Article
Chemistry, Multidisciplinary
Michihisa Ueda, Tsubasa Aoki, Takayoshi Akiyama, Takayuki Nakamuro, Keitaro Yamashita, Haruaki Yanagisawa, Osamu Nureki, Masahide Kikkawa, Eiichi Nakamura, Takuzo Aida, Yoshimitsu Itoh
Summary: In this study, a novel nonplanar-core monomer was used for polymerization, resulting in the formation of an alternating heterochiral supramolecular copolymer. The heterochiral copolymer displayed an alternating arrangement of H-bonded and polar p-stacked parts, which was found to be due to the effective cancellation of in-plane dipole moments between two thiophene amide moieties.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Daniele Florio, Concetta Di Natale, Pasqualina Liana Scognamiglio, Marilisa Leone, Sara La Manna, Sarah Di Somma, Paolo Antonio Netti, Anna Maria Malfitano, Daniela Marasco
Summary: Peptide hydrogels, derived from natural protein fragments, have unique advantages in compatibility and low cost, leading to their wide application. Changing the chirality of single amino acids can modulate the self-assembly mechanism. A study on amyloid sequences in the C-terminal domain of NPM1 revealed that structural features of hexapeptides in hydrogels can be finely tuned by introduced chirality.
BIOORGANIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Haitao Hu, Wenbin Dai, Yuhuang Zhang, Yue Huang, Jun Qian, Qiao Jin, Jian Ji, Zhe Tang
Summary: In this study, glutathione-activatable photosensitizer-conjugated nanoassemblies were fabricated using dual supramolecular self-assembly. The nanoassemblies showed unique properties in acidic tumor microenvironment, including charge conversion and enhanced cellular internalization. The research provides an innovative approach to fabricate drug nanocarriers.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Keigo Tashiro, Takuho Saito, Hironari Arima, Natsuki Suda, Balaraman Vedhanarayanan, Shiki Yagai
Summary: Chemists have constructed sophisticated artificial nanostructured systems through self-assembly, including scissor-shaped photochromic dyads that hierarchically self-assemble into discrete nanostructures with photoresponsive properties. These nanostructures, such as azobenzene dyads, can be dissociated and reorganized through the photoisomerization of azobenzene units, enabling controllable and adjustable structures.
Article
Chemistry, Multidisciplinary
Ikuya Matsumoto, Ryo Sekiya, Takeharu Haino
Summary: By decorating nanographenes with alkyl chains and controlling concentration, solvent polarity, temperature, and sonication, it is possible to achieve self-assembly and formation of stacked structures. Optical measurements and AFM images confirm the presence of stacked structures, while molecular mechanics calculations model the interactions within the aggregates. The nanographenes exhibit concentration-dependent morphologies, forming stacked structures at low concentrations and polymer-like network structures at higher concentrations on mica.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medicine, Research & Experimental
Jingjing Wang, Xiaoqiang Zheng, Xiao Fu, Aimin Jiang, Yu Yao, Wangxiao He
Summary: This article introduces a new method for the treatment of metastatic melanoma by using a bifunctional supramolecular peptide HBBplus@CA, which simultaneously inhibits both the Wnt/β-catenin and MAPK/ERK signaling pathways. It effectively suppresses melanoma cell proliferation, migration, and invasion, and inhibits lung metastasis and prolongs survival in a mouse model.
Article
Chemistry, Multidisciplinary
Lei Fang, Rong Huang, Wenqi Gong, Yuanhui Ji, Yanyan Sun, Shaohua Gou, Jian Zhao
Summary: This study proposes an effective approach to improve the electron transfer efficiency of Type-I photosensitizers by self-assembly-induced exciton delocalization. A proof of concept is demonstrated using a perylene diimide-based photosensitizer that can generate singlet oxygen in the monomeric state, but superoxide anion in the aggregated state. The addition of a specific substance can revert the aggregated state back to monomeric state, resulting in the recovery of singlet oxygen generation. The supramolecular nanoparticles derived from this photosensitizer show superior phototherapeutic performance against cancer through synergistic Type-I PDT and mild PTT.
Article
Chemistry, Multidisciplinary
Jian-Cai Liu, Jie-Fei Wang, Qing Han, Ping Shangguan, Lu-Lu Liu, Li-Juan Chen, Jun-Wei Zhao, Carsten Streb, Yu-Fei Song
Summary: The study demonstrates how the aggregation of giant molecular metal oxide superstructures can be driven using organotin and lanthanide cations, with detailed structural analysis. Initial biomedical tests show inhibitory effects of the compound on cancer cell proliferation, indicating potential applications in cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Huyeon Choi, Gaeun Park, Eunhye Shin, Seon Woo Shin, Batakrishna Jana, Seongeon Jin, Sangpil Kim, Huaimin Wang, Sang Kyu Kwak, Bing Xu, Ja-Hyoung Ryu
Summary: Mitochondria-targeting nucleopeptide can sequester ATP by self-assembling, leading to apoptosis of cancer cells.
Review
Chemistry, Multidisciplinary
Jingjing Han, Haoning Gong, Xiaokang Ren, Xuehai Yan
Summary: This article introduces the research field of peptide-based supramolecular nanozymes, emphasizing the importance and versatility of peptides as building blocks, as well as the potential for regulating catalytic performance.
Article
Chemistry, Multidisciplinary
Zongshang Li, Ke Xiao, Qingyun Wan, Rui Tang, Kam-Hung Low, Xiaodong Cui, Chi-Ming Che
Summary: The introduction of multiple kinetic aggregation states (Aggs) into the self-assembly pathway can increase the complexity and flexibility of the self-assemblies. This was achieved by using a series of chiral and achiral d(10) Au-I bis(N-heterocyclic carbene, NHC) complexes, where the achiral complex could undergo self-assembly with multiple kinetic Aggs. The chiral Au-I self-assemblies exhibited nonlinear optical response of second harmonic generation (SHG) and could function as optical waveguides with strong emission polarization, while these properties were absent in the achiral analogue.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sangpil Kim, Batakrishna Jana, Eun Min Go, Ji Eun Lee, Seongeon Jin, Eun-Koung An, Juyoung Hwang, Youjung Sim, Sehee Son, Dohyun Kim, Chaekyu Kim, Jun-O Jin, Sang Kyu Kwak, Ja-Hyoung Ryu
Summary: The study developed an intramitochondrial polymerization-induced self-assembly system for regulating the fate of cancer cells, inducing cell necroptosis by increasing ROS levels. This in situ polymerization system shows great potential for cancer treatment, including drug-resistant cancers.
Article
Chemistry, Multidisciplinary
Sylvain Sudan, Farzaneh Fadaei-Tirani, Rosario Scopelliti, Kristina E. Ebbert, Guido H. Clever, Kay Severin
Summary: Thirteen palladium-ligand assemblies with different structures and topologies were studied for their ability to bind lithium ions. It was found that the addition of LiBF4 caused a significant structural rearrangement in one case, converting a dinuclear [Pd2L4](4+) complex into a low-symmetry [Pd4L8](8+) assembly with two binding pockets for solvated LiBF4 ion pairs. This rearrangement was only induced by Li+, indicating highly specific host-guest interactions. Structural analysis revealed that the [Pd4L8](8+) receptor had a compact structure with multiple intramolecular interactions, similar to natural and synthetic foldamers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Jurgen Schill, Bas J. H. M. Rosier, Berta Gumi Audenis, Eva Magdalena Estirado, Tom F. A. de Greef, Luc Brunsveld
Summary: This study introduces a hybrid DNA origami-based approach for dynamic templating of supramolecular architectures, allowing for selective recruitment of supramolecular polymers to the platform with dynamic tuning of composition. This platform aids in real-time study of supramolecular structures in their native environment and promotes new strategies for controlled multicomponent self-assembly.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Shi-Xin Nie, Teng-Yu Huang, Hao Guo, Li-Xia Wang, Jie Cui, Jun-Feng Xiang, Yu-Fei Ao, De-Xian Wang, Qi-Qiang Wang
Summary: In this study, it was found that xenon can selectively induce a heterochiral assembly as its preferred host even in homochiral structures, with higher binding affinity. Experimental approach and fitting model were developed to obtain binding constants associated with invisible assembly species, which have significant implications for investigating xenon binding.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Jong-Pil Jeon, Yu Jin Kim, Se Hun Joo, Hyuk-Jun Noh, Sang Kyu Kwak, Jong-Beom Baek
Summary: In this study, four benzotrithiophene-based covalent organic frameworks (COFs) with different conjugations were designed and synthesized, and it was found that the degree of conjugation can tune the rate of photocatalytic hydrogen production. The electron affinity and charge trapping of the electron accepting units were identified as the main factors affecting the photocatalytic performance. This research provides important insights for designing efficient photocatalysts using covalent organic frameworks.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Rizky Gilang Kurniawan, Neha Karanwal, Jaeyong Park, Deepak Verma, Sang Kyu Kwak, Seok Ki Kim, Jaehoon Kim
Summary: A Ni-CoOx-Al2O3 catalyst was used to convert furfural to 1,5-pentanediol efficiently. The proximity between Ni-0 and oxygen-vacant CoOx sites facilitated hydrogen adsorption and spillover, enabling catalytic reactions. The catalyst showed high efficiency, low cost, and environmental friendliness.
APPLIED CATALYSIS B-ENVIRONMENT AND ENERGY
(2023)
Article
Chemistry, Physical
Hyo-Geun Kwon, Seung Min Lee, Jehyeon Ryu, Ju Hyun Park, Sang Kyu Kwak, Sang-Wook Kim
Summary: We demonstrated the phase transformation from colloidal Cs3Cu2Cl5 nanocrystals to CsMCl (M = Zn, Bi, Cd) through cation exchange reaction. Cs2ZnCl4, Cs3BiCl6, and CsCdCl3 were successfully synthesized, and the feasibility of phase transformations was confirmed by density functional theory calculations, showing their high thermodynamic stability. The reactivity difference between Zn, Bi, and Cd cations was demonstrated by adjusting reaction temperatures, and the interactions between Cl- and the three cations were considered using chemical softness calculations. Moreover, the thermodynamic stability, estimated by formation energy, played a role in the reactivity of each cation exchange reaction. The addition of Cu cations to Cs2ZnCl4, Cs3BiCl6, and CsCdCl3 solutions resulted in the formation of CsCu2Cl3 instead of Cs3Cu2Cl5, and transmission electron microscopy revealed that nanoparticles were involved in the formation process of CsCu2Cl3 particles.
CHEMISTRY OF MATERIALS
(2023)
Article
Engineering, Environmental
Jun Yong Oh, Eun-Koung An, Batakrishna Jana, Hansol Kim, Seongeon Jin, Gyeongseok Yang, Jinsoo Kim, Eunshil Choi, Jun-O Jin, Ja-Hyoung Ryu
Summary: In order to improve drug delivery with nanoparticles, antibodies are used due to their high affinity to the target site. However, the traditional method of conjugating antibodies to nanoparticles can damage the antibody's ability to recognize its target. This study presents a simple approach to create a targeted delivery platform by coating the nanoparticle surface with a fusion protein consisting of glutathione-S-transferase (GST) and the antibody-binding domain (ABD) called Z domain. The antibody-plugged nanoparticle exhibits excellent stability and target-specific behavior, significantly enhancing drug delivery efficiency in various therapeutic applications both in vitro and in vivo.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Sang Eun Yoon, Yongjin Kim, Hyeongjun Kim, Hyo-Geun Kwon, Unjeong Kim, Sang Yeon Lee, Ju Hyun Park, Hyungtak Seo, Sang Kyu Kwak, Sang-Wook Kim, Jong H. Kim
Summary: The authors achieved metallic properties from semiconducting Cu-Fe-S colloidal nanocrystal (NC) solids through cation exchange method. By efficiently generating charge carriers onto a semiconducting Cu-S NC template via minimal Fe exchange, they realized an unprecedentedly high electrical conductivity. The obtained NC films exhibited metallic behaviour with high electrical conductivity, making them suitable for various optoelectronic devices.
Article
Chemistry, Multidisciplinary
Jun Yong Oh, Eunshil Choi, Batakrishna Jana, Eun Min Go, Eunji Jin, Seongeon Jin, Jinhyu Lee, Jong-hoon Bae, Gyeongseok Yang, Sang Kyu Kwak, Wonyoung Choe, Ja-Hyoung Ryu
Summary: In this study, protein corona-blocked Zr-6-based MOF (PCN-224) nanoparticles are used for targeted cancer therapy. The PCN-224 surface is precoated with GST-fused targetable affibody (GST-Afb) proteins to prevent unwanted interactions with external proteins. The effectiveness of the particles in inducing cell death in cancer cells is demonstrated both in vitro and in vivo using two different affibodies targeting HER2 and EGFR receptors. This study provides insights into regulating the protein-adhesive surface of MOF nanoparticles for the design of more effective targeted delivery systems.
Article
Nanoscience & Nanotechnology
Youjung Sim, Junmo Seong, Seonghwan Lee, Dohyun Kim, Eunshil Choi, Myoung Soo Lah, Ja-Hyoung Ryu
Summary: The integration of catalase (CAT) into metal-organic framework (MOF) nanoparticles (NPs) through supramolecular interactions enhances its cellular entry and improves the effectiveness of photodynamic therapy (PDT). This study demonstrates the potential of the protein-MOF integration strategy in overcoming tumor hypoxia and efficiently delivering biomolecular cargos.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Gyeongseok Yang, Sangpil Kim, Jun Yong Oh, Dohyun Kim, Seongeon Jin, Eunshil Choi, Ja-Hyoung Ryu
Summary: In this paper, a strategy for targeted delivery and controlled drug release using disulfide-incorporated mesoporous organosilica nanoparticles (MONs) was presented. The MONs were loaded with the chemodrug doxorubicin (DOX) and conjugated with a cell-specific affibody (Afb) fused with glutathione-S-transferase (GST). The particles exhibited prompt responsivity to the SS bond-dissociating glutathione (GSH), resulting in significant degradation of the particles and release of DOX, thereby enhancing cancer-therapeutic outcomes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Multidisciplinary Sciences
Jung-Hui Kim, Kyung Min Lee, Ji Won Kim, Seong Hyeon Kweon, Hyun-Seok Moon, Taeeun Yim, Sang Kyu Kwak, Sang-Young Lee
Summary: In this study, a new cationic semi-interpenetrating polymer network (c-IPN) binder is proposed to regulate electrostatic phenomena and improve the performance of high-capacity positive electrodes for Li metal batteries. The c-IPN binder suppresses crack evolution and improves the dispersion state of electrode components by surface charge-driven electrostatic repulsion and mechanical toughness. It also immobilizes anions of liquid electrolytes inside the electrodes via electrostatic attraction, facilitating Li+ conduction and forming stable cathode-electrolyte interphases.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Hoai Thu Luong, Ja Won Kim, Jiyun Lee, Yi Young Kang, Yumi Cho, Jae-Won Ka, Sang Kyu Kwak, Ji-Hoon Lee
Summary: Artificial materials with negative dispersion play a crucial role in the development of geometric phase retarders, compensation films, and augmented reality. However, there is still a lack of reported negative dispersion materials and a clear understanding of the correlation between dispersion and molecular structure. In this study, new H-shaped reactive molecules with different structures were synthesized, demonstrating an early conversion from positive to negative dispersion. The experimental and theoretical investigations revealed that the molecular structure affects the dispersion of retardation through molecular orientation and refractive index dispersion.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Chemistry, Physical
Hyungsu Jang, Hyeong Yong Lim, Chan Beom Park, Jongdeuk Seo, Jung Geon Son, Taehee Song, Jaehwi Lee, Yun Seop Shin, Jina Roe, Sang Kyu Kwak, Dong Suk Kim, Jin Young Kim
Summary: In this study, Zn metal powder and Zn2+ were introduced to reduce Sn oxidation and decrease the intrinsic defects and lattice strain of Sn-based perovskite films. This led to improved efficiency of the perovskite solar cell.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Nayeong Jeon, In -Ho Jeong, Eunyeong Cho, Ilhyung Choi, Jiyeon Lee, Eun Hee Han, Hee Jung Lee, Peter C. W. Lee, Eunji Lee
Summary: Psychro-philic organisms produce Ice-binding proteins (IBPs) for survival in subzero conditions, and the interaction of IBPs with ice and water is critical for their freeze avoidance. Metal-organic frameworks (MOFs) can offer periodically ordered ice-binding sites and were used as cryoprotectants in this study. The study provides a strategy for the fabrication of low-cost, high-volume antifreeze nanoagents with potential applications in organ transplantation, cord blood storage, and vaccines/drugs.
Article
Chemistry, Multidisciplinary
Eun Seong Choi, Sangpil Kim, Dohyun Kim, Eunshil Choi, Ja-Hyoung Ryu
Summary: This study presents a nanogel system for co-delivery of an anticancer drug and mitochondria-targeting monomer, which can cooperatively activate cell death mechanisms and enhance cancer therapy.
Article
Chemistry, Multidisciplinary
Hosoowi Lee, Minhyeong Lee, Jun Ho Hwang, Inhye Kim, Eunji Lee, Woo-Dong Jang
Summary: Porphyrin dyads (PDMs) composed of diphenylporphyrin and tetraphenylporphyrin units, designated as DPDMs and TPDMs, respectively, exhibited remarkable differences in molecular assemblies depending on the coordination metal ion. Furthermore, TPDMs showed self-sorting behavior through the recognition of atomic-level difference during the formation of supramolecular assemblies.
Article
Chemistry, Multidisciplinary
Sangpil Kim, Huyeon Choi, Seongeon Jin, Sehee Son, Yeji Lee, Kibeom Kim, Ja-Hyoung Ryu
Summary: Self-assembly is a process of constructing three-dimensional structures through non-covalent interactions between building blocks of different sizes. It has attracted attention in cancer treatment due to its advantages in targeted therapy and overcoming the side effects of traditional chemotherapy. However, precise control of self-assembly in intracellular environments is challenging, prompting researchers to focus on self-assembly inside cellular organelles.