Review
Sport Sciences
Francisco Javier Soto-Rodriguez, Eva Isidoro Cabanas, Jose Manuel Perez-Marmol
Summary: Prolonged sitting can affect endothelial function, and strategies that interrupt sitting have shown significant improvements in shear rate, flow-mediated dilation, and blood flow, thus playing a crucial role in preventing endothelial dysfunction.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Heiss, Ana Rodriguez-Mateos, Mariam Bapir, Simon S. Skene, Helmut Sies, Malte Kelm
Summary: This study aims to assess Flow-Mediated Dilation (FMD) values in healthy individuals and provides reference values for cardiovascular health measurement. The study found that FMD values are inversely correlated with age, body mass index (BMI), glucose, cholesterol, and blood pressure. Individuals with higher FMD values are younger and have smaller brachial artery diameter, lower blood pressure and cholesterol. Comparisons with coronary artery disease (CAD) patients also showed that FMD values can be used to exclude cardiovascular disease and determine the health status. The meta-analysis results showed that the average FMD in healthy individuals is 6.4%, with a decline trend associated with age.
CARDIOVASCULAR RESEARCH
(2023)
Article
Physiology
Tianxiang Ma, Xiao Liu, Quan Ren, Zhexi Zhang, Xiaoning Sun, Yuehong Zheng, Xiaoyan Deng, Xiaojun Yu, Yubo Fan
Summary: This study developed an analytical model of FMD process coupled with nitric oxide, introducing FFMD% and epsilon as potential indicators to distinguish endothelial function between young and middle age groups. Results showed no significant difference in mFMD% and eFMD% between the groups, but significant differences were found in FFMD% and epsilon, suggesting potential for specific diagnosis of endothelial function.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Jeremie Joffre, Lisa Raia, Tomas Urbina, Vincent Bonny, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Paul Coppo, Bertrand Guidet, Eric Maury, Hafid Ait-Oufella
Summary: This pilot observational study aimed to explore endothelial-mediated vasoreactivity in immune-mediated thrombotic thrombocytopenic purpura (iTTP) patients at admission and its changes after plasma exchange therapy (PE). The study found that iTTP patients had impaired endothelial-mediated skin microvascular reactivity at admission, but it improved after PE.
Article
Medicine, General & Internal
Sunni Patel, Hala Shokr, Adam Greenstein, Doina Gherghel
Summary: This study aimed to investigate microvascular function in healthy individuals with early signs of macrovascular endothelial dysfunction. The results showed that early signs of vascular dysfunction are reflected simultaneously at both macro- and microvascular levels.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jin-Su Kim, Do Gyun Lee, Moon-Hyon Hwang
Summary: This study aimed to compare the vascular responses to moderate-intensity treadmill running in high PM2.5 (HPM2.5) and low PM2.5 (LPM2.5) conditions in healthy young males. The results showed that acute PM2.5 exposure can counteract the positive effect of aerobic exercise on vascular endothelial function in young males.
APPLIED SCIENCES-BASEL
(2023)
Article
Peripheral Vascular Disease
Zachary S. Clayton, Vienna E. Brunt, David A. Hutton, Abigail G. Casso, Brian P. Ziemba, Simon Melov, Judith Campisi, Douglas R. Seals
Summary: Research suggests that doxorubicin can induce aortic stiffening by increasing intrinsic mechanical wall stiffness and causing collagen deposition, elastin degradation, and AGEs formation, ultimately increasing the risk of cardiovascular diseases.
Article
Nutrition & Dietetics
Louise H. Naylor, Diane Zimmermann, Marjorie Guitard-Uldry, Laure Poquet, Antoine Leveques, Bjorn Eriksen, Rachid Bel Rhlid, Nicola Galaffu, Carmine D'Urzo, Antonio De Castro, Erno Van Schaick, Daniel J. Green, Lucas Actis-Goretta
Summary: The study demonstrated an acute improvement in endothelial function over time after ingestion of a CGA-rich DGCE, partially explained by the presence of CGAs and their metabolites in the blood circulation. The different doses of DGCE resulted in dose-proportional increases in total polyphenol concentrations, and the systemic appearance of total CGAs was biphasic.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Chemistry, Medicinal
Yahya Jalilpiran, Maryam Hajishafiee, Masoud Khorshidi, Hamid Rezvani, Mohsen Mohammadi-Sartang, Jamal Rahmani, Seyed Mohammad Mousavi
Summary: The systematic review and meta-analysis found that ALA supplementation significantly increased FMD levels, with effects potentially influenced by participant age and health status. Dose-response analysis also indicated a significant non-linear effect of ALA dosage on FMD levels. Further research is needed to explore the effects of ALA supplementation on other biomarkers of EF.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemical Research Methods
Caterina Amendola, Mauro Buttafava, Talyta Carteano, Letizia Contini, Lorenzo Cortese, Turgut Durduran, Lorenzo Frabasile, Claudia nunzia Guadagno, Umut Karadeinz, Michele Lacerenza, Jaume Mesquida, Shahrzad Parsa, Rebecca Re, Diego sanoja Garcia, Sanathana konugolu venkata Sekar, Lorenzo Spinelli, Alessandro Torricelli, Alberto Tosi, Udo m. Weigel, M. atif Yaqub, Marta Zanoletti, Davide Contini
Summary: In this study, a hybrid TD-NIRS and DCS device was used to study hemoglobin and blood flow oscillations in skeletal muscle microvasculature. The findings highlight differences in microvascular hemodynamic oscillations between different muscles and show that blood flow has larger power spectral density compared to hemoglobin concentration. Furthermore, differences in oscillations were observed between a septic patient and healthy subjects.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Physiology
Max E. Weston, Jodie L. Koep, Alice B. Lester, Alan R. Barker, Bert Bond
Summary: This study found that acute improvements in peripheral vascular function following high-intensity interval exercise were not reflected in changes in cerebrovascular reactivity in healthy young adults. High-intensity interval exercise at both 75% and 90% <(V) over dot>O-2max increased brachial artery flow-mediated dilation 1 and 3 hours post-exercise, compared to continuous moderate-intensity exercise and sedentary control. Cerebrovascular reactivity, on the other hand, remained unchanged across all conditions.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Le-Ying Li, Shuai Chen, Yi-Xuan Wang, Ri Ji, Feng-Hua Ding, Xiao-Qun Wang, Qiu-Jing Chen, Lin Lu, Yang Dai
Summary: Serum apoA-IV levels are associated with FMD, suggesting that apoA-IV protects endothelial function in patients with T2DM.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Physiology
Celine Boudart, Fuhong Su, Lorenzo Pitisci, Arnaud Dhoine, Olivier Duranteau, Pascale Jespers, Antoine Herpain, Rebecca Vanderpool, Serge Brimioulle, Jacques Creteur, Robert Naeije, Luc Van Obbergh, Laurence Dewachter
Summary: In an experimental porcine model of early hyperdynamic sepsis, autoregulation and metabolic blood flow regulation were impaired in the coronary circulation, while endothelial vasodilatory response was preserved.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas B. Gevaert, Birgit Boehm, Haley Hartmann, Inge Goovaerts, Tibor Stoop, Caroline M. Van De Heyning, Paul J. Beckers, Flavia Baldassarri, Stephan Mueller, Renate Oberhoffer, Andre Duvinage, Mark J. Haykowsky, Ulrik Wisloff, Volker Adams, Burkert Pieske, Martin Halle, Emeline M. Van Craenenbroeck
Summary: This study investigated the effects of MICT and HIIT on vascular function and repair in HFpEF. The results showed that these training methods did not change vascular function or cellular endothelial repair. This did not significantly contribute to the improvement of VO2peak in HFpEF patients.
JACC-HEART FAILURE
(2023)
Article
Physiology
Andrea Tryfonos, Joseph Mills, Daniel J. Green, Anton J. M. Wagenmakers, Ellen A. Dawson, Matthew Cocks
Summary: This study examined the relationships between in vivo measures of vascular function and the expression of atherogenic risk-modulating proteins in endothelial cells (ECs) isolated from the radial artery of CAD patients. The results revealed a difference in the regulation of endothelium-dependent vasodilation measured in vivo between patients with CAD compared to previously reported data in subjects without a clinical diagnosis, suggesting that eNOS Ser(1177) phosphorylation may be the key to maintain vasodilation in CAD patients.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Lukas Brandt, Janee D. Terwoord, Andreas M. Beyer, David D. Gutterman
CARDIOVASCULAR RESEARCH
(2022)
Letter
Cardiac & Cardiovascular Systems
Yoshinori Nishijima, Shelby N. Hader, Alena J. Hanson, David X. Zhang, Rodney Sparapani, David D. Gutterman, Andreas M. Beyer
CARDIOVASCULAR RESEARCH
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Lukas Brandt, Shelby N. Hader, Laura E. Norwood Toro, David D. Gutterman, Andreas M. Beyer
Meeting Abstract
Biochemistry & Molecular Biology
Shelby N. Hader, Janee D. Terwoord, Laura E. Norwood Toro, David D. Gutterman, Andreas M. Beyer
Review
Pharmacology & Pharmacy
Janee D. Terwoord, Andreas M. Beyer, David D. Gutterman
Summary: Recent advances in anti-cancer therapeutics have improved the survival of cancer patients and led to an increasing number of cancer survivors dying from other causes. However, treatment-induced cardiotoxicity is a complication with acute and long-term consequences for cancer patients. This review summarizes the clinical evidence for endothelial dysfunction following anti-cancer therapy and discusses the impact of therapeutic agents on the blood vessels, highlighting the underlying pathogenic mechanisms of treatment-induced vascular toxicity.
PHARMACOLOGY & THERAPEUTICS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Yoshinori Nishijima, Shelby N. Hader, Andreas M. Beyer
CARDIOVASCULAR RESEARCH
(2023)
Article
Neurosciences
Dawid S. S. Chabowski, William E. E. Hughes, Joseph C. C. Hockenberry, John LoGiudice, Andreas M. M. Beyer, David D. D. Gutterman
Summary: Microvascular dysfunction can predict adverse cardiovascular events even without large vessel disease. In patients with coronary artery disease (CAD), the mediator of flow-mediated dilatation (FMD) shifts from nitric oxide (NO) to mitochondrial-derived hydrogen peroxide (H2O2) in arterioles. The role of lipid phosphate phosphatase 3 (LPP3) and miR-92a in this shift and microvascular dysfunction in CAD was investigated. LPP3 and miR-92a play crucial roles in regulating the mediator of FMD in CAD, and their modulation can restore or induce dilatation in CAD and non-CAD cases respectively.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Plant Sciences
Laura Toro, Damaris Pereira-Arias, Daniel Perez-Aviles, G. German Vargas, Fiona M. Soper, Jessica Gutknecht, Jennifer S. Powers
Summary: Tropical forests with low soil phosphorus availability have different responses in plant growth and phosphorus acquisition strategies between nitrogen-fixing and non-fixing species. Nitrogen fixers showed larger growth with increasing phosphorus addition, while non-fixers had fewer responses. Both functional types increased foliar phosphorus with phosphorus addition, but nitrogen fixers had higher root phosphatase activity. The differences in limitation and phosphorus acquisition traits have implications for forest succession and earth system models.
Article
Biology
Leland K. Werden, Colin Averill, Thomas W. Crowther, Erick Calderon-Morales, Laura Toro, J. Pedro Alvarado, L. Milena Gutierrez, Danielle E. Mallory, Jennifer S. Powers
Summary: This study investigated the role of traits in mediating seedling survival and the coordination of traits across plant structures in tropical dry forest restoration. The results highlight the importance of below-ground traits in determining early restoration outcomes and show little coordination between above- and below-ground traits.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jean C. Bikomeye, Joanna S. Balza, Jamila L. Kwarteng, Andreas M. Beyer, Kirsten M. M. Beyer
Summary: Cardiovascular disease and cancer are leading causes of morbidity and mortality worldwide. Greenspaces and nature-based interventions have been shown to have a positive impact on health outcomes and climate change resilience. This study aims to summarize the evidence on the impact of greenspaces and nature-based interventions on cardiovascular health and cancer-related outcomes.
Meeting Abstract
Peripheral Vascular Disease
Kaleigh Kozak, Alexa Derayunan, Rosinda De La Pena, Andreas M. Beyer, David D. Gutterman, Jennifer McIntosh
Meeting Abstract
Oncology
Mary Hidde, Andreas M. Beyer, Kirsten M. M. Beyer, Matthew J. Durand, Shane A. Phillips, Georgios Grigoriadis, Courtney Jankowski, Madeline Berendt, Bethany Canales, Laura Norwood Toro, Amanda L. Kong, Kent Hoskins, Sherry-Ann Brown, David Gutterman, Melinda Stolley
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Cell Biology
K. Ait-Aissa, L. E. Norwood-Toro, J. Terwoord, M. Young, L. A. Paniagua, S. N. Hader, W. E. Hughes, J. C. Hockenberry, J. E. Beare, J. Linn, T. Kohmoto, J. Kim, D. H. Betts, A. J. LeBlanc, D. D. Gutterman, A. M. Beyer
Summary: Research found that mitochondrial TERT plays a critical role in preserving NO-mediated vasodilation and the balance of mitochondrial to nuclear TERT is fundamentally altered in states of human disease that are driven by increased expression of dominant negative splice variants.