Article
Environmental Sciences
Dan Wang, Hongbo Guan, Ying Wang, Guiyu Song, Yajun Xia
Summary: This study explores the mechanism of m6A-modified circSETD2 in trophoblast biological behaviors and finds that m6A modification suppresses miR-181a-5p and increases MCL1 transcription, thus regulating trophoblasts. The findings suggest the important role of m6A modification in the development of PE.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Zhou, Ning Ma, Weiying Lu, Zhi Zhou, Suju Liu
Summary: The purpose of this study was to screen micro-ribonucleic acids (miRNAs) in the pathological processes of preeclampsia (PE) and evaluate their effects on HTR-8/SVneo cell proliferation and apoptosis. MiRNAs in PE patients and healthy puerperae were screened and verified. The expression level of miR-19a was found to affect HTR-8/SVneo cell proliferation, cell cycle, and apoptosis. MiR-19a targets PTEN to activate the Akt signaling pathway, promoting cell proliferation and inhibiting apoptosis. This provides potential drug targets for future treatment of PE.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chao Tang, Meiyuan Jin, Bingbing Ma, Bin Cao, Chao Lin, Shouying Xu, Jiayong Li, Qiang Xu
Summary: Production of estradiol (E2) by the placenta during human pregnancy is crucial for successful placental development and fetal growth. However, the mechanisms inhibiting E2 biosynthesis remain unclear. This study reveals that regulator of G-protein signaling 2 (RGS2) affects E2 levels by regulating aromatase, a key enzyme for E2 production. RGS2 enhances the degradation of HAND1, a transcription factor involved in E2 regulation, leading to increased E2 levels. Additionally, RGS2 and aromatase expression were found to be correlated in normal and preeclamptic placental tissues.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lingfang Zhuang, Kangni Jia, Chen Chen, Zhigang Li, Jiaxin Zhao, Jian Hu, Hang Zhang, Qin Fan, Chunkai Huang, Hongyang Xie, Lin Lu, Weifeng Shen, Guang Ning, Jiqiu Wang, Ruiyan Zhang, Kang Chen, Xiaoxiang Yan
Summary: This study reveals the significant role of DYRK1B in mitochondrial bioenergetics and the progression of cardiac hypertrophy and heart failure. DYRK1B promotes impaired mitochondrial bioenergetics by directly binding with STAT3, leading to the downregulation of PGC-1 alpha. Inhibition of DYRK1B or STAT3 activity restores cardiac performance by rejuvenating mitochondrial bioenergetics. These findings may offer new therapeutic options for heart failure patients.
Article
Oncology
He Huang, Jun Zhang, Fei Ling, Yuhong Huang, Min Yang, Yao Zhang, Yuanyi Wei, Qingqing Zhang, Honghai Wang, Lin Song, Ying Wu, Jiayu Yang, Jianwu Tang
Summary: The study found that LEPR is highly expressed in liver cancer tissues, promoting the proliferation, migration, and invasion of hepatocarcinoma lymphatic metastatic cells while inhibiting apoptosis. Furthermore, LEPR regulated ERK1/2 and JAK2/STAT3 expression via ANXA7, revealing a potential therapeutic target for liver cancer treatments.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Matthew Man-Kin Wong, Sancy Mary Joyson, Heiko Hermeking, Sung Kay Chiu
Summary: AP4 plays a crucial role in cancer by regulating cell fate decisions that impact tumor initiation and progression. It is associated with poor patient prognosis in various tumor types and functions downstream of c-Myc and N-Myc through complex interactions with other molecules.
Letter
Dermatology
Wanlong Wu, Jinju Chen, Linling Zhu, Yaping Sha, Kaiwen Wang, Jiangfeng Zhao, Chunhua Ye, Shuang Ye
Summary: In this retrospective case series, the off-label use of Janus kinase inhibitor significantly improved the active cutaneous disease in glucocorticoid-resistant patients with cancer-associated dermatomyositis who had anti-transcription intermediary factor 1-gamma antibodies. The treatment showed a promising steroid-sparing effect and was generally well-tolerated beyond 1-year follow-up.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Linmei Zheng, Jie Song, Rong Tang, Xiaoju Chen, Li Wang, Dongcai Wu, Hui Cen, Lei Shi
Summary: miR-524-5p expression levels are lower in patients with preeclampsia, and it regulates the proliferation and invasion of HTR-8/SVneo cells by targeting NUMB and affecting the Notch signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Xiaohui Liang, Ping Wang, Chun Yang, Fei Huang, Hui Wu, Hailian Shi, Xiaojun Wu
Summary: Galangin inhibits the growth of MGC 803 cells by inducing apoptosis and decreasing cell proliferation, possibly mediated by modulating the STAT3/ROS axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Sunghark Kwon
Summary: JAKs are important enzymes in the JAK-STAT signaling pathway, and dysfunctional JAKs can lead to severe immune system-related diseases. Various JAK inhibitors have been developed to block abnormal JAK-STAT signaling, but drug selectivity and resistance to these inhibitors remain challenges. This review discusses the role and structure of JAKs, as well as strategies for disrupting JAK dimerization to develop novel inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Genetics & Heredity
Elham Zeinalzadeh, Alexey Valerievich Yumashev, Heshu Sulaiman Rahman, Faroogh Marofi, Navid Shomali, Hossein Samadi Kafil, Saeed Solali, Mehdi Sajjadi-Dokht, Sajjad Vakili-Samiani, Mostafa Jarahian, Majid Farshdousti Hagh
Summary: The JAK-STAT signaling pathway plays a crucial role in cell growth, differentiation, immune cell survival, and hematopoietic system development, with STAT3 acting as a key regulator. Prolonged activation of STAT3 is associated with tumor cell survival, proliferation, and invasion, making the pathway a potential target for treating hematological malignancies. Epigenetic modifications are important in regulating the activity and function of STAT3, and there are developing compounds targeting these mechanisms in blood cancers.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Hongli Mao, Jinlin Jia, Jinxiu Sheng, Shanfeng Zhang, Kaida Huang, Hongle Li, Fucheng He
Summary: The study found that Regenerating islet-derived protein 1-alpha (REG1A) was significantly increased in inflamed colorectal tissues of inflammatory bowel disease (IBD) patients, and it could inhibit inflammatory responses, promote cell proliferation, and suppress epithelial apoptosis. IL-6 and IL-22 activated REG1A transcription through the JAK/STAT3 signaling pathway. Overexpression of REG1A in mice alleviated DSS-induced inflammatory injury and maintained intestinal mucosal barrier integrity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Reproductive Biology
Chie-Pein Chen, Liang-Kai Wang, Chen-Yu Chen, Chia-Yu Chen, Yi-Hsiu Kuo, Yi-Hsin Wu
Summary: The protein JAM3 is involved in the structure and regulation of placental cells, affecting their fusion, differentiation, proliferation, apoptosis, and motility. Dysregulation of JAM3 expression is crucial in the development of preeclampsia.
BIOLOGY OF REPRODUCTION
(2022)
Article
Cell Biology
Hai-Yan Yang
Summary: The study elucidates the role of miR-133b in oxidative stress injury of trophoblasts in preeclampsia by activating the JAK2/STAT3 pathway to promote cell migration and invasion.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Kim
Summary: The study found that kahweol induces apoptosis in hepatocellular carcinoma cells by inhibiting the phosphorylation of specific signaling pathways, suggesting it as a potential inhibitor of HCC cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)