Article
Biochemistry & Molecular Biology
Kai-Yan Xu, Xue-Ting Wang, Lei Cheng, Qi-Hang Cui, Jian-Tao Shi, Li-Wen Zhang, Shi-Wu Chen
Summary: A series of quinoxalinone derivatives were designed and synthesized as BRD4 inhibitors, among which compound X9 showed potent activity against BRD4 and HepG2 cell proliferation with less toxicity. Furthermore, compound X9 could inhibit colony formation and migration of HepG2 cells, induce apoptosis, and arrest cell cycle progression. In conclusion, quinoxalinone derivatives are potential core structures as BRD4 inhibitors, and compound X9 may be effective for liver cancer therapy.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Jintian Dai, Jianqing Zhang, Dongxue Fu, Meng Liu, Han Zhang, Sheng Tang, Linxiao Wang, Shan Xu, Wufu Zhu, Qidong Tang, Pengwu Zheng, Ting Chen
Summary: In this study, a total of 36 derivatives of 4-(4-aminophenoxy)pyridinamide were designed and synthesized based on the analysis of the binding patterns of cabozantinib and BMS-777607 to MET protein. Most of the target compounds showed moderate to excellent anti-proliferative activity against three different cell lines. Compound 46 exhibited the most promising results, with a 2.4 times higher activity than cabozantinib and good pharmacokinetic characteristics in rats.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Emil Johansson, Remi Caraballo, Mikael Elofsson
Summary: This paper describes the synthesis of 4-O-alkyl analogues of N-acetylneuraminic acid (Neu5Ac) and the scope of the reaction. It demonstrates that activated alkyl halides and sulfonates, as well as primary alkyl iodides, can give products in useful yields. The utility of the methodology is exemplified using a specific example of synthesizing a 4-O-alkyl DANA analogue. These results expand the toolbox of Neu5Ac chemistry and have value in drug discovery and the study of Neu5Ac lectins biology.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiaobo Liu, Yuzhen Li, Qian Zhang, Qingshan Pan, Pengwu Zheng, Xinyang Dai, Zhaoshi Bai, Wufu Zhu
Summary: In this study, a series of novel compounds were synthesized and evaluated for their inhibitory activities against cancer cells and their molecular interaction mechanisms. Compound 17l showed excellent antiproliferative activities and kinase inhibitory activities, and could intervene in cellular signaling pathways.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Feiyi Yang, Qian Zhang, Qiuyan Guo, Qingshan Pan, Chunping Wen, Xinya Lv, Wufu Zhu, Pengwu Zheng
Summary: A class of 4-phenoxy-pyridine/pyrimidine derivatives were synthesized and evaluated as potent dual VEGFR-2/c-Met inhibitors. Among them, compound 23k showed excellent anti-cancer cell proliferative activity and low toxicity. Further studies demonstrated that compound 23k induced apoptosis and blocked the cell cycle. Molecular docking and simulation revealed the binding modes of 23k to VEGFR-2 and c-Met.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qi-Hang Cui, Wen-Bo Li, Zhao-Yang Wang, Kai-Yan Xu, Shuai Wang, Jian-Tao Shi, Li-Wen Zhang, Shi-Wu Chen
Summary: The structure of BRD(4)i ABBV-075 was modified and a novel series of coumarin derivatives were synthesized as BRD4 inhibitors. Compound 27d showed excellent inhibitory activities against various cancer cells and exhibited good stability, indicating it as a promising lead compound for further drug development.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shan Xu, Leixuan Luo, Xin Sun, Yang Yang, Qiuyan Guo, Zhiyan Jiang, Yingliang Wu
Summary: In this study, we developed and synthesized a series of novel thiophene-triazine derivatives containing arylurea unit as potent dual PI3K/mTOR inhibitors. We evaluated their cytotoxicity against nine cancer cell lines and their kinase inhibitory activity against PI3K/mTOR kinases. Most of the target compounds showed excellent activity and selectivity against one or more cancer cell lines. The most promising compound exhibited significantly better activity than the lead compound GDC-0941 with excellent inhibitory activity against PI3K alpha and mTOR kinase. Its introduction of the arylurea group improved the cellular and kinase activities of the target compounds. Additionally, it demonstrated low toxicity and good safety in toxicity and hemolysis experiments.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Srishylam Penjarla, Paidi Yella Reddy, Santhosh Penta, Yogesh S. Sanghvi, Ludek Eyer, Michal Stefanik, Daniel Ruzek, Shyamapada Banerjee
Summary: An efficient synthetic approach leading to novel C-nucleosides containing oxadiazole or thiadiazole ring system is reported. This provides an ideal framework for the development of new antiviral and antitumor drugs. Two of the synthesized compounds showed mild anti-SARS-CoV-2 activity, with a decrease in viral titers by <1 log10 PFU/ml compared with controls. Mechanism for the formation of 5-substituted 1,3,4-thiadiazole ring is proposed and a structure-activity relationship is established with these C-nucleosides.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Ju Liu, Fang Liu, Zhen Li, Chunyan Li, Shuang Wu, Jiwei Shen, Huan Wang, Siyuan Du, Hao Wei, Yunlei Hou, Shi Ding, Ye Chen
Summary: Two series of novel 4-phenoxypyridine derivatives containing imidazole-4-carboxamide and 4-methyl-5-oxo-4,5dihydro-1,2,4-triazole-3-carboxamide moieties were synthesized and evaluated for their antitumor activities. The results showed that most of the compounds exhibited moderate to good antitumor activities. Compound T14 demonstrated the most promising antiproliferative activities against three cancer cell lines.
BIOORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Xi-Xi Hou, Long-Fei Mao, Yajie Guo, Chaoxuan Lou, Lan Wang, Rui-Fang Li, Huili Wang, San-Qiang Li, Jian-Xue Yang
Summary: Based on structural modification, novel dolutegravir derivatives containing 1,2,3-triazole moieties with different substituted groups were synthesized. The derivatives exhibited good inhibitory effects on A549 cells, with compounds 4b and 4g being the most effective, showing IC50 values of 8.72 +/- 0.11 mu M and 12.97 +/- 0.32 mu M, respectively. Furthermore, compound 4g induced apoptosis and clonal suppression in A549 tumor cells, activated LC3 signaling pathway to induce autophagy, and activated gamma-H2AX signaling pathway to induce DNA damage in tumor cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yifei Yang, Pan Chen, Leilei Zhao, Bing Zhang, Changliang Xu, Huibin Zhang, Jinpei Zhou
Summary: BRD4 inhibitor HB100-A7 showed excellent inhibitory activities against BRD4 protein in vitro, suppressing pancreatic cancer cell proliferation and inducing apoptosis. In vivo study further confirmed its significant tumor growth inhibition effect in a pancreatic mouse tumor model, suggesting its potential as a promising lead compound for further development as a new generation of small molecule inhibitors targeting BRD4.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiang Nan, Qiu-Xu Wang, Shao-Jun Xing, Zhi-Gang Liang
Summary: In this study, four series of thiazole/thiadiazole carboxamide-derived analogues were designed, synthesized, and evaluated as novel c-Met inhibitors for antitumor therapy. Compound 51am was identified as the most promising inhibitor with significant activity against c-Met and several c-Met mutants. Mechanistically, 51am not only induced cell cycle arrest and apoptosis in MKN-45 cells but also inhibited c-Met phosphorylation in both cell and cell-free systems. In addition, 51am showed good pharmacokinetic properties in mice and its binding mode with c-Met and VEGFR-2 provided new insights for the discovery of selective c-Met inhibitors. These findings suggest that 51am has the potential to be further developed as an antitumor candidate.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yu-juan Feng, Yu-Lin Ren, Li-Ming Zhao, Guo-Qiang Xue, Wen-Hao Yu, Jia-Qi Yang, Jun-Wei Liu
Summary: The study identified compound 25s as a promising lead compound with potent antiproliferative activities against multiple cancer cell lines, inducing apoptosis in A549 cells and inhibiting c-Met phosphorylation. This compound showed potential for further development as an anticancer drug.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Wen-Ge Guo, Jun-Ru Zhao, Min Li, Ting Hu, Zengyangzong Dan, Qian Zhang, Li-Ying Ma, Sai-Yang Zhang, Bing Zhao
Summary: In this study, 29 pyrido[3,4-d]pyrimidine compounds were designed and synthesized, and compound 30 showed the best anti-tumor activity against MGC803 cells. Mechanistic studies revealed that compound 30 inhibited cell migration and induced apoptosis. Compound 30 might be a potential lead agent for the treatment of human gastric cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yuting Guo, Xia Peng, Yinchun Ji, Yitong Zhang, Jian Ding, Zhengsheng Zhan, Jing Ai, Wenhu Duan
Summary: The synthesized compound 8 was found to have potent antitumor activity by forming two canonical hydrogen bonds and a pi-pi stacking interaction with the ATP binding site of c-Met kinase domain.
MOLECULAR DIVERSITY
(2021)
Article
Cell Biology
Yu Tang, Ying Zhang, Lixiang Liu, Yifeng Yang, Yan Wang, Baozeng Xu
Summary: Glycine treatment during vitrification significantly increases the efficiency of porcine oocytes, while adding melatonin further enhances the developmental potential. Mitigating osmotic and oxidative stresses during vitrification and thawing can improve the competency of vitrified porcine oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Physical
Xu Zheng, Jiao Tan, Qianqian Wang, Chan Gao, Xiaohui Yu, Wenhui Xie, Yifeng Yang, Yujie Wang, Changqing Jin
Summary: In this study, MnN single crystal was synthesized under high pressure and temperature, and a first-order phase transition accompanied by an antiferromagnetic to ferromagnetic magnetic structure transition was observed. The magnetic and structural transition of MnN was found to be induced by the enhanced ferromagnetic double exchange interactions in the [001] plane. These findings provide important insights for the development of GaMnN or MnN layer diluted magnetic semiconductor materials.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Chen, Xuewen Hou, Yifeng Yang, Qianqian Ge, Yan Zhou, Shengdong Nie
Summary: This study proposes a novel lung nodule detection model with high detection sensitivity and low false-positive rate, which shows potential for clinical application.
JOURNAL OF DIGITAL IMAGING
(2023)
Review
Physics, Condensed Matter
Yi-feng Yang
Summary: Recent advances in experimental techniques have provided new insights into heavy fermion physics. This article summarizes the author's research in this area, specifically focusing on five major topics: development of phase coherence and two-stage hybridization, two-fluid behavior and hidden universal scaling, quantum phase transitions and fractionalized heavy fermion liquid, quantum critical superconductivity, and material-specific properties. These findings go beyond conventional mean-field or local approximation-based theories, leading to an emerging global picture of heavy fermion physics.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2023)
Article
Engineering, Industrial
Xiaoyu Yang, Liyang Xie, Yifeng Yang, Bingfeng Zhao, Yuan Li
Summary: The Weibull distribution is widely used for reliability analysis. This paper presents a simple method called the minimum discrepancy method for parameter estimation of the Weibull distribution using both complete and censored data. The study also compares thirteen methods using several criteria in a small sample size. The results recommend the generalized least square 1, the weighted least square 1, the weighted maximum likelihood estimation, and the minimum discrepancy method for parameter estimation with small samples.
QUALITY ENGINEERING
(2023)
Article
Geriatrics & Gerontology
Zhaoshun Jiang, Yuxi Cai, Songbin Liu, Pei Ye, Yifeng Yang, Guangwu Lin, Shihong Li, Yan Xu, Yangjing Zheng, Zhijun Bao, Shengdong Nie, Weidong Gu
Summary: Using machine-learning algorithms, we identified abnormal functional connectivity patterns in the default mode network (DMN) of patients with delayed neurocognitive recovery (DNR), particularly in regions involved in visual processing, suggesting that these changes could serve as potential biomarkers for predicting DNR.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Polymer Science
Chengpeng Li, Yanting Shi, Huixin Su, Yifeng Yang, Wen Li, Tong Zhang, Weiyin Chen, Roujun Lin, Yongzheng Li, Lusheng Liao
Summary: Siloxane elastomers were enhanced with multi-strength hydrogen bonds and dynamic disulfide bonds to achieve high stretchability, mechanical strength, self-healing capacity, and recyclability. The ratio of hydrogen bonding networks was adjusted to tune the mechanical properties and self-healing efficiency of the elastomers. The introduction of aromatic disulfide resulted in significantly improved tensile strength, strain, and toughness, with a healing efficiency of 75%. A self-healing flexible bifunctional sensor was also developed using liquid metal alloy encapsulated between the elastomers layers for pressure and motion detection.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Civil
Xiaoyu Yang, Liyang Xie, Jiaxin Song, Jianpeng Chen, Bingfeng Zhao, Yifeng Yang
Summary: In this paper, an optimal probability estimator for Weibull parameters is obtained through Monte Carlo simulations, and it is found to exhibit stronger robustness and higher accuracy compared to five commonly used estimators, especially in cases of small sample sizes. The recommended optimal probability estimator is the midpoint rank for LRE, MDE, and EIV in practical applications.
INTERNATIONAL JOURNAL OF STRUCTURAL STABILITY AND DYNAMICS
(2023)
Article
Physics, Multidisciplinary
Dongchen Huang, Junde Liu, Tian Qian, Yi-Feng Yang
Summary: De-noising is crucial in spectrum post-processing. In this study, we propose a de-noising method for angle-resolved photoemission spectroscopy (ARPES) to extract intrinsic spectral information without a training set. Our method utilizes the self-correlation information of the spectra themselves, preserving the intrinsic energy band features for further analysis and processing. It has the potential to be extended to other fields and application scenarios with challenging training data acquisition.
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
(2023)
Article
Multidisciplinary Sciences
Haifeng Yang, Jingjing Gao, Yingying Cao, Yuanji Xu, Aiji Liang, Xiang Xu, Yujie Chen, Shuai Liu, Kui Huang, Lixuan Xu, Chengwei Wang, Shengtao Cui, Meixiao Wang, Lexian Yang, Xuan Luo, Yuping Sun, Yi-feng Yang, Zhongkai Liu, Yulin Chen
Summary: Mott physics plays a critical role in materials with strong electronic correlations. The transition from Mott insulator to metal in transition metal oxides is mainly driven by chemical doping, external pressure, temperature, and gate voltage, while in 4f-electron systems, it is mainly driven by Kondo hybridization. However, in YbInCu4, an unusual Mott instability is found to accompany its first-order valence transition, challenging the prevalent Kondo picture. This work provides important insight into the understanding and manipulation of correlated quantum phenomena in the f-electron system.
NATIONAL SCIENCE REVIEW
(2023)
Article
Multidisciplinary Sciences
Hanghui Chen, Yi-feng Yang, Guang-Ming Zhang, Hongquan Liu
Summary: In this study, first-principles calculations are used to demonstrate a charge-transfer-driven charge order mechanism in infinite-layer nickelates, resulting in a characteristic stripe state. The stability of this charge order arises from the competition between Hubbard interaction on Ni-d orbitals and charge transfer energy between Ni-d orbitals and conduction bands.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jiangfan Wang, Yi-feng Yang
Summary: Understanding the nature of local-itinerant transition of strongly correlated electrons is a central problem in condensed matter physics. A solvable Kondo-Heisenberg model is proposed to investigate this issue, which reveals the continuous evolution of Fermi surfaces and two-fluid behaviors, providing important insight into the microscopic description of two-fluid phenomenology in heavy fermion systems.
Article
Materials Science, Multidisciplinary
Junde Liu, Dongchen Huang, Yi-feng Yang, Tian Qian
Summary: Spectroscopic data often contains unwanted extrinsic signals. A deep learning method is proposed in this study to effectively overcome this problem by utilizing the self-correlation information within the spectra. This method can remove the grid structure and noise while optimizing the quality of the spectra, potentially enhancing spectral measurements in various spectroscopic experiments.
Article
Materials Science, Multidisciplinary
Jiangfan Wang, Yi-feng Yang
Summary: Metallic spin liquid has been observed in correlated metals, but a satisfactory theoretical description is lacking. This study proposes a potential approach to achieve metallic spin liquid by constructing an effective gauge theory with charged fractionalized excitations on the triangular Kondo lattice. The resulting Z(2) metallic spin liquid exhibits long-lived, heavy holon excitations of spin 0 and charge +e, as well as a partially enlarged electron Fermi surface.
Article
Materials Science, Multidisciplinary
Yutao Sheng, Yu Li, Yi-feng Yang
Summary: Despite ongoing experimental and theoretical efforts, the pairing symmetry of superconductivity in Sr2RuO4 remains uncertain. In this study, a phenomenological model combining realistic electronic band structures and all symmetry-allowed multipole fluctuations was constructed to investigate potential pairing states within the Eliashberg framework. The findings suggest that the dx2-y2 + ig pairing state can naturally arise from the interplay of various types of fluctuations, including antiferromagnetic, ferromagnetic, and electric multipole fluctuations.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
