Hormonal Modulation of Dendritic Cells Differentiation, Maturation and Function: Implications for the Initiation and Progress of Systemic Autoimmunity

Gestational Hypothyroidism Improves the Ability of the Female Offspring to ClearStreptococcus pneumoniaeInfection and to Recover From Pneumococcal Pneumonia

(2016) Pamela A. Nieto et al.   ENDOCRINOLOGY

What's new in estrogen receptor action in the female reproductive tract

(2016) Sylvia C Hewitt et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases

(2016) Deena Khan et al.   Frontiers in Immunology

Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus

(2015) Sarah A Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of subcutaneous tabalumab in patients with systemic lupus erythematosus: results from ILLUMINATE-1, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study

(2015) D A Isenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Altered IgG autoantibody levels and CD4+T cell subsets in lupus-proneNba2mice lacking the nuclear progesterone receptor

(2015) Alan H. Wong et al.   AUTOIMMUNITY

Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases

(2015) Juan Pablo Mackern-Oberti et al.   AUTOIMMUNITY REVIEWS

Estrogen receptors regulate innate immune cells and signaling pathways

(2015) Susan Kovats   CELLULAR IMMUNOLOGY

Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function

(2015) Hai Jing Wu et al.   CLINICAL IMMUNOLOGY

Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice

(2015) Shayla D. Yoachim et al.   CLINICAL IMMUNOLOGY

Glucocorticoid receptor genetic polymorphisms is associated with improvement of health-related quality of life in Chinese population with systemic lupus erythematosus

(2015) Yan-Feng Zou et al.   CLINICAL RHEUMATOLOGY

Medroxyprogesterone acetate impairs human dendritic cell activation and function

(2015) N.E. Quispe Calla et al.   HUMAN REPRODUCTION

17β-Estradiol influences in vitro response of aged rat splenic conventional dendritic cells to TLR4 and TLR7/8 agonists in an agonist specific manner

(2015) Zorica Stojić-Vukanić et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Estrogen Receptor α Deficiency Modulates TLR Ligand–Mediated PDC-TREM Expression in Plasmacytoid Dendritic Cells in Lupus-Prone Mice

(2015) Jennifer L. Scott et al.   JOURNAL OF IMMUNOLOGY

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1

(2015) Vasiliki Pelekanou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

(2015) James Bentham et al.   NATURE GENETICS

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis

(2015) Caiyi C. Li et al.   PLOS BIOLOGY

Estrogen Receptor Alpha Modulates Mesangial Cell Responses to Toll-Like Receptor Ligands

(2014) John Svenson et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Rituximab versus an alternative TNF inhibitor in patients with rheumatoid arthritis who failed to respond to a single previous TNF inhibitor: SWITCH-RA, a global, observational, comparative effectiveness study

(2014) P Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Upregulation of TLR2 expression is induced by estrogen via an estrogen-response element (ERE)

(2014) Xi Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Estrogen modulation of endosome-associated toll-like receptor 8: An IFNα-independent mechanism of sex-bias in systemic lupus erythematosus

(2014) Nicholas A. Young et al.   CLINICAL IMMUNOLOGY

Estrogen Receptor  , but Not  , Is Required for Optimal Dendritic Cell Differentiation and CD40-Induced Cytokine Production

(2014) V. Douin-Echinard et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Progesterone Regulates IFN-  Production by Plasmacytoid Dendritic Cells

(2014) G. C. Hughes et al.   JOURNAL OF IMMUNOLOGY

Estradiol Acts Directly on Bone Marrow Myeloid Progenitors to Differentially Regulate GM-CSF or Flt3 Ligand-Mediated Dendritic Cell Differentiation

(2014) E. Carreras et al.   JOURNAL OF IMMUNOLOGY

17 -Estradiol Alters the Activity of Conventional and IFN-Producing Killer Dendritic Cells

(2014) M. C. Siracusa et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Self-Antigen Controls the Balance between Effector and Regulatory T Cells in Peripheral Tissues

(2014) I. K. Gratz et al.   JOURNAL OF IMMUNOLOGY

X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women

(2014) Sophie Laffont et al.   JOURNAL OF IMMUNOLOGY

The BAFF/APRIL system in SLE pathogenesis

(2014) Fabien B. Vincent et al.   Nature Reviews Rheumatology

Association study of glucocorticoid receptor genetic polymorphisms with efficacy of glucocorticoids in systemic lupus erythematosus: A prospective cohort study

(2013) Yan-Feng Zou et al.   AUTOIMMUNITY

Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity

(2013) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

Glucocorticoid receptor translational isoforms underlie maturational stage-specific glucocorticoid sensitivities of dendritic cells in mice and humans

(2013) Y. Cao et al.   BLOOD

Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis

(2013) Jun-Ho Lee et al.   CARDIOVASCULAR RESEARCH

Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease

(2013) Maria Victoria Legorreta-Haquet et al.   Clinical & Developmental Immunology

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release

(2013) Oliver Brain et al.   IMMUNITY

Interview: Immunoregulatory dendritic cells to treat autoimmunity are ready for the clinic

(2013) Nick Giannoukakis   Immunotherapy

Autoantibody Induction by DNA-Containing Immune Complexes Requires HMGB1 with the TLR2/MicroRNA-155 Pathway

(2013) Z. Wen et al.   JOURNAL OF IMMUNOLOGY

Estradiol Promotes Functional Responses in Inflammatory and Steady-State Dendritic Cells through Differential Requirement for Activation Function-1 of Estrogen Receptor  

(2013) C. Seillet et al.   JOURNAL OF IMMUNOLOGY

Belimumab for Systemic Lupus Erythematosus

(2013) Bevra Hannahs Hahn   NEW ENGLAND JOURNAL OF MEDICINE

Targeting CD28, CTLA-4 and PD-L1 Costimulation Differentially Controls Immune Synapses and Function of Human Regulatory and Conventional T-Cells

(2013) Nahzli Dilek et al.   PLoS One

Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring

(2013) Eduardo A. Albornoz et al.   THYROID

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

(2012) Yvonne Döring et al.   CIRCULATION

Prolactin rescues and primes autoreactive B cells directly and indirectly through dendritic cells in B6.Sle3mice

(2012) J. Gonzalez et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Estrogen receptor alpha modulates toll-like receptor signaling in murine lupus

(2012) Melissa A. Cunningham et al.   CLINICAL IMMUNOLOGY

Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: Mechanisms and implications for immunity

(2012) Susan Kovats   HORMONES AND BEHAVIOR

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

(2012) Nir Yogev et al.   IMMUNITY

Murine BAFF expression is up-regulated by estrogen and interferons: Implications for sex bias in the development of autoimmunity

(2012) Ravichandran Panchanathan et al.   MOLECULAR IMMUNOLOGY

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

B-cell depletion in the treatment of lupus nephritis

(2012) Jon W. Gregersen et al.   Nature Reviews Nephrology

17β-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner

(2011) Hao Xie et al.   ARTHRITIS AND RHEUMATISM

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor   signaling

(2011) C. Seillet et al.   BLOOD

Genetic and Pharmacological Modulation of Dendritic Cell-T Cell Interactions as a Therapeutic Strategy for Systemic Lupus Erythematosus

(2011) Carolina Llanos et al.   CURRENT GENE THERAPY

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Estriol Generates Tolerogenic Dendritic Cells In Vivo That Protect against Autoimmunity

(2011) T. L. Papenfuss et al.   JOURNAL OF IMMUNOLOGY

A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus

(2011) Xiaobing Luo et al.   PLoS Genetics

Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner

(2010) Zheng Liu et al.   ARTHRITIS AND RHEUMATISM

Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70

(2010) J. Shaw et al.   BLOOD

Virulence Mechanisms Displayed by Salmonella to Impair Dendritic Cell Function

(2010) S. Bueno et al.   CURRENT MEDICINAL CHEMISTRY

Regulation of specific target genes and biological responses by estrogen receptor subtype agonists

(2010) Dale C Leitman et al.   CURRENT OPINION IN PHARMACOLOGY

Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease

(2010) Sienmi Du et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cells in Lupus Are Not Required for Activation of T and B Cells but Promote Their Expansion, Resulting in Tissue Damage

(2010) Lino L. Teichmann et al.   IMMUNITY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Toll-Like Receptors, Tissue Injury, and Tumourigenesis

(2010) Savvas Ioannou et al.   MEDIATORS OF INFLAMMATION

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW mice

(2009) Grant C. Hughes et al.   ARTHRITIS AND RHEUMATISM

Induction of Treg by monocyte-derived DC modulated by vitamin D3or dexamethasone: Differential role for PD-L1

(2009) Wendy W. J. Unger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fcγ receptors and costimulatory molecules on dendritic cells

(2009) Leandro J. Carreño et al.   IMMUNOLOGY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Direct B cell stimulation by dendritic cells in a mouse model of lupus

(2008) Suigui Wan et al.   ARTHRITIS AND RHEUMATISM

Estrogen inhibits dendritic cell maturation to RNA viruses

(2008) M. M. Escribese et al.   BLOOD

Activating and inhibitory Fcγ receptors can differentially modulate T cell-mediated autoimmunity

(2008) Mirentxu I. Iruretagoyena et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibitory effects of progesterone differ in dendritic cells from female and male rodents

(2008) Cherié L. Butts et al.   Gender Medicine

Estrogen receptor-α deficiency attenuates autoimmune disease in (NZB × NZW)F1 mice

(2008) K K Bynoté et al.   GENES AND IMMUNITY

Estrogen Modulates Bone Marrow-Derived DCs in SLE Murine Model-(NZB × NZW) F1 Female Mice

(2008) Bo Jiang et al.   IMMUNOLOGICAL INVESTIGATIONS

Development of TLR inhibitors for the treatment of autoimmune diseases

(2008) Franck J. Barrat et al.   IMMUNOLOGICAL REVIEWS

PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon

(2008) H. Watarai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1

(2008) N. Mozaffarian et al.   RHEUMATOLOGY

Engagement of NOD2 has a dual effect on proIL-1β mRNA transcription and secretion of bioactive IL-1β

(2007) Gerben Ferwerda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY