Review
Chemistry, Organic
Tarek H. El-Assaad, Jayden Zhu, Anjitha Sebastian, Dominic McGrath, Ishita Neogi, Keshaba N. Parida
Summary: Dioxiranes are versatile reagents with mild and selective oxygen transfer properties, capable of various transformations such as oxidations, epoxidations, and C-H hydroxylation. They find wide applications in the synthesis of natural products, drugs, and biomolecules.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Editorial Material
Clinical Neurology
Peter Alfred LeWitt
Summary: Awakenings, written by Oliver Sacks, is a remarkable book that explores the aftermath of encephalitis lethargica and the effects of a new treatment for Parkinson's disease.
Article
Oncology
Di Zhang, Jintao Hu, Zhuojie Liu, Haoyu Wu, HanWen Cheng, Chunhai Li
Summary: This study developed an effective survival prediction model for patients with epithelial sarcoma. Using this nomogram can assist in clinical decision-making with satisfactory accuracy. However, additional external validation is needed.
Review
Oncology
Shijun Xia, Wenjiang Wu, Lijuan Ma
Summary: This case report describes a rare case of proximal-type epithelioid sarcoma of the perineum in a 31-year-old male who underwent wide excision. The disease is characterized by an indetectable early symptom and frequent recurrences. A review of the current literature on the differential diagnosis and management of this disease is also presented.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Elisa Del Savio, Roberta Maestro
Summary: This review summarizes the pathobiology of epithelioid sarcoma, including defects in chromatin remodeling and other signaling pathways, and their role as therapeutic vulnerabilities.
Review
Oncology
Caleb N. Seavey, Ajaybabu V. Pobbati, Brian P. Rubin
Summary: Epithelioid hemangioendothelioma (EHE) is a rare vascular cancer with a unique WWTR1(TAZ)-CAMTA1 gene fusion. Studying this disease can provide insights into how dysregulation of TAZ promotes tumorigenesis and these findings can be applied to other YAP/TAZ-dependent cancers.
Article
Pathology
Laura M. Warmke, Jeanne M. Meis
Summary: Sclerosing epithelioid fibrosarcoma (SEF) is a distinct sarcoma with genetic and behavioral differences compared to low grade fibromyxoid sarcoma (LGFMS). SEF behaves more aggressively than LGFMS with a shorter survival, higher metastatic rate, and a greater propensity to involve deep soft tissue and bone.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Samuel Rasmussen, Jia Xiang Jin, Lissett R. Bickford, Andrew D. Woods, Felix Sahm, Kenneth A. Crawford, Kiyo Nagamori, Hiroaki Goto, Keila E. Torres, Angelo Sidoni, Erin R. Rudzinski, Khin Thway, Robin L. Jones, Alessio Ciulli, Hollis Wright, Melvin Lathara, Ganapati Srinivasa, Kavya Kannan, Paul H. Huang, Thomas G. P. Grunewald, Noah E. Berlow, Charles Keller
Summary: This study used a functional genomics approach to identify key signaling pathway vulnerabilities in EPS patient samples, revealing subtle differences between distal, pediatric/young adult-associated EPS and proximal, adult-associated EPS. These differences highlight the need to approach the two subtypes as molecularly and clinically distinct diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Andrew W. Artenstein
Summary: The first safe and effective vaccine for invasive meningococcal disease was developed 50 years ago, utilizing polysaccharide capsular antigen. Subsequent advancements in vaccine technology led to the development of more effective vaccines against other meningococcus serogroups. These novel vaccines have had a significant global impact on invasive meningococcal disease, paving the way for future vaccine efforts against other infectious threats.
Article
Dentistry, Oral Surgery & Medicine
Chao-ji Shi, Sheng-ming Xu, Chu-wen Li, Zhen Tian, Li-zhen Wang, Yu-hua Hu, Rong-hui Xia, Zhi-yuan Zhang, Jiang Li
Summary: Epithelioid sarcoma in the head and neck region presents more commonly in younger males, has a poor prognosis, and consists of a higher proportion of the classic subtype compared to the proximal subtype. EZH2 inhibitor has therapeutic potential in treating HNES.
Article
Pediatrics
Carrie K. Shapiro-Mendoza, Vincent J. Palusci, Benjamin Hoffman, Erich Batra, Marc Yester, Tracey S. Corey, Mary Ann Sens
Summary: Effective communication and consistent terminology are crucial when dealing with sudden infant deaths, as they help families understand the cause of death and facilitate monitoring trends and developing interventions. Inconsistent terminology can lead to confusion and hinder progress in diagnosing and preventing these tragic events.
Article
Oncology
Simon Haefliger, Olga Chervova, Christopher Davies, Steven Nottley, Steven Hargreaves, Vaiyapuri P. Sumathi, Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephan Beck, Adrienne M. Flanagan, Iben Lyskjaer
Summary: Epithelioid sarcoma is a rare and aggressive tumor characterized by the loss of SMARCB1 expression. Limited research attention and therapeutic options exist for this disease. Methylation profiling helps distinguish epithelioid sarcoma from other tumors, and immunotherapy may be a promising treatment strategy.
JOURNAL OF PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Nathan Pacoureau, Cassandra L. Rigby, Peter M. Kyne, Richard B. Sherley, Henning Winker, John K. Carlson, Sonja V. Fordham, Rodrigo Barreto, Daniel Fernando, Malcolm P. Francis, Rima W. Jabado, Katelyn B. Herman, Kwang-Ming Liu, Andrea D. Marshall, Riley A. Pollom, Evgeny V. Romanov, Colin A. Simpfendorfer, Jamie S. Yin, Holly K. Kindsvater, Nicholas K. Dulvy
Summary: Overfishing is the primary cause of marine defaunation, with global abundance of oceanic sharks and rays declining by 71% since 1970. Three-quarters of the species in this important assemblage are now at risk of extinction. Urgent measures, such as strict fishing prohibitions and science-based catch limits, are needed to prevent further population collapse and promote species recovery.
Article
Oncology
Andrew J. Wagner, Vinod Ravi, Richard F. Riedel, Kristen Ganjoo, Brian A. Van Tine, Rashmi Chugh, Lee Cranmer, Erlinda M. Gordon, Jason L. Hornick, Heng Du, Berta Grigorian, Anita N. Schmid, Shihe Hou, Katherine Harris, David J. Kwiatkowski, Neil P. Desai, Mark A. Dickson
Summary: The study evaluated the efficacy and safety of nab-sirolimus in patients with malignant PEComa, showing an overall response rate of 39% with rapid and durable responses. Patients with TSC2 mutations were more likely to achieve a positive response. nab-sirolimus was considered an important new treatment option for this disease based on response rate, disease control, and safety profile.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Peng Jiang, Yan Jiao, Chun-Yuan Niu, Ya-Hui Liu
Summary: Undifferentiated embryonal sarcoma of the liver (UESL) is a rare form of liver malignancy, with most cases reported in the pediatric population. This case study highlights an extremely uncommon case of UESL with epithelioid features and a very poor prognosis, suggesting that complete intraoperative resection and postoperative adjuvant therapy should be considered to improve the prognosis of adult patients with UESL with epithelioid features.
Article
Surgery
Samer Elsamna, Omar Elkattawy, Aziz M. Merchant
AMERICAN JOURNAL OF SURGERY
(2020)
Article
Surgery
Samer T. Elsamna, Saif Hasan, Michael E. Shapiro, Aziz M. Merchant
Summary: The study identifies independent factors associated with extended length of stay (LOS) after emergency general surgery (EGS), including age, race, cardiopulmonary, hepatic, and renal disease, diabetes, recent weight loss, steroid use, and sepsis history. Factors like age (61+), hypertension, sepsis, cancer, and Black race were found to be significant across all four common EGS procedures.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Neurosciences
Ibraheem S. Shaikh, Samer T. Elsamna, Marco A. Zarbin, Neelakshi Bhagat
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Medicine, Research & Experimental
Samer T. Elsamna, Pooja Suri, Ghayoour S. Mir, Dylan F. Roden, Boris Paskhover
Summary: Thyroid cancer with distant metastasis (TCDM) at diagnosis has worse survival rates compared to localized/regional thyroid cancer. Surgical resection with radiation was found to be a significant predictor of survival for TCDM patients, except for medullary variants. Surgical intervention should be recommended for medically tolerant patients to increase survival.
Article
Otorhinolaryngology
Samer T. Elsamna, Pooja Suri, Ghayoour S. Mir, Dylan F. Roden, Boris Paskhover
Summary: Patients with MetS undergoing thyroidectomy are at significantly increased risk of complications, extended length of stay, medical and surgical complications, and mortality.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Letter
Otorhinolaryngology
Samer T. Elsamna, Pooja Suri, Ghayoour S. Mir, Dylan F. Roden, Boris Paskhover
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Medicine, Research & Experimental
Samer T. Elsamna, Salma Ahsanuddin, Ghayoour S. Mir, Donata Sukyte-Raube, Christina H. Fang, Soly Baredes, Jean Anderson Eloy
Summary: This study evaluated the impact of treatment modality and positive surgical margin (PSM) on survival following resection of sinonasal mucosal melanoma (SNMM). The results suggest that PSM did not show significant improvement in survival compared to no operation, emphasizing the importance of negative surgical margin for SNMM.
Review
Multidisciplinary Sciences
Hael F. Abdulrazeq, Ira M. Goldstein, Samer T. Elsamna, Beth A. Pletcher
Article
Orthopedics
Brianna L. Siracuse, Joseph A. Ippolito, Peter D. Gibson, Pamela A. Ohman-Strickland, Kathleen S. Beebe
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2017)