4.7 Article Proceedings Paper

Impact of growth factors on wound healing in polysaccharide blend thin films

Journal

APPLIED SURFACE SCIENCE
Volume 489, Issue -, Pages 485-493

Publisher

ELSEVIER
DOI: 10.1016/j.apsusc.2019.06.054

Keywords

Wound healing; Thin films; Growth factors; Alginate; Carboxymethyl cellulose

Funding

  1. Slovenian Research Agency for Research Core Funding [P2-0118, P3-0036, I0-0029, Z2-8168]

Ask authors/readers for more resources

The potential of alginate/carboxymethyl cellulose based thin films was demonstrated as a testing platform for evaluation of the influence of in situ incorporated growth factors into formulations intended for 3D bio-printed wound healing materials. Actual formation of blend films with and without included growth factors was analysed using ATR-IR spectroscopy. Surface morphology and topography were evaluated by atomic force and scanning electron microscopies, whereas the hydrophilicity of all tested materials was determined using the water contact angle measurement method. The inclusion of growth factors into blend films did not affect the films' formation, nor their morphology, whereas their highly hydrophilic character was even slightly enhanced by the added growth factors. Further, several aspects (viability, proliferation and cell morphology), in regard to the blend films included growth factors' influence on both of the most abundant skin cell types (keratynocytes and fibroblasts) were tested. A significantly improved cell viability was detected for films with incorporated growth factors. The prepared thin film-based testing platform could present an important tool to aid the development of novel printable (bio)inks.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Nanoscience & Nanotechnology

One-Step Fabrication of Hollow Spherical Cellulose Beads: Application in pH-Responsive Therapeutic Delivery

Tamilselvan Mohan, Urban Ajdnik, Chandran Nagaraj, Florian Lackner, Andreja Dobaj Stiglic, Thirvengadam Palani, Lunjakorn Amornkitbamrung, Lidija Gradisnik, Uros Maver, Rupert Kargl, Karin Stana Kleinschek

Summary: This study developed a facile method for the fabrication of hollow cellulose beads that can release drugs in response to external pH stimuli. These hollow cellulose structures exhibit pH-responsive fluid uptake properties and high drug encapsulation efficiency, and their drug release can be fine-tuned by adjusting the pH of the release medium. The modified beads show excellent characteristics for drug delivery and are biocompatible, making them a promising platform for the development of sustainable and effective drug delivery systems.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Analytical

The development of an electropolymerized, molecularly imprinted polymer (MIP) sensor for insulin determination using single-drop analysis

Tanja Zidaric, David Majer, Tina Maver, Matjaz Finsgar, Uros Maver

Summary: An electrochemical sensor based on molecularly imprinted polymers (MIP) was developed for the detection of insulin in a single drop. The MIP receptors were assembled on a screen-printed carbon electrode (SPCE) through electropolymerization, creating imprinting cavities for insulin detection. The sensor showed a linear concentration range, a low detection limit, and good accuracy and precision.

ANALYST (2023)

Article Materials Science, Multidisciplinary

Algorithmic linearization improves Syringe-based extrusion in elastic systems using Hydrogel-based materials

Jernej Vajda, Luka Banovic, Mihael Misko, Igor Drstvensek, Marko Milojevic, Uros Maver, Bostjan Vihar

Summary: Accuracy and precision are crucial in extrusion-based material handling, such as 3D bioprinting. To address the issue of discrepancies between piston motion and material extrusion, we propose an algorithmic approach that optimizes piston movements based on extrusion analysis. This approach improves the accuracy and precision of complex extrusion-based bioprinting systems.

MATERIALS & DESIGN (2023)

Article Chemistry, Physical

Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief

Tanja Zidaric, Kristijan Skok, Kristjan Orthaber, Matevz Pristovnik, Lidija Gradisnik, Tina Maver, Uros Maver

Summary: This study presents an innovative wound dressing system that combines diclofenac and a biocompatible matrix for targeted pain relief. The multilayer structure of the dressing, achieved through layer-by-layer coating technique and inclusion of superparamagnetic iron platinum nanoparticles, allows for sustained drug release and precise application. The dressings were characterized for their physicochemical, structural, and morphological properties and found to be biocompatible with human skin fibroblasts. The findings suggest that this wound dressing system can contribute to tailored therapeutic strategies for local pain relief.

MATERIALS (2023)

Review Chemistry, Physical

Review of Potential Drug-Eluting Contact Lens Technologies

Tina Lovrec-Krstic, Kristjan Orthaber, Uros Maver, Tomislav Sarenac

Summary: The field of ophthalmology is rapidly expanding with the increasing incidence of eye-related diseases. Due to an aging population and climate change, the number of ophthalmic patients will continue to rise, leading to potential under-treatment. Drug-loaded contact lenses provide a promising alternative to eye drops for ocular therapy, potentially transforming clinical practice. This review focuses on current roles, materials, drug binding, and future developments of contact lenses in ocular drug delivery.

MATERIALS (2023)

Article Polymer Science

Efficient and Green Isolation of Keratin from Poultry Feathers by Subcritical Water

Mojca Skerget, Maja Colnik, Lidija Fras Zemljic, Lidija Gradisnik, Tanja Zivkovic Semren, Blanka Tariba Lovakovic, Uros Maver

Summary: The isolation of keratin from poultry feathers using subcritical water was studied. The optimal operating parameters for obtaining a high molecular weight protein hydrolysate from poultry feathers were determined. The obtained hydrolysate showed a positive influence on skin fibroblast viability, making it potentially useful for biomedical applications.

POLYMERS (2023)

Article Materials Science, Multidisciplinary

Sr2? vs. Ca2? as post-processing ionic crosslinkers: implications for 3D bioprinting of polysaccharide hydrogels in tissue engineering

Jernej Vajda, Bostjan Vihar, Laura Cinc Curic, Uros Maver, Matej Vesenjak, Polona Dobnik Dubrovski, Marko Milojevic

Summary: In this study, the effects of CaCl2 and SrCl2 as ionic crosslinkers on alginate- and cellulose-based materials were compared. Results showed that Sr2 crosslinked scaffolds had higher compressive strength, faster swelling, slower degradation, and rougher surface. Both crosslinking agents were non-toxic to cells and allowed stable culture for 30 days, but Sr2 crosslinked scaffolds exhibited higher metabolic activity. Overall, Sr2 is a viable alternative to Ca2 for crosslinking.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2023)

Article Materials Science, Multidisciplinary

The synthesis, surface analysis, and cellular response of titania and titanium oxynitride nanotube arrays prepared on TiAl6V4 for potential biomedical applications

Katja Andrina Kravanja, Luka Suhadolnik, Marjan Bele, Uros Maver, Jan Rozanc, Zeljko Knez, Masa Knez Marevci, Matjaz Finsgar

Summary: This study synthesized titania and titanium oxynitride (Ti-O-N) nanotubular arrays on TiAl6V4 substrates using an anodic oxidation process followed by annealing in air or additional nitridation in NH3 atmosphere, and investigated their morphology, structure, and biocompatibility. Surface analysis techniques such as FE-SEM, AFM, XRD, XPS, and ToF-SIMS were performed. Cell testing with adipose-derived mesenchymal stem cells and human fetal osteoblasts demonstrated the favorable effects of Ti-O-N nanotubes on cell viability, proliferation, and morphology.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2023)

Review Pharmacology & Pharmacy

Single-Strain Probiotic Lactobacilli for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis

Sabina Fijan, Nina Kolc, Metka Hrasovec, Gro Jamtvedt, Maja Sikic Pogacar, Dusanka Micetic Turk, Uros Maver

Summary: This study evaluated the effect of single-strain probiotic lactobacilli on treating children's atopic dermatitis. The results showed that certain strains were more effective in reducing the severity of atopic dermatitis, and treatment time and patient age also played a role.

PHARMACEUTICS (2023)

Review Materials Science, Biomaterials

Cell Electrospinning: A Mini-Review of the Critical Processing Parameters and Its Use in Biomedical Applications

Beste Elveren, Manja Kurecic, Tina Maver, Uros Maver

Summary: Functional tissue engineering is an important field in regenerative medicine and drug discovery, with electrospinning being a widely used method. This review discusses the process and materials of cell electrospinning (C-ES) and highlights recent advances in its applications for tissue engineering.

ADVANCED BIOLOGY (2023)

Article Green & Sustainable Science & Technology

Understanding stability, oligomerization and deactivation during catalytic lignin hydrodeoxygenation by mechanistic reaction micro-kinetics linked with 3D catalyst particle nanotomography

Tina Rocnik Kozmelj, Matej Zula, Janvit Terzan, Blaz Likozar, Uros Maver, Laura Cinc Curicc, Edita Jasiukaityte-Grojzdeka, Miha Grilc

Summary: The mechanisms, activity, and selectivity of the acid-supported transition metal rate catalyst (NiMo/Al2O3) for the hydrogenation, hydrodeoxygenation (HDO), and defunctionalization of lignin model compounds were investigated. The commercially available NiMo/Al2O3 intermediates showed strong acidity, which did not promote complete bond saturation but instead favored the formation of higher molecular weight compositions. The study provides insights for understanding and optimizing efficient valorization processes.

JOURNAL OF CLEANER PRODUCTION (2023)

Review Urology & Nephrology

Renal Proximal Tubular Epithelial Cells: From Harvesting to Use in Studies

Tadej Petreski, Luka Varda, Lidija Gradisnik, Uros Maver, Sebastjan Bevc

Summary: The kidneys are the primary excretion organ with various functions, and the nephron is their central structural unit. The treatment of acute kidney injury or chronic kidney disease is complex due to limited regeneration potential. The development of in vitro cell models based on patient-derived renal cells provides an opportunity to address issues related to drug-drug interactions and complications.

NEPHRON (2023)

Review Engineering, Biomedical

Practical Use of Quartz Crystal Microbalance Monitoring in Cartilage Tissue Engineering

Jakob Naranda, Matej Bracic, Matjaz Vogrin, Uros Maver, Teodor Trojner

Summary: This review focuses on the use of Quartz Crystal Microbalance (QCM) in the tissue engineering of cartilage. QCM is an accurate technique that can monitor key parameters in developing cellular scaffolds, such as interactions with extracellular matrix components, adsorption of proteins onto biomaterials, and biomaterial-cell interactions. The review highlights the importance of material selection and proposes the use of QCM as a screening tool to improve the process. The future trends of QCM application in 3D printing of cellular scaffolds are also discussed.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

Article Biotechnology & Applied Microbiology

The Endplate Role in Degenerative Disc Disease Research: The Isolation of Human Chondrocytes from Vertebral Endplate-An Optimised Protocol

Lidija Gradisnik, Uros Maver, Boris Gole, Gorazd Bunc, Matjaz Vorsic, Janez Ravnik, Tomaz Smigoc, Roman Bosnjak, Tomaz Velnar

Summary: This study established a quick and simple method for isolating human chondrocytes, which showed high viability and proliferative capacity. The cell model created in this study can be used to study the cellular properties, biochemical aspects, and potential therapeutic candidates for disc degeneration, as well as toxicology studies.

BIOENGINEERING-BASEL (2022)

Article Chemistry, Physical

Multifunctional continuous solid solution Na0.9Mg0.45Ti3.55O8-Na2Fe2Ti6O16: Preparation, characterization, magnetism, dual absorption, adsorption, and photocatalysis

Qi-Wen Chen, Ze-Qing Guo, Jian-Ping Zhou

Summary: Multifunctional continuous solid solutions NFMTO-x were successfully synthesized via a one-step hydrothermal method by controlling the ratio of Mg and Fe. The NFMTO-x materials exhibited enhanced visible light response, effective adsorption and photocatalytic degradation of organic pollutants, CO2 methanation capability, and easy recyclability due to their magnetic properties. This research provides a significant multifunctional material for water purification.

APPLIED SURFACE SCIENCE (2024)

Review Chemistry, Physical

Critical advances in the field of magnetron sputtered bioactive glass thin-films: An analytical review

George E. Stan, Maziar Montazerian, Adam Shearer, Bryan W. Stuart, Francesco Baino, John C. Mauro, Jose M. F. Ferreira

Summary: Bioactive glasses have the ability to form strong bonds with tissues and release therapeutic ions. However, their biomechanical compatibility limits their use in load-bearing applications. The use of magnetron sputtering technology to fabricate BG coatings shows promise in improving their efficacy and potential for application.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Corrosion mode evaluation of Fe-based glassy alloys with metalloid elements by electrochemical noise (EN)

Zhaoxuan Wang, Zhicheng Yan, Zhigang Qi, Yu Feng, Qi Chen, Ziqi Song, Meng Huang, Peng Jia, Ki Buem Kim, Weimin Wang

Summary: The corrosion behavior of Fe-60 and Fe-83 ribbons in 0.6 M NaCl was studied. Fe-60 exhibited a local corrosion mode and formed a stable passivation film with higher corrosion resistance, while Fe-83 showed a combination of local and global corrosion modes and had lower corrosion resistance. Controlling the precipitation of nanocrystalline phases and increasing the POx content in the passivation film significantly improved the corrosion resistance of Fe-based glassy alloys.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Impacts of Zr content of HfZrOx-Based FeFET memory on resilience towards proton radiation

Hao-Kai Peng, Sheng-Yen Zheng, Wei-Ning Kao, Ting-Chieh Lai, Kai-Sheun Lee, Yung- Hsien Wu

Summary: This study investigates the effects of high energy/fluence proton radiation on the performance of HfZrOx-based FeFETs memory with different Zr content. The results show that the characteristics of FeFETs are influenced by proton radiation, and the extent of the influence depends on the Zr content. FeFETs with 50% Zr content exhibit minimal changes in memory window and demonstrate good endurance and retention performance.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Excellent crystalline silicon surface passivation by transparent conductive Al-doped ZnO/ITO stack

Zongyi Yue, Guangyi Wang, Zengguang Huang, Sihua Zhong

Summary: In this study, AZO and ITO films were successfully tuned as excellent passivation layers for c-Si surfaces, achieving effective minority carrier lifetime and outstanding optical properties through the optimization of annealing temperature and interfacial silicon oxide.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Hydrogen sensing capabilities of highly nanoporous black gold films

Martin Hruska, Jan Kejzlar, Jaroslav Otta, Premysl Fitl, Michal Novotny, Jakub Cizek, Oksana Melikhova, Matej Micusik, Peter Machata, Martin Vrnata

Summary: This paper presents a detailed study on the hydrogen sensing capabilities of highly nanoporous black gold films. The films exhibit fast response and recovery times at low temperatures. Different levels of nanoporosity were prepared and tested to investigate the sensing properties, and it was found that nanoporous black gold is suitable for hydrogen sensing. The sensitivity of the film depends on its nanoporosity.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Abnormal stability of hydrogenic defects and magnetism near the HSrCoO2.5(001) surface

Yupu Wang, Gaofeng Teng, Chun To Yiu, Junyi Zhu

Summary: In the study of BM-SCO and HSCO thin films, it was found that H vacancies tend to prefer sites near the external surface or oxygen vacancy channels (OVCs), while H interstitials prefer sites of oxygen on a layer that contains six-fold coordinated Co. These findings not only enrich the understanding of complex surface phenomena of defect formation but also provide an explanation for the reversibility during phase transformation.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Space variant fiber nanogratings induced by femtosecond laser direct writing

Jiafeng Lu, Linping Teng, Qinxiao Zhai, Chunhua Wang, Matthieu Lancry, Ye Dai, Xianglong Zeng

Summary: In this study, we achieved full control of fiber nanograting orientation by manipulating laser polarization, and tailored space variant fiber nanogratings, which expanded the diversity in fiber nanograting engineering.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Wetting mechanisms in the mass transfer process of CuSi3 droplets on the TC4 and 304SS multi-metal system controlled by the hybrid shielding gas atmosphere

Yibo Liu, Yujie Tao, Yue Liu, Qi Sun, Qinrong Lin, Kexin Kang, Qinghua Zhang, Qingjie Sun

Summary: This study investigates the wettability of the Ti-Cu-Fe multi-metal system, specifically the wetting behaviors of CuSi3 droplets on TC4 and 304SS plates. The results show that the CO2 + Ar gas atmosphere significantly affects interfacial mass transfer, thus influencing the wettability of the systems.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Size-regulated Co-doped hetero-interfaced 3D honeycomb MXene as high performance electromagnetic absorber with anti-corrosion performance

Jimei Liu, Fei Wang, Rong Guo, Yuqi Liu, Mengyu Zhang, Jaka Sunarso, Dong Liu

Summary: This study developed Co/MXene composites with anti-corrosion properties by varying the cobalt content. These composites exhibited remarkable electromagnetic absorption performance and high resistance to corrosion under various corrosive conditions. The study also revealed the mechanism of electron transfer from cobalt to MXene and the electromagnetic dissipation behavior originated from polarization loss alone.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Ultrafine Ru nanoparticles on nitrogen-doped CNT arrays for HER: A CVD-based protocol achieving microstructure design and strong catalyst-support interaction

Moujie Huang, Yongsong Ma, Jingbo Yang, Lingyun Xu, Hangqi Yang, Miao Wang, Xin Ma, Xin Xia, Junhao Yang, Deli Wang, Chuang Peng

Summary: Strong metal-support interactions (SMSIs) are important for enhancing catalytic activities and stability in thermal catalysis. This study demonstrates a method to create SMSIs in electrocatalysis using carbon nanotubes and Ru nanoparticles, resulting in excellent catalytic activity and stability.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Novel biphenylene as cisplatin anticancer drug delivery carrier; insight from theoretical perspective

Ravi Trivedi, Brinti Mondal, Nandini Garg, Brahmananda Chakraborty

Summary: This study explores the potential of biphenylene as a nanocarrier for the delivery of the anticancer drug cisplatin. It is found that biphenylene offers physical stability, rapid release rate, solubility, and bio-compatibilities compared to other nanocarriers. The adsorption of cisplatin on the surface of biphenylene involves charge transfer from cisplatin to biphenylene. The drug is shown to be released at body temperature in an acidic environment. Biphenylene also exhibits excellent cytotoxicity activity and cellular uptake of the drug. Overall, biphenylene shows promise as a potential nanocarrier for cisplatin delivery.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Platform for surface-enhanced Raman scattering in layered quantum materials

Hyun Jeong, Hyeong Chan Suh, Ga Hyun Cho, Rafael Salas-Montiel, Hayoung Ko, Ki Kang Kim, Mun Seok Jeong

Summary: In this study, a potential platform to enhance Raman scattering and increase the number of observable Raman modes in monolayer transition metal dichalcogenides (TMDs) was proposed. The platform consisted of large-scale arrays of gold micropillars (MPs), which were able to enhance the Raman intensity of TMDs and make difficult-to-detect Raman modes observable. The platform showed great industrial advantages and wide applicability due to its low cost, simple process, large controllable area, and short process time.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Cyclotriphosphazene (P3N3) derived FeOx@SPNO-C core-shell nanospheres as peroxymonosulfate activator for degradation via non-radical pathway

Yasir Abbas, Shafqat Ali, Sajjad Ali, Waqar Azeem, Zareen Zuhra, Haoliang Wang, Mohamed Bououdina, Zhenzhong Sun

Summary: In this study, FeOx@SPNO-C core-shell nanospheres as a catalyst for degradation of sulfamethoxazole (SMX) were successfully synthesized. The synergistic interaction between FeOx and SPNO-C, high carbon charge density, and the presence of C = O groups and N/Fe-Nx sites were found to be key factors for the enhanced degradation of SMX.

APPLIED SURFACE SCIENCE (2024)

Article Chemistry, Physical

Hierarchical confinement of Prussian blue nanoparticles via NH2-MIL-88B (Fe): Rational design and electrocatalytic application

Qiaoting Yang, Yuxiao Gong, Yan Qian, Zhou-Qing Xiao, Serge Cosnier, Xue-Ji Zhang, Robert S. Marks, Dan Shan

Summary: This study proposes a hierarchical confinement strategy to design Prussian blue nanoparticles (PB NPs) with satisfactory electrocatalytic ability and stability. The catalytic synthesis of PB NPs is achieved through a hydrothermal process, and the as-prepared PB@NH2MIL exhibits efficient electronic transmission and enhanced electrocatalytic properties.

APPLIED SURFACE SCIENCE (2024)