Article
Pharmacology & Pharmacy
Chotima Seripracharat, Chomdao Sinthuvanich, Thitinun Karpkird
Summary: In this study, an inclusion complex of cationic beta-cyclodextrins and adamantane conjugated poly (vinyl alcohol) was successfully designed and synthesized as a siRNA carrier. The nanoparticles formed by this complex and siRNA showed efficient gene knockdown in vitro, indicating its potential as a siRNA delivery system.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Ke Li, Guangsen Fan, Huafeng Tian, Li Yuan, Yuanyuan Yao, Aimin Xiang, Xiaogang Luo
Summary: By using ethylene glycol as a plasticizer, controlling the stretching temperature and draw ratio can significantly improve the mechanical properties of PVA films, making them have better processing performance and enhanced properties.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Polymer Science
Muhammad Suhail, Yi-Han Hsieh, Arshad Khan, Muhammad Usman Minhas, Pao-Chu Wu
Summary: A new type of aspartic acid/alginic acid-co-poly(acrylic acid) hydrogels was developed for the controlled delivery of ibuprofen, exhibiting pH-dependent swelling and drug release properties. Various analytical techniques confirmed the structural properties and stability of the hydrogels.
Article
Chemistry, Multidisciplinary
Oudong Hu, Jing Lu, Guoqi Chen, Kai Chen, Jianfeng Gu, Sen Weng, Linxi Hou, Xi Zhang, Xiancai Jiang
Summary: A hydrogel electrolyte with good flexibility and strong ion transport ability is ideal for flexible energy storage equipment. However, traditional hydrogel electrolytes have limitations such as being unable to be reshaped after forming and reused after dehydration. The new PVA/SA/PEG organohydrogel electrolyte shows great potential with improved recyclability, self-healing ability, and low-temperature resistance, making it a promising candidate for next-generation flexible energy storage devices.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Arn Mignon, Tom Gheysens, Sander Walraet, Pieter Tack, Petra Rigole, Tom Coenye, Laszlo Vincze, Sandra Van Vlierberghe, Peter Dubruel
Summary: Infections are still a major cause of morbidity in burn wounds. Complexing iodine in acrylate-endcapped urethane-based poly(ethylene glycol) (AUP) polymers with or without poly(vinyl pyrrolidone) (PVP) leads to antimicrobial wound dressings with superior swelling and mechanical strength than commercial wound dressings, holding potential for future application in treating infected wounds.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Zishuo Ye, Hailin Lu, Guiquan Chai, Changlei Wu, Jian Chen, Leifeng Lv
Summary: In this study, a PVA/PEG-glycerol composite hydrogel was successfully synthesized and demonstrated suitable mechanical properties and good biocompatibility. The hydrogel with 20 wt% glycerol plasticizer achieved a tensile strength of 26.6 MPa at fracture, meeting the requirements of natural cartilage. Furthermore, the composite gel showed excellent self-healing ability and lubricating properties.
POLYMER INTERNATIONAL
(2023)
Article
Chemistry, Physical
Jinlong Cao, Xiaowen Zhao, Lin Ye
Summary: In this work, a self-healing PVA-based hydrogel was fabricated by grafting benzaldehyde groups onto a PVA molecular chain and forming reversible imine bonds with amine groups on a quaternized chitosan chain. The hydrogel showed high healing efficiency, rapid recovery, and dynamic features. It has great potential application in biomedical fields such as smart infill biomaterials and tissue engineering scaffolds.
Article
Biochemistry & Molecular Biology
Martyna Zagorska-Dziok, Patrycja Kleczkowska, Ewa Oledzka, Ramona Figat, Marcin Sobczak
Summary: Polymeric hydrogels play an increasingly important role in medicine, pharmacy, and cosmetology due to their favorable physicochemical properties and biocompatibility. This study synthesized new poly(chitosan-ester-ether-urethane) hydrogels and studied the kinetic release of genistein from these biomaterials. The developed hydrogels show non-toxicity to skin cells and a relatively highly controlled release profile of genistein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Ja-Rok Kim, Sung-Ho Woo, You-Lim Son, Jae-Ryong Kim, Rajeswari M. Kasi, Seong-Cheol Kim
Summary: A new three-step strategy has been developed to increase both the mechanical strength and swelling ratio of hydrogels. By cross-linking PAAm with PVA, obtaining a dual network through acid treatment and drying, and converting cross-linked PAAm into polyelectrolyte in the dual network, the hydrogel achieves excellent mechanical properties and remarkable swelling, allowing for anisotropic swelling through simple stretching.
Review
Pharmacology & Pharmacy
Jagadeeshwar Kodavaty
Summary: Hydrogels with high water content are potential biomaterials that resemble the human body. Both natural and synthetic polymers have been suggested for use as biomaterials, with natural polymers having excellent biocompatibility but poor mechanical properties, while synthetic polymers have better mechanical properties but poorer biodegradability. By combining synthetic and natural polymers, hydrogels with moderate mechanical properties and good biodegradability can be achieved. Rheological properties can provide important clues about the viscoelasticity and strength of hydrogels. This review focuses on hydrogels made of polysaccharides and synthetic polymers, particularly polyvinyl alcohol and hyaluronic acid, discussing their applications and rheological properties in recent research.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Andrew Chung, Burak Tavsanli, Elizabeth R. Gillies
Summary: Hydrogels have diverse applications, and OPF has attracted attention for its tunable degradation. By introducing protected amines into OPF, the degradation rate can be controlled by triggering the cleavage of the polymer backbone. This approach can be applied to other stimuli, providing a versatile method to control OPF degradation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Chemical
Sania Kadanyo, Nozipho N. Gumbi, Christine N. Matindi, Derrick S. Dlamini, Yunxia Hu, Zhenyu Cui, Hong Wang, Mengyang Hu, Jianxin Li
Summary: In this study, hydrophilic poly (ethylene-co-vinyl alcohol) (EVOH) and hydrophobic polysulfone (PSF) were blended together using polyethylene glycol (PEG) as a hydrophilic additive and compatibilizer, which resulted in ultrafiltration (UF) membranes with high porosity and antifouling properties. The optimal PEG content for blending with PSF/EVOH was found to be 20 wt%. The blended membranes exhibited improved miscibility, pure water permeance, and antifouling properties, making them suitable for wastewater treatment.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Polymer Science
Denitsa Nikolova, Christo Tzachev, Lachezar Christov, Elena Vassileva
Summary: The study presents the development of novel hydrogels for the delivery of timolol maleate (TM) in contact lenses. The copolymer networks showed different swelling kinetics depending on the composition, with VP hydrophilicity and SB physical network playing important roles. The loading efficiency of TM slightly increased with an increase in VP monomeric units, while the release of TM was prolonged with an increase in SB monomeric units. The transparency of the hydrogels was also studied, showing their potential as materials for soft contact lenses.
Article
Pharmacology & Pharmacy
Irina Mihaela Pelin, Mihaela Silion, Irina Popescu, Cristina Mihaela Rimbu, Gheorghe Fundueanu, Marieta Constantin
Summary: This study prepared pullulan/poly (vinyl alcohol) (P/PVA) hydrogels using an eco-friendly method, and loaded them with hydroalcoholic extract of Calendula officinalis. The hydrogels exhibited high loading efficiency and showed high antioxidant and antibacterial activity, while being non-toxic to human cells.
Article
Biochemistry & Molecular Biology
Eva Mueller, Fei Xu, Todd Hoare
Summary: This study demonstrates the 3D printing of hydrazone-crosslinked POEGMA hydrogels using the FRESH technique and a low-cost extrusion bioprinter. The dynamic nature of the hydrazone cross-links allows for the reconfiguration of the gel structure and maintains the degradability of the scaffold. Moreover, the POEGMA hydrogels support cell adhesion and viability.
