Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1868, Issue 1, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbapap.2019.140271
Keywords
beta-Galactosidase; Lactose hydrolysis; Lactose upgrading; Transgalactosylation; Lactose-derived prebiotics
Categories
Funding
- Fondecyt Grants (Government of Chile) [3170133, 11180282, 1190104]
- Pontificia Universidad Catolica de Valparaiso [DI 37.0/2019]
- PCI-Conicyt Grant [170057]
- Fondef Grant [17AM0009]
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beta-Galactosidase is one of the most important industrial enzymes, that has been used for many decades in the dairy industry. The main application of beta-galactosidase is related to the production of low-lactose and lactose-free milk and dairy products, which are now common consumer goods in supermarket shelves. This is a well-established market that is expected to keep on growing as these products become more accessible to mid-income people worldwide. However, a fresh air has come into the p-galactosidase business as non-conventional applications arose in recent decades based on its transgalactosylation activity. This capacity is certainly a major asset for a commodity enzyme that can be used now as a catalyst for the upgrading of readily available and cheap lactose into high added-value glycosides in processes of organic synthesis in tune with green chemistry principles within the framework of sustainability. This is a reflection of a paradigm shift, where enzymes are now being considered as apt catalysts for the synthesis of valuable organic compounds. This article reviews the main applications of P-galactosidase, going from its conventional use related to its hydrolytic activity to the ongoing non-conventional applications in the synthesis of high added-value oligosaccharides based on its transgalactosylation activity.
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