Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence

Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease

(2018) E.P. Lebois et al.   NEUROPHARMACOLOGY

A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats

(2018) Benoit Forget et al.   CURRENT BIOLOGY

Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism

(2017) Taryn E. Grieder et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons

(2017) Cristina Deflorio et al.   FASEB JOURNAL

α5 nicotinic receptors link smoking to schizophrenia

(2017) Xin-an Liu et al.   NATURE MEDICINE

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

(2017) Fani Koukouli et al.   NATURE MEDICINE

Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

(2017) Marisela Morales et al.   NATURE REVIEWS NEUROSCIENCE

Rethinking the Pedunculopontine Nucleus: From Cellular Organization to Function

(2017) Juan Mena-Segovia et al.   NEURON

Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain

(2017) Can Peng et al.   PLoS One

One Hundred Years in the Making: The Global Tobacco Epidemic

(2016) Heather Wipfli et al.   Annual Review of Public Health

Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia

(2016) Thomas K. Roseberry et al.   CELL

Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits

(2016) Daniel Dautan et al.   NATURE NEUROSCIENCE

Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways

(2016) Cheng Xiao et al.   NEURON

Vulnerability to nicotine self-administration in adolescent mice correlates with age-specific expression of α4* nicotinic receptors

(2016) Anthony Renda et al.   NEUROPHARMACOLOGY

Midbrain dopamine neurons signal aversion in a reward-context-dependent manner

(2016) Hideyuki Matsumoto et al.   eLife

Functional Upregulation of  4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward

(2015) J. Ngolab et al.   JOURNAL OF NEUROSCIENCE

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice

(2015) Michael J. Marks et al.   NEUROPHARMACOLOGY

α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity

(2015) J.N. Berry et al.   NEUROSCIENCE

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration

(2014) Michael J. Marks et al.   JOURNAL OF NEUROCHEMISTRY

Intermittent nicotine exposure upregulates nAChRs in VTA dopamine neurons and sensitises locomotor responding to the drug

(2013) Lorinda K. Baker et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Nicotine consumption is regulated by a human polymorphism in dopamine neurons

(2013) C Morel et al.   MOLECULAR PSYCHIATRY

Pedunculopontine nucleus: Functional organization and clinical implications

(2013) E. E. Benarroch   NEUROLOGY

The α5 Subunit Regulates the Expression and Function of α4*-Containing Neuronal Nicotinic Acetylcholine Receptors in the Ventral-Tegmental Area

(2013) Susmita Chatterjee et al.   PLoS One

Dissecting the diversity of midbrain dopamine neurons

(2013) Jochen Roeper   TRENDS IN NEUROSCIENCES

Molecular Mechanisms Underlying Behaviors Related to Nicotine Addiction

(2013) M. R. Picciotto et al.   Cold Spring Harbor Perspectives in Medicine

Endogenous Cholinergic Inputs and Local Circuit Mechanisms Govern the Phasic Mesolimbic Dopamine Response to Nicotine

(2013) Michael Graupner et al.   PLoS Computational Biology

Striatal  5 Nicotinic Receptor Subunit Regulates Dopamine Transmission in Dorsal Striatum

(2012) R. Exley et al.   JOURNAL OF NEUROSCIENCE

Impact of Prefrontal Cortex in Nicotine-Induced Excitation of Ventral Tegmental Area Dopamine Neurons in Anesthetized Rats

(2012) D. Zhang et al.   JOURNAL OF NEUROSCIENCE

Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement

(2012) S Tolu et al.   MOLECULAR PSYCHIATRY

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Reward, Addiction, Withdrawal to Nicotine

(2011) Mariella De Biasi et al.   Annual Review of Neuroscience

Partial agonists for α4β2 nicotinic receptors stimulate dopaminergic neuron firing with relatively enhanced maximal effects

(2011) Ying Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

 4 2 Nicotinic Acetylcholine Receptors on Dopaminergic Neurons Mediate Nicotine Reward and Anxiety Relief

(2011) T. M. McGranahan et al.   JOURNAL OF NEUROSCIENCE

Habenular α5 nicotinic receptor subunit signalling controls nicotine intake

(2011) Christie D. Fowler et al.   NATURE

Habenula “Cholinergic” Neurons Corelease Glutamate and Acetylcholine and Activate Postsynaptic Neurons via Distinct Transmission Modes

(2011) Jing Ren et al.   NEURON

Cholinergic modulation of mesolimbic dopamine function and reward

(2011) Gregory P. Mark et al.   PHYSIOLOGY & BEHAVIOR

M5 Muscarinic Receptors Mediate Striatal Dopamine Activation by Ventral Tegmental Morphine and Pedunculopontine Stimulation in Mice

(2011) Stephan Steidl et al.   PLoS One

Distinct contributions of nicotinic acetylcholine receptor subunit  4 and subunit  6 to the reinforcing effects of nicotine

(2011) R. Exley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double target concept for smoking cessation

(2010) Jie Wu   ACTA PHARMACOLOGICA SINICA

Differential region-specific regulation of α4β2* nAChRs by self-administered and non-contingent nicotine in C57BL/6J mice

(2010) Athanasios Metaxas et al.   ADDICTION BIOLOGY

The pedunculopontine tegmental nucleus: from basic neuroscience to neurosurgical applications

(2010) Edgar Garcia-Rill et al.   JOURNAL OF NEURAL TRANSMISSION

Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

(2009) Henry A. Lester et al.   AAPS Journal

Understanding of nicotinic acetylcholine receptors

(2009) Jie Wu   ACTA PHARMACOLOGICA SINICA

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

(2009) Nancy L. Saccone et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans

(2009) N. L. Saccone et al.   CANCER RESEARCH

Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat

(2009) Hui-Ling Wang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

(2009) Esther H Lips et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The M5muscarinic receptor as possible target for treatment of drug abuse

(2009) R. B. Raffa   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Chronic Nicotine Selectively Enhances  4 2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway

(2009) C. Xiao et al.   JOURNAL OF NEUROSCIENCE

Dopamine Signaling Differences in the Nucleus Accumbens and Dorsal Striatum Exploited by Nicotine

(2009) T. Zhang et al.   JOURNAL OF NEUROSCIENCE

Nicotinic Receptors in the Habenulo-Interpeduncular System Are Necessary for Nicotine Withdrawal in Mice

(2009) R. Salas et al.   JOURNAL OF NEUROSCIENCE

Properties of distinct ventral tegmental area synapses activated via pedunculopontine or ventral tegmental area stimulationin vitro

(2009) Cameron H. Good et al.   JOURNAL OF PHYSIOLOGY-LONDON

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

(2009) L. Zhang et al.   MOLECULAR PHARMACOLOGY

The CHRNA5/A3/B4 Gene Cluster Variability as an Important Determinant of Early Alcohol and Tobacco Initiation in Young Adults

(2008) Isabel R. Schlaepfer et al.   BIOLOGICAL PSYCHIATRY

Cholinergic modulation of midbrain dopaminergic systems

(2008) J. Mena-Segovia et al.   BRAIN RESEARCH REVIEWS

Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal

(2008) Mariella De Biasi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype

(2008) Heather Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons

(2008) Kechun Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking

(2008) W Berrettini et al.   MOLECULAR PSYCHIATRY

In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6∗ Nicotinic Acetylcholine Receptors

(2008) Ryan M. Drenan et al.   NEURON