Article
Nutrition & Dietetics
Xuejiao Zhang, Bowei Zhang, Bo Peng, Jin Wang, Yaozhong Hu, Ruican Wang, Shuo Wang
Summary: The study demonstrates that sucrose has differential effects on colitis at different doses. Low-dose sucrose intervention alleviates colitis by reducing inflammation and repairing mucosal damages while high-dose sucrose intervention exacerbates colitis. Additionally, the three doses of sucrose administration significantly alter gut microbiota composition, with low-dose sucrose restoring microbial dysfunction and enhancing the production of short chain fatty acids.
Article
Biochemistry & Molecular Biology
Yong-er Chen, Shi-jie Xu, Ying-yu Lu, Shu-xian Chen, Xian-hua Du, Shao-zhen Hou, Hai-yang Huang, Jian Liang
Summary: The research demonstrates that asperuloside (ASP) has anti-inflammatory and antioxidant effects on DSS-induced chronic colitis, activating the Nrf2/HO-1 signaling pathway and inhibiting the NF-kappa B signaling pathway, making it a potential effective candidate for the treatment of IBD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Hanan S. Althagafy, Fares E. M. Ali, Emad H. M. Hassanein, Zuhair M. Mohammedsaleh, Mohamed I. Kotb El-Sayed, Ahmed M. Atwa, Ahmed M. Sayed, Ayman A. Soubh
Summary: This study demonstrates that canagliflozin can effectively attenuate ulcerative colitis by regulating multiple pathways and targets, reducing inflammation, alleviating oxidative stress, and restoring colonic function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Amir Mohamed Abdelhamid, Ahmed Ramadan Elsheakh, Ghada Mohamed Suddek, Rania Ramadan Abdelaziz
Summary: Telmisartan (TEL) exerts hepatoprotective effects against alcoholic liver disease (ALD) through its anti-inflammatory and anti-oxidant activities, potentially via modulation of the PPAR-gamma/Nrf-2/NF-kappa B crosstalk.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohamed A. Morsy, Seham A. Abdel-Gaber, Rehab A. Rifaai, Mostafa M. Mohammed, Anroop B. Nair, Walaa Yehia Abdelzaher
Summary: Telmisartan demonstrates protective effects against hepatic I/R injury in rats by modulating oxidative stress parameters, myeloperoxidase levels, PPARγ and TLR4 mRNA expression, as well as NF-κB and caspase-3 immunoexpression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Bayan Y. Ghanim, Nidal A. Qinna
Summary: This review highlights the important role of the Nrf2-ARE transcriptional pathway in regulating cellular defence systems and discusses different modes of hepatocyte cell death. Research suggests that Nrf2 plays a critical and complex regulatory role in cell death.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Immunology
Keyvan Amirshahrokhi, Mahsa Imani
Summary: This study aimed to investigate the potential protective effect of the antiepileptic drug levetiracetam against ulcerative colitis (UC) in mice. The results showed that levetiracetam can alleviate colonic mucosal injury in UC mice, promote antioxidant responses, reduce lipid peroxidation and myeloperoxidase activity, decrease inflammatory mediator expression, and increase anti-inflammatory cytokine levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ashrafullah Khan, Adnan Khan, Bushra Shal, Abdul Aziz, Sajjad Ahmad, Muhammad Usman Amin, Muhammad Naeem Ahmed, Zia-ur-Rehman, Salman Khan
Summary: Environmental factors and genetic vulnerability can trigger inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn's disease. This study found that NCHDH and NTHDH compounds have positive effects on DSS-induced colitis in mice. Treatment improved behavioral parameters, reduced oxidative stress and inflammatory cytokines, and attenuated immune cell infiltration and fibrosis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Cheng Cheng, Wei Zhang, Cong Zhang, Peng Ji, Xiaohui Wu, Zhou Sha, Xiang Chen, Yongkang Wang, Yugen Chen, Haibo Cheng, Liyun Shi
Summary: The study demonstrates that HYP treatment effectively alleviates ulcerative colitis in mice by reducing pathological scores, suppressing colonic inflammation, and balancing Th17/Treg response. Mechanistically, HYP enhances PPAR γ signaling by inhibiting MKRN1, promoting Treg differentiation and suppressing Th17 cell development.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Adel T. Osman, Souty M. Z. Sharkawi, Mohamed I. A. Hassan, Amira M. Abo-Youssef, Ramadan A. M. Hemeida
Summary: The study demonstrated that EMPA and NHD have protective effects on MTX-induced liver injury by modulating multiple signaling pathways, enhancing anti-tumor activity, and potentially delaying the onset of toxicity.
Article
Chemistry, Medicinal
Congcong Guo, Yue Zhang, Tao Ling, Chongjie Zhao, Yanru Li, Meng Geng, Sailun Gai, Wei Qi, Xuegang Luo, Liehuan Chen, Tongcun Zhang, Nan Wang
Summary: Chitosan oligosaccharides (COS) can improve colitis by regulating intestinal microbiota and the PPAR gamma/SIRT1-mediated NF-kappa B pathway.
Article
Biochemistry & Molecular Biology
Shuang Chen, Chun-Lei Zhang, Hai-Qing Shen, Xiao-Fei Zhou, Jing-He Li, Jia-Lin Yu, Qiang An, Ben-Dong Fu, Peng-Fei Yi
Summary: The study showed that sesamin has protective effects on colitis in mice induced by DSS, reducing colon damage and inflammatory responses. Sesamin alleviates colon damage by modulating the NF-kappa B and MAPK signaling pathways.
Article
Biochemistry & Molecular Biology
Yeo Jin Park, Hye Jin Yang, Wei Li, You-Chang Oh, Younghoon Go
Summary: In this study, the effects of Menthae Herba (MH) on the inflammatory response and molecular mechanisms in activated microglia were evaluated. The results showed that MH inhibited the production of proinflammatory enzymes and mediators, reduced reactive oxygen species (ROS) levels, and activated antioxidant signaling pathways. These findings suggest the potential therapeutic use of MH in neuroinflammatory diseases.
Article
Pharmacology & Pharmacy
Amir Mohamed Abdelhamid, Mahmoud E. Youssef, Simona Cavalu, Gomaa Mostafa-Hedeab, Amal Youssef, Sara T. Elazab, Samar Ibrahim, Shady Allam, Rehab Mohamed Elgharabawy, Eman El-Ahwany, Noha A. Amin, Ahmed Shata, Osama A. Mohammed, Mahmoud Said Ibrahim Abdeldaiem, Ahmed Alhowail, Gaber El-Saber Batiha, Engy A. El-Mahmoudy, Maram Attia, Alaa Allam, Mona Y. Zaater, Mona M. Osman, Manar Nader, Aya Taha, Nada Abul Makarem, Sameh Saber
Summary: This study investigated the potential coloprotective role of carbocisteine in acetic acid-induced colitis in rats. The results showed that carbocisteine improved colon histology, macroscopic features, and disease activity. It also enhanced colon antioxidant defense mechanisms, suppressed neutrophil infiltration and activation, and modulated the expression of multiple cytokines. The study suggests that carbocisteine has the potential to be repurposed as a treatment for ulcerative colitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Ting Zuo, Yinzi Yue, Xiaohui Wang, Huan Li, Shuai Yan
Summary: The study demonstrated that luteolin effectively improved colon health indicators and reduced inflammation levels in the affected areas by regulating the signaling pathways in the intestine to alleviate colitis.
Article
Medicine, Research & Experimental
Amir Mohamed Abdelhamid, Sameh Saber, Mahmoud E. Youssef, Ahmed Gaafar Ahmed Gaafar, Hanan Eissa, Marwa A. Abd-Eldayem, Mohammed Alqarni, Gaber El-Saber Batiha, Ahmad J. Obaidullah, Mohamed Awad Shahien, Eman El-Ahwany, Noha A. Amin, Mohamed Ali Etman, Mohamed M. Y. Kaddah, Eslam E. Abd El-Fattah
Summary: The combination of empagliflozin and metformin shows potential benefits in controlling the progression of hepatocellular carcinoma, providing anti-inflammatory and antioxidant effects. This combination enhances the antitumorigenic activity, prolongs survival, and improves histological features in non-diabetic mice with HCC-induced.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Mahmoud E. Youssef, Mona F. El-Azab, Marwa A. Abdel-Dayem, Galal Yahya, Ibtesam S. Alanazi, Sameh Saber
Summary: Diabetes can lead to abnormal heart function, affecting cardiac structure and causing changes in electrocardiograms, particularly in diabetic rats, such as elevated ST-segment, prolonged QT interval, and QRS complex, which may serve as markers for the development of diabetic cardiomyopathy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Eslam E. Abd El-Fattah, Sameh Saber, Mahmoud E. Youssef, Hanan Eissa, Eman El-Ahwany, Noha A. Amin, Mohammed Alqarni, Gaber El-Saber Batiha, Ahmad J. Obaidullah, Mohamed M. Y. Kaddah, Ahmed Gaafar Ahmed Gaafar, Ahmed A. E. Mourad, Gomaa Mostafa-Hedeab, Amir Mohamed Abdelhamid
Summary: This study demonstrates that sitagliptin inhibits the activation of HIF-1α by interfering with the AKT-AMPKα-mTOR axis and interrupting IKKβ, P38α, and ERK1/2 signals. Sitagliptin prolongs survival, improves liver function, inhibits angiogenesis and tissue invasion, promotes apoptosis, inhibits proliferation, reduces inflammation, and has antifibrotic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Environmental Sciences
Sameh Saber, Suliman Y. Alomar, Galal Yahya
Summary: This article discusses the crucial role of inflammatory responses in the early phase of schistosomiasis infection and the potential of modulating PGE2 and IL10 to counteract the immune response against the parasite.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Physical
Mohamed Nasr, Sameh Saber, Alaa Y. Bazeed, Heba A. Ramadan, Asmaa Ebada, Adela Laura Ciorba, Simona Cavalu, Heba I. Elagamy
Summary: This study demonstrated that the use of cubosomal nanoparticles as a drug delivery system can enhance the corneal permeation of gatifloxacin, reduce the minimum inhibitory concentration, and significantly improve the treatment efficacy for ocular bacterial infections.
Article
Medicine, General & Internal
Dhekra Hasan Khudhair, Ali I. Al-Gareeb, Hayder M. Al-kuraishy, Aya H. El-Kadem, Engy Elekhnawy, Walaa A. Negm, Sameh Saber, Simona Cavalu, Adrian Tirla, Saqer S. Alotaibi, Gaber El-Saber Batiha
Summary: Vitamin C and curcumin pretreatment, either alone or in combination, have significant hepatoprotective effects against MTX-induced liver toxicity, alleviating liver damage and exerting their effects through antioxidant and anti-inflammatory mechanisms.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Amir Mohamed Abdelhamid, Mahmoud E. Youssef, Simona Cavalu, Gomaa Mostafa-Hedeab, Amal Youssef, Sara T. Elazab, Samar Ibrahim, Shady Allam, Rehab Mohamed Elgharabawy, Eman El-Ahwany, Noha A. Amin, Ahmed Shata, Osama A. Mohammed, Mahmoud Said Ibrahim Abdeldaiem, Ahmed Alhowail, Gaber El-Saber Batiha, Engy A. El-Mahmoudy, Maram Attia, Alaa Allam, Mona Y. Zaater, Mona M. Osman, Manar Nader, Aya Taha, Nada Abul Makarem, Sameh Saber
Summary: This study investigated the potential coloprotective role of carbocisteine in acetic acid-induced colitis in rats. The results showed that carbocisteine improved colon histology, macroscopic features, and disease activity. It also enhanced colon antioxidant defense mechanisms, suppressed neutrophil infiltration and activation, and modulated the expression of multiple cytokines. The study suggests that carbocisteine has the potential to be repurposed as a treatment for ulcerative colitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Ahmed A. Shaaban, Amir Mohamed Abdelhamid, Mohamed E. Shaker, Simona Cavalu, Adrian Marius Maghiar, Abdulrahman A. Alsayegh, Ahmad O. Babalghith, Eman El-Ahwany, Noha A. Amin, Osama A. Mohammed, Hanan Eissa, Ahmed Gaafar Ahmed Gaafar, Gaber El-Saber Batiha, Sameh Saber
Summary: The study evaluated the effect of autophagy induction and HSP90 inhibition in colitis-related diseases, revealing that the combination treatment was effective in combating colon damage and immune-cell infiltration. Further biochemical analysis showed reduced inflammation and oxidative injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mahmoud E. Youssef, Mustafa A. Abdel-Reheim, Mohamed A. Morsy, Mahmoud El-Daly, Gamal M. K. Atwa, Galal Yahya, Simona Cavalu, Sameh Saber, Ahmed Gaafar Ahmed Gaafar
Summary: This study examined the effectiveness of the antithrombotic agent dabigatran in treating arthritis in rats. The results showed that dabigatran had anti-inflammatory and antioxidant effects, making it a potential novel therapeutic strategy for arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Mohamed El-Telbany, Alzhraa Ali Mohamed, Galal Yahya, Aliaa Abdelghafar, Mahmoud Saad Abdel-Halim, Sameh Saber, Mohamed A. Alfaleh, Asmaa H. Mohamed, Fatma Abdelrahman, Hoda A. Fathey, Gehad H. Ali, Mohamed Abdel-Haleem
Summary: This study assessed the inhibitory action of ZnO nanoparticles against biofilms formed by multidrug-resistant P. aeruginosa strains. The results showed that the combination of ZnO nanoparticles and meropenem significantly changed the resistance profile and inhibited the formation of biofilms in P. aeruginosa. Additionally, ZnO nanoparticles reduced the expression of biofilm regulating genes, enhancing the antibiofilm effect. In vivo application of this antimicrobial mixture completely cured P. aeruginosa-induced keratitis in rats.
Review
Biochemistry & Molecular Biology
Ihtisham Ul Haq, Katarzyna Krukiewicz, Galal Yahya, Mehboob Ul Haq, Sajida Maryam, Rasha A. Mosbah, Sameh Saber, Mohammed Alrouji
Summary: Phages are widely used tools in molecular biology and recombinant DNA technology due to their ubiquity. The development of phage display technology revolutionized the design of phage-based vaccines. Phages are now recognized as universal adjuvant-free nanovaccine platforms, thanks to their stability and ease of large-scale production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mahmoud E. Youssef, Galal Yahya, Mihaela Simona Popoviciu, Simona Cavalu, Marwa A. Abd-Eldayem, Sameh Saber
Summary: The number of diabetic patients has significantly increased due to the rising prevalence of type 2 diabetes mellitus. Various oral antidiabetic medications, such as SGLT2 inhibitors, have been used for the treatment of type 2 diabetes. SGLT2 inhibitors not only improve glycemic control, but also have potential effects on other body systems, including cardiovascular, adipose tissue, bone, cancer, and neurological systems. These effects include cardiac remodeling, enhanced myocardial function, decreased bone mineral deposition, and improved neuroprotection. However, further studies are needed to fully evaluate the role of SGLT2 inhibitors in these areas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mahmoud E. Youssef, Simona Cavalu, Alexandru Madalin Hasan, Galal Yahya, Marwa A. Abd-Eldayem, Sameh Saber
Summary: Heat-shock proteins are upregulated in cancer and protect client proteins from degradation, contributing to tumorigenesis and cancer metastasis. Inhibiting HSP90 activity with ganetespib is a promising strategy in cancer treatment, as it has shown strong activity against various cancers and low adverse effects. Ganetespib is being tested in phase II clinical trials as a first-line therapy for metastatic breast cancer, and it has been found to induce apoptosis and growth arrest in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Sameh Saber, Mohannad Mohammad S. Alamri, Jaber Alfaifi, Lobna A. Saleh, Sameh Abdel-Ghany, Adel Mohamed Aboregela, Alshaimaa A. Farrag, Abdulrahman H. Almaeen, Masoud I. E. Adam, AbdulElah Al Jarallah AlQahtani, Ali M. S. Eleragi, Mustafa Ahmed Abdel-Reheim, Heba A. Ramadan, Osama A. Mohammed
Summary: This study examined the potential benefits of consuming (R,R)-BD-AcAc2, a type of ketone ester, and intermittent fasting in treating chronic colitis in rats. The findings showed that consuming the ketone ester improved disease activity, reduced inflammation, and increased survival rate in the rats.
Article
Pharmacology & Pharmacy
Rania Khalil, Galal Yahya, Walied S. Abdo, Ghada S. El-Tanbouly, Dina Johar, Mahmoud Saad Abdel-Halim, Hanan Eissa, Calin Magheru, Sameh Saber, Simona Cavalu
Summary: This study investigated the effects of a Hibiscus sabdariffa (HS)-loaded ointment on wound healing and found that it enhanced skin regeneration by stimulating biomarkers and reduced inflammation through TLR4 inhibition. The HS extract also demonstrated antimicrobial properties. Overall, this study suggests that HS-loaded topical preparations could be valuable as adjuvants to accelerate burn wound healing.
SCIENTIA PHARMACEUTICA
(2022)