkell, Chiara Cicatiello, Ahmad Moniri, Luca Miglietta, Wen-Hung Wang, Sheng Fan Wang, Alison Holmes, Yen-Hsu Chen, Pantelis Georgiou
Summary: In this study, a smartphone-connected handheld Lab-on-Chip platform was translated for quantitative detection of dengue virus. The platform utilizes microchip technology and a reverse-transcriptase loop mediated isothermal amplification assay to achieve rapid and accurate detection. The platform communicates with a smartphone app and cloud server for real-time synchronization, enabling epidemiological surveillance. This technology shows promise for clinical diagnosis in low-resource settings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Philip L. Early, Niamh A. Kilcawley, Niamh A. McArdle, Marine Renou, Sinead M. Kearney, Rohit Mishra, Nikolay Dimov, Macdara T. Glynn, Jens Ducree, David J. Kinahan
Summary: Due to the automation capabilities of centrifugal microfluidic systems, they have gained significant interest in industry and academia over the past 25 years. These systems, also known as Lab-on-a-Disc platforms, are primarily used for decentralized bioanalytical point-of-use/point-of-care testing. Flow control plays a crucial role in coordinating multi-step/multi-reagent assay formats on these platforms. Traditional flow control methods, such as capillary burst valves, have been replaced by programmable rotational pulse actuated valves, which use digital pulsing to improve flow control. In this work, High-Low-High (HLH) pulse-actuated valves are introduced for high spin-rate operations, such as blood centrifugation. The combination of HLH valves with Low-High-Low (LHL) valves is used to implement a time-dependent liquid handling protocol for a liver function test panel.
Article
Chemistry, Analytical
Snehan Peshin, Marc Madou, Lawrence Kulinsky
Summary: Over the past 20 years, numerous immunoassays have been successfully integrated on CD platforms, enabling portable POC platforms with sample-to-answer capabilities. This study demonstrates the simultaneous integration of blood plasma separation (BPS) and reciprocation on a CD platform, allowing for the separation of plasma from red blood cells without inflow into the reciprocation chamber. Experimental results showed that the integrated design had significantly higher fluorescent signal compared to the standard design when the reciprocation time was increased to 7 minutes.
Article
Chemistry, Multidisciplinary
Jiang Xu, Wenhao Suo, Youlian Goulev, Lei Sun, Liam Kerr, Johan Paulsson, Yan Zhang, Taotao Lao
Summary: The novel microfluidic test kit combines ultra-high throughput hydrodynamic filtration and sandwich immunoassay techniques for rapid separation and enrichment of antigens, demonstrating high detection sensitivity, low cost, and suitability for areas with inadequate medical infrastructure and limited laboratory resources.
Article
Biochemical Research Methods
Azim Parandakh, Oriol Ymbern, William Jogia, Johan Renault, Andy Ng, David Juncker
Summary: Researchers have developed a novel chip-based ELISA technology that enables rapid and highly sensitive antibody detection. The chip simplifies chip loading and pipetting through autonomous aliquoting functionality, and can accommodate higher surfactant concentrations. The ELISA chip can complete the assay in 1.5 hours and exhibits comparable accuracy and performance to central laboratory ELISA.
Review
Biochemistry & Molecular Biology
Yi Zhang
Summary: POC testing decentralizes diagnostic tests to locations near the patient, and magnetic digital microfluidics show compelling advantages in POC diagnostics. The review categorizes POC settings into three classes and evaluates the suitability of magnetic digital microfluidics in various settings.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Sebastian Hin, Nils Paust, Markus Rombach, Jan Lueddecke, Mara Specht, Roland Zengerle, Konstantinos Mitsakakis
Summary: Centrifugal microfluidics enables automated molecular diagnostics, but integrating solid-phase nucleic acid extraction remains challenging. We developed a magnetophoresis technique under continuous rotation for magnetic bead-based extraction, achieving easy cartridge integration and high yield and purity of nucleic acid extraction.
Article
Chemistry, Analytical
Snehan Peshin, Derosh George, Roya Shiri, Lawrence Kulinsky, Marc Madou
Summary: Compact disc (CD)-based centrifugal microfluidics is a popular choice for portable biological and chemical assays. This study presents two new multiple-use wax valve designs driven by capillary or magnetic forces. The capillary-driven wax valve was analyzed through numerical simulations and experimental results, and the parameters of the valve were measured and analyzed theoretically.
Article
Chemistry, Analytical
Rohit Mishra, Rizwan Alam, Darren McAuley, Tirinder Bharaj, Danielle Chung, David J. Kinahan, Charles Nwankire, Karen S. Anderson, Jens Ducree
Summary: The success of bioanalytical technologies deployed in decentralised settings relies on factors such as user-friendliness, ease-of-use, cost per-test (at low sample throughput), and adaptability to a wide range of analytes. The centrifugal microfluidic Lab-on-a-Disc (LoaD) platform, which can meet these criteria, faces challenges in implementing reliable flow routing and valving on a rapidly rotating cartridge. In this study, we demonstrate the automation of a bead-based Enzyme-Linked Immuno-Sorbent Assay (ELISA) using a novel membrane and centrifugal-stratification enabled router architecture. The assay is implemented in an entirely automated fashion using minimal instrumentation, showing the potential for customisation to specific targets.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Huynh Quoc Nguyen, Hoang Khang Bui, Vu Minh Phan, Tae Seok Seo
Summary: The urgent need for rapid and accurate testing tools for SARS-CoV-2 detection can be met by IoT-based diagnostic devices, which can provide real-time monitoring with high sensitivity and accuracy.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Van Dan Nguyen, Huynh Quoc Nguyen, Khang Hoang Bui, Young Soo Ko, Bum Jun Park, Tae Seok Seo
Summary: The study successfully developed an integrated micro-capillary electrophoresis system controlled by a smartphone, which is efficient and accurate for on-site molecular diagnostics.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Huynh Quoc Nguyen, Tae Seok Seo
Summary: In this study, a droplet device with controllable droplet size and generation frequency was rapidly prototyped using 3D printing technology. The device utilized a screw-and-nut combination for easy and precise control of the gap height between the dispersed phase outlet and the orifice. The 3D printed device was successfully employed for synthesizing A549 cell-encapsulated microspheres of various sizes, which can be used for drug screening.
ANALYTICA CHIMICA ACTA
(2022)
Article
Agricultural Engineering
Hoa Thi Quynh Le, Eun Yeol Lee
Summary: The study explores the metabolic pathways of methane and methanol to produce 1,2-propanediol (1,2-PDO) using the type I methanotroph Methylotuvimicrobium alcaliphilum 20Z. It finds that the carbon flux from methane to the EMP pathway restricts the production of 1,2-PDO. Co-utilization of C1 substrates and glycerol enhances the production of 1,2-PDO, although lactate is co-produced in higher amounts. The study provides insights into metabolic routes for 1,2-PDO and lactate co-production from C1 and C3 compounds in methanotrophs.
BIORESOURCE TECHNOLOGY
(2022)
Article
Engineering, Environmental
Jiyeong Jeong, Tae Hyun Kim, Nulee Jang, Minji Ko, Seong Keun Kim, Georgii Emelianov, Eugene Rha, Kil Koang Kwon, Haseong Kim, Eun Yeol Lee, Dae-Hee Lee, Hyewon Lee, Seung-Goo Lee
Summary: Methanotrophs have been successfully engineered to produce valuable bioproducts from methane by utilizing a phenol-inducible gene expression system and a CRISPR-based genome editing tool. The engineered strain achieved the highest concentration of synthetic biochemicals produced from methane in methanotrophs.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Environmental
Diep Ngoc Pham, Anh Duc Nguyen, Eun Yeol Lee
Summary: Methane and carbon dioxide are the most abundant greenhouse gases, and reducing their emissions is crucial for mitigating climate change. Utilizing methylotrophic bacteria-based technologies to capture and utilize these gases shows promise in lowering their concentrations. This article highlights the advantages of methylotrophs in bioconversion of methane, CO2, methanol, and formate, and discusses innovative strategies to improve conversion efficiency.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Applied
Van Nhieu Le, Dieu-Phuong Phan, Seung-Soo Kim, Eun Yeol Lee, Jinsoo Kim
Summary: By using response surface methodology combined with the central composite design, the operating conditions for catalytic hydrodeoxygenation of anisole were optimized, resulting in high conversion rates. It was found that temperature had the greatest effect on the conversion rate.
FUEL PROCESSING TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Linh Thanh Nguyen, Dung Hoang Anh Mai, Arslan Sarwar, Eun Yeol Lee
Summary: This study constructed a production pathway for short-chain-length polyhydroxyalkanoates (PHAs) in P. putida KT2440 and enhanced the product yield by reconstructing the ethanol catabolic pathway. Transcriptome analysis was conducted to gain insights into central metabolic pathways and gene expression patterns in response to substrate changes. Furthermore, the potential of P. putida KT2440 for producing copolymers from different carbon sources was demonstrated.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Genetics & Heredity
Dung Hoang Anh Mai, Linh Thanh Nguyen, Eun Yeol Lee
Summary: NLP models have been used to predict and analyze the promoters in freshwater cyanobacteria, with the help of a custom pipeline and an integrated platform. The models achieved high AUROC and F1 scores, indicating their effectiveness in understanding the sequential structure of DNA.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Multidisciplinary
Hoang Khang Bui, Vu Minh Phan, Huynh Quoc Nguyen, Van Dan Nguyen, Hiep Van Nguyen, Tae Seok Seo
Summary: We proposed a portable sample pretreatment microsystem that can be operated automatically through speech recognition in a smartphone app. The microsystem includes a microfluidic chip, an air router, pressure and vacuum lines with air pump motors, six 3-way solenoid valves, and a microcontroller with a Bluetooth module. The entire DNA extraction process from pathogenic bacterial samples is controlled by human voice commands, eliminating manual interference and potential infection. The palm-sized microsystem can be powered by a portable battery or a conventional smartphone charger, achieving a DNA extraction efficiency of 70 +/- 5% for Salmonella typhimurium in less than 1 minute.
Review
Biotechnology & Applied Microbiology
Ushasree Mrudulakumari Vasudevan, Dung Hoang Anh Mai, Shyam Krishna, Eun Yeol Lee
Summary: Methanotrophs have the potential to produce various bioactive secondary metabolites including iso-prenoids, polymers, peptides, and vitamins. Genome mining of these microbes revealed the hidden biosynthetic potential of these microbes. Through advanced synthetic biology tools, the central carbon metabolism in methanotrophs can be modified to produce valuable secondary metabolites. This review summarizes the possibilities of developing methanotrophs as microbial chassis for high-value secondary metabolites.
BIOTECHNOLOGY ADVANCES
(2023)
Review
Chemistry, Multidisciplinary
My Ha Tran, Eun Yeol Lee
Summary: This article reviews the methods for producing polyols from vegetable oil, lignin, and carbohydrates, as well as the production of polyurethane from biomass polyols. Conversion of vegetable oil involves epoxidation, hydroformylation, and transesterification, while conversion of lignin involves solvothermal liquefaction, hydroxymethylation, oxypropylation, and phenolation.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
Sanzhar Naizabekov, Seung Woon Hyun, Jeong-Geol Na, Sukhwan Yoon, Ok Kyung Lee, Eun Yeol Lee
Summary: Comparative genomic analysis revealed the potential of newly isolated methanotroph Methylocystis sp. MJC1 as a biodegradable polyhydroxybutyrate (PHB) producer. Under nitrogen-limiting conditions, Methylocystis sp. MJC1 can accumulate up to 44.5% PHB based on dry cell weight. Functional annotation and comparison with other Methylocystis species showed that Methylocystis sp. MJC1 contains all major biochemical pathways of type II methanotrophs and possesses both particulate and soluble methane monooxygenases, which are not commonly found in other Methylocystis species. These findings open up possibilities for future practical applications such as organism-specific genome-scale models and metabolic engineering strategies.
Article
Chemistry, Multidisciplinary
Dieu-Phuong Phan, My Ha Tran, Eun Yeol Lee
Summary: Polymeric materials play a crucial role in modern society, and biomass can be utilized as a renewable carbon source for the production of bio-based plastics. This review summarizes the applications of Metal-Organic Framework (MOF)-based catalysts in the production of renewable bio-plastic-derived materials and highlights the effects of reaction conditions.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Arslan Sarwar, Eun Yeol Lee
Summary: Methanol is gaining attention as a potential carbon substrate for the production of fuels and chemicals due to its high reduction degree, abundance, and low price. Both native and synthetic methylotrophic microorganisms have been investigated for the production of biofuels and chemicals. However, the complex metabolic pathways, limited availability of genetic tools, and toxicity issues still pose challenges for achieving high-level production for commercial purposes. This article reviews the production of biofuels and chemicals from methanol by native and synthetic methylotrophs and discusses ways to improve their efficiency.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
