Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Article
Clinical Neurology
Francisca A. de Leeuw, Hata Karamujic-Comic, Betty M. Tijms, Carel F. W. Peeters, Maartje I. Kester, Philip Scheltens, Shahzad Ahmad, Dina Vojinovic, Hieab H. H. Adams, Thomas Hankemeier, Daniel Bos, Aad van der Lugt, Meike W. Vernooij, M. Arfan Ikram, Najaf Amin, Frederik Barkhof, Charlotte E. Teunissen, Cornelia M. van Duijn, Wiesje M. van der Flier
Summary: The study found that high glucose levels were associated with brain atrophy and WMH, while levels of small HDL particles were linked to brain atrophy. The research suggests that circulating metabolites may help in the development of future intervention trials.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Elodie Bertrand, Eelco van Duinkerken, Jerson Laks, Marcia Cristina Nascimento Dourado, Gabriel Bernardes, Jesus Landeira-Fernandez, Daniel C. Mograbi
Summary: The study found that extensive regions of the brain are linked to self-awareness, with particular frontal and temporal alterations leading to unawareness, in agreement with theoretical models indicating executive and mnemonic forms of anosognosia in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Yaqing Li, Jiaxin Zheng, Tian Li, Junjian Zhang
Summary: In this study, we did not find significant causal evidence of a relationship between white matter injuries and AD. However, we found that the risk of white matter damage in AD might be mediated by SNPs near the APOE region.
NEUROLOGY AND THERAPY
(2022)
Article
Clinical Neurology
Christina Mueller, Adam M. Goodman, Jane B. Allendorfer, Rodolphe Nenert, Tyler E. Gaston, Leslie E. Grayson, Stephen Correia, Noah S. Philip, W. Curt LaFrance, Jerzy P. Szaflarski
Summary: This study aimed to quantify changes in white matter morphology using neurite orientation dispersion and density imaging (NODDI) after neurobehavioral therapy (NBT) for functional seizures (FS). The results showed that patients with FS exhibited white matter plasticity in specific regions, which correlated with improvements in psychosocial functioning. NODDI could be considered for future assessments of interventions in patients with FS.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Nathan R. DeJong, Jacobus F. A. Jansen, Martin P. J. van Boxtel, Miranda T. Schram, Coen D. A. Stehouwer, Pieter C. Dagnelie, Carla J. H. van der Kallen, Abraham A. Kroon, Anke Wesselius, Annemarie Koster, Walter H. Backes, Sebastian Koehler
Summary: This study examined the associations between white matter connectivity, brain damage markers, and cognition in middle-aged individuals. The results showed that increasing connectivity moderated the negative association between brain damage and cognition, supporting the reserve hypothesis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Zsolt Bagi, Christopher D. Kroenke, Katie Anne Fopiano, Yanna Tian, Jessica A. Filosa, Larry S. Sherman, Eric B. Larson, C. Dirk Keene, Kiera Degener O'Brien, Philip A. Adeniyi, Stephen A. Back
Summary: Patients with Alzheimer's disease often show dysfunction in vasodilation of white matter-penetrating arterioles, which is associated with white matter injury and disrupted white matter microstructural integrity. This dysfunction may be related to reduced nitric oxide levels and excess reactive oxygen species-mediated vascular endothelial dysfunction.
Article
Clinical Neurology
Malo Gaubert, Catharina Lange, Antoine Garnier-Crussard, Theresa Kobe, Salma Bougacha, Julie Gonneaud, Robin de Flores, Clemence Tomadesso, Florence Mezenge, Brigitte Landeau, Vincent de la Sayette, Gael Chetelat, Miranka Wirth
Summary: This study found that local white matter damage is correlated with multimodal brain biomarkers of AD. The results highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter. Overall, these cross-sectional findings corroborate associations of regional WMH with AD-typical Ass deposition and neurodegeneration.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Helena U. Zacharias, Antoine Weihs, Mohamad Habes, Katharina Wittfeld, Stefan Frenzel, Tanweer Rashid, Beate Stubbe, Anne Obst, Andras Szentkiralyi, Robin Bulow, Klaus Berger, Ingo Fietze, Thomas Penzel, Norbert Hosten, Ralf Ewert, Henry Volzke, Hans J. Grabe
Summary: This study found significant associations between obstructive sleep apnea (OSA) and brain white matter hyperintensities (WMHs), indicating a novel, potentially treatable WMH pathomechanism.
Article
Geriatrics & Gerontology
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
Summary: This study aimed to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. The results showed that disrupted white matter integrity is associated with visuomotor processing speed, semantic memory, and executive function, while cortical surface area is related to cognitive scores. These findings contribute to a better understanding of the pathological process underlying cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Janik Goltermann, Jonathan Repple, Ronny Redlich, Katharina Dohm, Claas Flint, Dominik Grotegerd, Lena Waltemate, Hannah Lemke, Stella Mercedes Fingas, Susanne Meinert, Verena Enneking, Tim Hahn, Jochen Bauer, Simon Schmitt, Tina Meller, Frederike Stein, Katharina Brosch, Olaf Steinstraeter, Andreas Jansen, Axel Krug, Igor Nenadic, Bernhard T. Baune, Marcella Rietschel, Stephanie Witt, Andreas J. Forstner, Markus Noethen, Andreas Johnen, Judith Alferink, Tilo Kircher, Udo Dannlowski, Nils Opel
Summary: The present study investigated the association between APOE genotype and cortical gray matter structure as well as white matter microstructure. The findings showed pronounced and widespread reductions in cortical surface area and white matter microstructure in homozygous APOE 84 carriers, supporting a global rather than regionally specific effect of the allele status.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Jose Bernal, Stefanie Schreiber, Inga Menze, Anna Ostendorf, Malte Pfister, Jonas Geisendoerfer, Aditya Nemali, Anne Maass, Renat Yakupov, Oliver Peters, Lukas Preis, Luisa Schneider, Ana Lucia Herrera, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjoern H. Schott, Ayda Rostamzadeh, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Laura Dobisch, Peter Dechent, Klaus Scheffler, Stefan Hetzer, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Frank Jessen, Miranka Wirth, Emrah Duezel, Gabriel Ziegler
Summary: Hypertension and A-beta positivity are associated with larger volumes of white matter hyperintensities (WMH), which in turn negatively impact cognition. Both hypertension and A-beta positivity are related to worse cognitive performance, and the relationship is partially mediated by WMH in specific brain regions.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Endocrinology & Metabolism
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfager, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Jordan A. Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the relationship between A beta-PET signal in white matter (WM) regions and diffusion MRI-based microstructural alterations. The results showed that decreased A beta-PET signal in WMH regions was closely associated with higher free water and higher WMH volume, while increased A beta-PET signal in normal-appearing WM was closely associated with higher cortical A beta and lower free water-adjusted FA. Furthermore, cognitive impairment was more closely related to higher free water than to either free water-adjusted FA or WM PET.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi
Summary: Palmitoylethanolamide (PEA) is a naturally occurring amide compound with analgesic, neuroprotective, immune-modulating, and anti-inflammatory effects. Recent studies have shown that PEA promotes oligodendrocyte differentiation, which is crucial for myelin formation. PEA has therapeutic potential in restoring white matter defects.
Article
Immunology
Yuting Hu, Xiaoyu Sun, Shang Wang, Chao Zhou, Li Lin, Xiaohui Ding, Jingjing Han, Yan Zhou, Guoliang Jin, Yuqiao Wang, Wei Zhang, Hongjuan Shi, Zuohui Zhang, Xinxin Yang, Fang Hua
Summary: The study found that TLR2KO mice exhibited decreased cognitive function and locomotor activity, as well as increased anxiety from middle age to old age. Furthermore, significant reductions in regional cerebral blood flow, inhibited long-term potentiation, and increased blood-brain barrier permeability were observed in 12-month-old TLR2KO mice. Additionally, TLR2KO mice showed decreased levels of tight junction proteins and increased neurofilament protein, as well as decreased myelin basic protein, compared to age-matched WT mice.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Neurosciences
Jing Zhang, Ping Sun, Chao Zhou, Xuejing Zhang, Feifei Ma, Yang Xu, Milton H. Hamblin, Ke-Jie Yin
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Review
Clinical Neurology
Wenjing Song, Hafiz Khuram Raza, Li Lu, Zuohui Zhang, Jie Zu, Wei Zhang, Liguo Dong, Chuanying Xu, Xiangyao Gong, Bingchen Lv, Guiyun Cui
Summary: Freezing of gait is a common and disabling symptom of Parkinson's disease, and studies using fMRI have shown abnormal brain connectivity patterns in PD-FOG patients. Standardized imaging protocols and detailed subtypes of PD-FOG are needed for further elucidation of the underlying pathophysiological mechanisms.
NEUROLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Ping Sun, Feifei Ma, Yang Xu, Chao Zhou, R. Anne Stetler, Ke-Jie Yin
Summary: Deletion of the miR-15a/16-1 cluster in endothelial cells promotes post-stroke angiogenesis and improves long-term neurological recovery by activating the Src signaling pathway. Administration of the selective Src family inhibitor AZD0530 exacerbated cognitive impairments and brain atrophy, as well as attenuated blood flow recovery and inhibited new microvessel formation in the penumbra of stroke-affected mice.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Xiaoyu Sun, Yuting Hu, Hui Zhou, Shang Wang, Chao Zhou, Li Lin, Taiyang Zhu, Ji Ge, Jingjing Han, Yan Zhou, Guoliang Jin, Yuqiao Wang, Jie Zu, Hongjuan Shi, Xingxing Yang, Kun Zan, Jun Wang, Fang Hua
Summary: This study found that the expression of pgrmc1 significantly increased in the cortex and hippocampus after neonatal hypoxic-ischemic brain injury, and inhibiting pgrmc1 exacerbated brain damage in male neonatal mice. The inhibition of pgrmc1 also worsened neurological dysfunction in the acute stage of hypoxic-ischemic injury.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Chao Zhou, Moxi Su, Ping Sun, Xuelian Tang, Ke-Jie Yin
Summary: Nitro-oleic acid may serve as a therapeutic agent for ischemic brain injury by preserving BBB integrity, reducing brain infarct size, improving sensorimotor functions, and inhibiting inflammation and cell infiltration induced by ischemia.
EXPERIMENTAL NEUROLOGY
(2021)
Meeting Abstract
Clinical Neurology
Chao Zhou, Ping Sun, Yuang Chen, Milton H. Hamblin, T. Kevin Hitchens, Li Song, Yin Kejie
Meeting Abstract
Clinical Neurology
Sun Ping, Xu Yang, Zhou Chao, Yin Kejie
Review
Neurosciences
Chao Zhou, Wanyan Ni, Taiyang Zhu, Shuyu Dong, Ping Sun, Fang Hua
Summary: Alzheimer's disease is a common age-related dementia that currently has no cure. The underlying mechanisms of the disease, such as amyloid-beta deposition and tau hyperphosphorylation, are complex. Cellular reprogramming techniques offer a potential new approach for AD therapy by restoring functional neurons and integrating myelin.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Chao Zhou, Ping Sun, Yang Xu, Yuang Chen, Yixian Huang, Milton H. Hamblin, Lesley Foley, T. Kevin Hitchens, Song Li, Ke-Jie Yin
Summary: The study found that knockout mice of miR-15a/16-1 exhibited fewer cognitive and sensorimotor deficits after VCID. The deficiency of miR-15a/16-1 also reduced myelin degeneration, axonal injury, and neuronal loss in VCID mice. The miR-15a/16-1-IL/10RA/AKT3 axis played a critical role in regulating vascular brain damage and cognitive decline after VCID. Targeting miR-15a/16-1 could be a novel therapeutic approach for the treatment of VCID.
Article
Biochemistry & Molecular Biology
Miao Wang, Chao Zhou, Lu Yu, Delian Kong, Weijing Ma, Bingchen Lv, Yan Wang, Weifeng Wu, Mingyue Zhou, Guiyun Cui
Summary: This study demonstrates that HDAC6 knockout mice are resistant to oxidative stress following intracerebral hemorrhage (ICH) and have reduced neuronal apoptosis. HDAC6 interacts with MDH1, and HDAC6 inhibition protects neurons from oxidative injury through MDH1 acetylation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Chao Zhou, Ping Sun, Milton H. Hamblin, Ke-Jie Yin
Summary: Genetic deletion of KLF11 exacerbates sensorimotor and cognitive deficits, brain tissue loss and neuronal death, accelerates post-trauma astrocytic activation, promotes microglial polarization to a pro-inflammatory phenotype, and increases the infiltration of peripheral neutrophils and macrophages into the brain parenchyma in mice with traumatic brain injury. Loss-of-KLF11 function also directly increases the expression of pro-inflammatory cytokines in the brains of TBI mice.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Chao Zhou, Taiyang Zhu, Wanyan Ni, Hui Zhou, Jiaxing Song, Miao Wang, Guoliang Jin, Yan Zhou, Jingjing Han, Fang Hua
Summary: Protein PGRMC2 is upregulated after ischemic stroke, and treatment with its agonist CPAG-1 can reduce brain damage and improve functional recovery after stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Shang Wang, Taiyang Zhu, Wanyan Ni, Chao Zhou, Hui Zhou, Li Lin, Yuting Hu, Xiaoyu Sun, Jingjing Han, Yan Zhou, Guoliang Jin, Jie Zu, Hongjuan Shi, Xingxing Yang, Zuohui Zhang, Fang Hua
Summary: This study investigates the role of early activation of Toll-like receptor 3 (TLR3) in the pathophysiological process of Alzheimer's disease (AD). The results showed that the early activation of TLR3 attenuated neuronal loss and neurobehavioral dysfunction in a mouse model of AD. This could be attributed to its role in A beta clearance, the inhibition of glial cells, and the regulation of neuroinflammation in the hippocampus.
ALZHEIMERS RESEARCH & THERAPY
(2023)