Article
Medicine, Research & Experimental
Ching Zhu, Pradeep S. Rajendran, Peter Hanna, Igor R. Efimov, Guy Salama, Charless C. Fowlkes, Kalyanam Shivkumar
Summary: This study used a high-resolution pipeline and computer vision algorithms to investigate microstructural changes on the heart after myocardial infarction (MI) and their association with electrical dysfunction. The results established clear structure-function relationships and identified potential neural substrates for cardiac arrhythmia after MI, providing a framework for understanding arrhythmogenic mechanisms with microscopic precision.
Article
Cardiac & Cardiovascular Systems
Marie Gunthel, Karel van Duijvenboden, Dennis E. M. de Bakker, Ingeborg B. Hooijkaas, Jeroen Bakkers, Phil Barnett, Vincent M. Christoffels
Summary: Myocardial infarction leads to changes in gene expression and epigenetic states of border zone cardiomyocytes, which may play a crucial role in maintaining the metabolic switch in these cells.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Article
Physiology
Vincenzo Gionti, Simone Scacchi, Piero Colli Franzone, Luca F. Pavarino, Roberto Dore, Cesare Storti
Summary: By numerical simulations based on left ventricular models derived from post myocardial infarction patients, this study aims to identify proarrhythmic geometric configurations of scars and border zones. It was found that the extent of the infarct scar and the presence of transmural BZ isthmuses and thin subendo- and subepicardial BZs promote sustained ventricular tachycardia (VT).
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Mathematics
Pavel Konovalov, Daria Mangileva, Arsenii Dokuchaev, Olga Solovyova, Alexander V. Panfilov
Summary: The rotating waves of electrical excitation around an obstacle in a heart damaged by post-infarction scar, surrounded by a region of heterogeneity known as a gray zone, can lead to dangerous cardiac arrhythmias. The study reveals different wave rotation regimes depending on the radius of the obstacle and the width of the gray zone, aiding in identifying factors influencing arrhythmia periods in post-infarction patients.
Article
Cardiac & Cardiovascular Systems
J. Caleb Snider, Lance A. Riley, Noah T. Mallory, Matthew R. Bersi, Prachi Umbarkar, Rekha Gautam, Qinkun Zhang, Anita Mahadevan-Jansen, Antonis K. Hatzopoulos, Luc Maroteaux, Hind Lal, W. David Merryman
Summary: Inhibiting 5-HT2B can reduce fibrotic scar formation after MI, thereby protecting cardiac structure and function. The redistribution of collagen fibers to thinner, more anisotropic fibers enhances left ventricular contractility, while decreasing fibrotic tissue stiffness limits the hypertrophic response of uninjured cardiomyocytes. Ablation of 5-HT2B in cardiac fibroblasts or myofibroblasts contributes to excessive scar formation and impairs cardiac function after MI.
Article
Integrative & Complementary Medicine
Tan Yu, Bie Yu-long, Chen Li, Zhao Yi-han, Song Lei, Miao Li-na, Yu Yan-qiao, Chai Hua, Ma Xiao-juan, Shi Da-zhuo
Summary: Lingbao Huxin Pill (LBHX) protects against acute myocardial infarction (AMI) by regulating apoptosis and inflammation through the SIRT1-mediated signaling pathways, reducing ischemic injury to myocardial tissue.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Chemistry, Analytical
Dewei Song, Min Zhou, Haofeng Sun, Lingyun Ma, Jianyi Liu, Yanhong Gao, Qi Zhang, Peng Xiao, Keqi Sun, Min Shen, Xiaojian Wang
Summary: Cardiac troponin I (cTnI) is the preferred biomarker for diagnosing acute myocardial infarction, but the quantitative results from different manufacturers' cTnI assay kits are not comparable. Using HDX-MS, we developed a strategy to evaluate the interactions between epitopes and antibody cocktails, and found that the quantitative result bias of different reagents is due to their ability to recognize different forms of cTnI complexes based on different epitopes. Thorough investigation of epitopes recognized by antibodies in diagnostic kits can improve the consistency of quantitative results and standardize cTnI diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Review
Hematology
David Schumacher, Rafael Kramann
Summary: Lack of targeted therapies for cardiac remodeling and fibrosis results in high long-term morbidity and mortality after myocardial infarction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nitish Bhatt, Venkat Ramanan, Hayden Gunraj, Fumin Guo, LaBonny Biswas, Xiuling Qi, Idan Roifman, Graham A. Wright, Nilesh R. Ghugre
Summary: The study introduced a fully automated cardiac relaxometry framework (FASTR) for segmental analysis of T1 maps, achieving accurate myocardial segmentations without manual intervention. FASTR showed comparable myocardial Dice coefficients and strong correlations with expert observers, making it suitable for high volume clinical protocols.
Article
Cardiac & Cardiovascular Systems
Hanjay Wang, Terrence Pong, Oluwatomisin O. Obafemi, Haley J. Lucian, Joy Aparicio-Valenzuela, Nicholas A. Tran, Danielle M. Mullis, Stefan Elde, Yuko Tada, Sam W. Baker, Caroline Y. Wang, Kevin J. Cyr, Michael J. Paulsen, Yuanjia Zhu, Anson M. Lee, Y. Joseph Woo
Summary: Newborn piglets are capable of natural heart regeneration after myocardial infarction (MI) on the first day of birth, but this ability is lost by the seventh day. A study using magnetic resonance imaging and mapping arrays found that the epicardial conduction dynamics are well preserved in the naturally regenerated myocardium.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Tiit Ord, Kadri Ounap, Lindsey K. Stolze, Redouane Aherrahrou, Valtteri Nurminen, Anu Toropainen, Ilakya Selvarajan, Tapio Lonnberg, Einari Aavik, Seppo Yla-Herttuala, Mete Civelek, Casey E. Romanoski, Minna U. Kaikkonen
Summary: This study utilized single-nucleus chromatin accessibility profiling to investigate atherosclerotic lesions in humans and found that CAD-associated genetic variants are enriched in endothelial and smooth muscle cell-specific open chromatin, providing a new perspective for interpreting CAD-related genetic variations.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Giacomo Pambianchi, Martina Giannetti, Livia Marchitelli, Giulia Cundari, Viviana Maestrini, Massimo Mancone, Marco Francone, Carlo Catalano, Nicola Galea
Summary: This study aimed to assess the diagnostic performance of nT1 and PPM-ls in the identification of iPPM, which is associated with increased risk of mitral valve regurgitation or PPM rupture after myocardial infarction. The study found that higher nT1 values and lower PPM-ls were effective indicators for identifying iPPM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Fernando O. Campos, Michele Orini, Robert Arnold, John Whitaker, Mark O'Neill, Reza Razavi, Gernot Plank, Ben Hanson, Bradley Porter, Christopher Aldo Rinaldi, Jaswinder Gill, Pier D. Lambiase, Peter Taggart, Martin J. Bishop
Summary: This study evaluates the ability of different substrate mapping approaches to identify VT exit sites using computer simulations. Results showed that voltage cut-offs applied to bipolar electrograms could delineate the scar, but not the VT circuit; electrogram fractionation had the highest correlation with scar transmurality; activation-repolarization interval identified regions closest to VT exit site but was outperformed by activation time gradients combined with voltage cut-offs; the performance of all metrics was affected by pacing location.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-xi Yang, Yong He, Min Ma, Qin Zhao, Hua-yan Xu, Chun-chao Xia, Wan-lin Peng, Zhen-lin Li, Hong Li, Ying-kun Guo, Zhi-gang Yang
Summary: ECVAI is associated with LV remodeling in all patients while native T1(AI) may be feasible when MVO is absent.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Chemistry, Analytical
Mohamed Hammad, Samia Allaoua Chelloug, Reem Alkanhel, Allam Jaya Prakash, Ammar Muthanna, Ibrahim A. Elgendy, Pawel Plawiak
Summary: An electrocardiogram (ECG) is a vital medical equipment for diagnosing heart-related conditions. This paper proposes a new deep learning approach, based on large ECG data, for detecting myocardial infarction (MI) and conduction disorders (CDs). The method successfully addresses the challenging issues of heart signals, extracts deep features using a custom activation function, and achieves high accuracy with an overall accuracy of 99.20%.
Article
Cardiac & Cardiovascular Systems
Bryan J. Caldwell, Mark L. Trew, Arkady M. Pertsov
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Bryan J. Caldwell, Mark L. Trew, Ian J. Legrice, Bruce H. Smaill
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2017)
Article
Engineering, Biomedical
Mark L. Trew, Bryan J. Caldwell, Gregory B. Sands, Ian J. LeGrice, Bruce H. Smaill
ANNALS OF BIOMEDICAL ENGINEERING
(2011)
Article
Biophysics
Bryan J. Caldwell, Marcel Wellner, Bogdan G. Mitrea, Arkady M. Pertsov, Christian W. Zemlin
BIOPHYSICAL JOURNAL
(2010)
Article
Cardiac & Cardiovascular Systems
Bryan J. Caldwell, Mark L. Trew, Gregory B. Sands, Darren A. Hooks, Ian J. LeGrice, Bruce H. Smaill
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2009)
Article
Biochemical Research Methods
Bogdan G. Mitrea, Bryan J. Caldwell, Arkady M. Pertsov
BIOMEDICAL OPTICS EXPRESS
(2011)
Article
Cardiac & Cardiovascular Systems
Darren A. Hooks, Mark L. Trew, Bryan J. Caldwell, Gregory B. Sands, Ian J. LeGrice, Bruce H. Smaill
CIRCULATION RESEARCH
(2007)
Article
Anatomy & Morphology
Dane A. Gerneke, Gregory B. Sands, Ramanujan Ganesalingam, Purva Joshi, Bryan J. Caldwell, Bruce H. Smaill, Ian J. Legrice
MICROSCOPY RESEARCH AND TECHNIQUE
(2007)
Article
Physiology
ML Trew, BJ Caldwell, GB Sands, DA Hooks, DCS Tai, TM Austin, IJ LeGrice, AJ Pullan, BH Smaill
EXPERIMENTAL PHYSIOLOGY
(2006)
Article
Cardiac & Cardiovascular Systems
BJ Caldwell, IJ Legrice, DA Hooks, DCS Tai, AJ Pullan, BH Smaill
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2005)
Article
Pharmacology & Pharmacy
BH Smaill, IJ LeGrice, DA Hooks, AJ Pullan, BJ Caldwell, PJ Hunter
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2004)
Article
Cardiac & Cardiovascular Systems
DCS Tai, BJ Caldwell, IJ LeGrice, DA Hooks, AJ Pullan, BH Smaill
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2004)