Article
Public, Environmental & Occupational Health
Anna E. Austin, Vito Di Bona, Mary E. Cox, Scott Proescholdbell, Michael Dolan Fliss, Rebecca B. Naumann
Summary: The study estimated the use of medication for opioid use disorder (MOUD) and prescription opioids in pregnancy among mothers in the North Carolina Medicaid population. Results indicated that 60% of mothers of infants with neonatal opioid withdrawal syndrome (NOWS) had claims for MOUD or prescription opioids during pregnancy.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Biotechnology & Applied Microbiology
Uppala Radhakrishna, Sangeetha Vishweswaraiah, Lavanya Uppala, Marta Szymanska, Jacqueline Macknis, Sandeep Kumar, Fozia Saleem-Rasheed, Buket Aydas, Ariadna Forray, Srinivas B. Muvvala, Nitish K. Mishra, Chittibabu Guda, David J. Carey, Raghu P. Metpally, Richard C. Crist, Wade H. Berrettini, Ray O. Bahado-Singh
Summary: Opioid abuse during pregnancy can lead to Neonatal Opioid Withdrawal Syndrome (NOWS). Methylation dysregulation of placental tissue in NOWS development was identified in the study, and accurate AI prediction for NOWS diagnosis was reported. The study showed strong evidence of the importance of methylation dysregulation in NOWS pathophysiology.
Article
Medicine, General & Internal
Leslie W. Young, Songthip T. Ounpraseuth, Stephanie L. Merhar, Zhuopei Hu, Alan E. Simon, Andrew A. Bremer, Jeannette Y. Lee, Abhik Das, Margaret M. Crawford, Rachel G. Greenberg, P. Brian Smith, Brenda B. Poindexter, Rosemary D. Higgins, Michele C. Walsh, Ward Rice, David A. Paul, Jessie R. Maxwell, Sucheta Telang, Camille M. Fung, Tanner Wright, Anne Marie Reynolds, Devon W. Hahn, Julie Ross, Jennifer M. McAllister, Moira Crowley, Sophie K. Shaikh, Karen M. Puopolo, Lori Christ, Jaime Brown, Julie Riccio, Kara Wong Ramsey, Erica F. Braswell, Lauren Tucker, Karen R. McAlmon, Krishna Dummula, Julie Weiner, Jessica R. White, Meghan P. Howell, Sarah Newman, Jessica N. Snowden, Lori A. Devlin
Summary: A study conducted at 26 hospitals in the United States found that the use of the "Eat, Sleep, Console" care approach significantly reduced the time until infants with neonatal opioid withdrawal syndrome were medically ready for discharge, without increasing specified adverse outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Daina B. Esposito, Krista F. Huybrechts, Martha M. Werler, Loreen Straub, Sonia Hernandez-Diaz, Helen Mogun, Brian T. Bateman
Summary: This study compared the risk of neonatal opioid withdrawal syndrome (NOWS) among neonates exposed to different types of opioids during the last 3 months of pregnancy, finding that strong agonists with long half-lives were associated with a higher risk of NOWS. This information can help healthcare providers make informed decisions when prescribing opioids for pain management in late pregnancy.
Article
Pharmacology & Pharmacy
Daniel Smolyak, Elizabeth M. Humphries, Abhinav Parikh, Mathangi Gopalakrishnan, Fulden Aycan, Margret Bjarnadottir, Seth A. Ament, Dina El-Metwally, Amber Beitelshees, Ritu Agarwal
Summary: Morphine treatment for infants with neonatal opioid withdrawal syndrome has variable effectiveness. This study used early FNASS scores, PRS, and drug exposure to predict treatment response. The results showed meaningful connections between early FNASS scores and PRS, as well as between both of those and later in-hospital outcomes.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Medicine, General & Internal
Elizabeth E. Krans
Summary: The opioid crisis in the United States has had significant impacts on pregnant individuals and their children. The rate of opioid-related diagnoses during pregnancy has been consistently rising across all states and demographic groups, and overdose has become a leading cause of pregnancy-related deaths. Treatment with medications like methadone and buprenorphine is recommended to reduce the risks of overdose and preterm birth for pregnant individuals with opioid use disorder.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Obstetrics & Gynecology
Max Jordan Nguemeni Tiako, Ari Friedman, Jennifer Culhane, Eugenia South, Zachary F. Meisel
Summary: This study found that although medication administration for OUD among pregnant women has increased in recent years, retention in treatment has decreased. Individuals with a history of at least one prior treatment episode were more likely to receive medication for OUD and remain in treatment.
OBSTETRICS AND GYNECOLOGY
(2021)
Review
Cell Biology
Vikram Vasan, Yuma Kitase, Jessie C. Newville, Shenandoah Robinson, Gwendolyn Gerner, V. Joanna Burton, Lauren L. Jantzie
Summary: The abuse of opioid drugs among pregnant women poses a significant public health issue, especially in regards to its impact on newborns. Further research is needed to understand the long-term consequences of prenatal opioid exposure on neurodevelopment in order to develop appropriate interventions.
NEURAL REGENERATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Amanda H. Mahnke, Melissa H. Roberts, Lawrence Leeman, Xingya Ma, Ludmila N. Bakhireva, Rajesh C. Miranda
Summary: This study found that analyzing miRNAs in the umbilical cord plasma of infants can predict the severity of neonatal opioid withdrawal syndrome (NOWS). This is important for early identification of high-risk infants and making necessary monitoring and intervention decisions.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Uppala Radhakrishna, Swapan K. Nath, Sangeetha Vishweswaraiah, Lavanya Uppala, Ariadna Forray, Srinivas B. Muvvala, Nitish K. Mishra, Siddesh Southekal, Chittibabu Guda, Hiranjith Govindamangalam, Derek Vargas, William G. Gardella, Richard C. Crist, Wade H. Berrettini, Raghu P. Metpally, Ray O. Bahado-Singh
Summary: Excessive prenatal opioid exposure can lead to Neonatal Opioid Withdrawal Syndrome (NOWS). RNA-seq analysis of placental tissue samples from mothers with opioid use disorder and newborns with NOWS identified 93 differentially expressed genes, with 7 genes potentially playing a key role in the etiology of NOWS. This study provides insights into the genetic mechanisms underlying the development of NOWS.
Article
Pediatrics
Stephanie L. Merhar, Songthip Ounpraseuth, Lori A. Devlin, Brenda B. Poindexter, Leslie W. Young, Sean D. Berkey, Moira Crowley, Adam J. Czynski, Autumn S. Kiefer, Bonny L. Whalen, Abhik Das, Janell F. Fuller, Rosemary D. Higgins, Vaishali Thombre, Barry M. Lester, P. Brian Smith, Sarah Newman, Pablo J. Sanchez, M. Cody Smith, Alan E. Simon
Summary: A retrospective cohort study evaluated the outcomes of infants receiving secondary therapy with phenobarbital or clonidine for treatment of NOWS, in comparison to morphine treatment. Infants treated with phenobarbital had shorter hospital stays and durations of morphine treatment compared to clonidine-treated infants, with higher rates of continued medication use upon discharge.
Article
Public, Environmental & Occupational Health
Virginia A. Reising, Ashley Horne, Amanda C. Bennett
Summary: Efforts to increase OUD treatment options for pregnant women insured by Medicaid should focus on geographic areas with limited access and high need. Across Illinois, 89 treatment resources were identified for pregnant women insured by Medicaid, concentrated in 36% of Illinois' counties. However, rural counties had less access to medication-assisted treatment (MAT) for OUD compared with other counties in the state.
PUBLIC HEALTH NURSING
(2021)
Article
Obstetrics & Gynecology
Michelle Petrich, Megan Battin, Erin Walker, Morgan Brown, Mahmoud Abdelwahab, Marwan Maayeh, Kara M. Rood
Summary: The aim of this study was to compare neonatal opioid withdrawal syndrome (NOWS) prevalence and characteristics among neonates born to women prescribed methadone and buprenorphine/naloxone. The study found that buprenorphine/naloxone treatment for OUD in pregnancy appears safe and has decreased NOWS and pharmacologic intervention for the neonate.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pediatrics
Ludmila N. Bakhireva, Aydan Sparks, Michael Herman, Lauren Hund, Malia Ashley, Amy Salisbury
Summary: This study suggests that the use of SRIs among pregnant women undergoing treatment for opioid use disorder may lead to more severe neonatal opioid withdrawal syndrome.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Micah Piske, Fahmida Homayra, Jeong E. Min, Haoxuan Zhou, Carolyn Marchand, Annabel Mead, Jennifer Ng, Megan Woolner, Bohdan Nosyk
Summary: The incidence of perinatal OUD tripled in British Columbia over a 20-year period. Sustained opioid agonist treatment during pregnancy reduced the risk of adverse birth outcomes.
Editorial Material
Critical Care Medicine
Frederick B. Rogers, Katelyn J. Rittenhouse, Brian W. Gross
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2015)
Article
Surgery
Chet Morrison, Brian Gross, Michael Horst, Katherine Bupp, Katelyn Rittenhouse, Carissa Harnish, Ashley Vellucci, Frederick B. Rogers
JOURNAL OF SURGICAL RESEARCH
(2015)
Article
Surgery
John C. Lee, Brian W. Gross, Katelyn J. Rittenhouse, Autumn R. Vogel, Ashley Vellucci, James Alzate, Maria Gillio, Frederick B. Rogers
JOURNAL OF SURGICAL RESEARCH
(2016)
Article
Surgery
Alan D. Cook, Brian W. Gross, Turner M. Osler, Katelyn J. Rittenhouse, Eric H. Bradburn, Steven R. Shackford, Frederick B. Rogers
Article
Critical Care Medicine
Hans Andrews, Katelyn Rittenhouse, Brian Gross, Frederick B. Rogers
JOURNAL OF TRAUMA NURSING
(2017)
Article
Multidisciplinary Sciences
Katelyn J. Rittenhouse, Bellington Vwalika, Alexander Keil, Jennifer Winston, Marie Stoner, Joan T. Price, Monica Kapasa, Mulaya Mubambe, Vanilla Banda, Whyson Muunga, Jeffrey S. A. Stringer
Article
Obstetrics & Gynecology
Joan T. Price, Bellington Vwalika, Jennifer Winston, Andrew Kumwenda, Mwansa K. Lubeya, Katelyn J. Rittenhouse, Elizabeth Stringer, Margaret P. Kasaro, Jeffrey S. A. Stringer
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2019)
Article
Multidisciplinary Sciences
Joan T. Price, Bellington Vwalika, Marcia Hobbs, Julie A. E. Nelson, Elizabeth M. Stringer, Fei Zou, Katelyn J. Rittenhouse, Andrea Azcarate-Peril, Margaret P. Kasaro, Jeffrey S. A. Stringer
Article
Immunology
Katelyn J. Rittenhouse, Humphrey Mwape, Julie A. E. Nelson, John Mwale, Gabriel Chipili, Joan T. Price, Michael Hudgens, Elizabeth M. Stringer, Kristina De Paris, Bellington Vwalika, Jeffrey S. A. Stringer
Summary: This study evaluated plasma and vaginal inflammation in three different antenatal groups and found that HIV-infected women not on ART had higher levels of vaginal inflammation at baseline and subsequent time points, with vaginal inflammation being associated with spontaneous preterm birth. Plasma inflammation did not differ by HIV or ART exposure and was not linked to sPTB.
Article
Multidisciplinary Sciences
Joan T. Price, Bellington Vwalika, Michael France, Jacques Ravel, Bing Ma, Humphrey Mwape, Katelyn J. Rittenhouse, Kristina De Paris, Marcia Hobbs, Julie A. Nelson, Margaret P. Kasaro, Elizabeth M. Stringer, Jeffrey S. A. Stringer
Summary: A Lactobacillus-deficient, anaerobe-rich vaginal microbiome is associated with local inflammation and spontaneous preterm birth (sPTB) in the setting of HIV. Inflammatory scores positively correlate with vaginal microbiome diversity. HIV is associated with anaerobe-rich vaginal microbiome. High abundance of a novel Gardnerella metagenomic subspecies in the vaginal microbiome predicts sPTB. The risk for sPTB among women with HIV may be mediated by the vaginal microbiome and inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Joan T. Price, Bellington Vwalika, Jessie K. Edwards, Stephen R. Cole, Margaret P. Kasaro, Katelyn J. Rittenhouse, Andrew Kumwenda, Mwansa K. Lubeya, Jeffrey S. A. Stringer
Summary: The study found that maternal HIV infection increased the risk of spontaneous preterm birth, but had a protective effect against provider-initiated preterm birth.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Surgery
Daniel Wu, Brian Gross, Katelyn Rittenhouse, Carissa Harnish, Claire Mooney, Frederick B. Rogers
Article
Surgery
Chet A. Morrison, Brian W. Gross, Matthew Kauffman, Katelyn J. Rittenhouse, Frederick B. Rogers
Article
Surgery
Mathew Edavettal, Brian W. Gross, Katelyn Rittenhouse, James Alzate, Amelia Rogers, Jo Ann Miller, Frederick B. Rogers