Journal
BIOCONJUGATE CHEMISTRY
Volume 30, Issue 9, Pages 2317-2322Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.9b00509
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Funding
- National Institute of Health of US [1R01EB02565101, 1R01CA207584]
- National Natural Science Foundation of China [81402845]
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In comparison with the popular Ac(4)ManNAz applied as cell labels via Cu-free click chemistry, two novel azido mannosamine lipids with C6 and C12 esters on anomeric hydroxyl groups were prepared and encapsulated in a liposome delivery system, which enhanced chemical stabilities and showed good cell-metabolizable labeling efficiency on MDA-MB-231 cells with strong fluorescence after the treatment of DBCO-Cy5 by triazole formation via click chemistry.
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