Journal
METABOLITES
Volume 9, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/metabo9070128
Keywords
metabolomics; visualizations; clinical outcomes research; epidemiology
Categories
Funding
- National Institutes of Health [T32-ES007142, K01-HL135342, K01-DK116917, N01-HC-25195, HHSN268201500001I, R01-HL134168, R01-HL143227, R01-ES027595]
- Emil Aaltonen Foundation
- Finnish Medical Foundation
- Paavo Nurmi Foundation
- Frontiers of Innovation Scholars Program
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To assist with management and interpretation of human metabolomics data, which are rapidly increasing in quantity and complexity, we need better visualization tools. Using a dataset of several hundred metabolite measures profiled in a cohort of similar to 1500 individuals sampled from a population-based community study, we performed association analyses with eight demographic and clinical traits and outcomes. We compared frequently used existing graphical approaches with a novel ` rain plot' approach to display the results of these analyses. The ` rain plot' combines features of a raindrop plot and a conventional heatmap to convey results of multiple association analyses. A rain plot can simultaneously indicate e ff ect size, directionality, and statistical significance of associations between metabolites and several traits. This approach enables visual comparison features of all metabolites examined with a given trait. The rain plot extends prior approaches and o ff ers complementary information for data interpretation. Additional work is needed in data visualizations for metabolomics to assist investigators in the process of understanding and convey large-scale analysis results e ff ectively, feasibly, and practically.
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