Journal
ARTIFICIAL ORGANS
Volume 41, Issue 1, Pages 88-98Publisher
WILEY
DOI: 10.1111/aor.12704
Keywords
Adsorption; endothelial dysfunction; Hemodiafiltration with endogenous reinfusion; Inflammation; Online-hemodiafiltration; Uremic toxins
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Funding
- Plan Nacional Proyectos de Investigacion en Salud of Instituto de Salud Carlos III (ISCIII) Fondos Feder Grants [PI10/00960, PI11/01536, PI12/01489, PI14/00806]
- Junta de Andalucia [P010-CTS-6337, P11-CTS-7352]
- Fundacion Nefrologica
- Bellco S.r.l., Mirandola, Italy
- Fundacion de Investigaciones Biomedicas de Cordoba (Servicio Andaluz de Salud, Programa Nicolas Monardes)
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Hemodiafiltration with endogenous reinfusion (HFR) after ultrafiltrate passage through a resin cartridge combines adsorption, convection, and diffusion. Our prospective single-center crossover study compared HFR and online-hemodiafiltration (OLHDF) effects on two uremic toxins and 13 inflammatory, endothelial status, or oxidative stress markers. After an 8-week run-in period of high-flux hemodialysis, 17 eligible stable dialysis patients (median age 65 years, 10 male) without overt clinical inflammation were scheduled for four 8-week periods in the sequence: HFR/OLHDF/HFR/OLHDF. Relative to OLHDF, HFR was associated with greater indoxyl sulfate removal and lesser abnormalities in all other study variables, namely circulating interleukin-6, tumor necrosis factor-alpha, proportions of activated proinflammatory (CD14+CD16+, CD14++CD16+) monocytes, endothelial progenitor cells, apoptotic endothelial microparticles, vascular endothelial growth factor, vascular cellular adhesion molecule, angiopoietins 2 and 1, annexin V, and superoxide dismutase. Differences were significant (P<0.05) in median values of 13/15 variables. Study period comparisons were generally consistent with dialysis technique comparisons, as were data from the subgroup completing all study periods (n=9). Our investigation provides hypothesis-generating results suggesting that compared with OLHDF, HFR improves protein-bound toxin removal, inflammatory and endothelial status, and oxidative stress.
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