Review
Biochemistry & Molecular Biology
Eleni A. Karatrasoglou, Maria Dimou, Alexia Piperidou, Eleftheria Lakiotaki, Penelope Korkolopoulou, Theodoros P. Vassilakopoulos
Summary: This review focuses on discussing the oncogenic mechanisms of the PI3K/v-akt/mTOR pathway in B cell non-Hodgkin lymphoma (NHL), and summarizes the clinical applications of mTOR inhibitors in B cell NHLs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Lanlan Tang, Yu Fu, Jiarun Song, Taibing Hu, Kun Li, Zhi Li
Summary: This study demonstrates that TAK-228 is a dual inhibitor of retinoblastoma and angiogenesis, and achieves this inhibition through the inhibition of mTOR signaling.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Oncology
Sapna Oberoi, Amria Qumseya, Wei Xue, Douglas J. Harrison, Erin R. Rudzinski, Suzanne L. Wolden, Roshni Dasgupta, Rajkumar Venkatramani, Abha A. Gupta
Summary: This study aimed to determine the feasibility of incorporating temsirolimus into the standard COG chemotherapy regimen for intermediate-risk rhabdomyosarcoma. The results showed that weekly temsirolimus during VAC/VI chemotherapy was feasible and well tolerated. The efficacy of this regimen is currently being tested in a phase III randomized trial.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Sonia M. Abuzakhm, Vineeth Sukrithan, Briant Fruth, Rui Qin, Jonathan Strosberg, Timothy J. Hobday, Thomas Semrad, Diane Reidy-Lagunes, Hedy Lee Kindler, George P. Kim, Jennifer J. Knox, Andreas Kaubisch, Miguel Villalona-Calero, Helen Chen, Charles Erlichman, Manisha H. Shah
Summary: This study assessed the efficacy and safety of combining bevacizumab with temsirolimus for advanced extra-pancreatic neuroendocrine tumors. The results showed minimal efficacy and increased side effects with this combination therapy, and it is not recommended for use in these patients.
ENDOCRINE-RELATED CANCER
(2023)
Article
Genetics & Heredity
Lawrence Liu, Carina Dehner, Nikhil Grandhi, Yang Lyu, Dana C. Borcherding, John S. A. Chrisinger, Xiao Zhang, Jingqin Luo, Yu Tao, Amanda Parkes, Nam Q. Bui, Elizabeth J. Davis, Mohammed M. Milhem, Varun Monga, Mia Weiss, Brian Van Tine, Angela C. Hirbe
Summary: This study investigated the impact of genetic mutations in PEComa patients on treatment response, and found no significant association between gene mutations and survival rate or progression-free survival after treatment. Further research should focus on identifying other TSC-1/-2 silencing driver genes to predict response to mTOR inhibition therapy.
Article
Pharmacology & Pharmacy
Shiyong Huang, Ke Du, Zeng Liu, Jiangping Li
Summary: Radio-resistance in nasopharyngeal carcinoma (NPC) can be overcome by inhibiting mTOR signaling, as demonstrated in this study. The combination of mTOR inhibitor and radiation therapy shows promising efficacy in treating radio-resistant NPC, providing preclinical evidence for further clinical trials.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Oncology
Susana M. Campos, Suzanne Berlin, Carolyn N. Krasner, Christin Whalen, Tina Atkinson, Kristin Meegan, Lauren Pereira, Karin Tyburski, Weixiu Lou, Hang Lee, Neil Horowitz, Richard T. Penson
Summary: The study aimed to investigate the safety of Temsirolimus and AZD2171 in patients with gynecological malignancies, and to evaluate the maximum tolerated dose of the combination. However, the study was halted at dose level 1 due to significant toxicities, and no maximum tolerated dose was determined.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Oncology
Neel D. Trivedi, Samantha Armstrong, Hongkun Wang, Marion Hartley, John Deeken, A. Ruth He, Deepa Subramaniam, Heather Melville, Chris Albanese, John L. Marshall, Jimmy Hwang, Michael J. Pishvaian
Summary: The combination of temsirolimus and capecitabine at the recommended Phase II doses showed promising evidence of disease control in patients with advanced solid tumors. The most common adverse events were mucositis, fatigue, and thrombocytopenia, with hypophosphatemia and anemia being the most common grade 3/4 adverse events. Overall disease control rate was 52%, with one patient having a partial response and 19 having stable disease.
Article
Oncology
Andrew J. Wagner, Vinod Ravi, Richard F. Riedel, Kristen Ganjoo, Brian A. Van Tine, Rashmi Chugh, Lee Cranmer, Erlinda M. Gordon, Jason L. Hornick, Heng Du, Berta Grigorian, Anita N. Schmid, Shihe Hou, Katherine Harris, David J. Kwiatkowski, Neil P. Desai, Mark A. Dickson
Summary: The study evaluated the efficacy and safety of nab-sirolimus in patients with malignant PEComa, showing an overall response rate of 39% with rapid and durable responses. Patients with TSC2 mutations were more likely to achieve a positive response. nab-sirolimus was considered an important new treatment option for this disease based on response rate, disease control, and safety profile.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Shunsuke Kondo, Hitoshi Hirakawa, Taro Ikegami, Takayuki Uehara, Shinya Agena, Jin Uezato, Hidetoshi Kinjyo, Noritomo Kise, Yukashi Yamashita, Katsunori Tanaka, Narumi Hasegawa, Asanori Kiyuna, Hiroyuki Maeda, Mikio Suzuki, Akira Gahana
Summary: This study aimed to investigate the role of the mTOR pathway in HPV-related oropharyngeal squamous cell carcinoma (OPSCC). The results showed that raptor and rictor were overexpressed in HPV-related OPSCC, and patients with high expression tended to have a worse prognosis. Temsirolimus was also identified as a potential therapeutic agent for HPV-related OPSCC.
Article
Oncology
Eddy S. Yang, Amin H. Nassar, Elio Adib, Opeyemi A. Jegede, Sarah Abou Alaiwi, Deborah L. Della Manna, David A. Braun, Mahsa Zarei, Heng Du, Sumanta K. Pal, Gurudatta Naik, Guru P. Sonpavde
Summary: The study investigated the relationship between gene expression and treatment benefit of Everolimus in metastatic renal cell carcinoma patients. Specific gene signatures were identified that could potentially predict the response to Everolimus monotherapy or combination therapy with a vascular disrupting agent. Further validation of these gene signatures is needed to determine their clinical utility in patient selection.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Oncology
Marie Moosburner, Lamija Alibegovic, Korbinian Hasselmann, Anton Gaiderov, Johannes Hildebrand, Julia Philippou-Massier, Helmut Blum, Luca Fischer, Martin Dreyling, Elisabeth Silkenstedt
Summary: Constitutive activation of the PI3K/AKT/mTOR pathway is important in the development of mantle cell lymphoma (MCL), and the mTOR inhibitor temsirolimus is approved for treating relapsed or refractory MCL. However, early relapses have been observed despite favorable initial response rates. This study establishes a new temsirolimus-resistant MCL cell line and identifies upregulated pathways, such as PI3K/AKT/mTOR, RAS, and RTK-dependent PDGFR, FGFR, Met, and ALK signaling, in the resistant cells. MET overexpression is found to play a crucial role in mediating temsirolimus resistance, and combined treatment with temsirolimus and the RTK inhibitor crizotinib effectively restores sensitivity to temsirolimus.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guiqin Ye, Mengting Xu, Yuhan Shu, Xin Sun, Yuanyuan Mai, Yupeng Hong, Jianbin Zhang, Jingkui Tian
Summary: This study revealed the mechanism of Eurycomanone against colon cancer by inhibiting autophagy and angiogenesis, suggesting its potential as a novel anti-cancer agent.
Article
Biophysics
Jing Li, Yao Min
Summary: Salinomycin shows positive effects on retinoblastoma cells by suppressing growth, inducing apoptosis, particularly inhibiting cells with stemness and highly invasive phenotypes. Using a mouse model, non-toxic doses of salinomycin effectively inhibit growth and induce apoptosis. Mechanistic studies reveal that salinomycin inhibits mitochondrial respiration by specifically suppressing complex I and II activities, leading to oxidative stress and damage, AMPK activation and mTOR inhibition.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Review
Clinical Neurology
Jiale Gao, Mingjiang Yao, Dennis Chang, Jianxun Liu
Summary: Ischemic stroke is a leading cause of morbidity and disability globally. The body's limited repair capacity makes the sequelae of serious neurological damage irreversible. However, endogenous neurogenesis induced by cerebral ischemia plays a critical role in the repair and regeneration of impaired neural cells after ischemic brain injury.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)