Article
Pharmacology & Pharmacy
Sa Li, Jiaguo Zhan, Yucheng Wang, Patrick Kwabena Oduro, Felix Boahen Owusu, Jiale Zhang, Ling Leng, Ruiqiao Li, Shujie Wei, Jun He, Qilong Wang
Summary: Suxiao Jiuxin Pill (SJP) is an effective traditional Chinese medicine used for heart diseases. This study investigated the pharmacological effects of SJP in acute myocardial infarction (AMI) and the molecular pathways involved in coronary artery vasorelaxation. The results showed that SJP improved cardiac function and elevated ST segment in AMI rat models. Analysis of the compounds in SJP-treated rats' sera detected various non-volatile and volatile compounds. Network pharmacology analysis identified eNOS and PTGS2 as key drug targets, and SJP-induced coronary artery relaxation was mediated through the eNOS-NO pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Yiping Li, Ruixia Lu, Zhenchao Niu, Dan Wang, Xiaolong Wang
Summary: Suxiao Jiuxin Pill (SJP) is an effective traditional Chinese medicine for myocardial ischemia-reperfusion injury (MIRI), which alleviates myocardial damage by inhibiting autophagy and apoptosis.
Article
Plant Sciences
Jingyu Liao, Yuhao Zhang, Chi Ma, Gaosong Wu, Weidong Zhang
Summary: This study aimed to investigate the cardioprotective effect of Suxiao Jiuxin pill (SJP) against isoproterenol-induced acute myocardial infarction (AMI) and its relationship with the gut microbiota. The results showed that SJP could restore the richness and diversity of gut microbiota and exert cardioprotective effects through regulating host fatty acid metabolism.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Tingting Qiang, Yiping Li, Keyan Wang, Wenyong Lin, Zhenchao Niu, Dan Wang, Xiaolong Wang
Summary: Suxiao jiuxin pill (SJP) is a Chinese medical drug used for the treatment of coronary heart disease and angina. It has been found to inhibit the activity of certain CYP450 enzymes, especially CYP1A2, 2B6, 2C19, and 3A4, while also showing inhibitory effects on human OATP1B1 and BCRP. Potential herb-drug interactions should be considered when using SJP in combination with other drugs.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Qi Jian-Yong, Kang Dong-yuan, Yu Juan, Zhang Min-zhou
Summary: This study showed that Suxiao Jiuxin Pills (SJP) can inhibit the occurrence of ventricular fibrillation (VF) by affecting the L-type calcium channel current, without significantly influencing other ion channels. Computer simulation also confirmed that the reduction in calcium channel current by SJP can improve the electrocardiogram. These experimental results provide a basis for the anti-VF clinical application of SJP.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xiaofen Ruan, Yiping Li, Yuanlong Sun, Meijun Jia, Xiaowen Xu, Li Huo, Wei Song, Yili Yao, Xiaolong Wang
Summary: This study aims to evaluate the clinical effectiveness and safety of Suxiao Jiuxin Pill for chronic stable angina through a double-blind, placebo-controlled trial, providing high-quality clinical research evidence.
Review
Cardiac & Cardiovascular Systems
Wei Yuan, Chong Xu, Bo Li, Hao Xia, Yingjie Pan, Wei Zhong, Liangjie Xu, Rui Chen, Bin Wang
Summary: CD137 is a surface glycoprotein found on various immune and non-immune cells, with unclear mechanisms in endothelial cells. Endothelial cells form the innermost layer of blood vessels, serving as a functional interface and participating in local inflammatory responses.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Zicen Fang, Zhenhui Luo, Yanying Ji, Rihong Yang, Jintian Gao, Nana Zhang
Summary: This study investigated the mechanisms of Ligustilide (LIG) in atherosclerosis using network pharmacology and molecular docking. The findings suggest that LIG inhibits cell migration and regulates protein translation to reduce the development of atherosclerosis. This provides new insights into the anti-atherosclerotic actions of LIG and identifies potential targets for its treatment.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Oncology
Han Jin, Pieter Goossens, Peter Juhasz, Wouter Eijgelaar, Marco Manca, Joel M. H. Karel, Evgueni Smirnov, Cornelis J. J. M. Sikkink, Barend M. E. Mees, Olivia Waring, Kim van Kuijk, Gregorio E. Fazzi, Marion J. J. Gijbels, Martina Kutmon, Chris T. A. Evelo, Ulf Hedin, Mat J. A. P. Daemen, Judith C. Sluimer, Ljubica Matic, Erik A. L. Biessen
Summary: The study integrated multiple omics data and identified a protein-gene associated multiomics model with high predictive performance in distinguishing intraplaque hemorrhage and stable plaques, revealing cardiovascular disease features related to plaque vulnerability, and validated the findings in several independent cohorts.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yan Lei, Jianmei Huang, Zhongshui Xie, Can Wang, Yihong Li, Yutong Hua, Chuanxin Liu, Ruijuan Yuan
Summary: This study investigated the pharmacological components and molecular mechanism of Yuquan Pill (YQW) in the treatment of Type 2 diabetes mellitus (T2DM). The results showed that YQW could effectively reduce glucose and lipid metabolism disorders in T2DM rats. Through serum pharmacochemistry, network analysis, and transcriptomics, key targets and pathways for YQW intervention were identified. The study highlighted the importance of certain components and the activation of specific signaling pathways in the mechanism of YQW's intervention in T2DM.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Hua Wang, Changjuan Zhan, Yi Wang
Summary: In this study, an HPLC method was established for simultaneous quantification of paeoniflorin, hesperidin and ligustilide in Fuke Yangrong pill. The method was shown to be accurate and suitable for the quality control of Fuke Yangrong pill.
ACTA CHROMATOGRAPHICA
(2023)
Article
Integrative & Complementary Medicine
You Wu, Boju Sun, Xiaoyuan Guo, Lili Wu, Yaomu Hu, Lingling Qin, Tao Yang, Mei Li, Tianyu Qin, Miao Jiang, Tonghua Liu
Summary: ZSP treatment significantly improved glucose metabolism and weight gain in db/db mice by enhancing the PI3K/AKT signaling pathway, increasing the expression of genes related to glycogen synthesis and glycolysis, and reducing gluconeogenesis.
Article
Biochemistry & Molecular Biology
Yu Xu, Yue Zhang, Yao Xu, Guangyao Zang, Bo Li, Hao Xia, Wei Yuan
Summary: CD137 signaling induces macrophage apoptosis by promoting mitochondrial fission dependent on the p38 MAPK pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lotte C. A. Stiekema, Lisa Willemsen, Yannick Kaiser, Koen H. M. Prange, Nicholas J. Wareham, S. Matthijs Boekholdt, Carlijn Kuijk, Menno P. J. de Winther, Carlijn Voermans, Matthias Nahrendorf, Erik S. G. Stroes, Jeffrey Kroon
Summary: The study shows that LDL-C affects monocyte production in the BM compartment, leading to increased circulating proinflammatory monocytes. It also reveals the potential contributory role of HSPC transcriptomic reprogramming in residual inflammatory risk in FH patients.
EUROPEAN HEART JOURNAL
(2021)
Review
Integrative & Complementary Medicine
Shiqi Chen, Xiaoxiao Wu, Tong Li, Yang Li, Baofu Wang, Weiting Cheng, Yu Teng, Jingjing Yang, Hui Meng, Lei Wang, Ziwen Lu, Yangyang Jiang, Yahong Wang, Mingjing Zhao
Summary: The study reviewed 60 experiments and found that 23 Chinese patent formulas could alleviate atherosclerosis by improving plaque, enhancing plaque stability, modifying lipid levels, metabolism, and exhibiting anti-inflammatory and antioxidant effects. However, the methodological quality of the included literature was low and incomplete.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemical Research Methods
Wei Lei, Jianan Ni, Xueting Xia, Min Jiang, Gang Bai
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2018)
Article
Pharmacology & Pharmacy
Zhiyong Du, Zeliu Shu, Wei Lei, Chun Li, Kewu Zeng, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Plant Sciences
Wei Lei, Xiao Li, Lin Li, Ming Huang, Yu Cao, Xingyi Sun, Min Jiang, Boli Zhang, Han Zhang
Summary: The study aimed to explore the biological mechanism of constituents in CDDP synergistically improving post ischemic myocardial inflammation. The results demonstrated that CDDP effectively ameliorated post ischemic myocardial inflammation through simultaneously modulating MAPK, PI3K/AKT and PPAR pathways in a multi-components synergetic manner.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wei Lei, Yiqi Yan, Yaolei Ma, Min Jiang, Boli Zhang, Han Zhang, Yuhong Li
Summary: This study investigated the cardioprotective mechanism of notoginsenoside R1 (NGR1) in improving ischemic heart diseases. The results showed that NGR1 improved echocardiographic, tissue pathological, and serum biochemical perturbations in myocardial ischemic rats. Network pharmacology studies indicated that NGR1 mainly regulated smooth muscle cell proliferation, vasculature development, and lipid metabolism signaling. Myocardial proteomics revealed that NGR1 focused on regulating metabolic and energy supply processes. The study demonstrated that NGR1 modulated lipid metabolism in ischemic myocardia by interacting with mTOR and AKT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Ke Zan, Wei Lei, Yaolei Li, Ying Wang, Lina Liu, Tiantian Zuo, Hongyu Jin, Shuangcheng Ma
Summary: This study investigated the hepatotoxicity of total alkaloids in Eupatorium fortunei and found that it induced severe liver toxicity by disrupting glycerophospholipid metabolism, leading to inflammation, fibrosis, and apoptosis.
Article
Chemistry, Multidisciplinary
Wei Lei, Fukui Shen, Nianwei Chang, Lin Niu, Yuanyuan Hou, Boli Zhang, Min Jiang, Gang Bai
Summary: Atherosclerosis is a chronic inflammatory condition, with vascular endothelial fibrosis being a primary contributor to its development. A study found that ligustilide (Lig) inhibits the phosphorylation and nuclear translocation of SMAD3, a key player in promoting vascular fibrosis, by disrupting its interaction with TGF-beta receptor 1, offering a potential therapeutic strategy for preventing vascular fibrosis.
CHINESE CHEMICAL LETTERS
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)