Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

Inborn errors of coenzyme A metabolism and neurodegeneration

(2018) Ivano Di Meo et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia

(2017) Jingshu Xu et al.   Metallomics

Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection

(2017) Yevgeniya Shurubor et al.   MOLECULES

Brain urea increase is an early Huntington’s disease pathogenic event observed in a prodromal transgenic sheep model and HD cases

(2017) Renee R. Handley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological and transcriptomic characteristics of the aged brain

(2017) Jeremy A Miller et al.   eLife

Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease

(2017) Véronique Gaura et al.   JAMA Neurology

Vitamin B1 (thiamine) and dementia

(2016) Gary E. Gibson et al.   Annals of the New York Academy of Sciences

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain

(2016) Stefano Patassini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder

(2016) Jingshu Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The societal cost of Huntington's disease: are we underestimating the burden?

(2016) C. Jones et al.   EUROPEAN JOURNAL OF NEUROLOGY

Current status of PET imaging in Huntington’s disease

(2016) Gennaro Pagano et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Mutations in SLC5A6 associated with brain, immune, bone, and intestinal dysfunction in a young child

(2016) Veedamali S. Subramanian et al.   HUMAN GENETICS

Metabolomics studies in brain tissue: A review

(2016) Carolina Gonzalez-Riano et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review

(2016) David Kennedy   Nutrients

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington’s Disease Patients

(2016) Nima N. Naseri et al.   PLoS One

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease

(2015) Stefano Patassini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Major involvement of Na+-dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells

(2015) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Abnormalities in the Tricarboxylic Acid Cycle in Huntington Disease and in a Huntington Disease Mouse Model

(2015) Nima N. Naseri et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Treating the whole body in Huntington's disease

(2015) Jeffrey B Carroll et al.   LANCET NEUROLOGY

Evidence of Extensive Alternative Splicing in Post Mortem Human Brain HTT Transcription by mRNA Sequencing

(2015) Adam T. Labadorf et al.   PLoS One

Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals

(2014) Robert Clarke et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Defective pantothenate metabolism and neurodegeneration

(2014) Susan J. Hayflick   BIOCHEMICAL SOCIETY TRANSACTIONS

Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes: Table 1

(2014) Paola Venco et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Brain Region Mapping Using Global Metabolomics

(2014) Julijana Ivanisevic et al.   CHEMISTRY & BIOLOGY

Discovery of essential fatty acids

(2014) Arthur A. Spector et al.   JOURNAL OF LIPID RESEARCH

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Preanalytical Aspects and Sample Quality Assessment in Metabolomics Studies of Human Blood

(2013) P. Yin et al.   CLINICAL CHEMISTRY

Alkylsilyl derivatives for gas chromatography

(2013) Colin F. Poole   JOURNAL OF CHROMATOGRAPHY A

Metabolic network as a progression biomarker of premanifest Huntington’s disease

(2013) Chris C. Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption

(2012) Abhisek Ghosal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

(2011) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Neuroacanthocytosis Syndromes

(2011) Hans H Jung et al.   Orphanet Journal of Rare Diseases

Rapid metabolic evolution in human prefrontal cortex

(2011) X. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

(2010) Ruben t’Kindt et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Recommendations for Biomarker Identification and Qualification in Clinical Proteomics

(2010) H. Mischak et al.   Science Translational Medicine

Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

(2009) Paul Begley et al.   ANALYTICAL CHEMISTRY

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

(2009) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Comprehensive profiling of the human circulating endocannabinoid metabolome: clinical sampling and sample storage parameters

(2008) JodiAnne T. Wood et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning1H NMR

(2008) Kirstie S. Opstad et al.   NMR IN BIOMEDICINE